Healthy Food Broccoli's Sulforaphane (SFN) Blocks the Onset of Diabetic Cardiomyopathy in Diabetes

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

Diabetic complications are any diseases associated with hyperglycemia if the blood glucose is not managed properly. Patients with diabetes may induce a number of complications including cardiovascular disease, neuropathy, nephropathy, retinopathy, and foot ulcer.

Cardiomyopathy is a disease associated with heart muscle, leading to reduce functions of the heart to pump blood to the rest of the body.


Diabetic cardiomyopathy is a complication found in patients with diabetes associated with reducing the heart function in circulating blood through the body, leading to heart failure and increased accumulation of fluid in the lungs.

Diabetic cardiomyopathy is classified into different types, depending on the damage that has been affected, including
* Microangiopathy is a disorder that affects small blood vessels, leading to impaired myocardial blood flow reserve.

* Autonomic neuropathy is a disorder that affects the nerves that manage everyday body functions, leading to abnormal blood pressure, heart rate.

* Endothelial dysfunction is a disorder associated with the damage of vascular endothelium. The condition is considered an early event of cardiovascular disease.

The most common causes of diabetic cardiomyopathy are myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of diabetic complications, researchers examined the effect of sulforaphane (SFN) on T2DM-induced cardiac lipid accumulation and subsequent cardiomyopathy.

The study included male C57BL/6J mice fed a high-fat diet for 3months to induce insulin resistance, followed by treatment with 100mg/kg body-weight streptozotocin to induce hyperglycemia as the T2DM mouse model compared to age-matched mice fed a normal diet as control.

According to the tested analysis,
* SFN treatment significantly attenuated cardiac remodeling and dysfunction induced by T2DM.

* SFN treatment also significantly inhibited cardiac lipid accumulation, measured by Oil Red O staining, and improved cardiac inflammation oxidative stress and fibrosis, shown by down-regulating diabetes-induced PAI-1, TNF-α, CTGF, TGF-β, 3-NT, and 4-HNE expression involved in oxidation.

* SFN upregulated the expression of the gene associated with the promotion of antioxidant enzyme and decreased the expression in enhancing the initiation of oxidative stress.


* SFN also reversed diabetes-induced inhibition of LKB1/AMPK and its downstream targets associated with the regulation of lipid, cholesterol and glucose metabolism.

Based on the results, researchers wrote, " SFN treatment to T2DM mice may attenuate the cardiac oxidative stress-induced inhibition of LKB1/AMPK signaling pathway, thereby preventing T2DM-induced lipotoxicity and cardiomyopathy".

Taken altogether, broccoli processed abundantly SFN may be considered supplements for the prevention of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane prevents the development of cardiomyopathy in type 2 diabetic mice probably by reversing oxidative stress-induced inhibition of LKB1/AMPK pathway by Zhang Z1, Wang S1, Zhou S1, Yan X2, Wang Y1, Chen J3, Mellen N3, Kong M4, Gu J5, Tan Y2, Zheng Y6, Cai L. (PubMed)

Ginger, the Potential Anti-Septic Functional Remedy, Scientists Show

Sepsis is a medical condition caused by the body over-response to infection by releasing a large number of chemicals into the bloodstream, leading to chemicals imbalance that can damage multiple organ systems.

The most common sites of infection leading to sepsis are found in older patients with the lungs, urinary tract, tummy (abdomen), and pelvis.

The causes of sepsis, in most cases, are involved in people with a weakened immune system or a severe infection that allows the inflammation to spread to the entire body.

Sepsis can be life-threatening due to the interruption of blood flow to the body caused by inflammation in the induction of blood vessel constriction.

The risk factors of sepsis include any medical conditions which can lead to a weakened immune system, such as AIDs and chemotherapy, the very young (immature immune system) and old (weakened immune system due to aging), pregnancy and diabetes.

The most common symptoms of sepsis are associated with symptoms of reduced blood flow, including, a decrease in mental ability, problems breathing. abnormal heart functions, fall blood pressure, fall in body temperature. unconsciousness.

If your child or yourself experience some of the above symptoms, please call the emergency services right the way.

Some researchers suggested that people who are obese may have a negative implication on the immune system in fighting against infection that can cause sepsis.


Dr. A S Kolyva, the lead scientists said, "Sepsis is one of the most important causes of mortality in the developed world, where almost two-thirds of the population suffer from obesity".

And, "Obesity is associated with elevated TNFα adipose tissue production and increased oxidative stress biomarkers, promoting the proinflammatory response in septic patients".

These results strongly suggested that obesity may induce overexpression of proinflammatory cytokines that not only initiates the onset of sepsis and also increases the potential negative impact on the outcome.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural compound or food for the treatment of sepsis, researchers investigated the effects of a phenolic alkenone isolated from ginger in various pharmacological activities, including sepsis.

Injection of ginger exerted a modulatory effect on HMGB1-mediated septic responses and survival rate in a mouse model of sepsis.

The modulation of ginger was attributed to the suppression of the production of the inflammatory cytokines such as TNF-α and IL-6 and the activation of proteins associated with inflammation induced by HMGB.

High mobility group box 1 (HMGB1) is a protein associated with the immune protective response by restoring the endothelial cells which line the interior surface of blood vessels and lymphatic vessel integrity.

Furthermore, injection of ginger also inhibited HMGB1-mediated hyperpermeability and leukocyte migration in the initiation of inflammation in mice.

Moreover, in vivo, ginger inhibited the lymphopoiesis (CLP) in stimulating the production of the release of HMGB1, sepsis-related mortality, and tissue injury.

In order to reveal more information about ginger antisepsis activity, researchers examined zingerone (ZGR), a bioactive compound isolated from ginger on TGFBIp-mediated septic responses.

Similar to that of the above, ZGR reduced the TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice.

Injection of ZGR suppressed TGFBIp-induced sepsis lethality and pulmonary injury.

Dr. Min G, the lead scientist, after taking into account co and confounders wrote in the final report, "ZGR could be a potential therapeutic agent for the treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway".

Taken altogether, ginger may be considered a functional remedy for the treatment of sepsis, pending to the confirmation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Zingerone reduces HMGB1-mediated septic responses and improves survival in septic mice by Lee W1, Ku SK2, Bae JS. (PubMed)
(2) Suppressive effects of zingerone on TGFBIp-mediated septic responses by Min G1, Ku SK2, Lee T3, Bae JS4. (PubMed)
(3) The role of obesity in the immune response during sepsis by A S Kolyva,1 V Zolota,2 D Mpatsoulis,2 G Skroubis,3 E E Solomou,4 I G Habeos,5S F Assimakopoulos,1 N Goutzourelas,6 D Kouretas,6 and C A Gogos. (PMC).

Coffee and Coffee caffeine A Potent Depressive Beverage?

Epidemiological studies do not agree that coffee and coffee caffeine has a positive effect on reduced depression, a review literature study suggested.

Coffee, second to green tea, is a popular and social beverage all over the world, particularly in the West, made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Depression is a normal neuro response as part of our daily lives such as the loss of s job, the death of a loved one, and illness.
Over 30 million Americans suffer from depression and the amounts are increasing in an alarming rate.

According to the University of Naples Federico II, over 2 decades, many studies addressed the concerns of coffee intake may have an implication of incidence of depression, but several phytochemical studies indicated a different outcome as caffeine and certain major phyto constituents exhibited antidepressant effects through multiple molecular mechanisms.

Dr. Tenore GC, the lead researcher said, "coffee can be considered a drink which has different positive effects on human health such as cardioprotective, neuroprotective, hepatoprotective, nephroprotective, etc. However, heavy coffee consumption may be related to some unpleasant symptoms, mainly anxiety, headache, increased blood pressure, nausea, and restlessness".

Contrastively, caffeine in coffee showed a strong inverse association in cases of postpartum depression and comorbid panic disorder.

Other researchers in the searching of the efficacy of coffee and risk of depression through database from PubMed and PsychINFO insisted that although literature data are conflicting, caffeine found in coffee indicated a significantly reduced effect on symptoms of clinical depression.


Additionally, in a cross-sectional study in 10,177 Korean individuals aged 20-97 years with the prevalence of self-reported depression of 14.0% and that of self-reported clinical depression of 3.7%. participated in the fifth Korean National Health and Nutrition Examination Survey. to determine the effect of consumption of coffee and risk of depression, after adjusting to other factors, returned survey from patients, can be cataloged into the followings

For general depression
1. The relative odd ratio of patients drinking less than one cup/week was 0.84
2. The relative odd ratio of patients drinking one to six cups/week was 0.63
3. The relative odd ratio of patients drinking for one cup/day was 0.69
4. The relative odd ratio of patients drinking for two cups/day was 0.54
5. The relative odd ratio of patients drinking for three or more cups/day was .58


For clinical depression, similar observations also have been recorded
1. The relative odd ratio of patients drinking less than one cup/week was 1.00
2. The relative odd ratio of patients drinking one to six cups/week was 0.51
3. The relative odd ratio of patients drinking for one cup/day was 0.57
4. The relative odd ratio of patients drinking for two cups/day was 0.57
5. The relative odd ratio of patients drinking for three or more cups/day was 0.41

The findings although is not linearly, coffee and coffee caffeine intake expressed a protective effect in the ameliorated risk of depression.


Taking together, there is no doubt that coffee and coffee caffeine intake daily and regularly have a profound effect in depression but further cohost large sample sized studies are necessary to find out other factors may contribute to either outcome.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Coffee and Depression: A Short Review of Literature by Tenore GC1, Daglia M, Orlando V, D'Urso E, Saadat SH, Novellino E, Nabavi SF, Nabavi SM.(PubMed)
(2) [Coffee consumption in depressive disorders: it's not one size fits all].[Article in Italian] by Rusconi AC, Valeriani G, Carluccio GM, Majorana M, Carlone C, Raimondo P, Ripà S, Marino P, Coccanari de Fornari MA, Biondi M.(PubMed)

Ginger, the Herbal Remedy Which Promotes Weight Loss

On seeking natural therapy with no side effects, scientists may have a vegetable in the induction of weight loss, according to studies.

Weight loss is a process that intentionally reduces the total body mass, through the decrease of fluid, body fat or adipose tissue or lean mass.

Due to the widespread obesity in North America (over 68% of the US population is either overweight or obese), many weight loss products were created by manufacturers. The weight loss products is a 66 billion business in the US, according to the statistic provided by the Marketdata LLC research firm. And the business continues to grow at a rapid rate.

Is the weight loss products worked? I don't think so. Otherwise, the percentage of the overweight population in the US should be decreased substantially.

In other words, all weight loss products may have a complex structure or a long-term commitment before the results can be seen.

The National Institutes of Health wrote, "You might be surprised to learn that makers of weight-loss supplements rarely carry out studies in people to find out whether their product works and is safe. And when studies are done, they usually involve only small numbers of people who take the supplement for just a few weeks or months. To know whether a weight-loss supplement can help people lose weight safely and keep it off, larger groups of people need to be studied for a longer time.".

In short, most weight products are buy-at your own-risk products.

In fact, everyone knows, the proven ways to lose weight are eating healthful foods, cutting calories, and being physically active.

Dr. Catherine M. Champagne and colleagues in the investigation of healthy diets and weight loss, wrote, "Increased intake of fruits and vegetables was associated with weight loss in Phases I and II: 0.29 kg per 6-months (p<0.0001) and 0.04 kg per 6-months (p=0.0062), respectively, per 1-serving increase. Substitution of carbohydrates for fat and protein for carbohydrates were associated with weight loss during both phases".


And, "Increasing dairy intake was associated with significant weight loss during Phase II (−0.17 kg per 6-months per 1-serving increase, p=0.0002), but not in Phase I. Dietary fiber revealed no significant findings".

The results strongly suggested that if you want to lose weight, you better follow a healthy diet with an increased intake of fruits and vegetables.


Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Scientists on finding a herbal remedy that has potential in stimulating weight loss examined the dietary supplements containing green tea, capsaicin, and ginger extracts on weight loss and metabolic profiles among overweight women.

The randomized double-blind placebo-controlled clinical trial included 50 overweight women satisfied the criteria and guidelines.

Selected candidates were randomly divided into 2 groups. Group A received dietary supplements containing 125 mg green tea, 25 mg capsaicin, and 50 mg ginger extracts (n = 25) group B received placebos (n = 25) twice with lunch and twice with dinner daily for 8 weeks.


Supplement treatment groups showed a significant decrease in weight and body mass index compared to the control.


Women who received the supplement exerted a strong improvement on metabolic profiles including decreased serum insulin concentrations, insulin resistance (-0.5 ± 0.8 vs. -0.05 ± 0.6, p = 0.01), and increased insulin sensitivity, compared to control.

Furthermore, the antioxidant enzymes produced by the host in the supplement group also was enhanced compared to control.

The results indicated that daily intake of the supplement may have a positive impact on inducing weight loss through improving the body metabolism and antioxidant activity.

Dr, Taghizadeh M and colleagues wrote in the final report, "taking green tea, capsaicin and ginger co-supplements for 8 weeks among overweight women had beneficial effects on weight, BMI, markers of insulin metabolism and plasma GSH levels".

In order to reveal more information about using ginger to lose weight, researchers investigated the effect of ginger intake on weight loss, glycemic control, and lipid profiles among overweight and obese subjects by reaching the medical literature online.

The selection of the quality of the studies is based on guidelines of the Cochrane risk of bias tool.

According to the 14 studies with 473 subjects included in the meta-analysis, supplementation with ginger significantly decreased body weight (BW), waist-to-hip ratio (WHR), the hip ratio (HR), fasting glucose, compared to placebo.

Moreover, decreased insulin resistance and significantly increased HDL-cholesterol levels were also observed in the ginger treatment groups.

Surprisingly, ginger supplements showed no effect body mass index (BMI), insulin, triglycerides, total- and LDL-cholesterol.

Dr.Maharlouei N, the lead scientist after taking into account co and confounders said, "Overall, the current meta-analysis demonstrated that ginger intake reduced BW, WHR, HR, fasting glucose and HOMA-IR, and increased HDL-cholesterol, but did not affect insulin, BMI, triglycerides, total- and LDL-cholesterol levels".


Taken altogether, ginger used alone or combined with other supplements may be considered a functional remedy for inducing weight loss in overweight and obese population, pending to the confirmation of larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) The Effect of Dietary Supplements Containing Green Tea, Capsaicin and GingerExtracts on Weight Loss and Metabolic Profiles in Overweight Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial by Taghizadeh M1, Farzin N, Taheri S, Mahlouji M, Akbari H, Karamali F, Asemi Z. (PubMed)
(2) The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials by Maharlouei N1, Tabrizi R2, Lankarani KB1, Rezaianzadeh A3, Akbari M2, Kolahdooz F4, Rahimi M5, Keneshlou F6, Asemi Z7. (PubMed)
(3) Dietary intakes associated with successful weight loss and maintenance during the Weight Loss Maintenance Trial by Catherine M. Champagne, PhD, RD, LDN, FADA, Professor-Research, Stephanie T Broyles, PhD, Assistant Professor, Laura D. Moran, MS, RD, LDN, Clinical Dietitian, Katherine C. Cash, RD, LDN, Research Dietitian/Interventionist, Erma J. Levy, MPH, RD, Research Dietitian/Interventionist, Pao-Hwa Lin, PhD, Associate Research Professor, Bryan C. Batch, MD, Lillian F. Lien, MD, Medical Director, Duke Inpatient Diabetes Management, Assistant Professor, Department of Medicine, Kristine L. Funk, MS, RD, Research Associate III, Arlene Dalcin, RD, LDN, Research Associate, Catherine Loria, PhD, MS, MA, FAHA, Nutritional Epidemiologist, and Valerie H. Myers, PhD. (PMC)

Healthy Foods Broccoli May Process Anti-Influenza Virus Properties

Influenza also known as "the flu", is an infectious disease caused by an influenza virus.

In other words, flu (influenza) is an infectious disease caused by RNA viruses of the family Orthomyxoviridae (the influenza viruses) that can lead to symptoms of chills, fever, sore throat, muscle pains, severe headache, coughing, etc.

There are 3 types of flu influenza: A, B, and C. the influenza virus A and B are considered seasonal flu that causes sniffling, aching, coughing, and running and stuffy nose and fever to over 20% of the general population.

Influenza virus types C tends to cause mild upper respiratory infections, similar to those of cold.

Healthy individuals who have influenza are usually recovered within one week.

However, people with immature and weakened immune system such as young children under age 5, adults older than age 65 residents of nursing homes and other long-term care facilities, chronic illnesses, such as asthma, heart disease, kidney disease, liver disease, and diabetes are not only associated with the risk of influenza but also increase the risk of influenza deadly complication.

Pregnant women and women up to two weeks postpartum due to change of the immune system and other organs have been found to make a woman more prone to influenza and influenza complications.


Most common H and N subtype are influenza A that has been mutated to affect the combination of human, swine, and bird flu viruses, including
* H1N1 - Swine Flu
H1N1 normally is only transmitted among pigs. However, as of today, H1N1 became the first flu pandemic in the world that causes respiratory illness.

* H5N1 - Bird Flu
H5N1 is the strain of influenza known as a bird or avian flu. Before, it is transmitted between birds, but today, it now can be passed from bird to human. The strain is dangerous to humans with high death rates.

Broccoli is a mustard/cabbage plant, belongings to the family Brassicaceae. The veggie has large flower heads, usually green in color with a mass of flower heads surrounded by leaves and evolved from a wild cabbage plant from the continent of Europe.

With an aim to find a natural food for the prevention and treatment of viral diseases, researchers examined the effects of broccoli sprout homogenates (BSH) on nasal cytokines, virus replication, and Nrf2-dependent enzyme expression in smokers and nonsmokers.


The randomized, double-blind, placebo-controlled trial included healthy young adult smokers and nonsmokers ingested BSH or placebo (alfalfa sprout homogenate) for 4 days, designated Days -1, 0, 1, 2. and on day 0 they received standard vaccine dose of live attenuated influenza virus (LAIV) intranasally.
According to the tested analysis,
* In the area under curve analyses, post-LAIV IL-6 responses (P = 0.03) and influenza sequences (P = 0.01) were significantly reduced in NLF from BSH-treated smokers.

* However, In nonsmokers, a similar trend for reduction in virus quantity with BSH did not reach statistical significance.

In other words, in smokers, short term ingestion of broccoli sprout homogenates appears to significantly reduce some virus-induced markers of inflammation, and virus quantity compared to less significant in non-smokers.

Based on the results, researchers wrote, " Nutritional antioxidant interventions have promise as a safe, low-cost strategy for reducing influenza risk among smokers and other at-risk populations".
And "However, because variability exists in the timing and methods of detection for SFN conjugate levels, it is difficult to compare systemic SFN levels across studies".

In other words, SFN protected the integrity of the neurons against neuron damage through it's anti-neuroinflammatory and neuroprotective activities.

Taken altogether, broccoli sprouts may be considered supplements for the prevention of influenza, pending to the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of broccoli sprouts on nasal response to live attenuated influenza virus in smokers: a randomized, double-blind study by Noah TL1, Zhang H2, Zhou H2, Glista-Baker E3, Müller L4, Bauer RN5, Meyer M6, Murphy PC7, Jones S3, Letang B8, Robinette C3, Jaspers I. (PubMed)

Cruciferous Vegetables in the Prevention of Colon Cancer

Colon formed part of the digestive system including a large intestine that connects to the small intestines and rectum plays a critical role to reabsorb fluids and process waste products from the body and prepare for its elimination through the rectum.

Colon cancer is relatively very common and slowly growing and progresses cancer and in a predictable way. The disease is the third most commonly diagnosed cancer in developed countries, including the US and Canada.

Most cases of primary colon cancer start in the cell on the surface of the inner lining of the colon. At the early stage. most patients with colon cancer do not experience any symptoms.

However, at the advanced stage, the tumor not only can spread to other healthy tissue and organs a distance away through blood and fluid circulation but also suppress the nearby tissue and nerve cells.

The progression of colon cancer at this stage not only induces symptoms of the change in bowel habits, the change in the consistency of your stool, that lasts longer than four weeks but also causes rectal bleeding and persistent abdominal severe pain.

According to the statistic by the American Cancer Society, in the US, there are
97,220 new cases of colon cancer diagnosed in 2018. The lifetime risk of developing colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

The 5-year survival rate for patients diagnosed with localized stage colorectal cancer is 90%. About 39% of patients are diagnosed at this early stage.

Researchers do not know the exact causes of the disease. But they do know a history of polyps, ethnicity, high-fat diet and low fiber, the increase in age, the long-term infection of colon diseases are some of the prevalent factors associated with the onset and progression of colon cancer.


Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding a potential compound for the treatment of cancers, researchers examined the effects of diets containing cruciferous vegetables on colon cancer risk.


According to the experiments of* Expt. 1, with rats that were fed a vegetable-free (basal) diet or diets containing different lyophilized cruciferous vegetables in concentrations between 4 and 10%.

* Expt. 2, rats that were fed the basal diet or diets containing 10-22.6% fresh cruciferous vegetables. Diets were fed for 2 wk (Expt. 1) or 3 wk (Expt. 2) before and 7 wk (Expt. 1) or 12 wk (Expt. 2) after administration of the colon carcinogen 1,2-dimethylhydrazine.

Moreover, rats fed fresh vegetables were also injected with a low dose of carcinogen 18-24 h prior to termination.

According to the dietary information,
* Groups fed lyophilized vegetables did not differ in aberrant crypt foci (ACF), sialomucin-producing foci, or mucin-depleted foci (MDF) numbers.

Furthermore, all fresh vegetable diets significantly decreased ACF (approximately 40%) and MDF numbers, and the activities of the hepatic phase I enzyme CYP2E1 involved in drugs and alcohol metabolism did not differ among groups in either experiment.

Additionally, the levels of liver glutathione S-transferase (GST) and quinone reductase activities associated with detoxification did not differ among groups fed fresh vegetables, whereas the lyophilized cabbage diets decreased GST activity, compared with the basal diet.


Taken altogether, cruciferous vegetables may be considered functional foods for reducing the risk of colon cancer, pending to the confirmation of the larger sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cruciferous vegetables reduce morphological markers of colon cancer risk in dimethylhydrazine-treated rats by Arikawa AY1, Gallaher DD. (PubMed)

Ginger Protects Our Eyes Against Cataract

A cataract is a condition with a decrease in vision, caused by the clouding of the lens in the eye found mostly in older adults. Eye injuries, inflammation, and some other eye diseases are also found to initiate the condition.

According to the statistic provided by the World Health Organization, 51% of world blindness, which represents about 20 million people (2010) worldwide are the result of a cataract. The condition can be reversed by surgery.
Aging cataract can be classified into 3 primary types, including
* Nuclear sclerotic cataracts

It is the most common type of cataract in the elderly caused by the gradual clouding of the central portion of the lens.

* Cortical cataracts
It is a type of cloudiness that develops in the lens cortex outside the edge of the lens.

* Posterior subcapsular cataracts
It is a type of cataract that begins with a cloudy area on the back surface of the lens.


Epidemiological studies suggested that people who are smokers, occupations associated with ultraviolet light exposure, diabetes mellitus, and overweight are susceptible to the higher risk of the disease.

However, some researchers suggested that the widespread cataract in the aging population over the past few decades may be associated with the promotion of a high-fat diet.

Dr. Chung-Jung Chiu, the lead scientist said, "Two major dietary patterns were identified by principal component analysis and named Oriental and Western patterns. The Oriental pattern was characterized by a higher intake of vegetables, legumes, fruit, whole grains, tomatoes, and seafood. The Western pattern was characterized by higher intake of red meat, processed meat, high-fat dairy products, French fries, refined grains, and eggs".

And, "Our data indicate that consuming a Western dietary pattern is significantly associated with increased odds of early nuclear opacity".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound for the treatment of diabetic cataract caused by advanced glycation end products (AGE) examined ginger anti AGE activity.


The study included diabetes Wistar-NIN rats induced by intraperitoneal injection of streptozotocin (35 mg/kg body weight) and the control rats received vehicle alone.

In diabetics rats, a set of diabetic animals was given the AIN-93 diet, another set was given either 0.5 or 3% ginger in their diet for a period of two months.

According to the tested assays, ginger not only delayed the onset but also the progression of cataract in rats.

Ginger significantly inhibited the formation of various AGE products including carboxymethyl lysine in the eye lens.

Furthermore, the injection of ginger also inhibited the hyperglycemia-induced osmotic stress in the lens.

The results suggested ginger protects the eye against cataract in rats through a number of mechanisms involved in the development of several pathophysiologies, including diabetic cataract.


Dr. Saraswat M, the lead scientist wrote at the end of the study, "The results indicated that ginger was effective against the development of diabetic cataract in rats mainly through its antiglycating potential and to a lesser extent by inhibition of the polyol pathway".

Moreover, in the study of oxidative stress and aldose reductase induced diabetic complications, researchers analyzed the protective effect against diabetic eye complications of purple waxy corn and ginger.


The study included streptozotocin-induced diabetics with the blood glucose levels >250 mg·dL(-1) orally given the extract at doses of 50, 100, and 200 mg/kg·BW(-1) for 10 weeks.
All doses of PWCG showed significant inhibition of decreased lens opacity, the levels of oxidative stress Malondialdehyde (MDA), and anti-reflective coating (AR) in the lens of diabetic rats.

PWCG also improved the antioxidant profile in the treated rats.


Most importantly, the antiretinopathy property of the combined extract was also confirmed by the increased number of neurons in the ganglion cell layer and thickness of the total retina and retinal nuclear layer in diabetic rats.

Dr. Thiraphatthanavong P, the lead researcher said, "PWCG is the potential functional food to protect against diabetic cataract and retinopathy. However, further studies concerning toxicity and clinical trial are still essential".


Take all together, ginger processed a high amount of bioactive compounds may be considered a function alternative for prevention and treatment of cataract, pending to the confirmation of a large sample size and multicenter human study.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats by Saraswat M1, Suryanarayana P, Reddy PY, Patil MA, Balakrishna N, Reddy GB. (PubMed)
(2) The combined extract of purple waxy corn and ginger prevents cataractogenesis and retinopathy in streptozotocin-diabetic rats by Thiraphatthanavong P1, Wattanathorn J2, Muchimapura S2, Thukham-mee W2, Lertrat K3, Suriharn B. (PubMed)
(3) American Major Dietary Patterns and Age-related Cataract by Chung-Jung Chiu, Gary Gensler, and Allen Taylor. (FASEB Journal)