Healthy Food Brassica rapa vegetable Protects the Kidney Against Injury in Vivo

Kidneys, a pair of the bean-shaped organ in the human body not only filter out blood but also balances the body fluids by eliminating them and removes them through urinary secretion.

Additionally, the kidney accompanied by the liver and skin form also detoxes the toxins in the body.

Kidney disease is a medical condition associated with a gradually reduced function of the kidney.

Kidney diseases can be classified into 2 types
* Acute kidney disease is a sudden episode of kidney failure or kidney damage associated with reduced kidney function in keeping the right balance of fluid in the body, that lasts a few hours or a few days.

* Chronic kidney disease (CKD) is a condition of kidney damage, leading to a decreased level of kidney function that lasts more than three months.

Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness

Renal protection is a strategy that protects the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.

Renal toxicity or nephrotoxicity in most cases is toxicity in the kidneys caused by toxic chemicals and medications.

The most common symptoms of renal toxicity may cause reduced kidney function in eliminating toxins, leading to a reduced amount of urine. swelling of your legs, ankles, and feet from retention of fluids.

In a serious case, the condition can also result in unexplained shortness of breath. excessive drowsiness or fatigue. persistent nausea. confusion. pain or pressure in your chest.

Depending on the severity of kidney damage, kidney disease can range from mild to severe, including kidney failure.


With an aim to find a natural food for the prevention and treatment of renal diseases, researchers examined the effect of 3,3'‑Diindolylmethane (DIM), a naturally derived indole compound found in the Brassica family of vegetables on kidney injury.

The study included male BALB/c mouse models of AKI that were established using intraperitoneal injections of 10 mg/kg LPS followed by the DIM (40 mg/kg) administered intraperitoneally 24 and 2 h before LPS exposure.
According to the tested analysis,
* DIM significantly mitigated histopathological changes in the kidneys and improved the levels of blood urea nitrogen and serum creatinine.

* DIM also suppressed the LPS‑induced production of reactive oxygen species in the induction of cell apoptosis.

* DIM treatment also significantly decreased the expression of NADPH oxidase 2 (NOX2) and NOX4 which results in oxidative stress in LPS‑treated mice.


More precisely, DIM protected the kidney cell integrity against all parameters expressed by the injection of LPS.

Based on the results, researchers wrote, " Therefore, DIM may exert its renoprotective actions by inhibiting NOX‑mediated oxidative stress and the apoptosis of renal tubular epithelial cells"

Taken altogether, Brassica rapa vegetables may be considered supplements for the prevention of kidney injury, pending the confirmation of the larger sample size and multicenter human study.

Intake of SFN in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'‑Diindolylmethane mitigates lipopolysaccharide‑induced acute kidney injury in mice by inhibiting NOX‑mediated oxidative stress and the apoptosis of renal tubular epithelial cells by He J1, Huang T2, Zhao L. (PubMed)