Coffee and Coffee Caffeine In Reducing the Risk of Localized and Advanced Prostate Cancer

Good news for men coffee lovers, coffee and coffee caffeine consumption daily and regularly are associated with attenuated risk and treatment of prostate cancer, the epidemiological study suggested.

Coffee has become a popular and social beverage all over the world, particularly in the West, is a drink made from roast bean from the Coffea plant, native to tropical Africa and Madagascar.

Prostate Cancer is a medical condition characterized by cell growth disorderly and uncontrollable in the prostate.

The study of the efficacy of coffee intake and risk of prostate cancer (PC-3 and DU145) on 6,989 men of the Moli-Sani cohort aged ≥50 years showed that
1. Risk of prostate cancer reduced by 53% in people drinking over>3 cups/day is compared to participants at the lowest consumption (0-2 cups/day)
2. Injection of caffeine in both cancer cell lines PC-3 and DU145 showed substantial activity in the reduction of proliferative and metastatic behaviors.




Caffeine demonstration exerted significantly anti-proliferative and anti-metastatic activity on two prostate cancer cell lines may be attributed to its bioactive compounds in the expression of anti-cancer in various mechanisms.
Other, in the selection of twenty-eight studies (14 case-control and 14 cohort studies) on coffee caffeine (CC) with 42399 PC patients for the final meta-analysis searched from databases of Pubmed and Embase, researchers, filed the following results

1. There was no significant association of prostate cancer in regard to high versus non/lowest intake.
2. Coffee and coffee caffeine intake showed a localized effect in a subtype of prostate cancer but not advanced prostate cancer.


These result showed a significant effect of coffee in reduced risk of early stage prostate cancer and coffee do not associate with risk of prostate cancer.



More profoundly in the report of a prospective analysis of 47,911 men with an intake of regular and decaffeinated coffee in 1986 and every 4 years thereafter in the Health Professionals Follow-up Study
1. Men, drinking six or more cups per day had the lowest relative risk for overall prostate cancer compared to nondrinkers.

2. Overall, Coffee consumption was not associated with the risk of nonadvanced or low-grade prostate cancers and was only weakly inversely associated with high-grade prostate cancer

3. There was the no differential effect of regular and decaffeinated coffee in the ameliorated the risk of prostate cancer.
Taking all together, there is no doubt that coffee and coffee caffeine intake were associated linearly to
reduced risk of localized and advanced and lethal prostate cancer, Risk of cancer is also reduced proportionally with an additional cup of coffee consumed.


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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) An Up-to-date Meta-analysis of Coffee Consumption and Risk of Prostate Cancer by Xia J1, Chen J2, Xue JX3, Yang J3, Wang ZJ3.(PubMed)
(2) Reduction by coffee consumption of prostate cancer risk: Evidence from the Moli-sani cohort and cellular models by Pounis G1, Tabolacci C2, Costanzo S1, Cordella M2, Bonaccio M1, Rago L3, D'Arcangelo D4, Filippo Di Castelnuovo A1, de Gaetano G1, Donati MB1, Iacoviello L1,5, Facchiano F2; Moli-sani study investigators6.(PubMed)
(3) Coffee consumption and prostate cancer risk and progression in the Health Professionals Follow-up Study by Wilson KM1, Kasperzyk JL, Rider JR, Kenfield S, van Dam RM, Stampfer MJ, Giovannucci E, Mucci LA.(PubMed)