Tualang Honey May Process a Potential for the Prevention and Treatment of Osteosarcoma

Scientists may have found a natural ingredient for the prevention and treatment of osteosarcoma without inducing any side effects, according to some studies suggested.

Osteosarcoma is a medical condition caused by the production of immature bone, affecting mostly younger population under the age of 25.

Male are more susceptible to the incidence, compared to female.

At the advanced stage, cancer cells can travel a distance away to infect other healthy tissue and organs, particularly, the lung.

There are 2 types of osteosarcoma.

Localized osteosarcoma is seen only in the bone. This type of osteosarcoma.
normally started on the surface of the tissues next to the bone, such as muscle, tendon, or fat.

Metastatic osteosarcoma is a tumor which has spread to other parts of the body.

Genetic mutation of gene p53, the tumor suppressed gene is the most common cause of osteosarcoma.


However, the disease can also be acquired, due to the alternation of cells DNA caused by long-term exposure to toxic chemicals and radiation therapy.

Some researchers suggested that the increase in age, gender, height, ethnicity and other forms of bone diseases are also the prevalent risk factors associated with the onset of osteosarcoma.


Dr. Julie D. K. McNairn, the lead author in the cancer team at the SUNY Upstate Medical University examined the connection of the inheritance of osteosarcoma and Paget’s disease of bone, said, "Pagetoid osteosarcoma is a complication of Paget’s disease of bone. Sarcomatous transformation is most often seen in severe, long-standing Paget’s disease".


And, "some researchers have shown loss of heterozygosity in a region of chromosome 18q in a relatively high percentage of studied patients affected with either Paget’s disease alone, in Pagetoid osteosarcoma, and in uncomplicated osteosarcoma".

These results clearly suggested that the alternation of certain genetic material found in the chromosome 18q, more specifically 18q21-22 is associated with the onset of Pagetoid osteosarcoma.


Honey is the miraculous product made by bees using nectar from flowers.

The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.

With an aim to find a natural ingredient or whole food for the treatment of osteosarcoma without indiu=cuiing any side effects compared to the conventional treatment of surgery followed by the radio and chemotherapy, researchers investigated the antiproliferative activity of local honey (Tualang) on human osteosarcoma (HOS) cell lines.

Different concentrations of Tualang honey (1% - 20%) were applied on HOS cell lines for 3, 6, 12, 24, 48 and 72 hours.

Cellular apoptosis was done using the Annexin V-FITC Apoptosis Detection Kit.

By examining the morphological appearance after application of Tualang honey, HOS cell showed apoptotic cellular changes like becoming rounded, reduction in cell number, blebbed membrane and apoptotic nuclear changes like nuclear shrinkage, chromatin condensation, and fragmented nucleus.

In other words, Tualang honey incubated with the cancer cell line demonstrated a strong effect in inducing cell apoptosis through degradation.

The 50% inhibitory concentration (IC50) for HOS cell lines was found to be 3.5%.


The maximum inhibition of cell growth of ≥80% was at a concentration of 15%.


These results suggested that Tualang honey induces HOS cells apoptosis through suppressing the cancer cell viability and integrity.


Taken altogether, Tualang honey may be used as a functional food for the prevention and combined with the primary medicine for the treatment of osteosarcoma

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Tualang honey anti-osteosarcoma possibilities.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines by Ghashm AA1, Othman NH, Khattak MN, Ismail NM, Saini R.(PubMed)
(2) Inheritance of Osteosarcoma and Paget’s Disease of Bone. A Familial Loss of Heterozygosity Study by Julie D. K. McNairn,* Timothy A. Damron,† Steve K. Landas,* J. Lee Ambrose,‡ and Antony E. Shrimpton. (PMC)