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Saturday, March 25, 2017

Women Health: Cancer of Endometrium/Endometrial Cancer - Causes and risk factors

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                          Endometrial Cancer

Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.


                       Causes and risk factors 

1. Age
Most endometrial cancer occurs to women in mid thirty and older. It may be caused by often than other tissue in growth and repair of the uterus lining over decade or many decades.

2. Estrogen
Because of accumulation and exposure of estrogen hormone over a prolonged period over a life time, risk of endometrial cancer is much higher in older women. In fact risk of endometrial cancer increase with age after age of 40. Women who are under age of 40 have low risk of the disease unless under usually risk factors.

3. Hormone replacement therapy (HRT)
Women who is either with ovaries removed or in stage of menopause use hormone replacement therapy to relieve the symptoms of menopause, such as frequency of hot flash, loss of bone density, mineral deficiency, etc may slightly increase the risk of endometrial cancer due to exposure to synthesis estrogen.

4. Oral contraceptive pills
The study used population-based cancer registries in eight geographic regions across the United States showed that women who had used sequential oral contraceptives (estrogen and progestin components taken at different times of the month) appeared to have an increased risk of endometrial cancer.

5. Tamoxifen
Tamoxifen is a common chemotherapy medication for patients with breast cancer or to prevent the recurrence of breast cancer by blocking the action of estrogen on the breast cancer cells. might increase risk of endometrial cancer as tamoxifen is also acts like estrogen itself.

6. Obesity
Fatty tissue is a good source for the production of bad estrogen in large amounts in obese women, leading to high levels of estrogen in women resulting in increasing risk of endometrial cancer.

7. Heredity
Family history of endometrial, colon and breast cancer increases the risk of endometrial cancer.

8. Abnormal overgrowth of the endometrium
Women diagnosed with endometrial hyperplasia (abnormal overgrowth of cells in the lining of the uterus) have a higher risk of developing endometrial cancer.

9. Infertility
Study found that women who have never been pregnant have a slightly higher risk to develop endometrial cancer.

10. Early puberty before age 12
Women who begin their periods before 12 years of age have a higher risk to develop endometrial cancer due to increased the number of years that the immature inner uterine lining is exposed to estrogen.

11. Menopause after age 55
Women who go through Menopause after age 55 are at a higher risk of developing endometrial cancer because of increased the number of years that the inner uterine lining is exposed to estrogen.

12. History of having radiation therapy to the pelvis
Frequent use of radiation therapy to the pelvic may alter and damage the DNA of cells, leading to uncontrollable cells growth of inner lining of the uterus, causing endometrial cancer.

13. Other reproductive cancers
Breast or ovary cancer are associated with an increased risk of endometrial cancer due exposure to higher than normal amount of estrogen.

14. Intake high amount of fat
Intake high amount of fat is also linked to higher amount of estrogen produced by our body, the "good" source hormone for the development of endometrial cancer.

15. Heavy daily alcohol consumption
researcher found that high alcohol consumption not only affect just the liver, but increases the risk of with breast and endometrial cancer.

16. Etc.

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