Gut Microbiota is a community of microorganisms living in the gastrointestinal tract.
Under normal conditions, gut microbiota plays a critical role in overall health, including the impacts of
* In nutrient metabolism, gut microbiota improves the absorption of the dietary nutrients of the digestive system
* In xenobiotic and drug metabolism, gut microbiota protects the body against xenobiotics and drug toxicity through facilitating the excretion.
* Maintenance of the structural integrity of the gut mucosal barrier, gut microbiota enhances the epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of intestinal in nutrients adsorption.
* In immunomodulation, gut microbiota interact with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
However, imbalanced of the ratio of gut microbiota may have a negative on human health and diseases.
Dr. Yu-Jie Zhang wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function".
And, "However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for enhancing the ratio of dut microbiota composition researchers examined the effect of consuming tomato products and lycopene on chronic inflammatory disorders associated with intestinal bacteria in an animal model.
The study included Winnie mice as a model of spontaneous ulcerative colitis treated with or without chow enriched with 1% Bronze tomato.
At week 2, the Bronze-enriched chow treated group showed no macroscopic effect on the IBD symptoms.
However, levels of pro-inflammatory cytokines found in the treated mice were significantly reduced, observed by the levels of IL17A and IFNγ.
According to the analysis of the microbial composition, two weeks of Bronze enriched diet demonstrated a strong effect in the improvement of the gut microbiota ratio in the tested mice.
Additional differentiation of the results, researchers found that the efficacy of Bronze tomato in the promotion of gut health was attributed to the phytochemical polyphenols presented in the tomato.
Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplement for the gut health, pending to large sample size and multicenter human study.
Intake of polyphenols in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)
(2) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions.
Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(3) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang,1 Sha Li,2 Ren-You Gan,3 Tong Zhou,1 Dong-Ping Xu,1 and Hua-Bin Li. (PMC)
Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.
Tuesday, June 30, 2020
Monday, June 29, 2020
Honey, Better Than Over the Counter Medicine for Treatment of Acute Cough in Children
Scientists may have found a natural whole food that processes a significant activity in reducing the risk and treatment of acute coughing in children with no side effects, some studies suggested.
Coughing can be a natural and reflex reaction to expel phlegm from the airway or a result of viral and bacterial infection of the upper airway.
A cough that lasts less than three weeks is considered an acute cough.
A chronic cough is a medical condition that lasts more than 3 weeks. In children, the condition can be caused by allergies and sinusitis, asthma, whooping cough, cystic fibrosis, aspiration, acid reflux and a blockage in the airway.
The most common causes of acute cough are cold and flu. However, the chronic condition in adults can be the result of smoking, sinus infection, allergic rhinitis, and diseases associated with upper airway dysfunction, including asthma, chronic bronchitis, and long-term use of angiotensin-converting enzyme (ACE) inhibitors for the treatment of high blood pressure.
Most common symptoms of coughing in children are accompanied by the itchy throat, runny nose, watery eyes, sore throat, or rash.
Most parents use over the counter medicine for the treatment of acute coughing in children such as antitussives and expectorants
However, according to the warning from the FDA, warns that children younger than 12 shouldn’t take codeine products to treat pain or cough because of the risk of developing potentially life-threatening breathing problems.
"The FDA recommends against the use of codeine in youths ages 12 through 18 who are obese or have conditions such as obstructive sleep apnea (blocked airflow during sleep) or severe lung disease. These risk factors can increase their chances of developing serious breathing problems when taking these medications".
Therefore, if your child experiences severe coughing, you may want to check your doctor before applying any over the counter medicine. Most cases of acute coughing in children are recovered within a few days.
Please noted that there’s no cure for the common cold caused by viral infection. You will get better on your own in a week or two without needing medications and your child will get better on their own in a week or two without the need for medications.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient or whole food for the treatment of acute coughing accepted by children without inducing any side effects, researchers examined the effectiveness of honey for acute cough in children in ambulatory settings.
The study includes the searching of available randomized controlled trials (RCTs) comparing honey, given alone, or in combination with antibiotics, versus nothing, placebo or other over-the-counter (OTC) cough medications to participants aged from two to 18 years for acute cough in ambulatory settings.
Out of hundreds of studies reviewed by the researchers, only 2 studies were selected for the review.
Compared to dextromethorphan, diphenhydramine, and 'no treatment' on symptomatic relief of a cough using the 7-point Likert scale. honey was much better medicine than no treatment in reducing the frequency of cough and exerted similar or better effects to those of over counter medicine.
However, mild adverse events were found in seven children (9.3%) from the honey group and two (2.7%) from the dextromethorphan group.
After taking into account co and confounders, Dr. Oduwole O. the lead scientist said, "There was no significant difference between honey versus dextromethorphan or honey versus diphenhydramine".
Furthermore, in the concerns of the side effects of honey and over the counter medicine, researchers examine the effects of two kinds of Iranian honey with diphenhydramine (DPH) on nocturnal pediatric coughs and the sleep quality of children and their parents.
A total of 87 patients included in the study were randomly assigned to one of three treatment groups: Group 1, Honey type 1 (Kimia Company, Iran) (n = 42), Group 2, Honey type 2 (Shahde-Golha, Iran) (n = 25), and Group 3, DPH (n = 20).
Each group received double doses of the respective treatments on two successive nights, researchers indicated that
* Honey type 1 was superior to DPH in improving all aspects of coughs, except the frequency,
* Honey type 2 was more effective than DPH in improving all aspects of coughs, except the sleep quality of the child.
* There was no significant difference between Honey type 1 and 2 in any aspects of cough relief.
After examing the standard validated questionnaire completed by the parents before and after treatment.
Dr. Ayazi P, the lead author wrote in the final report, " honey may provide better cough relief than DPH in children and improve the sleep quality of children and their parents".
By comparing the above studies, there is no doubt that honey may be used for the treatment of acute cough in children.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Honey for an acute cough in children by Oduwole O1, Meremikwu MM, Oyo-Ita A, Udoh EE. (PubMed)
(2) Comparison of the Effect of Two Kinds of Iranian Honey and Diphenhydramine on Nocturnal Cough and the Sleep Quality in Coughing Children and Their Parents by Ayazi P1, Mahyar A2, Yousef-Zanjani M1, Allami A3, Esmailzadehha N4, Beyhaghi T. (PubMed)
Coughing can be a natural and reflex reaction to expel phlegm from the airway or a result of viral and bacterial infection of the upper airway.
A cough that lasts less than three weeks is considered an acute cough.
A chronic cough is a medical condition that lasts more than 3 weeks. In children, the condition can be caused by allergies and sinusitis, asthma, whooping cough, cystic fibrosis, aspiration, acid reflux and a blockage in the airway.
The most common causes of acute cough are cold and flu. However, the chronic condition in adults can be the result of smoking, sinus infection, allergic rhinitis, and diseases associated with upper airway dysfunction, including asthma, chronic bronchitis, and long-term use of angiotensin-converting enzyme (ACE) inhibitors for the treatment of high blood pressure.
Most common symptoms of coughing in children are accompanied by the itchy throat, runny nose, watery eyes, sore throat, or rash.
Most parents use over the counter medicine for the treatment of acute coughing in children such as antitussives and expectorants
However, according to the warning from the FDA, warns that children younger than 12 shouldn’t take codeine products to treat pain or cough because of the risk of developing potentially life-threatening breathing problems.
"The FDA recommends against the use of codeine in youths ages 12 through 18 who are obese or have conditions such as obstructive sleep apnea (blocked airflow during sleep) or severe lung disease. These risk factors can increase their chances of developing serious breathing problems when taking these medications".
Therefore, if your child experiences severe coughing, you may want to check your doctor before applying any over the counter medicine. Most cases of acute coughing in children are recovered within a few days.
Please noted that there’s no cure for the common cold caused by viral infection. You will get better on your own in a week or two without needing medications and your child will get better on their own in a week or two without the need for medications.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient or whole food for the treatment of acute coughing accepted by children without inducing any side effects, researchers examined the effectiveness of honey for acute cough in children in ambulatory settings.
The study includes the searching of available randomized controlled trials (RCTs) comparing honey, given alone, or in combination with antibiotics, versus nothing, placebo or other over-the-counter (OTC) cough medications to participants aged from two to 18 years for acute cough in ambulatory settings.
Out of hundreds of studies reviewed by the researchers, only 2 studies were selected for the review.
Compared to dextromethorphan, diphenhydramine, and 'no treatment' on symptomatic relief of a cough using the 7-point Likert scale. honey was much better medicine than no treatment in reducing the frequency of cough and exerted similar or better effects to those of over counter medicine.
However, mild adverse events were found in seven children (9.3%) from the honey group and two (2.7%) from the dextromethorphan group.
After taking into account co and confounders, Dr. Oduwole O. the lead scientist said, "There was no significant difference between honey versus dextromethorphan or honey versus diphenhydramine".
Furthermore, in the concerns of the side effects of honey and over the counter medicine, researchers examine the effects of two kinds of Iranian honey with diphenhydramine (DPH) on nocturnal pediatric coughs and the sleep quality of children and their parents.
A total of 87 patients included in the study were randomly assigned to one of three treatment groups: Group 1, Honey type 1 (Kimia Company, Iran) (n = 42), Group 2, Honey type 2 (Shahde-Golha, Iran) (n = 25), and Group 3, DPH (n = 20).
Each group received double doses of the respective treatments on two successive nights, researchers indicated that
* Honey type 1 was superior to DPH in improving all aspects of coughs, except the frequency,
* Honey type 2 was more effective than DPH in improving all aspects of coughs, except the sleep quality of the child.
* There was no significant difference between Honey type 1 and 2 in any aspects of cough relief.
After examing the standard validated questionnaire completed by the parents before and after treatment.
Dr. Ayazi P, the lead author wrote in the final report, " honey may provide better cough relief than DPH in children and improve the sleep quality of children and their parents".
By comparing the above studies, there is no doubt that honey may be used for the treatment of acute cough in children.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Honey for an acute cough in children by Oduwole O1, Meremikwu MM, Oyo-Ita A, Udoh EE. (PubMed)
(2) Comparison of the Effect of Two Kinds of Iranian Honey and Diphenhydramine on Nocturnal Cough and the Sleep Quality in Coughing Children and Their Parents by Ayazi P1, Mahyar A2, Yousef-Zanjani M1, Allami A3, Esmailzadehha N4, Beyhaghi T. (PubMed)
Sunday, June 28, 2020
Ginger, the Anti Cervical Cancer Functional Remedy, According to Studies
Scientists may have found a natural and pungent spice for the prevention and treatment of cervical cancer, according to the studies.
Cervical cancer is a medical condition characterized by cell growth disorderly and uncontrollably in the cervix tissue.
According to the statistics provided by the American Cancer Society, in 2018, approximately, 13,240 new cases of invasive cervical cancer were diagnosed. The disease causes the death of 4,170 women in the same year.
The 5-year survival rate for women with invasive cervical cancer is 92% if the cancer is detected at an early stage. About 46% of women with cervical cancer are diagnosed at an early stage.
Most cases of cervical cancer are detected during the annual physical exam during the Pap test.
The exact cause of cervical cancer is due to the alternation of the cells on the surface of the inner lining of the cervical tissue. Researchers do not know, Why? some women are more susceptible to the onset of cervical cancer while others do not, even have the same health conditions and family history in the same family.
However, researchers do know that certain risk factors such as human papillomavirus (HPV) infection, the increase in age, herpes infection, smoking are associated with the onset of cervical cancer.
Ethnicity also plays a critical role in cervical cancer, the American Cancer Society wrote, "In the United States, Hispanic women are most likely to get cervical cancer, followed by African-Americans, Asians, and Pacific Islanders, and whites. American Indians and Alaskan natives have the lowest risk of cervical cancer in this country".
Furthermore, some researchers suggested that oral sex which refers to sexual activities involving the stimulation of the genitalia by the use of the mouth, tongue, teeth, or throat also has a strong linkage to cervical cancer. Dr. Rajiv Saini examined the link between oral sex and cervical cancer wrote, "Current research suggests that oral sex may transmit human papillomavirus (HPV), the virus implicated in the majority of cervical cancers. HPV is ubiquitous, with 120 strains isolated from human beings, about 40 of which are in the mouth and genital tracts".
Researchers on finding a natural compound for the treatment of cervical cancer examined the antitumor activities of 6-Gingerol, a potent nutraceutical isolated from the ginger on human cervical cancer (HeLa) cell lines with or without wortmannin, rapamycin, and cisplatin.
Injection of 6-Gingerol showed dose-dependent cytotoxicity on human cervical cancer (HeLa) cell lines.
Combinations of 6-gingerol with wortmannin and cisplatin showed additive effects, while with rapamycin, it showed 50% cytotoxicity that was equivalent to IC50 of 6-gingerol alone.
Treatment with 6-gingerol resulted in G2-phase arrest in HeLa cells. 6-Gingerol, wortmannin, and rapamycin treatment showed almost two-fold higher expression of a pro-apoptotic protein in the tested cell line.
The finding strongly suggested that 6-gingerol may be a safe and potent chemotherapeutic/chemopreventive compound acting through cell cycle arrest and induction of apoptosis in cervical tumor cells.
In order to reveal more information about ginger Anti-cervical cancer properties, researchers examined the polyphenolic alkanone, 6-Gingerol (6G), presented in the pungent extracts of ginger (Zingiber officinale Roscoe) anti-tumorigenic and pro-apoptotic activities against cervical cancer.
In vivo. 6G potently inhibited the proliferation of the HPV positive cervical cancer cells.
Additionally, 6G was found to inhibit the chymotrypsin activity associated with the induced degradation of tumor suppressor proteins, reactivate the gene involved regulating cell cycle and tumor suppression, and suppress the protein involved a cellular response to cytokines, chemokines, stimuli.
More interestingly, injection 6G also expressed an inhibitory activity against cervical cancer cell lines through inducing DNA damage of the tumor cell and G2/M cell cycle arrest and potentiate the cytotoxicity of cisplatin
6G treatment induced a significant reduction of tumor volume, tumor weight, inhibition of proteasome that breaks down protein, and tumor-suppressive gene accumulation in HeLa xenograft tumor cells in vivo.
Dr. Rastogi N and colleagues said, " our data underscore the therapeutic and chemosensitizing effects of 6G in the management and treatment of cervical cancer".
Taken altogether, ginger with abundantly bioactive compound 6-gingerol may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of cervical cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) 6-Gingerol Mediates its Anti Tumor Activities in Human Oral and Cervical Cancer Cell Lines through Apoptosis and Cell Cycle Arrest by Kapoor V1, Aggarwal S1, Das SN. (PubMed)
(2) Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-gingerol in cervical cancer cells by Rastogi N1, Duggal S2, Singh SK3, Porwal K1, Srivastava VK2, Maurya R4, Bhatt ML2, Mishra DP. (PubMed)
(3) Oral sex and oral cancer: A virus link by Rajiv Saini. (PMC)
Cervical cancer is a medical condition characterized by cell growth disorderly and uncontrollably in the cervix tissue.
According to the statistics provided by the American Cancer Society, in 2018, approximately, 13,240 new cases of invasive cervical cancer were diagnosed. The disease causes the death of 4,170 women in the same year.
The 5-year survival rate for women with invasive cervical cancer is 92% if the cancer is detected at an early stage. About 46% of women with cervical cancer are diagnosed at an early stage.
Most cases of cervical cancer are detected during the annual physical exam during the Pap test.
The exact cause of cervical cancer is due to the alternation of the cells on the surface of the inner lining of the cervical tissue. Researchers do not know, Why? some women are more susceptible to the onset of cervical cancer while others do not, even have the same health conditions and family history in the same family.
However, researchers do know that certain risk factors such as human papillomavirus (HPV) infection, the increase in age, herpes infection, smoking are associated with the onset of cervical cancer.
Ethnicity also plays a critical role in cervical cancer, the American Cancer Society wrote, "In the United States, Hispanic women are most likely to get cervical cancer, followed by African-Americans, Asians, and Pacific Islanders, and whites. American Indians and Alaskan natives have the lowest risk of cervical cancer in this country".
Furthermore, some researchers suggested that oral sex which refers to sexual activities involving the stimulation of the genitalia by the use of the mouth, tongue, teeth, or throat also has a strong linkage to cervical cancer. Dr. Rajiv Saini examined the link between oral sex and cervical cancer wrote, "Current research suggests that oral sex may transmit human papillomavirus (HPV), the virus implicated in the majority of cervical cancers. HPV is ubiquitous, with 120 strains isolated from human beings, about 40 of which are in the mouth and genital tracts".
Researchers on finding a natural compound for the treatment of cervical cancer examined the antitumor activities of 6-Gingerol, a potent nutraceutical isolated from the ginger on human cervical cancer (HeLa) cell lines with or without wortmannin, rapamycin, and cisplatin.
Injection of 6-Gingerol showed dose-dependent cytotoxicity on human cervical cancer (HeLa) cell lines.
Combinations of 6-gingerol with wortmannin and cisplatin showed additive effects, while with rapamycin, it showed 50% cytotoxicity that was equivalent to IC50 of 6-gingerol alone.
Treatment with 6-gingerol resulted in G2-phase arrest in HeLa cells. 6-Gingerol, wortmannin, and rapamycin treatment showed almost two-fold higher expression of a pro-apoptotic protein in the tested cell line.
The finding strongly suggested that 6-gingerol may be a safe and potent chemotherapeutic/chemopreventive compound acting through cell cycle arrest and induction of apoptosis in cervical tumor cells.
In order to reveal more information about ginger Anti-cervical cancer properties, researchers examined the polyphenolic alkanone, 6-Gingerol (6G), presented in the pungent extracts of ginger (Zingiber officinale Roscoe) anti-tumorigenic and pro-apoptotic activities against cervical cancer.
In vivo. 6G potently inhibited the proliferation of the HPV positive cervical cancer cells.
Additionally, 6G was found to inhibit the chymotrypsin activity associated with the induced degradation of tumor suppressor proteins, reactivate the gene involved regulating cell cycle and tumor suppression, and suppress the protein involved a cellular response to cytokines, chemokines, stimuli.
More interestingly, injection 6G also expressed an inhibitory activity against cervical cancer cell lines through inducing DNA damage of the tumor cell and G2/M cell cycle arrest and potentiate the cytotoxicity of cisplatin
6G treatment induced a significant reduction of tumor volume, tumor weight, inhibition of proteasome that breaks down protein, and tumor-suppressive gene accumulation in HeLa xenograft tumor cells in vivo.
Dr. Rastogi N and colleagues said, " our data underscore the therapeutic and chemosensitizing effects of 6G in the management and treatment of cervical cancer".
Taken altogether, ginger with abundantly bioactive compound 6-gingerol may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of cervical cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) 6-Gingerol Mediates its Anti Tumor Activities in Human Oral and Cervical Cancer Cell Lines through Apoptosis and Cell Cycle Arrest by Kapoor V1, Aggarwal S1, Das SN. (PubMed)
(2) Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-gingerol in cervical cancer cells by Rastogi N1, Duggal S2, Singh SK3, Porwal K1, Srivastava VK2, Maurya R4, Bhatt ML2, Mishra DP. (PubMed)
(3) Oral sex and oral cancer: A virus link by Rajiv Saini. (PMC)
Saturday, June 27, 2020
Onion, the Best in the Management of Surgical Wounds
Surgery is a medical practice that uses operative manual and instrumental techniques on a patient to investigate or treat an injury or disease
The aim of the medical procedure is to promote bodily function,
Most common types of surgery in the US
* Appendectomy is the common surgery that removes the appendix in patients with acute inflammation of the appendix due to infection.
* Breast biopsy. A biopsy that removes breast tissue to diagnose cancer.
* Carotid endarterectomy is used to remove the blockage from carotid arteries
* Cataract surgery is to remove the cloudy lens and replace it with a clear artificial lens.
* Cesarean section or c-section helps to deliver a baby by making an incision through the mother's abdomen and uterus.
* Cholecystectomy is a surgery that removes the gallbladder.
The Atlantic General Hospital in examining the benefits and risk of surgery wrote,
"Benefits of having surgery
• Prevention of or improvements to medical conditions caused by a patient's obesity
• Surge in energy
• Increased life expectancy
• Increased self-esteem
• Weight loss
Risks to having surgery:
• A blood clot in a vein (deep venous thrombosis or DVT)
• Bleeding or infection
• Bowel obstruction caused by scar tissue
• Leakage of fluid (if opting for gastric banding)
• Adverse reaction to anesthesia
• Nausea and Vomiting
• Band slippage (if opting for gastric banding)
• Gallstones
• The overall risk of death".
Please make sure that you discuss all the health benefits and risks of having surgery with your surgeon ahead of the operation.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
On finding a natural compound for the reducing scar after surgery, researchers investigated the effects of onion extract-based topical gel (Mederma, Merz Pharmaceuticals, Greensboro, NC, USA) that has been marketed as a product to improve scar appearance and texture.
The randomized, double-blinded, split-scar study including 24 patients with new surgical wounds of at least 4 cm in length was divided into two equal portions with each half treated by either onion extract gel or petrolatum ointment at the time of suture removal by applying three times daily for 8 weeks.
By comparing the efficacy between the onion extract gel and a petrolatum-based emollient (Aquaphor, Beiersdorf, Inc., Wilton, CT, USA), researchers at the Harvard Medical School showed that
* According to patients evaluated at 2, 8, and 12 weeks following initiation of treatment and a follow-up telephone interview conducted at least 11 months postoperatively, onion extract gel improved the wound healing compared to those of petrolatum-based topical agents.
* According to the paired t-test and the Wilcoxon signed-rank test at the end of the experiment, there was no statistically significant difference (p < .1) between the two treatment groups.
In other words, onion extract-based topical gel demonstrated a similar effect as those of petrolatum ointment but did not improve scar cosmesis or symptomatology.
Where Petrolatum ointment has been used in standard therapy in the management of postoperative wounds.
Taken altogether, onion may be considered a remedy in the management of postoperative wounds, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Onion extract gel versus petrolatum emollient on new surgical scars: prospective double-blinded study by Chung VQ1, Kelley L, Marra D, Jiang SB. (PubMed)
(2) Risks & Benefits of Surgery by The Atlantic General Hospital
The aim of the medical procedure is to promote bodily function,
Most common types of surgery in the US
* Appendectomy is the common surgery that removes the appendix in patients with acute inflammation of the appendix due to infection.
* Breast biopsy. A biopsy that removes breast tissue to diagnose cancer.
* Carotid endarterectomy is used to remove the blockage from carotid arteries
* Cataract surgery is to remove the cloudy lens and replace it with a clear artificial lens.
* Cesarean section or c-section helps to deliver a baby by making an incision through the mother's abdomen and uterus.
* Cholecystectomy is a surgery that removes the gallbladder.
The Atlantic General Hospital in examining the benefits and risk of surgery wrote,
"Benefits of having surgery
• Prevention of or improvements to medical conditions caused by a patient's obesity
• Surge in energy
• Increased life expectancy
• Increased self-esteem
• Weight loss
Risks to having surgery:
• A blood clot in a vein (deep venous thrombosis or DVT)
• Bleeding or infection
• Bowel obstruction caused by scar tissue
• Leakage of fluid (if opting for gastric banding)
• Adverse reaction to anesthesia
• Nausea and Vomiting
• Band slippage (if opting for gastric banding)
• Gallstones
• The overall risk of death".
Please make sure that you discuss all the health benefits and risks of having surgery with your surgeon ahead of the operation.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild, or sweet.
On finding a natural compound for the reducing scar after surgery, researchers investigated the effects of onion extract-based topical gel (Mederma, Merz Pharmaceuticals, Greensboro, NC, USA) that has been marketed as a product to improve scar appearance and texture.
The randomized, double-blinded, split-scar study including 24 patients with new surgical wounds of at least 4 cm in length was divided into two equal portions with each half treated by either onion extract gel or petrolatum ointment at the time of suture removal by applying three times daily for 8 weeks.
By comparing the efficacy between the onion extract gel and a petrolatum-based emollient (Aquaphor, Beiersdorf, Inc., Wilton, CT, USA), researchers at the Harvard Medical School showed that
* According to patients evaluated at 2, 8, and 12 weeks following initiation of treatment and a follow-up telephone interview conducted at least 11 months postoperatively, onion extract gel improved the wound healing compared to those of petrolatum-based topical agents.
* According to the paired t-test and the Wilcoxon signed-rank test at the end of the experiment, there was no statistically significant difference (p < .1) between the two treatment groups.
In other words, onion extract-based topical gel demonstrated a similar effect as those of petrolatum ointment but did not improve scar cosmesis or symptomatology.
Where Petrolatum ointment has been used in standard therapy in the management of postoperative wounds.
Taken altogether, onion may be considered a remedy in the management of postoperative wounds, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Onion extract gel versus petrolatum emollient on new surgical scars: prospective double-blinded study by Chung VQ1, Kelley L, Marra D, Jiang SB. (PubMed)
(2) Risks & Benefits of Surgery by The Atlantic General Hospital
Friday, June 26, 2020
Healthy Food Tomato Promotes Immunomodulatory Activity Against the Onset of Colitis In Vivo
Colitis is chronic a condition associated with the inflammation of the large intestine, including the colon, caecum, and rectum.
Colitis can be classified into the microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis and Behcet's colitis(a), according to the Catholic University of the Sacred Heart.
Most common symptoms of colitis are totally depending on the types. However, the general symptoms include
* Adnominal pain and diarrhea
There is a report of a 25-year-old Iranian gentleman was admitted to hospital with severe bloody diarrhea and abdominal pain as a result of herbal-induced weight loss adverse effects. On flexible sigmoidoscopy, a continuous length of congested mucosa with multiple small ulcers was seen extending up to the mid-transverse colon, in keeping with ulcerative colitis, according to the study by
Homerton University Hospital NHS Foundation Trust(1)
2. Bleeding per rectum
Acute ischaemic colitis (AIC) is being increasingly recognized as an uncommon cause of abdominal pain associated with fresh bleeding per rectum and diarrhea, according to the study by University Central Hospital(2).
3. Distention with bloody diarrhea
The typical clinical presentation is acute sudden abdominal pain and distention with bloody diarrhea(3).
4. Abdominal bloating and flatulence
In the study to estimate the prevalence of microscopic colitis and SIBO in patients with IBS, to evaluate the symptoms and the efficacy of treatment found that out of the 132 patients initially diagnosed with IBS 3% (n=4) had microscopic colitis and 43.9% (n=58) had SIBO. Diarrhea was the main symptom in patients with microscopic colitis and SIBO (p=0.041), while abdominal pain, abdominal bloating, and flatulence were prominent in IBS patients (p=0.042; p=0.039; p=0.048)(4).
5. Changes in bowel habits
Abdominal pain, bloating, early satiety, and changes in bowel habits are common presenting symptoms in individuals with functional GI disorders(5).
6. Fever and severe dehydration
There is a report of a 19-year-old man with a 1-year history of ulcerative colitis presented with fever, bloody diarrhea, and severe dehydration. He was on po.48 mg methylprednisolone and 3 g mesalazine daily and has recently finished taking clarithromycin for Campylobacter jejuni infection(6).
7. Urgency
The study to examine the differing perspectives and perceptual gaps relating to ulcerative colitis (UC) symptoms and their management between patients and healthcare professionals (HCPs), indicated that fifty-five percent of patients stated that UC symptoms over the past year had affected their quality of life, while physicians and nurses estimated that 35% to 37% of patients would have a reduced quality of life over the same period. Patients ranked urgency and pain as the most bothersome symptoms(7)
8. Other symptoms
There is a report of a case of a 51-year-old Caucasian male who was evaluated for abdominal pain, elevated liver enzymes, leukopenia, thrombocytopenia, severe peripheral arthralgias, and chronic watery diarrhea as a result of granulomatous enterocolitis. due to Sarcoidosis(8). Another study conducted by Anhui University of Traditional Chinese Medicine, with rats in the model group, showed lethargy, poor appetite, loss of energy, diarrhea, and bloody stool(9).
If you have experienced some of the aforementioned symptoms persistently with no signs of stopping, please make sure you check with your doctor to rule out the possibility of colitis.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
On finding healthy foods for the treatment of colitis, researchers examined the impact of tomato lycopene extract (TLE) on intestinal inflammation.
The study included mice lipopolysaccharide (LPS)-induced innate signaling and experimental colitis fed a diet containing 0.5 and 2% TLE or isoflavone free control (AIN-76).
According to the tested assays, TLE blocked LPS-induced IkappaBalpha degradation and RelA translocation associated with the onset of colitis by blocking the inhibition of the protein involved in cytokine production.
Furthermore, MIP-2, a small cytokine mRNA accumulation in IEC-18 cells and pro-inflammatory cytokine Interleukin 12 (IL-12) induced by LPS were inhibited by the injection of TLE.
Moreover, the application of TLE also increased the expression of anti-inflammatory cytokines IL-6, TNF-alpha, a regulator of inflammation and MCP-1 mRNA associated with macrophage recruitment in the colon of TLE-fed subjects.
The results strongly suggested that tomato extract inhibited the colitis in mice through its modulatory of immune and inflammatory activity.
Taken altogether, tomato may be considered a dietary supplement for the prevention and treatment of colitis, pending to large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice by Joo YE1, Karrasch T, Mühlbauer M, Allard B, Narula A, Herfarth HH, Jobin C. (PubMed)
(2) Colitis - Types and Symptoms by Kyle J. Norton
Colitis can be classified into the microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis and Behcet's colitis(a), according to the Catholic University of the Sacred Heart.
Most common symptoms of colitis are totally depending on the types. However, the general symptoms include
* Adnominal pain and diarrhea
There is a report of a 25-year-old Iranian gentleman was admitted to hospital with severe bloody diarrhea and abdominal pain as a result of herbal-induced weight loss adverse effects. On flexible sigmoidoscopy, a continuous length of congested mucosa with multiple small ulcers was seen extending up to the mid-transverse colon, in keeping with ulcerative colitis, according to the study by
Homerton University Hospital NHS Foundation Trust(1)
2. Bleeding per rectum
Acute ischaemic colitis (AIC) is being increasingly recognized as an uncommon cause of abdominal pain associated with fresh bleeding per rectum and diarrhea, according to the study by University Central Hospital(2).
3. Distention with bloody diarrhea
The typical clinical presentation is acute sudden abdominal pain and distention with bloody diarrhea(3).
4. Abdominal bloating and flatulence
In the study to estimate the prevalence of microscopic colitis and SIBO in patients with IBS, to evaluate the symptoms and the efficacy of treatment found that out of the 132 patients initially diagnosed with IBS 3% (n=4) had microscopic colitis and 43.9% (n=58) had SIBO. Diarrhea was the main symptom in patients with microscopic colitis and SIBO (p=0.041), while abdominal pain, abdominal bloating, and flatulence were prominent in IBS patients (p=0.042; p=0.039; p=0.048)(4).
5. Changes in bowel habits
Abdominal pain, bloating, early satiety, and changes in bowel habits are common presenting symptoms in individuals with functional GI disorders(5).
6. Fever and severe dehydration
There is a report of a 19-year-old man with a 1-year history of ulcerative colitis presented with fever, bloody diarrhea, and severe dehydration. He was on po.48 mg methylprednisolone and 3 g mesalazine daily and has recently finished taking clarithromycin for Campylobacter jejuni infection(6).
7. Urgency
The study to examine the differing perspectives and perceptual gaps relating to ulcerative colitis (UC) symptoms and their management between patients and healthcare professionals (HCPs), indicated that fifty-five percent of patients stated that UC symptoms over the past year had affected their quality of life, while physicians and nurses estimated that 35% to 37% of patients would have a reduced quality of life over the same period. Patients ranked urgency and pain as the most bothersome symptoms(7)
8. Other symptoms
There is a report of a case of a 51-year-old Caucasian male who was evaluated for abdominal pain, elevated liver enzymes, leukopenia, thrombocytopenia, severe peripheral arthralgias, and chronic watery diarrhea as a result of granulomatous enterocolitis. due to Sarcoidosis(8). Another study conducted by Anhui University of Traditional Chinese Medicine, with rats in the model group, showed lethargy, poor appetite, loss of energy, diarrhea, and bloody stool(9).
If you have experienced some of the aforementioned symptoms persistently with no signs of stopping, please make sure you check with your doctor to rule out the possibility of colitis.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
On finding healthy foods for the treatment of colitis, researchers examined the impact of tomato lycopene extract (TLE) on intestinal inflammation.
The study included mice lipopolysaccharide (LPS)-induced innate signaling and experimental colitis fed a diet containing 0.5 and 2% TLE or isoflavone free control (AIN-76).
According to the tested assays, TLE blocked LPS-induced IkappaBalpha degradation and RelA translocation associated with the onset of colitis by blocking the inhibition of the protein involved in cytokine production.
Furthermore, MIP-2, a small cytokine mRNA accumulation in IEC-18 cells and pro-inflammatory cytokine Interleukin 12 (IL-12) induced by LPS were inhibited by the injection of TLE.
Moreover, the application of TLE also increased the expression of anti-inflammatory cytokines IL-6, TNF-alpha, a regulator of inflammation and MCP-1 mRNA associated with macrophage recruitment in the colon of TLE-fed subjects.
The results strongly suggested that tomato extract inhibited the colitis in mice through its modulatory of immune and inflammatory activity.
Taken altogether, tomato may be considered a dietary supplement for the prevention and treatment of colitis, pending to large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice by Joo YE1, Karrasch T, Mühlbauer M, Allard B, Narula A, Herfarth HH, Jobin C. (PubMed)
(2) Colitis - Types and Symptoms by Kyle J. Norton
Thursday, June 25, 2020
Manuka Honey, the Best for the Prevention and Treatment of Acute and Chronic Inflammatory Diseases
Honey may the next pharmaceutical target to identify the single ingredient medicine for the treatment of choric inflammatory disease, some scientists suggested.
Inflammation is a natural and systematic response of the immune system in the protection of the body against infection caused by the invasion of stimuli and pathogens.
After sensing the bodily injury or damage, the white blood cells of the immune first line of defense stimulates the production of a blood clot to seal the would quickly and proinflammatory cytokine to the site of infection with an aim to kill off all microorganisms which may cause harm to our body.
In this acute phase of the battle, most of the times are won by the immune system. However, overexpression of the pro-inflammatory cytokines can lead the death of nearby healthy cells and improper skin healing with the formation of scars.
In some cases, certain proteins with duo anti and proinflammatory function also can switch to pro-inflammatory cytokines depending on the severity of the infection.
Chronic inflammation is a medical condition that lasts longer than 8 weeks, caused by the inability of the immune system to kill off all the microorganisms that have successfully entered the body during the acute phase of infection.
Some researchers suggested that the evolution of the immune system is to kill off the foreign micro invaders within the time frames of 8 weeks. If not, the immune system will adapt to the change, leading to chronic low-grade inflammation, a major cause of many chronic illnesses, including diabetes.
In some instances, chronic inflammation can also be caused by the immune system that mistakenly attacks the bodily tissue.
Dr. Philip Hunter in the study "The inflammation theory of disease" pinpointed the important cause of diseases associated with chronic inflammation, "Maria Abreu's research group at the University of Miami's Miller School of Medicine in the USA found that the incidence of colon cancer was linked directly to the expression of the Toll-like receptor 4 (TLR4) gene".
"TLRs are crucial in alerting the immune system to microbial infection, triggering acute inflammatory responses that clear invading pathogens. However, TLR4 can also maintain chronic inflammation, for example by responding to commensal bacteria in the gut. As such bacteria are constantly replenished through food intake, and therefore cannot be permanently cleared by the immune system, this can lead to persistent chronic infection maintained by TLRs. "
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding an ingredient or whole food for the prevention and treatment of acute and chronic inflammatory diseases, scientists at the Menoufia University examine the honey effects in a rat model of colitis induced by the injection of dextran sodium sulfate (DSS).
Application of natural honey showed a strong effect in the prevention of tissue injury and inflammatory infiltration by inhibited by proteins associated with the production of proinflammatory cytokine and overexpression of reactive oxygen species.
Further examination of honey effect, researchers indicated that the honey-treated group had significantly improved macroscopic and microscopic scores and inhibited the apoptotic markers.
At the end of the experiment, researchers said, "the beneficial role of natural honey in the treatment of DSS-induced colitis via the inhibition of colonic motor dysfunction and the inflammatory-oxidative-apoptotic cascade" and "the role of honey in epithelial regeneration was clarified", after taking into account co and confounders.
Moreover, in order to understand the gastroprotective effects of manuka honey against ethanol-induced gastric ulcers in rats, researchers examined the joint studies led by King Abdulaziz University, including 4 our groups of rats randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.
During the stud, Manuka honey treated group displayed a significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein.
Manuka honey treated group also showed increased levels of antioxidants enzymes which were suppressed by the injection of ethanol to an induced ulcer.
Manuka honey also decreased gastric mucosal MDA, the oxidative stress marker and plasma of proinflammatory cytokines.
Dr. Almasaudi SB, the lead scientist wrote in the final report, "manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels".
Taken altogether, Manuka honey may be considered a functional food for the prevention of inflammation and combined with the primary medicine for the treatment of chronic inflammatory diseases with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) The dual anti-inflammatory and antioxidant activities of natural honey promote cell proliferation and neural regeneration in a rat model of colitis by Nooh HZ1, Nour-Eldien NM2.(PubMed)
(2) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(3) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
Wednesday, June 24, 2020
Thyme Honey, the Potential Anti Endometrial Cancer Functional Food
Honey may have a significant effect on reducing risk and treatment of endometrial cancer, some scientists suggested.
Endometrial cancer is a chronic condition characterized by the irregular cell in the tissue of the endometrium.
Most cases of endometrial cancer start on the cells in the surface of the inner lining of the endometrium. At the advanced stage, after penetrating into the deeper layers, malignant cancer cells may travel a distance away to infect other healthy tissue and organs.
Endometrial cancer has been found to metastasize to the rectum, bladder, pelvic and para-aortic lymph nodes, vagina.
The exact causes of endometrial cancer are unknown. Epidemiological studies suggested that the increase in age, more years of menstruation, never been pregnant, obesity and use of hormone therapy are some the major prevalent risk factors associated with endometrial cancer.
Some researchers indicated that hormone change in the women body such as higher androgen and estrogen levels and lower levels of progesterone due to polycystic ovarian syndrome (PCOs) also is a major cause of endometrial cancer.
Dr. Navaratnarajah R, the lead author in the concern of the association of polycystic ovarian syndrome (PCOs) and the risk endometrial cancer, said, "several studies have been published that appear to support this association, and it is common practice among gynecologists and physicians to prescribe hormonal treatment to reduce this perceived risk".
"The mechanism(s) underlying any association is also unclear, but it is again widely assumed that chronic anovulation, which results in continuous estrogen stimulation of the endometrium unopposed by progesterone, is a major factor".
These result clearly state that long-term overexpression of estrogen and reduced levels of progesterone are associated with the onset of the diseases. However, the study of PCOs in the endometrial cancer risk should also be taken into accounts of obesity, hyperinsulinemia, and hyperandrogenism, which are also features of PCOS and risk factors for endometrial carcinoma.
In the association of PCOs and endometrial cancer mortality, the doctor team indicated, there is no evidence to link the increased mortality from endometrial cancer in women with the syndrome.
The study once again reaffirms the link of the estrogen therapy used in menopause women for the treatment of climate symptoms. In other words, long-term high levels of estrogen compared to progesterone in the body is the major cause of endometrial cancer.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient or whole food for the prevention and treatment of endometrial cancer, researchers examined the honey influence the oestrogenic activity.
The chemical composition and the potential of Greek honey extracts (thyme, pine and fir honey) were classified to evaluate the most inhibitory activity against the endometrial cancer cells Ishikawa line.
Compared to other honey, thyme honey processes a highest total phenolics, phenolic acids, and hydroxymethylfurfural.
Thyme honey inhibited the expression of Ishikawa by reducing the cancer cells viability.
Moreover, application of thyme honey also exerted a significant effect against Ishikawa and other cancer cell lines by inhibiting the cancer cell proliferation, inducing apoptosis and cell cycle arrest.
Futhermore, the inhibition of Thyme honey also found to associated with its function in the mediation of estrogen via modulation of the estrogen receptor activity, as estrogen agonists or antagonists in cancer cell lines on a tissue type-specific manner.
The efficacy of thyme honey anti endometrial cancer was probably associated with its polyphenols and phenolic acids (vanillic acid and protocatechuic acid and p10 hydroxybenzoic acid) as these compounds have been proven to inhibit cancer-related pathways and processes
These results indicated that thyme honey monitored cell proliferation may be useful in cancer prevention, particularly, in endometrial cancer, though it's agonists/antagonists properties.
Dr. Mari Jaakkola, the lead scientist in the conclusion of the study said, " honey, especially the thyme honey, may be used as an alternative to sugar, while its incorporation in the human diet or as a food ingredient may prevent cancer-related processes, promoting thus the health of consumers".
Taken altogether, Thyme honey processed major bioactive compounds polyphenols and phenolic acids may be considered a functional food for the prevention and combined with other primary therapy for the treatment of endometrial cancer without inducing any side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Bioactivity of Greek honey extracts on breast cancer (MCF7), prostate cancer (PC3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts (Research Gate) PDF
(2) Polycystic ovary syndrome and endometrial cancer by Navaratnarajah R1, Pillay OC, Hardiman P. (PubMed)
Endometrial cancer is a chronic condition characterized by the irregular cell in the tissue of the endometrium.
Most cases of endometrial cancer start on the cells in the surface of the inner lining of the endometrium. At the advanced stage, after penetrating into the deeper layers, malignant cancer cells may travel a distance away to infect other healthy tissue and organs.
Endometrial cancer has been found to metastasize to the rectum, bladder, pelvic and para-aortic lymph nodes, vagina.
The exact causes of endometrial cancer are unknown. Epidemiological studies suggested that the increase in age, more years of menstruation, never been pregnant, obesity and use of hormone therapy are some the major prevalent risk factors associated with endometrial cancer.
Some researchers indicated that hormone change in the women body such as higher androgen and estrogen levels and lower levels of progesterone due to polycystic ovarian syndrome (PCOs) also is a major cause of endometrial cancer.
Dr. Navaratnarajah R, the lead author in the concern of the association of polycystic ovarian syndrome (PCOs) and the risk endometrial cancer, said, "several studies have been published that appear to support this association, and it is common practice among gynecologists and physicians to prescribe hormonal treatment to reduce this perceived risk".
"The mechanism(s) underlying any association is also unclear, but it is again widely assumed that chronic anovulation, which results in continuous estrogen stimulation of the endometrium unopposed by progesterone, is a major factor".
These result clearly state that long-term overexpression of estrogen and reduced levels of progesterone are associated with the onset of the diseases. However, the study of PCOs in the endometrial cancer risk should also be taken into accounts of obesity, hyperinsulinemia, and hyperandrogenism, which are also features of PCOS and risk factors for endometrial carcinoma.
In the association of PCOs and endometrial cancer mortality, the doctor team indicated, there is no evidence to link the increased mortality from endometrial cancer in women with the syndrome.
The study once again reaffirms the link of the estrogen therapy used in menopause women for the treatment of climate symptoms. In other words, long-term high levels of estrogen compared to progesterone in the body is the major cause of endometrial cancer.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural ingredient or whole food for the prevention and treatment of endometrial cancer, researchers examined the honey influence the oestrogenic activity.
The chemical composition and the potential of Greek honey extracts (thyme, pine and fir honey) were classified to evaluate the most inhibitory activity against the endometrial cancer cells Ishikawa line.
Compared to other honey, thyme honey processes a highest total phenolics, phenolic acids, and hydroxymethylfurfural.
Thyme honey inhibited the expression of Ishikawa by reducing the cancer cells viability.
Moreover, application of thyme honey also exerted a significant effect against Ishikawa and other cancer cell lines by inhibiting the cancer cell proliferation, inducing apoptosis and cell cycle arrest.
Futhermore, the inhibition of Thyme honey also found to associated with its function in the mediation of estrogen via modulation of the estrogen receptor activity, as estrogen agonists or antagonists in cancer cell lines on a tissue type-specific manner.
The efficacy of thyme honey anti endometrial cancer was probably associated with its polyphenols and phenolic acids (vanillic acid and protocatechuic acid and p10 hydroxybenzoic acid) as these compounds have been proven to inhibit cancer-related pathways and processes
These results indicated that thyme honey monitored cell proliferation may be useful in cancer prevention, particularly, in endometrial cancer, though it's agonists/antagonists properties.
Dr. Mari Jaakkola, the lead scientist in the conclusion of the study said, " honey, especially the thyme honey, may be used as an alternative to sugar, while its incorporation in the human diet or as a food ingredient may prevent cancer-related processes, promoting thus the health of consumers".
Taken altogether, Thyme honey processed major bioactive compounds polyphenols and phenolic acids may be considered a functional food for the prevention and combined with other primary therapy for the treatment of endometrial cancer without inducing any side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Bioactivity of Greek honey extracts on breast cancer (MCF7), prostate cancer (PC3) and endometrial cancer (Ishikawa) cells: Profile analysis of extracts (Research Gate) PDF
(2) Polycystic ovary syndrome and endometrial cancer by Navaratnarajah R1, Pillay OC, Hardiman P. (PubMed)
Tuesday, June 23, 2020
Manuka Honey, the Best for the Prevention and Treatment of Acute and Chronic Inflammatory Diseases
Honey may the next pharmaceutical target to identify the single ingredient medicine for the treatment of choric inflammatory disease, some scientists suggested.
Inflammation is a natural and systematic response of the immune system in the protection of the body against infection caused by the invasion of stimuli and pathogens.
After sensing the bodily injury or damage, the white blood cells of the immune first line of defense stimulates the production of a blood clot to seal the would quickly and proinflammatory cytokine to the site of infection with an aim to kill off all microorganisms which may cause harm to our body.
In this acute phase of the battle, most of the times are won by the immune system. However, overexpression of the pro-inflammatory cytokines can lead the death of nearby healthy cells and improper skin healing with the formation of scars.
In some cases, certain proteins with duo anti and proinflammatory function also can switch to pro-inflammatory cytokines depending on the severity of the infection.
Chronic inflammation is a medical condition that lasts longer than 8 weeks, caused by the inability of the immune system to kill off all the microorganisms that have successfully entered the body during the acute phase of infection.
Some researchers suggested that the evolution of the immune system is to kill off the foreign micro invaders within the time frames of 8 weeks. If not, the immune system will adapt to the change, leading to chronic low-grade inflammation, a major cause of many chronic illnesses, including diabetes.
In some instances, chronic inflammation can also be caused by the immune system that mistakenly attacks the bodily tissue.
Dr. Philip Hunter in the study "The inflammation theory of disease" pinpointed the important cause of diseases associated with chronic inflammation, "Maria Abreu's research group at the University of Miami's Miller School of Medicine in the USA found that the incidence of colon cancer was linked directly to the expression of the Toll-like receptor 4 (TLR4) gene".
"TLRs are crucial in alerting the immune system to microbial infection, triggering acute inflammatory responses that clear invading pathogens. However, TLR4 can also maintain chronic inflammation, for example by responding to commensal bacteria in the gut. As such bacteria are constantly replenished through food intake, and therefore cannot be permanently cleared by the immune system, this can lead to persistent chronic infection maintained by TLRs. "
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding an ingredient or whole food for the prevention and treatment of acute and chronic inflammatory diseases, scientists at the Menoufia University examine the honey effects in a rat model of colitis induced by the injection of dextran sodium sulfate (DSS).
Application of natural honey showed a strong effect in the prevention of tissue injury and inflammatory infiltration by inhibited by proteins associated with the production of proinflammatory cytokine and overexpression of reactive oxygen species.
Further examination of honey effect, researchers indicated that the honey-treated group had significantly improved macroscopic and microscopic scores and inhibited the apoptotic markers.
At the end of the experiment, researchers said, "the beneficial role of natural honey in the treatment of DSS-induced colitis via the inhibition of colonic motor dysfunction and the inflammatory-oxidative-apoptotic cascade" and "the role of honey in epithelial regeneration was clarified", after taking into account co and confounders.
Moreover, in order to understand the gastroprotective effects of manuka honey against ethanol-induced gastric ulcers in rats, researchers examined the joint studies led by King Abdulaziz University, including 4 of our groups of rats randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.
During the stud, Manuka honey treated group displayed a significantly decreased ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein.
Manuka honey treated group also showed increased levels of antioxidants enzymes which were suppressed by the injection of ethanol to an induced ulcer.
Manuka honey also decreased gastric mucosal MDA, the oxidative stress marker, and plasma of proinflammatory cytokines.
Dr. Almasaudi SB, the lead scientist wrote in the final report, "manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels".
Taken altogether, Manuka honey may be considered a functional food for the prevention of inflammation and combined with the primary medicine for the treatment of chronic inflammatory diseases with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) The dual anti-inflammatory and antioxidant activities of natural honey promote cell proliferation and neural regeneration in a rat model of colitis by Nooh HZ1, Nour-Eldien NM2.(PubMed)
(2) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(3) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
Inflammation is a natural and systematic response of the immune system in the protection of the body against infection caused by the invasion of stimuli and pathogens.
After sensing the bodily injury or damage, the white blood cells of the immune first line of defense stimulates the production of a blood clot to seal the would quickly and proinflammatory cytokine to the site of infection with an aim to kill off all microorganisms which may cause harm to our body.
In this acute phase of the battle, most of the times are won by the immune system. However, overexpression of the pro-inflammatory cytokines can lead the death of nearby healthy cells and improper skin healing with the formation of scars.
In some cases, certain proteins with duo anti and proinflammatory function also can switch to pro-inflammatory cytokines depending on the severity of the infection.
Chronic inflammation is a medical condition that lasts longer than 8 weeks, caused by the inability of the immune system to kill off all the microorganisms that have successfully entered the body during the acute phase of infection.
Some researchers suggested that the evolution of the immune system is to kill off the foreign micro invaders within the time frames of 8 weeks. If not, the immune system will adapt to the change, leading to chronic low-grade inflammation, a major cause of many chronic illnesses, including diabetes.
In some instances, chronic inflammation can also be caused by the immune system that mistakenly attacks the bodily tissue.
Dr. Philip Hunter in the study "The inflammation theory of disease" pinpointed the important cause of diseases associated with chronic inflammation, "Maria Abreu's research group at the University of Miami's Miller School of Medicine in the USA found that the incidence of colon cancer was linked directly to the expression of the Toll-like receptor 4 (TLR4) gene".
"TLRs are crucial in alerting the immune system to microbial infection, triggering acute inflammatory responses that clear invading pathogens. However, TLR4 can also maintain chronic inflammation, for example by responding to commensal bacteria in the gut. As such bacteria are constantly replenished through food intake, and therefore cannot be permanently cleared by the immune system, this can lead to persistent chronic infection maintained by TLRs. "
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding an ingredient or whole food for the prevention and treatment of acute and chronic inflammatory diseases, scientists at the Menoufia University examine the honey effects in a rat model of colitis induced by the injection of dextran sodium sulfate (DSS).
Application of natural honey showed a strong effect in the prevention of tissue injury and inflammatory infiltration by inhibited by proteins associated with the production of proinflammatory cytokine and overexpression of reactive oxygen species.
Further examination of honey effect, researchers indicated that the honey-treated group had significantly improved macroscopic and microscopic scores and inhibited the apoptotic markers.
At the end of the experiment, researchers said, "the beneficial role of natural honey in the treatment of DSS-induced colitis via the inhibition of colonic motor dysfunction and the inflammatory-oxidative-apoptotic cascade" and "the role of honey in epithelial regeneration was clarified", after taking into account co and confounders.
Moreover, in order to understand the gastroprotective effects of manuka honey against ethanol-induced gastric ulcers in rats, researchers examined the joint studies led by King Abdulaziz University, including 4 of our groups of rats randomly assigned to control, ethanol (ulcer), omeprazole, and manuka honey.
During the stud, Manuka honey treated group displayed a significantly decreased ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein.
Manuka honey treated group also showed increased levels of antioxidants enzymes which were suppressed by the injection of ethanol to an induced ulcer.
Manuka honey also decreased gastric mucosal MDA, the oxidative stress marker, and plasma of proinflammatory cytokines.
Dr. Almasaudi SB, the lead scientist wrote in the final report, "manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels".
Taken altogether, Manuka honey may be considered a functional food for the prevention of inflammation and combined with the primary medicine for the treatment of chronic inflammatory diseases with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) The dual anti-inflammatory and antioxidant activities of natural honey promote cell proliferation and neural regeneration in a rat model of colitis by Nooh HZ1, Nour-Eldien NM2.(PubMed)
(2) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Almasaudi SB1, El-Shitany NA2, Abbas AT3, Abdel-dayem UA4, Ali SS5, Al Jaouni SK6, Harakeh S. (PubMed)
(3) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
Monday, June 22, 2020
White Button Mushroom Which Processes A Potential to Cure Fatty Liver Disease
White button mushroom may have a protective effect against the onset and treatment nonalcoholic liver disease, some scientists suggested.
Fatty liver or hepatic steatosis is a disease caused by the buildup of fat in the liver. If the fat in your liver is over 5 percent proportional to the liver cells, you are considered to have the early stage of fatty liver disease.
According to the American liver foundation, the fatty liver is the most common disease in the US, affecting over affecting around 25 % of the population. The disease is most common in the age group between 40 and 60.
The common diseases associated with the onset of the nonalcoholic fatty liver disease include obesity hyperlipidemia, or high levels of fats in the blood, especially high triglycerides, diabetes, and genetic inheritance.
However, some researchers also found that long-term use of certain medications is the prevalent risk factor of fatty liver such as rapid weight loss side effects of certain medications, including methotrexate (Trexall), tamoxifen (Nolvadex), amiodarone (Pacerone), and valproic acid (Depakote).
Can the nonalcoholic fatty liver disease be prevented? Dr. William Nseir, the lead author in the study " Role of diet and lifestyle changes in nonalcoholic fatty liver disease", wrote, "there is no drug therapy that can be formulated for treating NAFLD. A combination of dietary modifications and increased physical activity remains the mainstay of NAFLD management" and
"NAFLD patients, whether obese or not, should be educated that a healthy diet and physical activity have benefits beyond weight reduction".
The result suggested that if you have followed a healthy diet high in fruits and vegetables, whole grain, and low in saturated and trans fat, red meat and processed food and lifestyle accompanied by moderate exercise, you risk of nonalcoholic fatty liver disease is closed to zero.
If you are experiencing the symptoms of a persistently enlarged fluid-filled abdomen, jaundice of the skin and eyes, confusion, and abnormal bleeding, please check with your doctor to rule out the possibility of fatty liver disease.
Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source,
It is a genus A. Muscaria and belongs to the family Amanitaceae and has been cultivated in many cultures all over the world for foods and health benefits.
The chemical constituents of white button mushroom include
Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil, and D-mannitol.
In the concerns of low estrogen production in the risk of nonalcoholic fatty liver disease in the menopause women, researchers at the cellular team at the Beckman Research Institute of the City of Hope launched an investigation to examine the effects of white mushroom in the groups of ovariectomized mice (a model of postmenopausal women).
Selected OVX mice were fed a high-fat diet supplemented with WBM powder before injection of white button mushroom to induce fatty disease patterns.
Application of white button mushroom (WBM) exerted a significant protective effect against liver steatosis in ovariectomized (OVX) mice.
As dietary WBM intake significantly lowered liver weight and hepatic injury markers in OVX mice.
The pathological examination also suggested that WBM lowers fat accumulation in tissue in the livers of mice.
Furthermore, the glucose clearance ability of tested mice also improved substantially compared to the untreated mice group.
According to the microarray analysis, genes associated to the fatty acid biosynthesis pathway, particularly the genes for fatty acid synthetase (Fas), a major determinant of the maximal hepatic capacity to generate fatty acids by de novo lipogenesis and fatty acid elongase 6 (Elovl6) which plays a key role in fat synthesis were down-regulated (reduced function).
Additionally, in vivo, the down-regulation of the expression of FAS and ELOVL6 in the HepG2 cell line by WBM extract was attributed to the inhibition of Liver X receptor (LXR) signaling and it's downstream transcriptional factor SREBP1c.
Where Liver X receptors (LXRs) are important regulators of cholesterol and fatty acid and SREBP-1c is associated with fatty liver and increased visceral fat mass.
The finding indicated that WBM is protective against hepatic steatosis and NAFLD in OVX mice as a model for postmenopausal women.
The study was published on October 25 on the US National Library of Medicine and National Institutes of Health. You can view the publication by clicking the link in the resources,
Taken altogether, white button mushroom may be considered a functional food for the prevention and treatment of nonalcoholic fatty liver disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL1, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) Protective effects of white button mushroom (Agaricus bisporus) against hepatic steatosis in ovariectomized mice as a model of postmenopausal women by Kanaya N1, Kubo M, Liu Z, Chu P, Wang C, Yuan YC, Chen S.(PubMed)
(2) Role of diet and lifestyle changes in nonalcoholic fatty liver disease by William Nseir, Elias Hellou, and Nimer Assy. (PubMed)
Fatty liver or hepatic steatosis is a disease caused by the buildup of fat in the liver. If the fat in your liver is over 5 percent proportional to the liver cells, you are considered to have the early stage of fatty liver disease.
According to the American liver foundation, the fatty liver is the most common disease in the US, affecting over affecting around 25 % of the population. The disease is most common in the age group between 40 and 60.
The common diseases associated with the onset of the nonalcoholic fatty liver disease include obesity hyperlipidemia, or high levels of fats in the blood, especially high triglycerides, diabetes, and genetic inheritance.
However, some researchers also found that long-term use of certain medications is the prevalent risk factor of fatty liver such as rapid weight loss side effects of certain medications, including methotrexate (Trexall), tamoxifen (Nolvadex), amiodarone (Pacerone), and valproic acid (Depakote).
Can the nonalcoholic fatty liver disease be prevented? Dr. William Nseir, the lead author in the study " Role of diet and lifestyle changes in nonalcoholic fatty liver disease", wrote, "there is no drug therapy that can be formulated for treating NAFLD. A combination of dietary modifications and increased physical activity remains the mainstay of NAFLD management" and
"NAFLD patients, whether obese or not, should be educated that a healthy diet and physical activity have benefits beyond weight reduction".
The result suggested that if you have followed a healthy diet high in fruits and vegetables, whole grain, and low in saturated and trans fat, red meat and processed food and lifestyle accompanied by moderate exercise, you risk of nonalcoholic fatty liver disease is closed to zero.
If you are experiencing the symptoms of a persistently enlarged fluid-filled abdomen, jaundice of the skin and eyes, confusion, and abnormal bleeding, please check with your doctor to rule out the possibility of fatty liver disease.
Mushroom is a standard name of white button mushroom, the fleshy, spore-bearing fruiting body of a fungus produced above ground on soil or on its food source,
It is a genus A. Muscaria and belongs to the family Amanitaceae and has been cultivated in many cultures all over the world for foods and health benefits.
The chemical constituents of white button mushroom include
Astraodorol, Psilocybin, Lectin, adustin, ribonuclease, nicotine, 2-hydroxy-4-methoxy-6-methylbenzoic acid, orsellinic acid, melleolide, ergosterol, genistein, daidzein, daucosterol, genistin, uracil, and D-mannitol.
In the concerns of low estrogen production in the risk of nonalcoholic fatty liver disease in the menopause women, researchers at the cellular team at the Beckman Research Institute of the City of Hope launched an investigation to examine the effects of white mushroom in the groups of ovariectomized mice (a model of postmenopausal women).
Selected OVX mice were fed a high-fat diet supplemented with WBM powder before injection of white button mushroom to induce fatty disease patterns.
Application of white button mushroom (WBM) exerted a significant protective effect against liver steatosis in ovariectomized (OVX) mice.
As dietary WBM intake significantly lowered liver weight and hepatic injury markers in OVX mice.
The pathological examination also suggested that WBM lowers fat accumulation in tissue in the livers of mice.
Furthermore, the glucose clearance ability of tested mice also improved substantially compared to the untreated mice group.
According to the microarray analysis, genes associated to the fatty acid biosynthesis pathway, particularly the genes for fatty acid synthetase (Fas), a major determinant of the maximal hepatic capacity to generate fatty acids by de novo lipogenesis and fatty acid elongase 6 (Elovl6) which plays a key role in fat synthesis were down-regulated (reduced function).
Additionally, in vivo, the down-regulation of the expression of FAS and ELOVL6 in the HepG2 cell line by WBM extract was attributed to the inhibition of Liver X receptor (LXR) signaling and it's downstream transcriptional factor SREBP1c.
Where Liver X receptors (LXRs) are important regulators of cholesterol and fatty acid and SREBP-1c is associated with fatty liver and increased visceral fat mass.
The finding indicated that WBM is protective against hepatic steatosis and NAFLD in OVX mice as a model for postmenopausal women.
The study was published on October 25 on the US National Library of Medicine and National Institutes of Health. You can view the publication by clicking the link in the resources,
Taken altogether, white button mushroom may be considered a functional food for the prevention and treatment of nonalcoholic fatty liver disease.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(a) [Chemical constituents from fungus Armillaria mellea]. by [Article in Chinese] by Yuan XL1, Yan LH, Zhang QW, Wang ZM.(PubMed)
(1) Protective effects of white button mushroom (Agaricus bisporus) against hepatic steatosis in ovariectomized mice as a model of postmenopausal women by Kanaya N1, Kubo M, Liu Z, Chu P, Wang C, Yuan YC, Chen S.(PubMed)
(2) Role of diet and lifestyle changes in nonalcoholic fatty liver disease by William Nseir, Elias Hellou, and Nimer Assy. (PubMed)
Sunday, June 21, 2020
Strawberry Effects on Human Type 1 Allergy
Scientists may have found a tasty whole food for the prevention and treatment of type 1 allergy with no side effects, according to studies.
The antigen is a toxin or other foreign pathogens that induce an immune response in the body, by stimulating the production of antibodies IgE.
According to the statistic, approximately 50 million Americans each year suffer from an allergy-related disease or condition. and the syndrome is a sixth leading cause of chronic illness in the US.
Epidemiological studies suggested that people with certain medical conditions such as asthma, family history of allergy and asthma and are younger than the age of 18 are at the increased risk of allergy.
Food allergies of type I which are mediated by food-specific IgE antibodies by signaling the release of histamine from the mast cells upon the contact with the relevant allergen, causing symptoms of skin, nose, throat, and lung irritation.
The genetic proposition is also one of the prevalent risk factors for the allergic onset. Dr. Romina A. Ortiz, the lead author in the examine the genetic risk in allergic diseases, wrote, "The allergic diseases are complex phenotypes for which a strong genetic basis has been firmly established" and "A major outcome of Genome-wide association studies (GWAS) in allergic disease has been the formation of national and international collaborations leading to consortia meta-analyses, and an appreciation for the specificity of genetic associations to sub-phenotypes of allergic disease".
The genes which have a potential cause of the allergic disease include ORMDL3 locus with childhood asthma and generalizability of FLG mutations with the allergic diathesis.,...
Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
On finding potential and natural whole food for the prevention and treatment of type 1 allergy with no side effects, scientists at the Gifu University evaluated the anti-allergic activity of chemical constituents isolated from the strawberry.
Linocinnamarin (LN), 1-O-trans-cinnamoyl-beta-d-glucopyranose (CG), and cinnamic acid (CA) from the fruit were found to exert a significant effect against the exhibited antigen (Ag) in stimulating the cellular process that releases antimicrobial cytotoxicity in rat basophilic leukemia RBL-2H3 cells.
On cellular responses induced by antigen stimulation, LN and CA markedly inhibited antigen-stimulated the elevation of intracellular free Ca(2+) concentration which plays an important role in T cell activation and reactive oxygen species (ROS).
The results were associated with the suppression of the Ag-stimulated spleen tyrosine kinase (Syk) activation that mediates immune receptors associated with antibody and antigen.
Further analysis of the efficacy of LN and CA, researchers discovered that the inhibition of antigen-by LN and CA is mainly due to the inactivation of Syk/phospholipase Cgamma (PLCgamma) pathways which control both the innate and adaptive immune systems.
Dr. Ninomiya M, said in the final report, "LN and CA isolated from F. ananassa Duch. (strawberry) could be beneficial agents for alleviating symptoms of type I allergy".
Other bioactive compounds isolated from strawberry including isolated the 4 kinds of flavonoids from strawberry 'Nohime' also were found to exert similar effects on the cellular process that releases antimicrobial cytotoxicity in RBL-2H3 cells in the Gifu International Institute of Biotechnology study.
The found flavonoids demonstrated a strong effect on the intracellular free Ca(2+) concentration ([Ca(2+)]i) and PLCgammas similar to those of the above study.
The treatment of flavonoids also displayed a strong effect on the intracellular signaling pathway associated with the regulation of immune cell function.
Dr. Itoh T, the lead author at the end of the experiment wrote, " suppression of Ag-stimulated degranulation by the flavonoids is mainly due to suppression of [Ca(2+)]i elevation and Syk activation".
Taken altogether, strawberry, the tasty fruit processed high amounts of bioactive compounds may be considered a function fruit for the prevention and treatment of type 1 allergy with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Genetics of Allergic Diseases by Romina A. Ortiz, MS and Kathleen C. Barnes, Ph.D. (PMC)
(2) Phenolic constituents isolated from Fragaria ananassa Duch. inhibit antigen-stimulated degranulation through direct inhibition of spleen tyrosine kinase activation by Ninomiya M, Itoh T, Ishikawa S, Saiki M, Narumiya K, Yasuda M, Koshikawa K, Nozawa Y, Koketsu M.(PubMed)
(3) Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 by Itoh T, Ninomiya M, Yasuda M, Koshikawa K, Deyashiki Y, Nozawa Y, Akao Y, Koketsu M.(PubMed)
The antigen is a toxin or other foreign pathogens that induce an immune response in the body, by stimulating the production of antibodies IgE.
According to the statistic, approximately 50 million Americans each year suffer from an allergy-related disease or condition. and the syndrome is a sixth leading cause of chronic illness in the US.
Epidemiological studies suggested that people with certain medical conditions such as asthma, family history of allergy and asthma and are younger than the age of 18 are at the increased risk of allergy.
Food allergies of type I which are mediated by food-specific IgE antibodies by signaling the release of histamine from the mast cells upon the contact with the relevant allergen, causing symptoms of skin, nose, throat, and lung irritation.
The genetic proposition is also one of the prevalent risk factors for the allergic onset. Dr. Romina A. Ortiz, the lead author in the examine the genetic risk in allergic diseases, wrote, "The allergic diseases are complex phenotypes for which a strong genetic basis has been firmly established" and "A major outcome of Genome-wide association studies (GWAS) in allergic disease has been the formation of national and international collaborations leading to consortia meta-analyses, and an appreciation for the specificity of genetic associations to sub-phenotypes of allergic disease".
The genes which have a potential cause of the allergic disease include ORMDL3 locus with childhood asthma and generalizability of FLG mutations with the allergic diathesis.,...
Strawberry is a genius of Fragaria × ananassa belongs to the family Roseaceae. They have been grown all over the world with a suitable climate for commercial profits and for health benefits.
The major chemical compounds include anthocyanin and ellagitannins and p-Hydroxybenzoic acid, p-coumaric acid, ellagic acid, cyanidin-3-glucoside, pelargonidin-3-glucoside, kaempferol, quercetin, and myricetin.
On finding potential and natural whole food for the prevention and treatment of type 1 allergy with no side effects, scientists at the Gifu University evaluated the anti-allergic activity of chemical constituents isolated from the strawberry.
Linocinnamarin (LN), 1-O-trans-cinnamoyl-beta-d-glucopyranose (CG), and cinnamic acid (CA) from the fruit were found to exert a significant effect against the exhibited antigen (Ag) in stimulating the cellular process that releases antimicrobial cytotoxicity in rat basophilic leukemia RBL-2H3 cells.
On cellular responses induced by antigen stimulation, LN and CA markedly inhibited antigen-stimulated the elevation of intracellular free Ca(2+) concentration which plays an important role in T cell activation and reactive oxygen species (ROS).
The results were associated with the suppression of the Ag-stimulated spleen tyrosine kinase (Syk) activation that mediates immune receptors associated with antibody and antigen.
Further analysis of the efficacy of LN and CA, researchers discovered that the inhibition of antigen-by LN and CA is mainly due to the inactivation of Syk/phospholipase Cgamma (PLCgamma) pathways which control both the innate and adaptive immune systems.
Dr. Ninomiya M, said in the final report, "LN and CA isolated from F. ananassa Duch. (strawberry) could be beneficial agents for alleviating symptoms of type I allergy".
Other bioactive compounds isolated from strawberry including isolated the 4 kinds of flavonoids from strawberry 'Nohime' also were found to exert similar effects on the cellular process that releases antimicrobial cytotoxicity in RBL-2H3 cells in the Gifu International Institute of Biotechnology study.
The found flavonoids demonstrated a strong effect on the intracellular free Ca(2+) concentration ([Ca(2+)]i) and PLCgammas similar to those of the above study.
The treatment of flavonoids also displayed a strong effect on the intracellular signaling pathway associated with the regulation of immune cell function.
Dr. Itoh T, the lead author at the end of the experiment wrote, " suppression of Ag-stimulated degranulation by the flavonoids is mainly due to suppression of [Ca(2+)]i elevation and Syk activation".
Taken altogether, strawberry, the tasty fruit processed high amounts of bioactive compounds may be considered a function fruit for the prevention and treatment of type 1 allergy with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Genetics of Allergic Diseases by Romina A. Ortiz, MS and Kathleen C. Barnes, Ph.D. (PMC)
(2) Phenolic constituents isolated from Fragaria ananassa Duch. inhibit antigen-stimulated degranulation through direct inhibition of spleen tyrosine kinase activation by Ninomiya M, Itoh T, Ishikawa S, Saiki M, Narumiya K, Yasuda M, Koshikawa K, Nozawa Y, Koketsu M.(PubMed)
(3) Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 by Itoh T, Ninomiya M, Yasuda M, Koshikawa K, Deyashiki Y, Nozawa Y, Akao Y, Koketsu M.(PubMed)
Saturday, June 20, 2020
Healthy Food Onion Reduces Risk of Endometrial Cancer
The endometrium is the inner lining of the mammalian uterus that is very susceptible to hormone change, particularly in the menstrual cycle.
The endometrium is also a reproductive organ where the implantation takes place. In the absence of periodic hormonal influence, before puberty or following menopause, this tissue has a constant morphology and thickness.
Endometrial cancer, a late adulthood cancer is a medical condition characterized by irregular cells growth that starts in the cell on the surface of the inner endometrial lining of the uterus due to the alternation of cells DNA.
Endometrial cancer is the fourth most common cancer among women worldwide, after breast, lung, and bowel cancer.
According to the statistics provided by the American Cancer Society, in the US, cancer of the endometrium is the most common cancer of the female reproductive organs. In 2019, approximately 61,000 cases of endometrial cancer will be diagnosed.
Most common types of endometrial cancer are
* Adenocarcinomas
Adenocarcinomas accounted for accounts for over 80% of cases of endometrial cancer that begins with irregular cells growth in the surface cells of the inner lining of the endometrium
Women who have an early onset of symptoms of peri-menopause are at a higher risk of adenocarcinomas.
* Uterine sarcoma
Uterine sarcoma, a rare uterine cancer containing malignant cells of the muscle and connective tissue of the uterus, is accounted for only 2 percent of all uterine cancer, including
** Endometrial stromal sarcomas
Endometrial stromal sarcomas are also endometrial cancers originated in the non-glandular connective tissue of the endometrium, with unknown origin.
* Leiomyosarcomas
Leiomyosarcomas is a form of endometrial cancer that originated from the smooth muscles of the uterus. Endometrial cancer has a resistant tendency and not very responsive to chemotherapy or radiation.
* Carcinosarcoma
Carcinosarcoma is a type of cancer caused by both epithelial and connective tissues of the uterus.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a potential compound for the treatment of endometrial cancer, researchers examined the relationship between onion and garlic intake on endometrial cancer, using data from an Italian case-control study.
According to the data of a multicentre case-control study of 454 endometrial cancer cases and 908 controls, admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions, the OR of endometrial cancer for successive categories of onion intake were 0.94 for <2 portions/week compared to garlic of 0.89.
The OR of onion intake was decreased to 0.40 (95% CI 0.22, 0.72) for > or =2 portions/week, compared to garlic of 0.62.
In other words, onion and garlic showed a significant inverse trend for the risk of endometrial cancer depending on the quality intake per week.
Furthermore, The OR for an increment of one portion (i.e. 80 g) of onions in the risk of endometrial cancer per week was 0.81.
Based on the finding, researchers said, "Our study found a moderate protective role of allium vegetables on the risk of endometrial cancer".
Taken altogether, onion may be considered a remedy for the prevention and treatment of endometrial cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Odds ratio analysis in women with endometrial cancer by Plagens-Rotman K1, Żak E1, Pięta B. (PubMed)
(2) Allium vegetables intake and endometrial cancer risk by Galeone C1, Pelucchi C, Dal Maso L, Negri E, Montella M, Zucchetto A, Talamini R, La Vecchia C. (PubMed)
(3) Most common Types of Cancer - Cancer of Endometrium/Endometrial Cancer by Kyle J. Norton
The endometrium is also a reproductive organ where the implantation takes place. In the absence of periodic hormonal influence, before puberty or following menopause, this tissue has a constant morphology and thickness.
Endometrial cancer, a late adulthood cancer is a medical condition characterized by irregular cells growth that starts in the cell on the surface of the inner endometrial lining of the uterus due to the alternation of cells DNA.
Endometrial cancer is the fourth most common cancer among women worldwide, after breast, lung, and bowel cancer.
According to the statistics provided by the American Cancer Society, in the US, cancer of the endometrium is the most common cancer of the female reproductive organs. In 2019, approximately 61,000 cases of endometrial cancer will be diagnosed.
Most common types of endometrial cancer are
* Adenocarcinomas
Adenocarcinomas accounted for accounts for over 80% of cases of endometrial cancer that begins with irregular cells growth in the surface cells of the inner lining of the endometrium
Women who have an early onset of symptoms of peri-menopause are at a higher risk of adenocarcinomas.
* Uterine sarcoma
Uterine sarcoma, a rare uterine cancer containing malignant cells of the muscle and connective tissue of the uterus, is accounted for only 2 percent of all uterine cancer, including
** Endometrial stromal sarcomas
Endometrial stromal sarcomas are also endometrial cancers originated in the non-glandular connective tissue of the endometrium, with unknown origin.
* Leiomyosarcomas
Leiomyosarcomas is a form of endometrial cancer that originated from the smooth muscles of the uterus. Endometrial cancer has a resistant tendency and not very responsive to chemotherapy or radiation.
* Carcinosarcoma
Carcinosarcoma is a type of cancer caused by both epithelial and connective tissues of the uterus.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
On finding a potential compound for the treatment of endometrial cancer, researchers examined the relationship between onion and garlic intake on endometrial cancer, using data from an Italian case-control study.
According to the data of a multicentre case-control study of 454 endometrial cancer cases and 908 controls, admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions, the OR of endometrial cancer for successive categories of onion intake were 0.94 for <2 portions/week compared to garlic of 0.89.
The OR of onion intake was decreased to 0.40 (95% CI 0.22, 0.72) for > or =2 portions/week, compared to garlic of 0.62.
In other words, onion and garlic showed a significant inverse trend for the risk of endometrial cancer depending on the quality intake per week.
Furthermore, The OR for an increment of one portion (i.e. 80 g) of onions in the risk of endometrial cancer per week was 0.81.
Based on the finding, researchers said, "Our study found a moderate protective role of allium vegetables on the risk of endometrial cancer".
Taken altogether, onion may be considered a remedy for the prevention and treatment of endometrial cancer, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Odds ratio analysis in women with endometrial cancer by Plagens-Rotman K1, Żak E1, Pięta B. (PubMed)
(2) Allium vegetables intake and endometrial cancer risk by Galeone C1, Pelucchi C, Dal Maso L, Negri E, Montella M, Zucchetto A, Talamini R, La Vecchia C. (PubMed)
(3) Most common Types of Cancer - Cancer of Endometrium/Endometrial Cancer by Kyle J. Norton
Friday, June 19, 2020
Healthy Food Tomatoes' Lycopene Inhibits Primary Lung Cancer
Primary lung cancer is a medical and chronic condition characterized by irregular cell growth in the tissues of the lung.
The lungs are a pair of spongy, air-filled organs located on either side of the chest, with the function of inspiration that takes oxygen from incoming air to the blood and releases carbon dioxide.
In other words, the lung exchanges carbon dioxide from the blood to oxygen.
Furthermore, the lung also filters out a small blood clot, balancing the Ph levels in the body, protecting the body from infection as well as speeching.
According to the statistics, in the US, approximately 228,000 people in the US will be diagnosed with lung cancer in 2019 or 1 in 16 people in the US will be diagnosed with lung cancer in their lifetime.
About 60% to 65% of all new lung cancer diagnoses are among people who have never smoked or are former smokers.
Most cases of lung cancer at the early stage are asymptomatic due to the very small size of the tumor. However, at the later stage, the oversize of the tumor that not only reduces the lung function and press on the nearby nerve cells and blood vessels, leading to symptoms of lung cancer, accompanied by general symptoms shared by other types of cancer.
The most common symptoms of lung cancer include a persistent cough, cough-up blood with rust-colored sputum (spit or phlegm) due to the oversize tumor that has pressed on nearby blood vessels, chest pain due to the oversize tumor that has pressed on the nerve cells and shortness of breath. Feeling tired or weak.
The other lung, adrenal gland, bones, brain, and liver are most common in primary lung cancer metastasis.
Some researchers suggested lung cancer in the US may be correlated to the rise of obesity.
Dr. Khemayanto Hidayat, the lead scientist said, "Several meta-analyses of observational studies have been performed to examine the association between general obesity, as measured by body mass index (BMI), and lung cancer. These meta-analyses suggest an inverse relationship between high BMI and this cancer. In contrast to general obesity, abdominal obesity appears to play a role in the development of lung cancer".
And, "greater WC was associated with increased lung cancer risk among never smokers (RR 1.11; 95% CI 1.00, 1.23), former smokers (RR 1.12; 95% CI 1.03, 1.22) and current smokers (RR 1.16; 95% CI 1.08, 1.25). The summary RRs for highest versus lowest categories of WC and WHR were 1.32 (95% CI 1.13, 1.54; I2 = 18.2%, p-heterogeneity = 0.281) and 1.10 (95% CI 1.00, 1.23; I2 = 24.2%, p-heterogeneity = 0.211), respectively".
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
On finding a natural compound for the treatment of lung cancer, researchers in the cancer team at the Tufts University investigated the effects of tomato's lycopene against tobacco carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced lesions in both lungs in an animal model.
The study included elected male ferrets (6 groups, n = 8-10) were treated either with NNK (50 mg/kg BW, i.p., once a month for four consecutive months) or saline with or without dietary lycopene supplementation (2.2 and 6.6 mg/kg BW/day, respectively) for 26 weeks.
Before the treatment of lycopene, NNK exposure ferrets showed higher incidences of lung tumors, HCC and steatohepatitis, and the elevations in bilirubin and AST levels.
Lycopene supplementation treatment at two doses prevented NNK-induced lung toxicity and inflammation. The expression of levels of CYP2E1 in the liver associated with the metabolism of xenobiotics in the liver was also inhibited by the injection of lycopene.
In other words, lycopene prevented the NNK in the induction of lung and liver damage in the tested animals.
Based on the findings, researchers said, "The present study provided strong experimental evidence that the tobacco carcinogen NNK can induce both HCC and steatohepatitis in the ferrets and can be a useful model for studying tobacco carcinogen-associated NAFLD and liver cancer".
Furthermore, in a mouse model associated with colon cancer metastatic to the lungs, Dr. Chattopadhyay A, the lead scientist wrote, "adding 0.06% of Tg6F, but not a control tomato concentrate (EV), to standard mouse chow reduced tumor-associated neutrophils by 94 ± 1.1%, and reduced tumor burden by two-thirds".
Taken altogether, cooked tomatoes processed abundantly bioactive compound lycopene may be considered supplements for the prevention and treatment of complications caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy of tomato concentrates in mouse models of dyslipidemia and cancer by Chattopadhyay A1, Grijalva V1, Hough G1, Su F2, Mukherjee P1, Farias-Eisner R2, Anantharamaiah GM3, Faull KF4, Hwang LH4, Navab M1, Fogelman AM1, Reddy ST. (PubMed)
(2) Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation by Aizawa K1,2, Liu C1, Tang S1, Veeramachaneni S1, Hu KQ1, Smith DE3, Wang XD. (PubMed)
(3) Abdominal Obesity and Lung Cancer Risk: Systematic Review and Meta-Analysis of Prospective Studies by Khemayanto Hidayat,1 Xuan Du,1 Guochong Chen,2 Minhua Shi,3 and Bimin Shi. (PMC)
The lungs are a pair of spongy, air-filled organs located on either side of the chest, with the function of inspiration that takes oxygen from incoming air to the blood and releases carbon dioxide.
In other words, the lung exchanges carbon dioxide from the blood to oxygen.
Furthermore, the lung also filters out a small blood clot, balancing the Ph levels in the body, protecting the body from infection as well as speeching.
According to the statistics, in the US, approximately 228,000 people in the US will be diagnosed with lung cancer in 2019 or 1 in 16 people in the US will be diagnosed with lung cancer in their lifetime.
About 60% to 65% of all new lung cancer diagnoses are among people who have never smoked or are former smokers.
Most cases of lung cancer at the early stage are asymptomatic due to the very small size of the tumor. However, at the later stage, the oversize of the tumor that not only reduces the lung function and press on the nearby nerve cells and blood vessels, leading to symptoms of lung cancer, accompanied by general symptoms shared by other types of cancer.
The most common symptoms of lung cancer include a persistent cough, cough-up blood with rust-colored sputum (spit or phlegm) due to the oversize tumor that has pressed on nearby blood vessels, chest pain due to the oversize tumor that has pressed on the nerve cells and shortness of breath. Feeling tired or weak.
The other lung, adrenal gland, bones, brain, and liver are most common in primary lung cancer metastasis.
Some researchers suggested lung cancer in the US may be correlated to the rise of obesity.
Dr. Khemayanto Hidayat, the lead scientist said, "Several meta-analyses of observational studies have been performed to examine the association between general obesity, as measured by body mass index (BMI), and lung cancer. These meta-analyses suggest an inverse relationship between high BMI and this cancer. In contrast to general obesity, abdominal obesity appears to play a role in the development of lung cancer".
And, "greater WC was associated with increased lung cancer risk among never smokers (RR 1.11; 95% CI 1.00, 1.23), former smokers (RR 1.12; 95% CI 1.03, 1.22) and current smokers (RR 1.16; 95% CI 1.08, 1.25). The summary RRs for highest versus lowest categories of WC and WHR were 1.32 (95% CI 1.13, 1.54; I2 = 18.2%, p-heterogeneity = 0.281) and 1.10 (95% CI 1.00, 1.23; I2 = 24.2%, p-heterogeneity = 0.211), respectively".
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
On finding a natural compound for the treatment of lung cancer, researchers in the cancer team at the Tufts University investigated the effects of tomato's lycopene against tobacco carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induced lesions in both lungs in an animal model.
The study included elected male ferrets (6 groups, n = 8-10) were treated either with NNK (50 mg/kg BW, i.p., once a month for four consecutive months) or saline with or without dietary lycopene supplementation (2.2 and 6.6 mg/kg BW/day, respectively) for 26 weeks.
Before the treatment of lycopene, NNK exposure ferrets showed higher incidences of lung tumors, HCC and steatohepatitis, and the elevations in bilirubin and AST levels.
Lycopene supplementation treatment at two doses prevented NNK-induced lung toxicity and inflammation. The expression of levels of CYP2E1 in the liver associated with the metabolism of xenobiotics in the liver was also inhibited by the injection of lycopene.
In other words, lycopene prevented the NNK in the induction of lung and liver damage in the tested animals.
Based on the findings, researchers said, "The present study provided strong experimental evidence that the tobacco carcinogen NNK can induce both HCC and steatohepatitis in the ferrets and can be a useful model for studying tobacco carcinogen-associated NAFLD and liver cancer".
Furthermore, in a mouse model associated with colon cancer metastatic to the lungs, Dr. Chattopadhyay A, the lead scientist wrote, "adding 0.06% of Tg6F, but not a control tomato concentrate (EV), to standard mouse chow reduced tumor-associated neutrophils by 94 ± 1.1%, and reduced tumor burden by two-thirds".
Taken altogether, cooked tomatoes processed abundantly bioactive compound lycopene may be considered supplements for the prevention and treatment of complications caused by oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy of tomato concentrates in mouse models of dyslipidemia and cancer by Chattopadhyay A1, Grijalva V1, Hough G1, Su F2, Mukherjee P1, Farias-Eisner R2, Anantharamaiah GM3, Faull KF4, Hwang LH4, Navab M1, Fogelman AM1, Reddy ST. (PubMed)
(2) Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation by Aizawa K1,2, Liu C1, Tang S1, Veeramachaneni S1, Hu KQ1, Smith DE3, Wang XD. (PubMed)
(3) Abdominal Obesity and Lung Cancer Risk: Systematic Review and Meta-Analysis of Prospective Studies by Khemayanto Hidayat,1 Xuan Du,1 Guochong Chen,2 Minhua Shi,3 and Bimin Shi. (PMC)
Thursday, June 18, 2020
Healthy Food Onion, the Potent Antioxidants
Antioxidants are stable molecules that inhibit oxidation.
Antioxidant enzymes either produced by the host body or from the dietary sources plays a critical role in the prevention of oxidative stress by balancing the expression of free radicals.
Free radicals are everywhere. Any chemical containing oxygen molecules including environmental and behavioral factors such as exposure to radiation and toxic chemicals and smoking can dramatically increase the number of free radicals in the body.
Free radical internally are produced during the course of cell metabolism.
Oxidative stress is caused by overexpression of free radicals compared to the low levels of antioxidant enzymes produced by the host. Over time, oxidative stress can induce proteins, lipids, and cell damage, leading to the facilitation of heart diseases, diabetes, stroke, cancer...
In other words, the chain reaction of free radicals that cannot be stopped is a leading cause of oxidative stress-induced chronic disease.
More precisely, if the antioxidant enzymes no longer can perform the function to balance the free radicals in the body, oxidative stress occurs.
Some researchers suggested the rise of oxidative stress in the US may be correlated to the promotion of the Western diet over the past few decades.
Dr. Ildiko Erdelyi wrote, "WD induces inflammatory changes, expression profiles of a broad spectrum of inflammatory proteins were performed and numbers of lamina propria macrophages were determined with semiquantitative morphometry".
And, "WD significantly alters the local colonic immune response. Collectively, these data suggest that consumption of a WD interferes with networks of related biological response pathways involving colonic lipid metabolism, oxidative stress, and the immune response".
The results strongly suggested that by maintaining the healthy ratio of antioxidants and free radicals, diseases associated with oxidative stress can be preventable.
The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential and natural compound for the prevention and treatment diseases associated with oxidative stress, researchers examined the effect of conventional, organic, and mixed cultivation practices on the content of total phenolics, total flavonoids and antioxidant activity in two varieties of onion grown over 4 years in a split-plot factorial systems comparison trial.
According to the experiment, levels of total phenolics and total flavonoids were significantly different between organic and conventional production systems.
Levels of antioxidants such as levels of total phenolics, total flavonoids are significantly higher under fully organic growth compared to conventional growth.
In other words, if you are looking for the best onion with antioxidant activity, organic cultivation onion is a better choice
Based on the findings, researchers said, "organic cultivation practices resulted in significantly higher levels of potentially bioactive compounds in onion".
Taken altogether, onion may be considered a remedy for the prevention and treatment of diseases associated with oxidation, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antihyperlipidemic and Antioxidative Potentials of Onion (Allium cepa L.) Extract Fermented with a Novel Lactobacillus casei HD-010 by Yang WS1,2, Kim JC3, Lee JY4, Kim CH5, Hwang CW6. (PubMed)
(2) Evaluation of polyphenolic content and antioxidant activity in two onion varieties grown under organic and conventional production systems by Ren F1,2, Reilly K1, Gaffney M1, Kerry JP2, Hossain M1, Rai DK. (PubMed)
(3) Western-Style Diets Induce Oxidative Stress and Dysregulate Immune Responses in the Colon in a Mouse Model of Sporadic Colon Cancer by Ildiko Erdelyi,4 Natasha Levenkova,5 Elaine Y. Lin,8 John T. Pinto,9 Martin Lipkin,4Fred W. Quimby,6 and Peter R. Holt. (PMC)
Antioxidant enzymes either produced by the host body or from the dietary sources plays a critical role in the prevention of oxidative stress by balancing the expression of free radicals.
Free radicals are everywhere. Any chemical containing oxygen molecules including environmental and behavioral factors such as exposure to radiation and toxic chemicals and smoking can dramatically increase the number of free radicals in the body.
Free radical internally are produced during the course of cell metabolism.
Oxidative stress is caused by overexpression of free radicals compared to the low levels of antioxidant enzymes produced by the host. Over time, oxidative stress can induce proteins, lipids, and cell damage, leading to the facilitation of heart diseases, diabetes, stroke, cancer...
In other words, the chain reaction of free radicals that cannot be stopped is a leading cause of oxidative stress-induced chronic disease.
More precisely, if the antioxidant enzymes no longer can perform the function to balance the free radicals in the body, oxidative stress occurs.
Some researchers suggested the rise of oxidative stress in the US may be correlated to the promotion of the Western diet over the past few decades.
Dr. Ildiko Erdelyi wrote, "WD induces inflammatory changes, expression profiles of a broad spectrum of inflammatory proteins were performed and numbers of lamina propria macrophages were determined with semiquantitative morphometry".
And, "WD significantly alters the local colonic immune response. Collectively, these data suggest that consumption of a WD interferes with networks of related biological response pathways involving colonic lipid metabolism, oxidative stress, and the immune response".
The results strongly suggested that by maintaining the healthy ratio of antioxidants and free radicals, diseases associated with oxidative stress can be preventable.
The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential and natural compound for the prevention and treatment diseases associated with oxidative stress, researchers examined the effect of conventional, organic, and mixed cultivation practices on the content of total phenolics, total flavonoids and antioxidant activity in two varieties of onion grown over 4 years in a split-plot factorial systems comparison trial.
According to the experiment, levels of total phenolics and total flavonoids were significantly different between organic and conventional production systems.
Levels of antioxidants such as levels of total phenolics, total flavonoids are significantly higher under fully organic growth compared to conventional growth.
In other words, if you are looking for the best onion with antioxidant activity, organic cultivation onion is a better choice
Based on the findings, researchers said, "organic cultivation practices resulted in significantly higher levels of potentially bioactive compounds in onion".
Taken altogether, onion may be considered a remedy for the prevention and treatment of diseases associated with oxidation, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antihyperlipidemic and Antioxidative Potentials of Onion (Allium cepa L.) Extract Fermented with a Novel Lactobacillus casei HD-010 by Yang WS1,2, Kim JC3, Lee JY4, Kim CH5, Hwang CW6. (PubMed)
(2) Evaluation of polyphenolic content and antioxidant activity in two onion varieties grown under organic and conventional production systems by Ren F1,2, Reilly K1, Gaffney M1, Kerry JP2, Hossain M1, Rai DK. (PubMed)
(3) Western-Style Diets Induce Oxidative Stress and Dysregulate Immune Responses in the Colon in a Mouse Model of Sporadic Colon Cancer by Ildiko Erdelyi,4 Natasha Levenkova,5 Elaine Y. Lin,8 John T. Pinto,9 Martin Lipkin,4Fred W. Quimby,6 and Peter R. Holt. (PMC)
Wednesday, June 17, 2020
Whole Food Tomato Improves Glucose Tolerance in Diabetics in Vivo
Glucose intolerance is a condition of the cluster of metabolic conditions associated with a higher than normal blood glucose levels.
Glucose tolerance is a test that examines how fast glucose is cleared from the blood.
Glucose intolerance is found in people with pre-diabetes or metabolic syndrome, the conditions of elevated blood glucose that is below the diabetes
* Impaired fasting glucose (IFG), a fasting blood glucose level that is above 6.0 mmol/L
* Impaired glucose tolerance (IGT), a blood glucose level that is over 7.8 mmol/L 2 hours after consuming 75g of glucose.
Glucose intolerance has been found to induce the risk of insulin resistance and increase the risk of cardiovascular disease and type 2 diabetes.
Most common symptoms of IGT are feeling thirsty, being tired or lethargic, frequent urination, and itchiness around the genitals.,
Out of many prevalent factors associated with the risk of IGT, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a strong and negative impact on the rise of glucose intolerance.
Dr. April J. Stull, wrote, "Glucose intolerance is a global health concern that encompasses glucose metabolism abnormalities such as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes (T2D)".
And "The progression from IGT to T2D can be prevented or delayed by modifying the lifestyles in high-risk individuals, and these health benefits are well documented in various ethnicities with prediabetes across the world".
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a phytochemical for the improvement of glucose tolerance, researchers examined the effects of dry tomato peel (DTP) on diabetes-induced by a high-saturated-fat (HSF) diet in vivo.
The study included BALB/c male mice (n=40) (8 weeks old, weighing 22.2±1.0 g) randomly divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP for 12 weeks.
According to the results of the tested assay, supplementation with DTP not only increased plasma lycopene concentration but also reduced the development of indicators of metabolic syndrome which was found non-DTP treated groups.
In other words, DTP supplementation demonstrated a beneficial effect on glucose tolerance through increasing insulin sensitivity in the tested subject.
Also, in high-fat diet (HF)-induced obese mice treated by tomato vinegar beverage (TVB), researchers found that TVB not only showed a significant anti-obesity activity by decreasing fatty acid β-oxidation and carnitine palmitoyltransferase activities in HF-fed mice but also improved glucose tolerance, hyperinsulinemia compared to control.
More precisely, TVB exerted anti-diabetic effect by TVB significantly increased glucokinase activity and decreased glucose-6-phosphatase activity in the liver, associated with the enhanced glucose metabolism in obese mice.
The findings strongly suggested that TVB inhibits glucose intolerance in obese mice through several mechanisms, including glucose metabolism.
Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplement for the improvement of glucose tolerance, pending to large sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets by Zidani S1, Benakmoum A2, Ammouche A3, Benali Y4, Bouhadef A4, Abbeddou S. (PubMed)
(2) Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice by Seo KI1, Lee J, Choi RY, Lee HI, Lee JH, Jeong YK, Kim MJ, Lee MK. (PubMed)
(3) Lifestyle Approaches and Glucose Intolerance by April J. Stull, PhD, RD. (PubMed)
Glucose tolerance is a test that examines how fast glucose is cleared from the blood.
Glucose intolerance is found in people with pre-diabetes or metabolic syndrome, the conditions of elevated blood glucose that is below the diabetes
* Impaired fasting glucose (IFG), a fasting blood glucose level that is above 6.0 mmol/L
* Impaired glucose tolerance (IGT), a blood glucose level that is over 7.8 mmol/L 2 hours after consuming 75g of glucose.
Glucose intolerance has been found to induce the risk of insulin resistance and increase the risk of cardiovascular disease and type 2 diabetes.
Most common symptoms of IGT are feeling thirsty, being tired or lethargic, frequent urination, and itchiness around the genitals.,
Out of many prevalent factors associated with the risk of IGT, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a strong and negative impact on the rise of glucose intolerance.
Dr. April J. Stull, wrote, "Glucose intolerance is a global health concern that encompasses glucose metabolism abnormalities such as impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes (T2D)".
And "The progression from IGT to T2D can be prevented or delayed by modifying the lifestyles in high-risk individuals, and these health benefits are well documented in various ethnicities with prediabetes across the world".
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a phytochemical for the improvement of glucose tolerance, researchers examined the effects of dry tomato peel (DTP) on diabetes-induced by a high-saturated-fat (HSF) diet in vivo.
The study included BALB/c male mice (n=40) (8 weeks old, weighing 22.2±1.0 g) randomly divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP for 12 weeks.
According to the results of the tested assay, supplementation with DTP not only increased plasma lycopene concentration but also reduced the development of indicators of metabolic syndrome which was found non-DTP treated groups.
In other words, DTP supplementation demonstrated a beneficial effect on glucose tolerance through increasing insulin sensitivity in the tested subject.
Also, in high-fat diet (HF)-induced obese mice treated by tomato vinegar beverage (TVB), researchers found that TVB not only showed a significant anti-obesity activity by decreasing fatty acid β-oxidation and carnitine palmitoyltransferase activities in HF-fed mice but also improved glucose tolerance, hyperinsulinemia compared to control.
More precisely, TVB exerted anti-diabetic effect by TVB significantly increased glucokinase activity and decreased glucose-6-phosphatase activity in the liver, associated with the enhanced glucose metabolism in obese mice.
The findings strongly suggested that TVB inhibits glucose intolerance in obese mice through several mechanisms, including glucose metabolism.
Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplement for the improvement of glucose tolerance, pending to large sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets by Zidani S1, Benakmoum A2, Ammouche A3, Benali Y4, Bouhadef A4, Abbeddou S. (PubMed)
(2) Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice by Seo KI1, Lee J, Choi RY, Lee HI, Lee JH, Jeong YK, Kim MJ, Lee MK. (PubMed)
(3) Lifestyle Approaches and Glucose Intolerance by April J. Stull, PhD, RD. (PubMed)
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