Tomato, the Anti-Insulin Resistance Natural Remedy

Insulin resistance is a condition in which cells that convert glucose to energy in the muscles, body fat, intestine, and liver ignore the signal o the hormone insulin signaling.


In other words, patients with insulin resistance are hyperglycemic. The syndrome is a hallmark of type 2 diabetes.

According to statistics, over 100 million Americans are living with insulin resistance. Approximately 1 in 3, including half of those age 60 and older have a silent blood sugar problem known as insulin resistance.


There are no single causes of insulin resistance, Epidemiologically, aging, ethnicity, overweight or obesity, too much belly fat, physical inactivity, smoking, and certain medical conditions such as Cushing’s disease or polycystic ovary disease are some of the prevalent factors that induce the risk of the condition.

However, most people with some of the aforementioned risk factors have never developed insulin resistance.


The most common symptoms of patients with insulin resistance are tiredness, hunger and difficulty concentrating.

If you have experienced the above symptoms persistently, you may have insulin resistance, please make sure that you check with your doctor to rule out the possibility.


Out of many factors that increase the risk of insulin resistance, some researchers suggested the promotion of a high-fat diet over the past few decades may have a strong and negative impact on the rise of insulin resistance in the US.


Dr. Chad R. Hancock, the lead scientist wrote, "feeding rats high-fat diets that cause muscle insulin resistance results in a concomitant gradual increase in muscle mitochondria"


And, "a high-fat diet that raises FFA results in a gradual increase in mitochondria in rat skeletal muscle, with an increase in the capacity for fat oxidation, concomitant with the development of muscle insulin resistance".

Tomato is red, edible fruit, genus Solanum, belonging to the family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

To find healthy food for controlling high blood glucose, researchers examined the effect of dry tomato peel (DTP) on insulin resistance, and atherogenic dyslipidemia induced by a high-saturated fat (HSF) diet in an animal model for 12 weeks.

The study included 40 selected BALB/c male mice (n=40) (8 weeks old, weighing 22.2±1.0 g) divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP.


According to the results from the tested assays, supplementation with DTP not only increased the plasma lycopene concentration and reduced the development of indicators of metabolic syndrome, particularly insulin resistance.

However, hepatic steatosis and inflammation caused by the injection of high-fat diet mice were not reversed with DTP supplementation.

In other words, DTP improved the plasma concentration of lycopene by normalizing the levels of blood glucose in tested mice through its anti-insulin resistance activity.

Dr. Zidani S, the lead scientist said, "Among mice fed the HSF/HC diet, DTP supplementation appears to have a beneficial effect on insulin resistance, which confirms the antiatherogenic effect of DTP".

In vivo, also in high-fat diet (HF)-induced obese mice, tomato vinegar beverage (TVB) at 14 mL kg(-1) body weight for 6 weeks not only inhibited the symptoms associated with fat accumulated in the liver but also promoted glucose tolerance, hyperinsulinemia, and HOMA-IR levels.



Levels of antioxidants in the tested were also significantly improved by TVB. TVB inhibited oxidative stress by significantly increasing glucokinase activity and decreased glucose-6-phosphatase activity in the liver,

More precisely, TVB enhanced glucose metabolism in obese mice. against the onset of insulin resistance.


Based on the findings, researchers wrote, "These results suggest that TVB prevents visceral obesity and insulin resistance via AMPK/PPARα-mediated fatty acid and glucose oxidation (Antioxidant property(TVB)".


Taken altogether, tomatoes may be considered a dietary supplement for the prevention and treatment of insulin resistance, pending to large sample size and multicenter human study.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effect of dry tomato peel supplementation on glucose tolerance, insulin resistance, and hepatic markers in mice fed high-saturated-fat/high-cholesterol diets by Zidani S1, Benakmoum A2, Ammouche A3, Benali Y4, Bouhadef A4, Abbeddou S. (PubMed)
(2) Anti-obesity and anti-insulin resistance effects of tomato vinegar beverage in diet-induced obese mice by Seo KI1, Lee J, Choi RY, Lee HI, Lee JH, Jeong YK, Kim MJ, Lee MK. (PubMed)
(3) High-fat diets cause insulin resistance despite an increase in muscle mitochondria by Chad R. Hancock, Dong-Ho Han, May Chen, Shin Terada, Toshihiro Yasuda, David C. Wright,and John O. Holloszy. (PubMed)