Anacardic acids, a phytochemical found abundantly in the may process a potential effect in reducing risk and treatment of breast cancer, some scientists suggested.
Breast cancer is a chronic condition associated with the irregular cell growth caused by the alternation of DNA of breast cell.
Most cases of breast cancer start on the cells in the surface of the in the inner lining tissue of the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
However, after colonizing most of the breast tissue, the cancer cell at the later stage can travel a distance away to infect other healthy tissue and organs through the circulation of lymph and blood.
According to the statistic, every year, 75,000 and 234,000 patients are diagnosed with breast cancer (BC) in Germany and in the USA, respectively.
In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during the lifetime of a woman is 1/8.
Although genetic preposition such as mutated gene BRCA 1 and 2 are the best-known risk factor associated with the 60% increased the risk of breast cancer.
Unhealthy lifestyle including poor diet and physical inactivity are also the most mentioned risk factor by scientists.
Dr. Max Dieterich, the lead scientist in the study "Influence of Lifestyle Factors on Breast Cancer Risk" wrote, "epidemiological studies that lifestyle factors play an important role in the development of BC. For example, daughters of Asian women who have migrated to the USA revealed an increased risk of developing BC, which was attributed to the exposure to a different lifestyle and nutritional factors".
These results suggested regardless of ethical origin, if you follow the Western diet and lifestyle, you are at the higher levels of risk, compared to those who follow the traditional diet.
More precisely, if you are following the diet high saturated and trans fat, red meat and processed food, regardless of where you're from, you are at higher risk of breast cancer.
Therefore by modifying the lifestyle risk factors to develop a strategy for BC prevention is an urgency for the prevention of breast cancer.
Other risk factors associated with breast cancer are age, family history of BC, personal breast history (pre-malignant lesions), breast density, thorax radiation, and a number of menstrual cycles during the lifetime.
In order to understanding the effect of Anacardic acid (AnAc; 2-hydroxy-6-alkylbenzoic acid), a dietary and medicinal phytochemical anticancer activity in cell and animal models, researchers at the cancer team program at the University of Louisville School of Medicine, conducted an experiment to test the mechanisms of the AnAc in the inhibition of breast cancer cell proliferation.
Application of the AnAc 24:1(omega5) purified from geranium (Pelargonium x hortorum) inhibited the proliferation of estrogen receptor alpha (ERalpha)-positive MCF-7 and endocrine-resistant LCC9 and LY2 breast cancer cells with greater efficacy than ERalpha-negative primary human breast epithelial cells, MCF-10A normal breast epithelial cells, and MDA-MB-231 basal-like breast cancer cells.
AnAc 24:1(omega5) inhibited cell cycle progression and induced apoptosis in a cell-specific manner.
AnAc 24:1(omega5) inhibited the breast cancer cell line was attributed to stimulation of proteins which are responsible for program cells death and anti-cell proliferation.
.
Dr. Schultz DJ, the lead scientist at the end of the study said, "These data indicate that AnAc 24:1(omega5) inhibits cell proliferation, cell cycle progression, and apoptosis in an ER-dependent manner by reducing ER-DNA interaction and inhibiting ER-mediated transcriptional responses".
Furthermore, in examining the series of N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-alkyl (and alkenyl) benzamides related to the anacardic acid derivative CTPB prepared from 2,6-dihydroxybenzoic acid, researchers found that In U937 cells
* Derivatives labeled 7 c, 7 d, 7, and 7 j exerted a potential effect in inducing cell-cycle arrest in the G1 phase,
* The derivative also cause apoptosis in about 20 % of the cells and increased the acetylation of H3. Loss of acylation levels of H3 was associated with patients with breast cancer.
Taken together, Anacardic acids may be considered a functional phytochemical for the prevention and an adjunct therapy combined with the primary medicine for the treatment of breast cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer cell proliferation by Schultz DJ, Wickramasinghe NS, Ivanova MM, Isaacs SM, Dougherty SM, Imbert-Fernandez Y, Cunningham AR, Chen C, Klinge CM. (PubMed)
(2) New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators.
Souto JA, Benedetti R, Otto K, Miceli M, Alvarez R, Altucci L, de Lera AR.(PubMed)
Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.
Thursday, February 28, 2019
Tualang Honey May Process a Potential for the Prevention and Treatment of Osteosarcoma
Scientists may have found a natural ingredient for the prevention and treatment of osteosarcoma without inducing any side effects, according to some studies suggested.
Osteosarcoma is a medical condition caused by the production of immature bone, affecting mostly younger population under the age of 25.
Male are more susceptible to the incidence, compared to female.
At the advanced stage, cancer cells can travel a distance away to infect other healthy tissue and organs, particularly, the lung.
There are 2 types of osteosarcoma.
Localized osteosarcoma is seen only in the bone. This type of osteosarcoma.
normally started on the surface of the tissues next to the bone, such as muscle, tendon, or fat.
Metastatic osteosarcoma is a tumor which has spread to other parts of the body.
Genetic mutation of gene p53, the tumor suppressed gene is the most common cause of osteosarcoma.
However, the disease can also be acquired, due to the alternation of cells DNA caused by long-term exposure to toxic chemicals and radiation therapy.
Some researchers suggested that the increase in age, gender, height, ethnicity and other forms of bone diseases are also the prevalent risk factors associated with the onset of osteosarcoma.
Dr. Julie D. K. McNairn, the lead author in the cancer team at the SUNY Upstate Medical University examined the connection of the inheritance of osteosarcoma and Paget’s disease of bone, said, "Pagetoid osteosarcoma is a complication of Paget’s disease of bone. Sarcomatous transformation is most often seen in severe, long-standing Paget’s disease".
And, "some researchers have shown loss of heterozygosity in a region of chromosome 18q in a relatively high percentage of studied patients affected with either Paget’s disease alone, in Pagetoid osteosarcoma, and in uncomplicated osteosarcoma".
These results clearly suggested that the alternation of certain genetic material found in the chromosome 18q, more specifically 18q21-22 is associated with the onset of Pagetoid osteosarcoma.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural ingredient or whole food for the treatment of osteosarcoma without indiu=cuiing any side effects compared to the conventional treatment of surgery followed by the radio and chemotherapy, researchers investigated the antiproliferative activity of local honey (Tualang) on human osteosarcoma (HOS) cell lines.
Different concentrations of Tualang honey (1% - 20%) were applied on HOS cell lines for 3, 6, 12, 24, 48 and 72 hours.
Cellular apoptosis was done using the Annexin V-FITC Apoptosis Detection Kit.
By examining the morphological appearance after application of Tualang honey, HOS cell showed apoptotic cellular changes like becoming rounded, reduction in cell number, blebbed membrane and apoptotic nuclear changes like nuclear shrinkage, chromatin condensation, and fragmented nucleus.
In other words, Tualang honey incubated with the cancer cell line demonstrated a strong effect in inducing cell apoptosis through degradation.
The 50% inhibitory concentration (IC50) for HOS cell lines was found to be 3.5%.
The maximum inhibition of cell growth of ≥80% was at a concentration of 15%.
These results suggested that Tualang honey induces HOS cells apoptosis through suppressing the cancer cell viability and integrity.
Taken altogether, Tualang honey may be used as a functional food for the prevention and combined with the primary medicine for the treatment of osteosarcoma
However, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Tualang honey anti-osteosarcoma possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines by Ghashm AA1, Othman NH, Khattak MN, Ismail NM, Saini R.(PubMed)
(2) Inheritance of Osteosarcoma and Paget’s Disease of Bone. A Familial Loss of Heterozygosity Study by Julie D. K. McNairn,* Timothy A. Damron,† Steve K. Landas,* J. Lee Ambrose,‡ and Antony E. Shrimpton. (PMC)
Osteosarcoma is a medical condition caused by the production of immature bone, affecting mostly younger population under the age of 25.
Male are more susceptible to the incidence, compared to female.
At the advanced stage, cancer cells can travel a distance away to infect other healthy tissue and organs, particularly, the lung.
There are 2 types of osteosarcoma.
Localized osteosarcoma is seen only in the bone. This type of osteosarcoma.
normally started on the surface of the tissues next to the bone, such as muscle, tendon, or fat.
Metastatic osteosarcoma is a tumor which has spread to other parts of the body.
Genetic mutation of gene p53, the tumor suppressed gene is the most common cause of osteosarcoma.
However, the disease can also be acquired, due to the alternation of cells DNA caused by long-term exposure to toxic chemicals and radiation therapy.
Some researchers suggested that the increase in age, gender, height, ethnicity and other forms of bone diseases are also the prevalent risk factors associated with the onset of osteosarcoma.
Dr. Julie D. K. McNairn, the lead author in the cancer team at the SUNY Upstate Medical University examined the connection of the inheritance of osteosarcoma and Paget’s disease of bone, said, "Pagetoid osteosarcoma is a complication of Paget’s disease of bone. Sarcomatous transformation is most often seen in severe, long-standing Paget’s disease".
And, "some researchers have shown loss of heterozygosity in a region of chromosome 18q in a relatively high percentage of studied patients affected with either Paget’s disease alone, in Pagetoid osteosarcoma, and in uncomplicated osteosarcoma".
These results clearly suggested that the alternation of certain genetic material found in the chromosome 18q, more specifically 18q21-22 is associated with the onset of Pagetoid osteosarcoma.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural ingredient or whole food for the treatment of osteosarcoma without indiu=cuiing any side effects compared to the conventional treatment of surgery followed by the radio and chemotherapy, researchers investigated the antiproliferative activity of local honey (Tualang) on human osteosarcoma (HOS) cell lines.
Different concentrations of Tualang honey (1% - 20%) were applied on HOS cell lines for 3, 6, 12, 24, 48 and 72 hours.
Cellular apoptosis was done using the Annexin V-FITC Apoptosis Detection Kit.
By examining the morphological appearance after application of Tualang honey, HOS cell showed apoptotic cellular changes like becoming rounded, reduction in cell number, blebbed membrane and apoptotic nuclear changes like nuclear shrinkage, chromatin condensation, and fragmented nucleus.
In other words, Tualang honey incubated with the cancer cell line demonstrated a strong effect in inducing cell apoptosis through degradation.
The 50% inhibitory concentration (IC50) for HOS cell lines was found to be 3.5%.
The maximum inhibition of cell growth of ≥80% was at a concentration of 15%.
These results suggested that Tualang honey induces HOS cells apoptosis through suppressing the cancer cell viability and integrity.
Taken altogether, Tualang honey may be used as a functional food for the prevention and combined with the primary medicine for the treatment of osteosarcoma
However, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Tualang honey anti-osteosarcoma possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines by Ghashm AA1, Othman NH, Khattak MN, Ismail NM, Saini R.(PubMed)
(2) Inheritance of Osteosarcoma and Paget’s Disease of Bone. A Familial Loss of Heterozygosity Study by Julie D. K. McNairn,* Timothy A. Damron,† Steve K. Landas,* J. Lee Ambrose,‡ and Antony E. Shrimpton. (PMC)
Wednesday, February 27, 2019
Cruciferous Vegetables, The Functional Food May Process Anti Bladder Cancer Potency
Cruciferous vegetables may process a significant effect in the reducing risk and treatment of bladder cancer, some scientists suggested.
The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.
Bladder cancer is a medical and chronic condition caused by cell growth irregularly and disorderly in the bladder tissue as a result of cell DNA alternation.
Most cases of primary bladder cancer start on the surface of the inner lining of the bladder. At the cancer progress, the cancerous cell can penetrate deeper in the bladder tissue and travel a distance away to infect other healthy tissue and organs.
According to the statistic, men are 4 times more likely than women to be diagnosed with the disease. and 90% of people with bladder cancer are older than 55, and the average age people are diagnosed with bladder cancer is 73.
Cancer causes 17,000 deaths (12,500 men and 4,500 women) every year.
Although there are many risk factors associated with the onset of bladder cancer, long-term cigarette smoking use is considered a significant cause of the disease. Smokers are 4 to 7 times more likely to develop bladder cancer than nonsmokers.
However, most of the cigarette smoker has never developed bladder cancer.
Dr. Neal D Freedman, the lead author in the concerns of bladder cancer widespread in men launched an investigation to evaluate the cigarette smoking in the risk of bladder cancer.
The study included a total of 81,394 men and 86,134 of women who complete the NIH-AARP cohort lifestyle questionnaire and followed from 1995 through Dec 31, 2006.
During 4,518,938 years of follow-up, incident bladder cancer occurred in 3,896 men (144.0/100,000 person-years) and 627 women (34.5/100,000 person-years).
Former smokers and current smokers were found to have higher risks of bladder cancer than never smokers.
The summary risk estimate for current smoking followed from 1963–1987) was 2.94.
The risk of bladder cancer of ever smoking in our study was 0.50 in men and 0.52 in women.
The findings not only suggested that the risk of bladder cancer not only increases in the current smoker but also elevates in previous smokers.
Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.
Its chemical constituents of cruciferous vegetables include glucosinolates, dithiolthiones, indoles, glucoraphanin, s-methyl cysteine sulfoxide, isothiocyanates, indole-3-carbinol, etc.
In the reaffirming the epidemiologic evidence suggests diets rich in cruciferous vegetables, particularly broccoli, are associated with lower bladder cancer risk, researchers at The Ohio State University conducted an evaluation to test the mechanisms whereby broccoli and broccoli sprout extracts and pure isothiocyanates inhibit normal, noninvasive (RT4), and invasive (J82, UMUC3) human urothelial cell viability.
Sulforaphane (IC(50) = 5.66 ± 1.2 μM) and erucin (IC(50) = 8.79 ± 1.3 μM), the major compounds found in the broccoli and broccoli sprout are the most potent inhibitors without harming to the normal cells.
Further analysis suggested that the efficacy of the tested veggies are attributed to the inhibition of survivin, which plays an important role in the protection of cell death, epidermal growth factor receptor (EGFR), a growth factor receptor that induces cell differentiation and proliferation upon and human epidermal growth factor receptor 2 (HER2/neu) in the initiation of cancer development, G(2) /M cell cycle accumulation, and apoptosis.
In a murine UMUC3 xenograft model, injection of diets containing 4% broccoli sprouts, or 2% broccoli sprout isothiocyanate extract; or gavaged pure sulforaphane or erucin (each at 295 μmol/kg, similar to dietary exposure) showed a tumor weight reduction of 42%, 42%, 33% and 58%, respectively.
These results showed that broccoli and broccoli sprout has a strong effect in targeting bladder cancer prevention.
Moreover, in the reconfirmation of the effects of Sulforaphane (SF) inhibits bladder cancer in vivo, researchers at the Roswell Park Cancer Institute conducted an investigation SF effect in both human bladder cells in vitro and mouse bladder tissue in vivo.
Application of SF activates NF-E2 related factor-2 (Nrf2), which is a well-recognized chemopreventive target and activates the Nrf2-regulated cytoprotective signaling pathway in response to oxidative stress.
Comparison between wild-type mice and mice without Nrf2 shows that Nrf2 activation is required by SF for inhibition of Androgen-binding protein (ABP)-induced DNA damage.
Additionally, Nrf2 activation by SF in the bladder occurs primarily in the epithelium, which is the principal site of bladder cancer development.
Accompanied with the result of SF-enriched broccoli sprout extracts strongly inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder cancer development, suggest that SF is a highly promising agent for bladder cancer prevention and provides a mechanistic insight into the repeated epidemiological observation that consumption of broccoli is inversely associated with bladder cancer risk and mortality.
Taken altogether, cruciferous vegetables, including broccoli and broccoli sprout processed high amounts of bioactive compounds may be considered functional for the prevention and an adjunct therapy combined with primary medicine for the treatment of bladder cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion by Abbaoui B, Riedl KM, Ralston RA, Thomas-Ahner JM, Schwartz SJ, Clinton SK, Mortazavi A.(PubMed)
(2) Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissues by Ding Y, Paonessa JD, Randall KL, Argoti D, Chen L, Vouros P, Zhang Y.(PubMed)
(3) Association between smoking and risk of bladder cancer among men and women by Neal D Freedman, PhD, MPH,1 Debra T Silverman, ScD, ScM,1 Albert R Hollenbeck, PhD,2Arthur Schatzkin, MD, DrPH,1 and Christian C Abnet, PhD, MPH. (PMC)
The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.
Bladder cancer is a medical and chronic condition caused by cell growth irregularly and disorderly in the bladder tissue as a result of cell DNA alternation.
Most cases of primary bladder cancer start on the surface of the inner lining of the bladder. At the cancer progress, the cancerous cell can penetrate deeper in the bladder tissue and travel a distance away to infect other healthy tissue and organs.
According to the statistic, men are 4 times more likely than women to be diagnosed with the disease. and 90% of people with bladder cancer are older than 55, and the average age people are diagnosed with bladder cancer is 73.
Cancer causes 17,000 deaths (12,500 men and 4,500 women) every year.
Although there are many risk factors associated with the onset of bladder cancer, long-term cigarette smoking use is considered a significant cause of the disease. Smokers are 4 to 7 times more likely to develop bladder cancer than nonsmokers.
However, most of the cigarette smoker has never developed bladder cancer.
Dr. Neal D Freedman, the lead author in the concerns of bladder cancer widespread in men launched an investigation to evaluate the cigarette smoking in the risk of bladder cancer.
The study included a total of 81,394 men and 86,134 of women who complete the NIH-AARP cohort lifestyle questionnaire and followed from 1995 through Dec 31, 2006.
During 4,518,938 years of follow-up, incident bladder cancer occurred in 3,896 men (144.0/100,000 person-years) and 627 women (34.5/100,000 person-years).
Former smokers and current smokers were found to have higher risks of bladder cancer than never smokers.
The summary risk estimate for current smoking followed from 1963–1987) was 2.94.
The risk of bladder cancer of ever smoking in our study was 0.50 in men and 0.52 in women.
The findings not only suggested that the risk of bladder cancer not only increases in the current smoker but also elevates in previous smokers.
Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli etc.
Its chemical constituents of cruciferous vegetables include glucosinolates, dithiolthiones, indoles, glucoraphanin, s-methyl cysteine sulfoxide, isothiocyanates, indole-3-carbinol, etc.
In the reaffirming the epidemiologic evidence suggests diets rich in cruciferous vegetables, particularly broccoli, are associated with lower bladder cancer risk, researchers at The Ohio State University conducted an evaluation to test the mechanisms whereby broccoli and broccoli sprout extracts and pure isothiocyanates inhibit normal, noninvasive (RT4), and invasive (J82, UMUC3) human urothelial cell viability.
Sulforaphane (IC(50) = 5.66 ± 1.2 μM) and erucin (IC(50) = 8.79 ± 1.3 μM), the major compounds found in the broccoli and broccoli sprout are the most potent inhibitors without harming to the normal cells.
Further analysis suggested that the efficacy of the tested veggies are attributed to the inhibition of survivin, which plays an important role in the protection of cell death, epidermal growth factor receptor (EGFR), a growth factor receptor that induces cell differentiation and proliferation upon and human epidermal growth factor receptor 2 (HER2/neu) in the initiation of cancer development, G(2) /M cell cycle accumulation, and apoptosis.
In a murine UMUC3 xenograft model, injection of diets containing 4% broccoli sprouts, or 2% broccoli sprout isothiocyanate extract; or gavaged pure sulforaphane or erucin (each at 295 μmol/kg, similar to dietary exposure) showed a tumor weight reduction of 42%, 42%, 33% and 58%, respectively.
These results showed that broccoli and broccoli sprout has a strong effect in targeting bladder cancer prevention.
Moreover, in the reconfirmation of the effects of Sulforaphane (SF) inhibits bladder cancer in vivo, researchers at the Roswell Park Cancer Institute conducted an investigation SF effect in both human bladder cells in vitro and mouse bladder tissue in vivo.
Application of SF activates NF-E2 related factor-2 (Nrf2), which is a well-recognized chemopreventive target and activates the Nrf2-regulated cytoprotective signaling pathway in response to oxidative stress.
Comparison between wild-type mice and mice without Nrf2 shows that Nrf2 activation is required by SF for inhibition of Androgen-binding protein (ABP)-induced DNA damage.
Additionally, Nrf2 activation by SF in the bladder occurs primarily in the epithelium, which is the principal site of bladder cancer development.
Accompanied with the result of SF-enriched broccoli sprout extracts strongly inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder cancer development, suggest that SF is a highly promising agent for bladder cancer prevention and provides a mechanistic insight into the repeated epidemiological observation that consumption of broccoli is inversely associated with bladder cancer risk and mortality.
Taken altogether, cruciferous vegetables, including broccoli and broccoli sprout processed high amounts of bioactive compounds may be considered functional for the prevention and an adjunct therapy combined with primary medicine for the treatment of bladder cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion by Abbaoui B, Riedl KM, Ralston RA, Thomas-Ahner JM, Schwartz SJ, Clinton SK, Mortazavi A.(PubMed)
(2) Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissues by Ding Y, Paonessa JD, Randall KL, Argoti D, Chen L, Vouros P, Zhang Y.(PubMed)
(3) Association between smoking and risk of bladder cancer among men and women by Neal D Freedman, PhD, MPH,1 Debra T Silverman, ScD, ScM,1 Albert R Hollenbeck, PhD,2Arthur Schatzkin, MD, DrPH,1 and Christian C Abnet, PhD, MPH. (PMC)
Ginger, the Potential Remedy for the Prevention and Treatment of Atherosclerosis with No Side Effects
Ginger may have a potential and profound effect in blocking the accumulation of plaques on the arterial wall in initiating the risk of atherosclerosis, some scientists suggested.
Atherosclerosis is a medical condition associated with plaque building up in the arteries, leading to the narrowing the arterial function in the transportation of oxygenated blood to the heart and other blood of the body.
Plaques are substance made up of the accumulated fat, cholesterol, calcium, and other substances found in the blood, including cadmium.
Long-term accumulation of plaque can also cause hardening and stiffing arterial wall can lead to the blockage of the arteries and risk of heart disease depending on the location of the blockage.
Most people in the early stage of atherosclerosis do not experience any symptoms. However, as the condition progresses and the location affected, patients may develop chest pain, shortness of breath, sweating, and anxiety.
Most common causes of atherosclerosis are the imbalance of the ratio of bad cholesterol and good cholesterol in the blood, long-term smoking, obesity, increase in age, obesity and some medical conditions, such as diabetes and high blood pressure.
Therefore adding a portion of olive oil into your daily diet can reduce the risk of high blood cholesterol
Dr. Siasos G, the lead scientists in the heart disease team in the concerns of the smoking detrimental effect to many organ systems and is responsible for illnesses such as lung cancer, pneumonia, chronic obstructive pulmonary disease said, " smoking is an important modifiable risk factor for the development of cardiovascular disease,....via initiation and progression of atherosclerosis".
And, " variety of studies has proved that cigarette smoking induces oxidative stress, vascular inflammation, platelet coagulation, vascular dysfunction and impairs serum lipid profile in both current and chronic smokers, active and passive smokers and results in detrimental effects on the cardiovascular system".
The statement clearly indicated that cigarette smoking has a strong implication of the onset and progression of atherosclerosis.
Some researchers suggested that cigarette smoke contain a high amount of toxic chemicals that cause inflammation and formation of blood clot in the arteries and oxidation of low-density lipoprotein cholesterol.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding a natural ingredient or whole food for the prevention and treatment, researchers at the joint study led by the University of Sistan and Baluchestan examined the potential protective effects of ginger in atherosclerosis and atherosclerotic cardiovascular disease.
The randomized, experimental, and controlled study included thirty healthy overweight women aged 20-30 years randomly divided into three equal groups, namely, ginger, ginger + high-intensity interval training (HIIT), and placebo + HIIT.
The training groups performed high-intensity interval exercises (i.e. 40-m maximal shuttle run) for ten consecutive weeks. The supplement groups daily took 3 g of ginger pills and the third group took the placebo.
The paired t-test revealed a significant decrease in the density of type 1 monocytes chemotactic protein (MCP-1) in HIIT + ginger (P = 0.026) and HIIT + placebo (P = 0.001) groups, an indication of reduced inflammation.
These results suggested that the relative and efficient role of HIIT combined with the ginger supplement in overweight women in inducing antioxidant/anti-inflammatory activity against atherosclerosis.
Furthermore, the investigation of the effects of air-dried ginger powder (0.1g/kg body weight, po, for 75 days) was carried out by the RNT Medical College, on experimentally induced atherosclerosis in rabbits by cholesterol feeding (0.3g/kg body weight, po).
Before administration of ginger powder, cholesterol feeding for 75 days led to the distinct development of atheroma in the aorta and coronary arteries of the rabbits.
The accumulation of plaque in the arteries was significantly inhibited by about 50% following ginger administration.
Moreover, ginger treatment also decreases lipid peroxidation and enhanced fibrinolytic activity associated to dissolve blood clots.
The findings indicated that ginger distinct protection from the development of atherosclerosis is attributed probably because of its free radical scavengings, prostaglandin inhibitory and fiber
properties.
Taken altogether, ginger may be considered a functional food for the prevention and adjunct therapy for the treatment of atherosclerosis without inducing any adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Spices and Atherosclerosis by Tsui PF1,2, Lin CS3, Ho LJ4, Lai JH. (PubMed)
(2) The effect of a 10-week high-intensity interval training and ginger consumption on inflammatory indices contributing to atherosclerosis in overweight women by Nayebifar S1, Afzalpour ME2, Kazemi T3, Eivary SH4, Mogharnasi M2. (PubMed)
(3) Protective effect of ginger, Zingiber officinale Rosc on experimental atherosclerosis in rabbits by Verma SK1, Singh M, Jain P, Bordia A.(PubMed)
(4) Smoking and atherosclerosis: mechanisms of disease and new therapeutic approaches by Siasos G, Tsigkou V, Kokkou E, Oikonomou E, Vavuranakis M, Vlachopoulos C, Verveniotis A, Limperi M, Genimata V, Papavassiliou AG, Stefanadis C, Tousoulis D. (PubMed)
Atherosclerosis is a medical condition associated with plaque building up in the arteries, leading to the narrowing the arterial function in the transportation of oxygenated blood to the heart and other blood of the body.
Plaques are substance made up of the accumulated fat, cholesterol, calcium, and other substances found in the blood, including cadmium.
Long-term accumulation of plaque can also cause hardening and stiffing arterial wall can lead to the blockage of the arteries and risk of heart disease depending on the location of the blockage.
Most people in the early stage of atherosclerosis do not experience any symptoms. However, as the condition progresses and the location affected, patients may develop chest pain, shortness of breath, sweating, and anxiety.
Most common causes of atherosclerosis are the imbalance of the ratio of bad cholesterol and good cholesterol in the blood, long-term smoking, obesity, increase in age, obesity and some medical conditions, such as diabetes and high blood pressure.
Therefore adding a portion of olive oil into your daily diet can reduce the risk of high blood cholesterol
Dr. Siasos G, the lead scientists in the heart disease team in the concerns of the smoking detrimental effect to many organ systems and is responsible for illnesses such as lung cancer, pneumonia, chronic obstructive pulmonary disease said, " smoking is an important modifiable risk factor for the development of cardiovascular disease,....via initiation and progression of atherosclerosis".
And, " variety of studies has proved that cigarette smoking induces oxidative stress, vascular inflammation, platelet coagulation, vascular dysfunction and impairs serum lipid profile in both current and chronic smokers, active and passive smokers and results in detrimental effects on the cardiovascular system".
The statement clearly indicated that cigarette smoking has a strong implication of the onset and progression of atherosclerosis.
Some researchers suggested that cigarette smoke contain a high amount of toxic chemicals that cause inflammation and formation of blood clot in the arteries and oxidation of low-density lipoprotein cholesterol.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On finding a natural ingredient or whole food for the prevention and treatment, researchers at the joint study led by the University of Sistan and Baluchestan examined the potential protective effects of ginger in atherosclerosis and atherosclerotic cardiovascular disease.
The randomized, experimental, and controlled study included thirty healthy overweight women aged 20-30 years randomly divided into three equal groups, namely, ginger, ginger + high-intensity interval training (HIIT), and placebo + HIIT.
The training groups performed high-intensity interval exercises (i.e. 40-m maximal shuttle run) for ten consecutive weeks. The supplement groups daily took 3 g of ginger pills and the third group took the placebo.
The paired t-test revealed a significant decrease in the density of type 1 monocytes chemotactic protein (MCP-1) in HIIT + ginger (P = 0.026) and HIIT + placebo (P = 0.001) groups, an indication of reduced inflammation.
These results suggested that the relative and efficient role of HIIT combined with the ginger supplement in overweight women in inducing antioxidant/anti-inflammatory activity against atherosclerosis.
Furthermore, the investigation of the effects of air-dried ginger powder (0.1g/kg body weight, po, for 75 days) was carried out by the RNT Medical College, on experimentally induced atherosclerosis in rabbits by cholesterol feeding (0.3g/kg body weight, po).
Before administration of ginger powder, cholesterol feeding for 75 days led to the distinct development of atheroma in the aorta and coronary arteries of the rabbits.
The accumulation of plaque in the arteries was significantly inhibited by about 50% following ginger administration.
Moreover, ginger treatment also decreases lipid peroxidation and enhanced fibrinolytic activity associated to dissolve blood clots.
The findings indicated that ginger distinct protection from the development of atherosclerosis is attributed probably because of its free radical scavengings, prostaglandin inhibitory and fiber
properties.
Taken altogether, ginger may be considered a functional food for the prevention and adjunct therapy for the treatment of atherosclerosis without inducing any adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Spices and Atherosclerosis by Tsui PF1,2, Lin CS3, Ho LJ4, Lai JH. (PubMed)
(2) The effect of a 10-week high-intensity interval training and ginger consumption on inflammatory indices contributing to atherosclerosis in overweight women by Nayebifar S1, Afzalpour ME2, Kazemi T3, Eivary SH4, Mogharnasi M2. (PubMed)
(3) Protective effect of ginger, Zingiber officinale Rosc on experimental atherosclerosis in rabbits by Verma SK1, Singh M, Jain P, Bordia A.(PubMed)
(4) Smoking and atherosclerosis: mechanisms of disease and new therapeutic approaches by Siasos G, Tsigkou V, Kokkou E, Oikonomou E, Vavuranakis M, Vlachopoulos C, Verveniotis A, Limperi M, Genimata V, Papavassiliou AG, Stefanadis C, Tousoulis D. (PubMed)
Tuesday, February 26, 2019
Avocado in the Prevention and Treatment of Cardiovascular Disease
Avocado may be considered a functional food in the prevention and treatment of cardiovascular disease, some studies suggested.
Cardiovascular disease is a group of conditions triggered by the abnormal function of the heart and blood vessels abnormality.
3 most common forms of cardiovascular disease in North America are coronary artery disease, peripheral artery disease, and carotid artery disease caused by plaques build-up of plaque in the arteries that supply blood to the heart, the arms and legs, and the brain, respectively.
What cause plaques building up in the wall of the arteries are debatable. Researchers do not why people who have the same health conditions, family history, and diet pattern, some are susceptible to the early onset of cardiovascular disease while others do not.
One of the most common and preventable risk factors has been under the intensified debate in the scientist community. If poor diet pattern and lifestyle can facilitate the onset of the disease, then a healthy diet choice and lifestyle with moderate exercise should provide a strong effect in the prevention and treatment of cardiovascular disease.
In other words, by replacing the Western diet characterized by higher loads of processed meats, salty snacks, sweets, and soft drinks and a dietary risk factor for CVD with the traditional diet characterized by high in fruits and vegetables and less in red meat and processed foods, cardiovascular disease is preventable.
Dr. Sonia S. Anand, the lead scientists in the study "Food Consumption and its impact on Cardiovascular Disease,... said, " Evidence from different countries, age/race/ethnicity/socioeconomic groups suggest the health effects studies of foods, macronutrients, and dietary patterns on CVD appear to be far more consistent though regional knowledge gaps are highlighted".
"Based on the current evidence, the traditional Mediterranean-type diet, including plant foods/emphasizing plant protein sources, provides a well-tested healthy dietary pattern to reduce CVD".
These result strongly suggested people who understand the effects of macronutrients and micronutrients of food in the contribution of cardiovascular disease, should be more likely to change the diet pattern, which not only prevents the disease onset in the borderline healthy individual but also reduces the risk of the disease progression and complications associated with patients with cardiovascular disease.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world.
The fruit is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
The fruit contains campesterol, high amounts of β-sitosterol (average 76.4 mg/100 g); fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins; persenones A and B..
In the finding, the natural ingredient for the treatment of cardiovascular disease without inducing any side effects researchers at the University of KwaZulu-Natal launched an investigation to examine the cardiovascular effects of Persea americana Mill (Lauraceae) aqueous leaf extract (PAE).
In healthy normal Wistar rats in vitro, application of the leaf extract exerted a significant effect in reducing the levels of high blood pressure.
On guinea pig P americana aqueous leaf extract (25-800 mg/ml) produced concentration-dependent, significant (p < 0.05-0.001), modified the force or speed of contraction of muscles. and heart rate by inhibiting the positive inotropic and chronotropic responses.
Like acetylcholine (ACh, 10(-8)-10(-5) M), the plant extract (25- 800 mg/ml) produced concentration-related relaxations pre-contracted with noradrenaline.
Furthermore, PAE (25-400 mg/kg iv) caused dose-related, transient but significant reductions in the systemic arterial blood pressure and heart rates of the anesthetized normotensive and hypertensive rats.
Dr.Ojewole JA, the lead scientist said, "the findings of this study tend to suggest that P americana leaf could be used as a natural supplementary remedy in essential hypertension and certain cases of cardiac dysfunctions".
Moreover, in the examine the cardio effects of avocado through its monounsaturated fatty acids (MUFA) dietary fiber, essential nutrients and phytochemicals, researchers at the Nutrition Impact launched a study to investigate the relationships between avocado consumption and overall diet quality, energy and nutrient intakes, physiological indicators of health, and risk of metabolic syndrome.
Diet quality was calculated using the USDA's Healthy Eating Index-2005. Subjects included 17,567 US adults ≥ 19 years of age (49% female), including 347 avocado consumers (50% female), examined in NHANES 2001-2008.
Avocado consumers had significantly higher intakes of vegetables (p<0.05); fruit, diet quality, total fat, monounsaturated and polyunsaturated fats, dietary fiber, vitamins E, K, magnesium, and potassium (p<0.0001); vitamin K (p=0.0013); and lower intakes of added sugars with no significant differences were seen in calorie or sodium intakes.
Body weight, BMI, and waist circumference were significantly lower (p<0.01), and HDL-C was higher (p<0.01) in avocado consumers.
The odds ratio for metabolic syndrome was 50% (95th CI: 0.32-0.72) lower in avocado consumers vs. non-consumers.
These findings suggested avocado consumption is associated with improved overall diet quality, nutrient intake, and reduced the risk of metabolic syndrome, the leading cause of cardiovascular disease.
Dr. Fulgoni VL 3rd, the lead author, after taking into account of co and confounders wrote, "Dietitians should be aware of the beneficial associations between avocado intake, diet, and health when making dietary recommendations".
Taken altogether, avocado processed a high amount of monounsaturated and polyunsaturated fats, dietary fiber may be considered a functional fruit for the prevention and adjunct therapy for the treatment of cardiovascular disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cardiovascular effects of Persea americana Mill (Lauraceae) (avocado) aqueous leaf extract in experimental animals by Ojewole JA1, Kamadyaapa DR, Gondwe MM, Moodley K, Musabayane CT.(PubMed)
(2) Avocado consumption is associated with better diet quality and nutrient intake, and lower metabolic syndrome risk in US adults: results from the National Health and Nutrition Examination Survey (NHANES) 2001-2008 by Fulgoni VL 3rd1, Dreher M, Davenport AJ. (PubMed)
(3) Food Consumption and its impact on Cardiovascular Disease: Importance of Solutions focused on the globalized food system. A Report from the Workshop convened by the World Heart Federation bySonia S. Anand,1,2,* Corinna Hawkes,3,* Russell J. de Souza,4 Andrew Mente,2Mahshid Dehghan,2 Rachel Nugent,5 Michael A. Zulyniak,1 Tony Weis,6 Adam M. Bernstein,7Ronald Krauss,8 Daan Kromhout,9 David J.A. Jenkins,10,11 Vasanti Malik,12Miguel A. Martinez-Gonzalez,13 Dariush Mozafarrian,14 Salim Yusuf,2 Walter C. Willett,12 andBarry M Popkin. (PMC)
Cardiovascular disease is a group of conditions triggered by the abnormal function of the heart and blood vessels abnormality.
3 most common forms of cardiovascular disease in North America are coronary artery disease, peripheral artery disease, and carotid artery disease caused by plaques build-up of plaque in the arteries that supply blood to the heart, the arms and legs, and the brain, respectively.
What cause plaques building up in the wall of the arteries are debatable. Researchers do not why people who have the same health conditions, family history, and diet pattern, some are susceptible to the early onset of cardiovascular disease while others do not.
One of the most common and preventable risk factors has been under the intensified debate in the scientist community. If poor diet pattern and lifestyle can facilitate the onset of the disease, then a healthy diet choice and lifestyle with moderate exercise should provide a strong effect in the prevention and treatment of cardiovascular disease.
In other words, by replacing the Western diet characterized by higher loads of processed meats, salty snacks, sweets, and soft drinks and a dietary risk factor for CVD with the traditional diet characterized by high in fruits and vegetables and less in red meat and processed foods, cardiovascular disease is preventable.
Dr. Sonia S. Anand, the lead scientists in the study "Food Consumption and its impact on Cardiovascular Disease,... said, " Evidence from different countries, age/race/ethnicity/socioeconomic groups suggest the health effects studies of foods, macronutrients, and dietary patterns on CVD appear to be far more consistent though regional knowledge gaps are highlighted".
"Based on the current evidence, the traditional Mediterranean-type diet, including plant foods/emphasizing plant protein sources, provides a well-tested healthy dietary pattern to reduce CVD".
These result strongly suggested people who understand the effects of macronutrients and micronutrients of food in the contribution of cardiovascular disease, should be more likely to change the diet pattern, which not only prevents the disease onset in the borderline healthy individual but also reduces the risk of the disease progression and complications associated with patients with cardiovascular disease.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world.
The fruit is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
The fruit contains campesterol, high amounts of β-sitosterol (average 76.4 mg/100 g); fatty acids (approximately 60% monounsaturated, 20% saturated, and 20% unsaturated); high amounts of glutathione (27.7 mg/100 g); approximately 2% protein; 6–9% carbohydrates and sugars (glucose, fructose, d-mannoheptulose, a taloheptulose, and an alloheptulose); two bitter substances (1-acetoxy-2,4-dihydroxyheptadeca-16-ene and 1,2,4-trihydroxyheptadeca-16-ene); carnitine; proanthocyanidins; persenones A and B..
In the finding, the natural ingredient for the treatment of cardiovascular disease without inducing any side effects researchers at the University of KwaZulu-Natal launched an investigation to examine the cardiovascular effects of Persea americana Mill (Lauraceae) aqueous leaf extract (PAE).
In healthy normal Wistar rats in vitro, application of the leaf extract exerted a significant effect in reducing the levels of high blood pressure.
On guinea pig P americana aqueous leaf extract (25-800 mg/ml) produced concentration-dependent, significant (p < 0.05-0.001), modified the force or speed of contraction of muscles. and heart rate by inhibiting the positive inotropic and chronotropic responses.
Like acetylcholine (ACh, 10(-8)-10(-5) M), the plant extract (25- 800 mg/ml) produced concentration-related relaxations pre-contracted with noradrenaline.
Furthermore, PAE (25-400 mg/kg iv) caused dose-related, transient but significant reductions in the systemic arterial blood pressure and heart rates of the anesthetized normotensive and hypertensive rats.
Dr.Ojewole JA, the lead scientist said, "the findings of this study tend to suggest that P americana leaf could be used as a natural supplementary remedy in essential hypertension and certain cases of cardiac dysfunctions".
Moreover, in the examine the cardio effects of avocado through its monounsaturated fatty acids (MUFA) dietary fiber, essential nutrients and phytochemicals, researchers at the Nutrition Impact launched a study to investigate the relationships between avocado consumption and overall diet quality, energy and nutrient intakes, physiological indicators of health, and risk of metabolic syndrome.
Diet quality was calculated using the USDA's Healthy Eating Index-2005. Subjects included 17,567 US adults ≥ 19 years of age (49% female), including 347 avocado consumers (50% female), examined in NHANES 2001-2008.
Avocado consumers had significantly higher intakes of vegetables (p<0.05); fruit, diet quality, total fat, monounsaturated and polyunsaturated fats, dietary fiber, vitamins E, K, magnesium, and potassium (p<0.0001); vitamin K (p=0.0013); and lower intakes of added sugars with no significant differences were seen in calorie or sodium intakes.
Body weight, BMI, and waist circumference were significantly lower (p<0.01), and HDL-C was higher (p<0.01) in avocado consumers.
The odds ratio for metabolic syndrome was 50% (95th CI: 0.32-0.72) lower in avocado consumers vs. non-consumers.
These findings suggested avocado consumption is associated with improved overall diet quality, nutrient intake, and reduced the risk of metabolic syndrome, the leading cause of cardiovascular disease.
Dr. Fulgoni VL 3rd, the lead author, after taking into account of co and confounders wrote, "Dietitians should be aware of the beneficial associations between avocado intake, diet, and health when making dietary recommendations".
Taken altogether, avocado processed a high amount of monounsaturated and polyunsaturated fats, dietary fiber may be considered a functional fruit for the prevention and adjunct therapy for the treatment of cardiovascular disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cardiovascular effects of Persea americana Mill (Lauraceae) (avocado) aqueous leaf extract in experimental animals by Ojewole JA1, Kamadyaapa DR, Gondwe MM, Moodley K, Musabayane CT.(PubMed)
(2) Avocado consumption is associated with better diet quality and nutrient intake, and lower metabolic syndrome risk in US adults: results from the National Health and Nutrition Examination Survey (NHANES) 2001-2008 by Fulgoni VL 3rd1, Dreher M, Davenport AJ. (PubMed)
(3) Food Consumption and its impact on Cardiovascular Disease: Importance of Solutions focused on the globalized food system. A Report from the Workshop convened by the World Heart Federation bySonia S. Anand,1,2,* Corinna Hawkes,3,* Russell J. de Souza,4 Andrew Mente,2Mahshid Dehghan,2 Rachel Nugent,5 Michael A. Zulyniak,1 Tony Weis,6 Adam M. Bernstein,7Ronald Krauss,8 Daan Kromhout,9 David J.A. Jenkins,10,11 Vasanti Malik,12Miguel A. Martinez-Gonzalez,13 Dariush Mozafarrian,14 Salim Yusuf,2 Walter C. Willett,12 andBarry M Popkin. (PMC)
Monday, February 25, 2019
Beet Juice Protects Your Heart and Arteries Against Cardiovascular Diseases
Scientists may have found a fruit or vegetable in the nightshade family consumed in many cultures with potential in reducing the risk and protected against CVD.
Cardiovascular disease (CVD) is a group of conditions associated with the heart and blood vessels.
The causes of cardiovascular diseases are associated with the accumulation of plaques in the arteries, impeding the blood flow which carries the nutrients and oxygen to the heart, causing damage to the heart tissue and reduced function of the arteries.
In other words, high blood pressure, high blood cholesterol, smoking, diabetes, weight, depression and family history associated with the early onset of plaques accumulated and impeding function of the arteries are the prevalent risk factors of cardiovascular diseases.
According to the statistic cardiovascular disease is the leading cause of death in women in the US with 90% of women having one risk factor.
Believe or not, women are 4 times more likely to die from heart disease than breast cancer and 2/3 of women are not aware heart disease is such a risk for them, according to the Jean Hailes for the Women Health in the article cardiovascular health.
Many people know that tobacco use is associated with an increased risk of bladder cancer, but most of them do not know that smoking is one of the leading cause of cardiovascular diseases.
Dr. Jaana Keto, the lead author in the concern of the widespread smoking habits in Southeast Asia due to 30 years of economic prosperity launched a population-based cohort study to examine the cardiovascular disease risk factors in relation to smoking behavior and history.
Data were collected at the 31-year and 46-year follow-ups when a total of 5038 and 5974 individuals participated in clinical examinations and questionnaires.
The results astonishingly suggested "the effect of past or present smoking on individual CVD risk parameters such as blood pressure and cholesterol seems to be of clinically minor significance in people aged 46 years" and "smoking seems to be above all an independent risk factor for CVD in the working-age population" and "quitting smoking in working age may thus reduce calculated CVD risk nearly to the same level with people who have never smoked".
In other words, smokers are associated with high risk of cardiovascular diseases in the working-age population and risk of CVD in smokers are reduced to the same level of nonsmokers, if they quit smoke.
Beet is best known as the beetroot or garden beet, belonging to the amaranth family.
The perennial plant with leafy stems can grow to 2 m tall.
Besides the major chemical constituents betalains and phenolics, beet also contains a lesser amount of isobetanin, probetanin, neobetanin, indicaxanthin, vulgaxanthins, etc.
In the finding, a fruit or vegetable which process a function in reducing blood pressure (BP) and the risk of adverse cardiovascular events, researchers at the Queen Mary University of London conducted an experiment to examine the effect of beet juice in risk of cardiovascular diseases.
Participants of healthy volunteers approximately 3 hours after ingestion of a dietary nitrate load (beetroot juice 500 mL) showed statistically clinical evidence of BP at-10.4/8 mm Hg, an effect that correlated with peak increases in plasma nitrite concentration.
Injection of the beet juice prevented endothelial dysfunction induced by an acute ischemic insult in the human forearm induced by the injection of adenosine diphosphate (ADP).
Beet juice in vivo also significantly attenuated platelet aggregation in response to collagen and adenosine diphosphate (ADP).
The results of these vasoprotective effects were attributed to the activity of nitrate converted from the ingested nitrate in the beet juice.
Dr.Webb AJ, the lead author said, "the beneficial effects of a vegetable-rich (beet juice) diet and highlights the potential of a "natural" low-cost approach for the treatment of cardiovascular disease".
Furthermore, in the study to reaffirm the effect of dietary nitrate wide range beneficial vascular effects, including reducing blood pressure, inhibiting platelet aggregation, preserving or improving endothelial dysfunction, enhancing exercise performance in healthy individuals and patients with the peripheral arterial disease, researchers found that pre-clinical studies with nitrate or nitrite also show the potential to protect against ischemia-reperfusion injury and reduce arterial stiffness, inflammation, and intimal thickness.
However, in the concerns of the injection of nitrate-rich vegetables (such as a Mediterranean diet) may have a possible small positive and negative associations with cancer and interactions with other nutrients such as vitamin C, polyphenols and fatty acids, researchers developed the Nitrate 'Veg-Table' with 'Nitrate Units' [each unit is 1 mmol of nitrate (62 mg)] to achieve a nitrate intake that is likely to be sufficient to derive benefit, but also to minimize the risk of potential side effects from excessive ingestion
These guidelines not only provide maximum benefits for the use of beet juice in reducing risk and treatment of cardiovascular diseases but also decrease the concerns of other scientists that high intake of nitrate may increase the risk of cancer and nutrients interaction.
Taken altogether, adding a cup of beet juice into your daily diet may have significant effects in reducing the risk of cardiovascular diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite By Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ, Ahluwalia A.(PubMed)
(2) Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway by Lidder S, Webb AJ.(PubMed)
(3) Cardiovascular disease risk factors in relation to smoking behaviour and history: a population-based cohort study by Jaana Keto,1,2 Hanna Ventola,2,3 Jari Jokelainen,1,4 Kari Linden,5Sirkka Keinänen-Kiukaanniemi,1 Markku Timonen,1 Tero Ylisaukko-oja,1,2 and Juha Auvinen. (PMC)
Sunday, February 24, 2019
Honey Protects Our Skin Pigment Against the Onset of Melanoma Skin Cancer
Scientists may have found a natural whole food for the prevention and treatment of skin melanoma cancer, according to some studies.
Skin melanoma is a skin cancer characterized by the alternation of the pigment-containing cells known as melanocytes. However, in the rare case, melanoma can also occur in the mouth, intestines, or eye.
The 4 most common types of skin melanoma include
1. Superficial spreading melanoma, the type of cancer has a tendency to spread grow outward and spread across the surface of the skin, accounted for 70% of all melanoma skin cancer.
2, Nodular melanoma normally grows down into the skin and has a tendency to spread more quickly than other types of melanoma skin cancer.
3. Lentigo maligna melanoma, most common in the older population, making up approximately 15% of all melanoma skin cancer.
4. Acral lentiginous melanoma, most common in people with the darker skin. Cancer first moves outward before spreading deeper into the skin.
According to the statistic, melanoma skin cancer is increasing and anticipated to continue to rise. In the United States, approximately 70,230 new cases of melanoma were diagnosed, causing the death of 8,790.
The causes of melanoma skin cancer are associated with the alternation of the pigment cells in the skin. Why some people are susceptible to the onset of the disease while others do not even they share similar health conditions, family history, and ethnicity.
However, according to the epidemiological studies, genetic mutation inherited from the parent, exposure to the environmental toxins and sun UV ray are the most common associated with the increased risk of melanoma skin cancer.
In fact, people who inherited the BRAF oncogene have a substantial risk to develop the melanoma skin cancer and the most common genes which have been primarily linked to familial melanoma, are CDKN2A and CDK4.
Dr. Miriam Potrony, the lead author in the study "Update in genetic susceptibility in melanoma" suggested that 10% of melanoma skin cancer are genetically related and cyclin-dependent kinase inhibitor 2A (CDKN2A), identified as the first melanoma susceptibility gene more than 20 years ago, is the main high-risk gene for melanoma.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the finding a natural ingredient for the reduction of risk and treatment of melanoma skin cancer, researchers launched an investigation to determine the effect of chrysin, a flavonoid present in honey, propolis, against human uveal melanoma cell lines (M17 and SP6.5)
Injection of chrysin reduced the viability of cultured human melanoma cells in a dose-dependent manner (0, 10, 30 and 100 µM) with IC50 at 28.3 and 35.8 µM in SP6.5 and M17 cell lines, respectively.
Chrysin at 30-100 µM levels selectively reduced the viability of melanoma cells without affecting the viability of nearby healthy cells.
Chrysin inhibited the melanoma skin cancer cells through the proteins associated with cancer cell death and degradation.
These results indicated chrysin induces apoptosis of human uveal melanoma cells via the mitochondrial signaling pathway in the increased mitochondrial permeability.
In the finding the scientist evidence for Manuka honey effect in the treatment of cancer, researchers at the UAE University conducted an investigation to examine the anti-cancer effect on three different cancer cell lines, murine melanoma (B16.F1) and colorectal carcinoma (CT26) as well as human breast cancer (MCF-7) cells in vitro.
Manuka honey has a potent anti-proliferative effect on all three cancer cell lines in a time- and dose-dependent manner, at the concentrations as low as 0.6% (w/v).
The efficacy of Manuka honey in the inhibitory melanoma skin cancer was attributed to the increased expression of proapoptotic and cell death programming activity.
Treatment with manuka honey alone resulted in about 33% inhibition of tumor growth, which correlated with a histologically observable increase in tumor apoptosis without inducing any side effects.
Dr. Fernandez-Cabezudo MJ, the lead author said, "Although better control of tumor growth was observed in animals treated with paclitaxel alone or in combination with manuka honey (61% inhibition), a dramatic improvement in host survival was seen in the co-treatment group".
In support of the above differentiation, a joint study led by Nazarbayev University also suggested that honey processed the anti-carcinogenic effects in vitro and in a murine model of melanoma.
Taken altogether, honey may be considered a functional food for the prevention of melanoma skin cancer and a secondary therapy combined with primary medicine for the treatment of melanoma skin cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis by Xue C1, Chen Y2, Hu DN3, Iacob C4, Lu C5, Huang Z. (PubMed)
(2) Honey: A Therapeutic Agent for Disorders of the Skin by McLoone P1, Oluwadun A2, Warnock M3, Fyfe L. (PubMed)
(3) Intravenous administration of manuka honey inhibits tumor growth and improves host survival when used in combination with chemotherapy in a melanoma mouse model by Fernandez-Cabezudo MJ1, El-Kharrag R, Torab F, Bashir G, George JA, El-Taji H, al-Ramadi BK. (PubMed)
(4) Update in genetic susceptibility in melanoma by Miriam Potrony,1 Celia Badenas,2,3 Paula Aguilera,1,2 Joan Anton Puig-Butille,2,3Cristina Carrera,1,2 Josep Malvehy,1,2 and Susana Puig. (PMC)
Skin melanoma is a skin cancer characterized by the alternation of the pigment-containing cells known as melanocytes. However, in the rare case, melanoma can also occur in the mouth, intestines, or eye.
The 4 most common types of skin melanoma include
1. Superficial spreading melanoma, the type of cancer has a tendency to spread grow outward and spread across the surface of the skin, accounted for 70% of all melanoma skin cancer.
2, Nodular melanoma normally grows down into the skin and has a tendency to spread more quickly than other types of melanoma skin cancer.
3. Lentigo maligna melanoma, most common in the older population, making up approximately 15% of all melanoma skin cancer.
4. Acral lentiginous melanoma, most common in people with the darker skin. Cancer first moves outward before spreading deeper into the skin.
According to the statistic, melanoma skin cancer is increasing and anticipated to continue to rise. In the United States, approximately 70,230 new cases of melanoma were diagnosed, causing the death of 8,790.
The causes of melanoma skin cancer are associated with the alternation of the pigment cells in the skin. Why some people are susceptible to the onset of the disease while others do not even they share similar health conditions, family history, and ethnicity.
However, according to the epidemiological studies, genetic mutation inherited from the parent, exposure to the environmental toxins and sun UV ray are the most common associated with the increased risk of melanoma skin cancer.
In fact, people who inherited the BRAF oncogene have a substantial risk to develop the melanoma skin cancer and the most common genes which have been primarily linked to familial melanoma, are CDKN2A and CDK4.
Dr. Miriam Potrony, the lead author in the study "Update in genetic susceptibility in melanoma" suggested that 10% of melanoma skin cancer are genetically related and cyclin-dependent kinase inhibitor 2A (CDKN2A), identified as the first melanoma susceptibility gene more than 20 years ago, is the main high-risk gene for melanoma.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
In the finding a natural ingredient for the reduction of risk and treatment of melanoma skin cancer, researchers launched an investigation to determine the effect of chrysin, a flavonoid present in honey, propolis, against human uveal melanoma cell lines (M17 and SP6.5)
Injection of chrysin reduced the viability of cultured human melanoma cells in a dose-dependent manner (0, 10, 30 and 100 µM) with IC50 at 28.3 and 35.8 µM in SP6.5 and M17 cell lines, respectively.
Chrysin at 30-100 µM levels selectively reduced the viability of melanoma cells without affecting the viability of nearby healthy cells.
Chrysin inhibited the melanoma skin cancer cells through the proteins associated with cancer cell death and degradation.
These results indicated chrysin induces apoptosis of human uveal melanoma cells via the mitochondrial signaling pathway in the increased mitochondrial permeability.
In the finding the scientist evidence for Manuka honey effect in the treatment of cancer, researchers at the UAE University conducted an investigation to examine the anti-cancer effect on three different cancer cell lines, murine melanoma (B16.F1) and colorectal carcinoma (CT26) as well as human breast cancer (MCF-7) cells in vitro.
Manuka honey has a potent anti-proliferative effect on all three cancer cell lines in a time- and dose-dependent manner, at the concentrations as low as 0.6% (w/v).
The efficacy of Manuka honey in the inhibitory melanoma skin cancer was attributed to the increased expression of proapoptotic and cell death programming activity.
Treatment with manuka honey alone resulted in about 33% inhibition of tumor growth, which correlated with a histologically observable increase in tumor apoptosis without inducing any side effects.
Dr. Fernandez-Cabezudo MJ, the lead author said, "Although better control of tumor growth was observed in animals treated with paclitaxel alone or in combination with manuka honey (61% inhibition), a dramatic improvement in host survival was seen in the co-treatment group".
In support of the above differentiation, a joint study led by Nazarbayev University also suggested that honey processed the anti-carcinogenic effects in vitro and in a murine model of melanoma.
Taken altogether, honey may be considered a functional food for the prevention of melanoma skin cancer and a secondary therapy combined with primary medicine for the treatment of melanoma skin cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis by Xue C1, Chen Y2, Hu DN3, Iacob C4, Lu C5, Huang Z. (PubMed)
(2) Honey: A Therapeutic Agent for Disorders of the Skin by McLoone P1, Oluwadun A2, Warnock M3, Fyfe L. (PubMed)
(3) Intravenous administration of manuka honey inhibits tumor growth and improves host survival when used in combination with chemotherapy in a melanoma mouse model by Fernandez-Cabezudo MJ1, El-Kharrag R, Torab F, Bashir G, George JA, El-Taji H, al-Ramadi BK. (PubMed)
(4) Update in genetic susceptibility in melanoma by Miriam Potrony,1 Celia Badenas,2,3 Paula Aguilera,1,2 Joan Anton Puig-Butille,2,3Cristina Carrera,1,2 Josep Malvehy,1,2 and Susana Puig. (PMC)
Friday, February 22, 2019
Ginger, The Pungent Spice Suppresses the Symptoms and Disability of Osteoarthritis
Ginger may be considered a natural whole food to treat osteoarthritis with no side effects, some scientists suggested.
Osteoarthritis is a chronic inflammatory disease, as a result of the protective cartilage on the ends of your bones were worn and torn down over time. The disease affects millions of people worldwide.
Contrast to the general belief, osteoarthritis only damages the joints of hands, knees, but also cause inflammation of the joints in your hips and spine.
The condition is a slow development disease, often starts in the 40s and 50s and affects almost all people to some degree by age 80.
The common risk factors of osteoarthritis are aging, gender, improper healing of injured joint at a young age, obesity and bone deformity. However, people who have a job with tasks that place repetitive stress on a particular joint are associated with the onset of osteoarthritis in most industrial countries.
Dr. Berran Yucesoy, the lead author in the concerns of the repetitive occupation associated with the risk of osteoarthritis launched an investigation to examine the occupational that contribute to this debilitating condition.
The results of searching the medical data on PubMed using the search terms osteoarthritis, occupation, work, and genetics wrote, " One of the most common occupational risk factors for knee OA is heavy physical workload" and "Other risk factors include frequent exposure to several biomechanical stressors such bending of the knee, kneeling or squatting, standing for long hours (≥ 2 hours per day), walking ≥ 3 km/day, regular stair climbing, heavy lifting (≥ 10 kg), jumping, and vibration".
Believe or not, the researcher continued, " a more than the five-fold greater risk of knee OA among workers ≥ 55 years who were exposed to a combination of heavy lifting (> 25 kg) and kneeling/squatting or climbing stairs".
If your occupation is in the group mentioned in the study, you are likely to develop osteoarthritis at a younger age. Please make sure you are taking all preventive measure to reduce the risk of the onset of the disease at the later life
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The pungent and kitchen spice has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find the evidence that ginger powder consumption can relieve pain and inflammation due to specific anti-inflammatory phytochemical constituents, researchers at the joint investigation led by the Shahid Sadoughi University of Medical Sciences launched a study to examine the effect of ginger supplementation on proinflammatory factors.
The randomized double-blind placebo-controlled 3-month clinical trial investigating knee osteoarthritis includes 120 participants assigned to one of two groups: the ginger group (GG) or the placebo group (PG).
Participants in the GG intervention received capsules containing 500 mg of ginger powder, while PG participants received capsules filled with 500 mg starch.
At 3 months, the expression of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) cytokines were found to decrease substantially in the GG compared to the PG.
Dr. Mozaffari-Khosravi H, the lead scientist wrote in the final report " ginger supplementation may have promising benefits for knee osteoarthritis".
Furthermore, the assessment of the clinical efficacy and safety of oral ginger for the symptomatic treatment of osteoarthritis (OA) by carrying out a systematic literature search followed by meta-analyses on selected studies in randomized controlled trials (RCTs) comparing oral ginger treatment with placebo in OA patients aged >18 years also suggested that
* Ginger intake shows a statistically significant pain reduction with a low degree of inconsistency among trials.
* The ginger treatment group also demonstrates a statistically significant reduction in disability.
* Patients given ginger are more than twice as likely to discontinue treatment compared to placebo. And,
* Ginger was modestly efficacious and reasonably safe for treatment of OA.
Taken altogether, through the inhibition of proinflammatory factors, ginger and ginger supplement may be considered for the prevention and adjunct therapies combined with primary medicine for the treatment of osteoarthritis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis: Outcomes of a Randomized Controlled Clinical Trial by Mozaffari-Khosravi H1,2, Naderi Z1, Dehghan A3, Nadjarzadeh A1, Fallah Huseini H. (PubMed)
(2) Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials by Bartels EM1, Folmer VN2, Bliddal H2, Altman RD3, Juhl C4, Tarp S2, Zhang W5, Christensen R. (PubMed)
(3) Occupational and genetic risk factors for osteoarthritis: A review by Berran Yucesoy,∗ Luenda E. Charles,b,1 Brent Baker,a and Cecil M. Burchfiel. (PMC)
Wednesday, February 20, 2019
Herbal Calendula in the Prevention and Treatment of Atherosclerosis
The finding a natural ingredient for the treatment of atherosclerosis without inducing any side effect has been a lifetime dream of many scientists.
Calendula, a herbal medicine under intensive studies may have a potential effect in the prevention and treatment of atherosclerosis, according to some studies.
Atherosclerosis is a medical condition caused by long-term plaques building up on the wall of the arteries, leading to the reduced oxygen-rich blood flow to the heart.
Plaques mostly are made up of fat, cholesterol, calcium, found in the blood.
Some researchers suggested the most common risk factors according to the epidemiological studies are a poor diet high in saturated and trans fat, red meat and processed foods and fewer fruits and vegetable and unhealthy lifestyle and physical inactivity.
However, the role of calcium in the diet is one of the less being mentioned in the medical literature.
In examining the complexity of the atherosclerotic process, researchers showed that calcium also plays an important role in the formation of plaques in the arteries.
The calcium mineralization of the lumen in the atherosclerotic artery promotes and solidifies plaque formation causing narrowing of the vessel, leading to the soft tissue calcification associated with tissue denegation.
The deposition of minerals in the form of calcium (Ca(2+)) initially transformed from the mineral octacalcium phosphate, a precursor of hydroxylapatite are found to contribute to calcium deposited in the wall of arteries.
Dr. John J. B. Anderson, the lead scientists in the study "Risk of High Dietary Calcium for Arterial Calcification in Older Adults" said, "high calcium intakes in free-living adults have relatively little or no beneficial impact on bone mineral density (BMD) and fracture rates suggest that current recommendations of calcium for adults may be set too high" and "The maintenance of BMD and bone health continues to be an important goal of adequate dietary calcium consumption, but eliminating potential risks of CVDs from excessive calcium intakes needs to be factored into policy recommendations for calcium by adults".
The differentiation indicated that elderly who are overtaking calcium supplements to improve bone density may be at the higher risk of the arterial calcification, a leading cause of atherosclerosis
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.
The plant has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and to treat abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
The chemical ingredients of calendula include triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, loliolide (calendin), calendulin and n-paraffins.
In the finding natural products including botanicals for both therapy of clinical manifestations of atherosclerosis and reduction of atherosclerosis risk factors, researchers examined the antiatherosclerotic effect of formulas Inflaminat (calendula, elder and violet), and phytoestrogen-rich Karinat (garlic powder, extract of grape seeds, green tea leafs, hop cones, β-carotene, α-tocopherol, and ascorbic acid).
In a total of 196 asymptomatic men aged 40-74 in the double-blinded placebo-controlled randomized clinical study, researchers found that both formulas have a direct anti-atherosclerotic effect on carotid atherosclerosis and this effect is likely to be due to serum atherogenicity inhibition, according to The AMAR (Atherosclerosis Monitoring and Atherogenicity Reduction) assay.
Further investigation of the natural products, the promising drugs for anti-atherosclerotic therapy, using cellular models and natural products, researchers suggested that the formula Inflaminat (calendula, elder, and violet), which possesses anti-cytokine activity, shows to induce the regression of carotid atherosclerosis following the treatment of asymptomatic men for one year.
Dr. Orekhov AN, after taking another assessment of the 2 studies wrote, "our basic findings were successfully translated into clinical practice. Because of this translation, a novel approach to antiatherosclerotic therapy was developed".
Moreover, in the study"Use of natural products in anti-cytokine therapy in the evaluation of botany products which has been used in traditional medicine for the treatment of atherosclerosis researchers also found a formula of medicinal plants (calendula, elder, and pansy) with maximum anti-inflammatory activity.
The application of the formula was found effective in reducing the production of a proinflammatory cytokine in facilitating the formation of plaques in the arteries.
Dr. Gorchakova TV, the lead author said, at the final report, "The combination can be used for pathogenetic therapy of various inflammatory diseases, including atherosclerosis".
Taken altogether, herbal calendula may be considered a functional food for the prevention and combined with other herbal medicines for the treatment of atherosclerosis, without inducing any side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-atherosclerotic therapy based on botanicals by Orekhov AN1, Sobenin IA, Korneev NV, Kirichenko TV, Myasoedova VA, Melnichenko AA, Balcells M, Edelman ER, Bobryshev YV.(PubMed)
(2) Direct anti-atherosclerotic therapy; development of natural anti-atherosclerotic drugs preventing cellular cholesterol retention by Orekhov AN(PubMed)
(3) Use of natural products in anti-cytokine therapy by Gorchakova TV1, Suprun IV, Sobenin IA, Orekhov AN(PubMed)
(4) Risk of High Dietary Calcium for Arterial Calcification in Older Adults by John J. B. Anderson1,* and Philip J. Klemmer. (PMC)
Phytochemical Isothiocyanates, The Potential Anti Cancers Phytochemicals
Dithiolthione, a phytochemical found abundantly in the cruciferous vegetables may be next target for the development of chemo medicine for the treatment of cancer without inducing any side effects, some study suggested.
Cancers are the class of chronic and medical condition characterized by cell growth disorderly and uncontrollably that start on the inner lining of the tissue of an organ due to the alternation of cell DNA.
At the advanced stage, most cancer cells can travel a distance away from the original site to infect other healthy tissue and organs through blood and fluids circulation.
The causes of cancer are unknown. Epidemiological studies suggested that depending to the types of cancer, most common risk factors are aging, tobacco, sun exposure, radiation exposure, chemicals toxins, viruses and bacteria, change of hormones, family history, excessive alcohol drinking, poor diet, lack of physical activity and overweight or obesity.
However, most people with some of the above risk factors have never developed cancer.
Genetic preposition and acquired genetic mutation are the most risk factors that can precisely predict the percentage of prevalent risk of the onset of the disease.
Mutation of gene TP53 and PTEN. which produce a protein that suppresses the growth of tumors, genetic mutation of BRCA1 and BRCA2 genes are associated with the higher risk of cancer.
In acquire genetic mutation, some researchers suggested that the result of errors in the cell cycle division caused by long-term exposure to carcinogenic substances such as tobacco smoke and occupations which are required to chemical exposure that also damage the cells DNA are also some prevalent factors associated to the increased risk of cancers.
The US National Library of Medine wrote "For example, certain mutations in the BRCA1 or BRCA2 genes greatly increase a person's risk of developing breast cancer and ovarian cancer. Variations in other genes, such as BARD1 and BRIP1, also increase breast cancer risk, but the contribution of these genetic changes to a person's overall risk appears to be much smaller".
Futhermore, on the other front of acquired genetic mutation, Dr. Michael R. Stratton, the lead author in the study "The cancer genome" said, "the cancer cell may have acquired, from exogenous sources, completely new DNA sequences, notably those of viruses such as human papillomavirus, Epstein Barr virus, hepatitis B virus, human T lymphotropic virus 1 and human herpesvirus 8, each of which is known to contribute to the genesis of one or more type of cancer".
Some researchers proposed that cancer may be results of weaken immunity, Dr. Louise M.E. Janssen, the lead scientist in the study "The immune system in cancer metastasis: friend or foe?" said, " the primary tumor induces an immune response, which may not be sufficient to destroy the primary tumor, but prevents the growth of a secondary tumor or metastases. Since that time, many different immune cells have been shown to play a role in both inhibiting and promoting metastatic disease".
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
In the concerns of chemo drugs side effect in the treatment of invasive cancers, researchers in the cancer team at the Shanghai Jiaotong University School of Medicine conducted an experiment to test the association between urinary levels of isothiocyanates (ITCs) and the risk of pancreatic cancer in urban Shanghai.
The case-control study has been conducted in urban Shanghai from December 2006 to December 2008) through a newly established "instant case reporting" system.
Intake of cruciferous vegetables intake and ITC consumption, urinary ITC levels (median (P25, P75)) were 95.0 (66.9, 135.8) g/d, 11.0 (7.1, 16.0) µmol/d, 0.95 (0.12, 2.92) µmol/g Cr respectively in treatment cases, all lower than those of controls, separately 107.4 (80.1, 154.1) g/d, 12.3 (8.0, 18.0) µmol/d, 1.78 (0.53, 5.28) µmol/g Cr with a statistically significant differences of 3.75.
The urinary levels of ITCs all cases were found to the correlation with cruciferous vegetable consumption and dietary ITC exposure.
Further analysis suggested that there is an inverse association between urinary ITCs and the risk of pancreatic cancer after adjusting for possible confounding factors such as age, sex, history of diabetes and pancreatitis.
Dr. the lead author said, " High levels of cruciferous vegetables or ITC consumption were associated with a reduced risk of pancreatic cancer (all P trend <0.05)".
Moreover, in the study to test the the combination of Thiazolo and isothiocyanates antiproliferative activity in a panel of 8 cancer cell lines, including lung (NCI-H322 and A549), epidermal (A431), glioblastoma (T98G), pancreatic (MIAPaCa-2), prostate (PC-3), human leukemia (HL-60) and breast (T47D) cells, researchers found that
* The combination injection showed antiproliferative activity in the lung (NCI-H322 and A549), epidermal (A431) and glioblastoma (T98G) cancer cell lines with IC50 values of 7.1, 1.4, 3.1 and 3.4 μM, respectively.
* The application compound showed the induction of apoptosis in A549 cells at 10 μM, as indicated by the increase in the sub-G1 population.
* The compounds also induced apoptosis in HL-60 cells at 20 μM. The effect of compound 4a on mitochondrial potential loss in HL-60 cells. was also studied.ct
These results suggested that Thiazolo under the influence of isothiocyanates demonstrated potency in the inhibition of all cancer cell lines in a concentration and dose-dependent manner without inducing any side effects.
More importantly, Dr.de Figueiredo SM, the lead scientist at the Campus Morro do Cruzeiro in the study "The anti-oxidant properties of isothiocyanates: a review" revealed that ITCs induce Phase II enzymes related to detoxification processes of chemical carcinogens to prevent the start of carcinogenesis and exhibits antitumor activity at post-initiation phase.
Additionally, the lead researcher also suggested that ITCs inhibit the cell viability of human cervical cancer cells, human pancreatic cancer cells, human hepatocellular carcinoma cells, human ovarian cancer cells, and have anti-inflammatory properties in the treatment of human T-cell leukemia cells probably through improving antioxidant status.
Taken altogether, Phytochemical Isothiocyanates found abundantly in cruciferous vegetable may be considered a bioactive functional ingredient for the prevention and treatment of cancers, depending on large sample size and multi-center in the human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [A case-control study on the association between urinary levels of isothiocyanates and the risk of pancreatic cancer].[Article in Chinese] by Wang J1, Han L, Zhang W, Wang J, Ni Q, Shen M, Gao Y2.(PubMed)
(2) Synthesis, antiproliferative and apoptosis-inducing activity of thiazolo[5,4-d]pyrimidines by Singh B1, Guru SK, Kour S, Jain SK, Sharma R, Sharma PR, Singh SK, Bhushan S, Bharate SB, Vishwakarma RA.(PubMed)
(3) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB.(PubMed)
(4) The immune system in cancer metastasis: friend or foe? by Janssen LME1, Ramsay EE2, Logsdon CD2, Overwijk WW. (PubMed)
Tuesday, February 19, 2019
Chaste Tree Berry (Vitex agnus-castus), in the Prevention and Treatment of Cancers
Chaste tree berry may have a potential effect in reducing risk and treatment of cancers, some studies proposed.
Cancer is the class of medical and chronic disease characterized by irregular cells growth, that starts on the cells on the surface of the inner lining of the organ tissue.
At the later stage, the cancerous cells can travel a distance away from the original site to infect other healthy tissue through DNA alternation visa fluid and blood circulation.
The exact causes of cancer are unknown. As of today, researchers do not know why people with the same health and family history, some are susceptible to the onset of the disease while others do not.
According to the statistic provided by the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with some forms of cancer at some point during their lifetimes.
In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer, causing 1,790 death.
Epidemiologically, depending on the primary onset of the disease, the most common risk factors of cancer are aging, tobacco, sun exposure, radiation exposure, chemicals, and toxic substances, certain hormones therapy, and family history,
However, excessive alcohol, poor diet, lack of physical activity, or being overweight also are considered some major acquired risks of cancer.
Dr. Karen Basen-Engquis, the lead author in the concerns of obesity in risk of cancer wrote, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%.".
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region,
The queen herb has been used in herbal medicine for thousands of year as an anaphrodisiac herb. It is considered a Queen herb in treating menstrual problems and discomforts by taking it in a prolonged period of time.
There was a report that chaste tree berry stems and leaves used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria.
In the findings a natural extract which proceeds anti-cancer potency, researchers at the launched an investigation to examine the anticancer extract preparation ethanol from dried ripened Vitex agnus-castus fruits growing in Israel (Vitex extract) against human uterine cervical canal fibroblast (HCF), human embryo fibroblast (HE-21), ovarian cancer (MCF-7), cervical carcinoma (SKG-3a), breast carcinoma (SKOV-3), gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), and small cell lung carcinoma (Lu-134-A-H) cells.
In the cell cultures, application of different concentration of Vitex extract after culture for 24 h (logarithmic growth phase) or 72 h (stationary growth phase), exerted a significant cytotoxic activity against all cell lines in logarithmic growth-phase cells, comp[ared to stationary growth-phase cells.
DNA fragmentation, an indication of cancer cells undergoing apoptosis was seen in SKOV-3, KATO-III, COLO 201, and Lu-134-A-H cells.
Furthermore, Vitex extract-treated KATO-III cells also inhibited the expression of heme oxygenase-1 and the active forms of caspases-3, -8 and -9 which play a critical role in the protection the cancer cell against cytotoxicity.
Dr. Ohyama K, the lead author, said, "(The) cytotoxic activity of Vitex extract may be attributed to the effect on cell growth, that cell death occurs through apoptosis, and that this apoptotic cell death may be attributed to increased intracellular oxidation by Vitex extract treatment".
In a human gastric signet ring carcinoma cell line, KATO-III. further analysis also suggested that application of ethanol extract of the dried ripe fruit of Vitex agnus-castus (Vitex) decrease the antioxidant enzyme produced by the cancer cells without affecting the levels of the level of GSSG, another indication of oxidative stress increased in the cancer cells.
The result indicated that, Vitex-induced apoptosis through intracellular oxidative stress and mitochondrial membrane damage by decreasing the antioxidant defense of the cancer cell lines.
Taken altogether, Chaste Tree Berry may be considered a functional food and adjunct therapy for the prevention and treatment of cancers, depending on the result of the large and multi-center studies in human consumption of the herb during the course of diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
(2) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress by Ohyama K1, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T.(PubMed)
(4) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
Cancer is the class of medical and chronic disease characterized by irregular cells growth, that starts on the cells on the surface of the inner lining of the organ tissue.
At the later stage, the cancerous cells can travel a distance away from the original site to infect other healthy tissue through DNA alternation visa fluid and blood circulation.
The exact causes of cancer are unknown. As of today, researchers do not know why people with the same health and family history, some are susceptible to the onset of the disease while others do not.
According to the statistic provided by the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with some forms of cancer at some point during their lifetimes.
In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer, causing 1,790 death.
Epidemiologically, depending on the primary onset of the disease, the most common risk factors of cancer are aging, tobacco, sun exposure, radiation exposure, chemicals, and toxic substances, certain hormones therapy, and family history,
However, excessive alcohol, poor diet, lack of physical activity, or being overweight also are considered some major acquired risks of cancer.
Dr. Karen Basen-Engquis, the lead author in the concerns of obesity in risk of cancer wrote, "In the United States, approximately 85,000 new cancer cases per year are related to obesity. Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%.".
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region,
The queen herb has been used in herbal medicine for thousands of year as an anaphrodisiac herb. It is considered a Queen herb in treating menstrual problems and discomforts by taking it in a prolonged period of time.
There was a report that chaste tree berry stems and leaves used by women as bedding "to cool the heat of lust" during the time of the Thesmophoria.
In the findings a natural extract which proceeds anti-cancer potency, researchers at the launched an investigation to examine the anticancer extract preparation ethanol from dried ripened Vitex agnus-castus fruits growing in Israel (Vitex extract) against human uterine cervical canal fibroblast (HCF), human embryo fibroblast (HE-21), ovarian cancer (MCF-7), cervical carcinoma (SKG-3a), breast carcinoma (SKOV-3), gastric signet ring carcinoma (KATO-III), colon carcinoma (COLO 201), and small cell lung carcinoma (Lu-134-A-H) cells.
In the cell cultures, application of different concentration of Vitex extract after culture for 24 h (logarithmic growth phase) or 72 h (stationary growth phase), exerted a significant cytotoxic activity against all cell lines in logarithmic growth-phase cells, comp[ared to stationary growth-phase cells.
DNA fragmentation, an indication of cancer cells undergoing apoptosis was seen in SKOV-3, KATO-III, COLO 201, and Lu-134-A-H cells.
Furthermore, Vitex extract-treated KATO-III cells also inhibited the expression of heme oxygenase-1 and the active forms of caspases-3, -8 and -9 which play a critical role in the protection the cancer cell against cytotoxicity.
Dr. Ohyama K, the lead author, said, "(The) cytotoxic activity of Vitex extract may be attributed to the effect on cell growth, that cell death occurs through apoptosis, and that this apoptotic cell death may be attributed to increased intracellular oxidation by Vitex extract treatment".
In a human gastric signet ring carcinoma cell line, KATO-III. further analysis also suggested that application of ethanol extract of the dried ripe fruit of Vitex agnus-castus (Vitex) decrease the antioxidant enzyme produced by the cancer cells without affecting the levels of the level of GSSG, another indication of oxidative stress increased in the cancer cells.
The result indicated that, Vitex-induced apoptosis through intracellular oxidative stress and mitochondrial membrane damage by decreasing the antioxidant defense of the cancer cell lines.
Taken altogether, Chaste Tree Berry may be considered a functional food and adjunct therapy for the prevention and treatment of cancers, depending on the result of the large and multi-center studies in human consumption of the herb during the course of diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cytotoxicity and apoptotic inducibility of Vitex agnus-castus fruit extract in cultured human normal and cancer cells and effect on growth by Ohyama K1, Akaike T, Hirobe C, Yamakawa T.(PubMed)
(2) Human gastric signet ring carcinoma (KATO-III) cell apoptosis induced by Vitex agnus-castus fruit extract through intracellular oxidative stress by Ohyama K1, Akaike T, Imai M, Toyoda H, Hirobe C, Bessho T.(PubMed)
(4) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
Monday, February 18, 2019
Manuka Honey, the Best for Tissue Regeneration
Scientists may have found a whole food which processes a significant effect in stimulating the regeneration of tissue, some study suggested.
Tissue regeneration is an act of regrowing non-injured tissues from the remaining tissue. Cells in the non-injured tissues are naturally regenerated over time by replaying the cells that have gone through certain cycle division and die.
One example is the liver grows back to its original size, though not its original shape.
However, the action totally contrasts to wound healing due to injury, involving the closing up injury site with a scar.
In fact, certain amphibians such as salamanders can regenerate lost limbs; skates, rays, and phylum Annelida, such as worms can even grow into two new, separate worms if they're cut in half.
Human, on the other hand, process very limited regeneration abilities.
According to the article "Tissue Regeneration" by Bob Hirshon wrote, "By blocking the function of just two proteins, called Rb and ARF, Blau's team was able to make mouse muscle cells regenerate like new cells"
"However, the new muscle cells merged successfully with the old cells only if the researchers turned Rb back on. If they didn't, the new cells grew too much and interfered with the function of the old muscle cells. In other words, they became tumors. And in fact, the function of both Rb and ARF in mammals is to suppress the growth of tumors".
Therefore, many works needed to be done. Dr. Vincent Falanga, the lead author in the study "Stem Cells in Tissue Repair and Regeneration" said, "We should remain hopeful that true regeneration is possible in adult human tissues. Thus far, the evidence has not been very encouraging, except for fetal wound healing" and
"We show Figure 1 to indicate the immense difficulties underlying chronic wounds. Regeneration of the tissue shown in the Figure would be extremely difficult, and would most likely first require complete removal of the non-healing and affected skin".
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient and whole food processed the tissue degenerative activity without inducing any side effects, researchers at the Tehran University of Medical Sciences and Khyber Medical University evaluated the effects of Manuka honey in wound healing, epithelial regeneration.
A joint study was conducted by searching the wide spectrum of sources from Google Scholar, PubMed, and Scopus.
Studies included in the investigation all suggested that Manuka honey not only processes anti carcinogenesis by controlling different molecular processes, and progression of cancer cells but also engineers the tissue regeneration.
The antibacterial property and tissue regeneration were attributed to the bioactive compound methylglyoxal (MGO) found abundantly in the honey.
After taking into account co and confounders, Dr. Niaz K wrote in the final report, "Manuka honey can enhance wound healing and tissue regeneration by their immunomodulatory property".
In order to understand the action of Manuka honey in tissue regeneration, researchers examined the effect of a scaffold electrospun based on polyurethane (PU), grape seed oil, honey, and propolis.
The prepared PU/grapeseed oil and PU/grapeseed oil/honey/propolis scaffold showed enhanced tissue regeneration through maintaining the thermal stability and reducing surface roughness compared to the control.
According to the hemolytic assay and cytocompatibility, the electrospun PU/grapeseed oil and PU/grapeseed oil/honey/propolis scaffold promoted the tissue regeneration through enhancing the red blood cells (RBC) and human fibroblast cells (HDF).
These result clearly suggested that the newly developed scaffold electrospun might be used as an alternative candidate for bone tissue engineering applications, Dr. Chao CY suggested.
Taken altogether, Manuka honey may be considered a functional food for speeding up wound healing and tissue regeneration, pending to the larger and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
(1) Health Benefits of Manuka Honey as an Essential Constituent for Tissue Regeneration by Niaz K1, Maqbool F1, Bahadar H2, Abdollahi M1.(PubMed)
(2) Engineering electrospun multicomponent polyurethane scaffolding platform comprising grapeseed oil and honey/propolis for bone tissue regeneration by Chao CY1, Mani MP2, Jaganathan SK3,4,5. (PubMed)
(2) Honey: an effective regenerative medicine product in wound management by Martinotti S1, Bucekova M2, Majtan J2, Ranzato E3. (PubMed)
(3) Tissue Regeneration by Bob Hirshon
(4) Stem Cells in Tissue Repair and Regeneration by Vincent Falanga, MD (PMC)
Tissue regeneration is an act of regrowing non-injured tissues from the remaining tissue. Cells in the non-injured tissues are naturally regenerated over time by replaying the cells that have gone through certain cycle division and die.
One example is the liver grows back to its original size, though not its original shape.
However, the action totally contrasts to wound healing due to injury, involving the closing up injury site with a scar.
In fact, certain amphibians such as salamanders can regenerate lost limbs; skates, rays, and phylum Annelida, such as worms can even grow into two new, separate worms if they're cut in half.
Human, on the other hand, process very limited regeneration abilities.
According to the article "Tissue Regeneration" by Bob Hirshon wrote, "By blocking the function of just two proteins, called Rb and ARF, Blau's team was able to make mouse muscle cells regenerate like new cells"
"However, the new muscle cells merged successfully with the old cells only if the researchers turned Rb back on. If they didn't, the new cells grew too much and interfered with the function of the old muscle cells. In other words, they became tumors. And in fact, the function of both Rb and ARF in mammals is to suppress the growth of tumors".
Therefore, many works needed to be done. Dr. Vincent Falanga, the lead author in the study "Stem Cells in Tissue Repair and Regeneration" said, "We should remain hopeful that true regeneration is possible in adult human tissues. Thus far, the evidence has not been very encouraging, except for fetal wound healing" and
"We show Figure 1 to indicate the immense difficulties underlying chronic wounds. Regeneration of the tissue shown in the Figure would be extremely difficult, and would most likely first require complete removal of the non-healing and affected skin".
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient and whole food processed the tissue degenerative activity without inducing any side effects, researchers at the Tehran University of Medical Sciences and Khyber Medical University evaluated the effects of Manuka honey in wound healing, epithelial regeneration.
A joint study was conducted by searching the wide spectrum of sources from Google Scholar, PubMed, and Scopus.
Studies included in the investigation all suggested that Manuka honey not only processes anti carcinogenesis by controlling different molecular processes, and progression of cancer cells but also engineers the tissue regeneration.
The antibacterial property and tissue regeneration were attributed to the bioactive compound methylglyoxal (MGO) found abundantly in the honey.
After taking into account co and confounders, Dr. Niaz K wrote in the final report, "Manuka honey can enhance wound healing and tissue regeneration by their immunomodulatory property".
In order to understand the action of Manuka honey in tissue regeneration, researchers examined the effect of a scaffold electrospun based on polyurethane (PU), grape seed oil, honey, and propolis.
The prepared PU/grapeseed oil and PU/grapeseed oil/honey/propolis scaffold showed enhanced tissue regeneration through maintaining the thermal stability and reducing surface roughness compared to the control.
According to the hemolytic assay and cytocompatibility, the electrospun PU/grapeseed oil and PU/grapeseed oil/honey/propolis scaffold promoted the tissue regeneration through enhancing the red blood cells (RBC) and human fibroblast cells (HDF).
These result clearly suggested that the newly developed scaffold electrospun might be used as an alternative candidate for bone tissue engineering applications, Dr. Chao CY suggested.
Taken altogether, Manuka honey may be considered a functional food for speeding up wound healing and tissue regeneration, pending to the larger and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
(1) Health Benefits of Manuka Honey as an Essential Constituent for Tissue Regeneration by Niaz K1, Maqbool F1, Bahadar H2, Abdollahi M1.(PubMed)
(2) Engineering electrospun multicomponent polyurethane scaffolding platform comprising grapeseed oil and honey/propolis for bone tissue regeneration by Chao CY1, Mani MP2, Jaganathan SK3,4,5. (PubMed)
(2) Honey: an effective regenerative medicine product in wound management by Martinotti S1, Bucekova M2, Majtan J2, Ranzato E3. (PubMed)
(3) Tissue Regeneration by Bob Hirshon
(4) Stem Cells in Tissue Repair and Regeneration by Vincent Falanga, MD (PMC)
Sunday, February 17, 2019
Herbal Cat' claw, The Herb Which Balances the Levels of Free Radicals and Antioxidants in the Body
Herbal Cat'claw may process a potential effect in balancing the ratio of free radicals and antioxidants in the body, some scientists suggested.
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction.
They may have positive, negative or zero charges. The unpaired electrons cause radicals to be highly chemically reactive in the human body.
Imbalance of the ratio of free radicals and antioxidants linking to the expression of oxidative stress has been associated with the onset of chronic illness, including atherosclerosis, inflammatory condition, certain cancers.
In other words, the presence of oxidative stress may be attributed to either the overexpression of free radicals generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states or reduced levels of antioxidant enzymes in the human.
In the concerns of free radicals in the expression of oxidative damage to protein and DNA, lipid peroxidation. oxidative damage to DNA, Dr. V. Lobo, the lead researcher. wrote in the study " Free radicals, antioxidants, and functional foods: Impact on human health" "A balance between free radicals and antioxidants is necessary for proper physiological function" and " Hence application of an external source of antioxidants can assist in coping this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".
The results clearly indicated, if our body can not produce the levels of antioxidant to counter the overexpression of free radicals reactive oxygen species and reactive nitrogen species, intake of antioxidants from the foods, herbs and synthetic sources may be necessary.
Some researchers also suggested that antioxidants from the food and herbal sources have been found to exert the significant effect in stimulating the antioxidants produced by the host tissue.
Cat's claw found in in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc.
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, Harman, hirsuteine, hirsutine, iso-pteropodine, etc.
In the aim to reaffirm the tradition use of Cat's claw as an anti-inflammatory disorder functional herbal medicine, researchers at the Albany Medical College, conducted an evaluation to examine the antioxidative and anti-inflammatory properties of alkaloids and flavanols isolated from the herb.
In vitro, application of alkaloids and flavanols isolated from the herb demonstrated significant anti-inflammatory activity by inhibition of TNF-alpha, the proinflammatory cytokines found in the early phase of infection and nitrite production from RAW 264.7 cells exposed to LPS (50 ng/ml) and in vivo using the indomethacin-induced gastritis model.
The IC50 value for inhibition of TNF-alpha production was significantly (P < 0.01);s higher for Uncaria tomentosa (UT) (14.1 ng/ml) vs Uncaria guianensis (UG).(9.5 ng/ml) compared to alkaloid content of Cat's claw.
Oral pretreatment for 3 d with UT protected against indomethcin-induced gastritis and prevented TNFalpha mRNA expression and apoptosis.
This demonstration reconfirms the anti-inflammatory and antioxidant activity of the herbal medicine
Furthermore, in the study to examine the ability of pteropodine to increase the antioxidant activity in mice induced oxidative stress by administered doxorubicin, researchers found that oxidative stress created by the injection of with 10 mg/kg of doxorubicin.was inhibited by pteropodine (100-600 mg/kg).
The bone marrow cytotoxicity induced by doxorubicin was also corrected by the administration of pteropodine.
In immune and antioxidant perspective, 600 mg/kg of pteropodine increased 25.8% of the production of lymphocytes over the control value along a 96-hr assay and exhibited a strong capacity to trap the DPPH-free radical (98.26% with 250 microg/ml).
Finally, in the analysis of the antioxidant properties of aqueous and ethanolic extracts of the Uncaria tomentosa bark, researchers showed that
* Both extracts process a high antioxidant capacity of the studied materials in comparison to the other extracts of fruits, vegetables, cereals, and medicinal plants.
* The alcoholic preparations exerts higher antioxidant activity and total phenolic compounds compared
Although the alcoholic preparations display a higher antioxidant potential, the highly elevated level of tannins in alcoholic extracts may cause undesirable gastric effects.
Taken altogether, Cat' claw and its extracts processed a strong antioxidant activity may be considered a functional food in the prevention of oxidative stress and combined with conventional medicine for treatment of overexpression of oxidative stress-related diseases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content by Sandoval M1, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ. (PubMed)
(2) Antigenotoxic, antioxidant and lymphocyte induction effects produced by pteropodine by Paniagua-Pérez R1, Madrigal-Bujaidar E, Molina-Jasso D, Reyes-Cadena S, Alvarez-González I, Sánchez-Chapul L, Pérez-Gallaga J.(PubMed)
(3) Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC by Pilarski R1, Zieliński H, Ciesiołka D, Gulewicz K.(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction.
They may have positive, negative or zero charges. The unpaired electrons cause radicals to be highly chemically reactive in the human body.
Imbalance of the ratio of free radicals and antioxidants linking to the expression of oxidative stress has been associated with the onset of chronic illness, including atherosclerosis, inflammatory condition, certain cancers.
In other words, the presence of oxidative stress may be attributed to either the overexpression of free radicals generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states or reduced levels of antioxidant enzymes in the human.
In the concerns of free radicals in the expression of oxidative damage to protein and DNA, lipid peroxidation. oxidative damage to DNA, Dr. V. Lobo, the lead researcher. wrote in the study " Free radicals, antioxidants, and functional foods: Impact on human health" "A balance between free radicals and antioxidants is necessary for proper physiological function" and " Hence application of an external source of antioxidants can assist in coping this oxidative stress. Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health".
The results clearly indicated, if our body can not produce the levels of antioxidant to counter the overexpression of free radicals reactive oxygen species and reactive nitrogen species, intake of antioxidants from the foods, herbs and synthetic sources may be necessary.
Some researchers also suggested that antioxidants from the food and herbal sources have been found to exert the significant effect in stimulating the antioxidants produced by the host tissue.
Cat's claw found in in the tropical jungles of South and Central America, is a genus Uncaria, belonging to the family Rubiaceae.
The herb has been used in traditional medicine over two thousand years as a tonic, contraceptive, anti-inflammatory, and infectious agent, and to treat diarrhea, rheumatic disorders, acne, diabetes, cancer and diseases of the urinary tract, etc.
The chemical constituents of Cat's claw include ajmalicine, akuammigine, campesterol, catechin, carboxyl alkyl esters, chlorogenic acid, cinchonain, corynantheine, corynoxeine, daucosterol, epicatechin, Harman, hirsuteine, hirsutine, iso-pteropodine, etc.
In the aim to reaffirm the tradition use of Cat's claw as an anti-inflammatory disorder functional herbal medicine, researchers at the Albany Medical College, conducted an evaluation to examine the antioxidative and anti-inflammatory properties of alkaloids and flavanols isolated from the herb.
In vitro, application of alkaloids and flavanols isolated from the herb demonstrated significant anti-inflammatory activity by inhibition of TNF-alpha, the proinflammatory cytokines found in the early phase of infection and nitrite production from RAW 264.7 cells exposed to LPS (50 ng/ml) and in vivo using the indomethacin-induced gastritis model.
The IC50 value for inhibition of TNF-alpha production was significantly (P < 0.01);s higher for Uncaria tomentosa (UT) (14.1 ng/ml) vs Uncaria guianensis (UG).(9.5 ng/ml) compared to alkaloid content of Cat's claw.
Oral pretreatment for 3 d with UT protected against indomethcin-induced gastritis and prevented TNFalpha mRNA expression and apoptosis.
This demonstration reconfirms the anti-inflammatory and antioxidant activity of the herbal medicine
Furthermore, in the study to examine the ability of pteropodine to increase the antioxidant activity in mice induced oxidative stress by administered doxorubicin, researchers found that oxidative stress created by the injection of with 10 mg/kg of doxorubicin.was inhibited by pteropodine (100-600 mg/kg).
The bone marrow cytotoxicity induced by doxorubicin was also corrected by the administration of pteropodine.
In immune and antioxidant perspective, 600 mg/kg of pteropodine increased 25.8% of the production of lymphocytes over the control value along a 96-hr assay and exhibited a strong capacity to trap the DPPH-free radical (98.26% with 250 microg/ml).
Finally, in the analysis of the antioxidant properties of aqueous and ethanolic extracts of the Uncaria tomentosa bark, researchers showed that
* Both extracts process a high antioxidant capacity of the studied materials in comparison to the other extracts of fruits, vegetables, cereals, and medicinal plants.
* The alcoholic preparations exerts higher antioxidant activity and total phenolic compounds compared
Although the alcoholic preparations display a higher antioxidant potential, the highly elevated level of tannins in alcoholic extracts may cause undesirable gastric effects.
Taken altogether, Cat' claw and its extracts processed a strong antioxidant activity may be considered a functional food in the prevention of oxidative stress and combined with conventional medicine for treatment of overexpression of oxidative stress-related diseases.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content by Sandoval M1, Okuhama NN, Zhang XJ, Condezo LA, Lao J, Angeles' FM, Musah RA, Bobrowski P, Miller MJ. (PubMed)
(2) Antigenotoxic, antioxidant and lymphocyte induction effects produced by pteropodine by Paniagua-Pérez R1, Madrigal-Bujaidar E, Molina-Jasso D, Reyes-Cadena S, Alvarez-González I, Sánchez-Chapul L, Pérez-Gallaga J.(PubMed)
(3) Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC by Pilarski R1, Zieliński H, Ciesiołka D, Gulewicz K.(PubMed)
(4) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PMC)
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