Stenosis of the arteries is a narrowing large artery caused by the accumulation of plaques located on each side of the neck that carries blood to the head, face, and brain.
Most common causes of stenosis of the arteries are results from atherosclerosis.
Untreated stenosis of the arteries has been found to induce complications of transient ischemic attack or stroke, depending on a blot clot that briefly blockage or partly or completely blockage of a blood vessel to the brain.
Atherosclerosis is a medical condition caused by plaque accumulated on the wall of arteries, leading to the narrowing of the artery and reducing oxygen risk blood flow to the heart and brain.
Depending on the location of the blockage, if the reduced blood flow occurred in the brain, it will cause the death of the brain cells, leading to stroke.
However, if the reduced blood flow occurred in the heart, it will cause damage to the heart tissues, leading to heart disease.
Most common disease associated with atherosclerosis is coronary artery disease. Plaques are made up of cholesterol, calcium and other chemical substances in the artery
Most people with atherosclerosis are asymptomatic at the early stage.
Some researchers suggested that atherosclerosis is a lipoprotein-driven disease. Therefore, people with high blood cholesterol are at an increased risk of atherosclerosis. Overuse of calcium supplement is also found to elevated the condition risk, particularly in the elderly.
Other risk factors that have bee found epidemiologically by studies are high blood pressure, triglycerides, smoking, insulin resistance, obesity or diabetes and inflammatory diseases, such as arthritis, lupus or infections.
Most cases of atherosclerosis can be reversed by making a change of lifestyle and moderate exercise. However, in severe cases surgery to remove plaque from the artery may be the only option.
Betaxanthins are Phytochemicals in the class of red and yellow indole-derived pigments, belonging to the group of Betalains, found abundantly in beets, Sicilian prickly pear, etc.
On finding a potent ingredient for the treatment of cardiovascular disease, researchers investigated the effects of betalains, consisting of betacyanins and betaxanthins on the stenosis of the arteries.
In vivo and in vitro studies, betalains and betalain-rich diets is not only safe but also inhibited oxidative stress-, inflammation-, and dyslipidemia-related diseases associated with narrowing arteries involved in atherosclerosis, or a build-up of plaque on the inside of the arteries.
Furthermore, betalains and betalain-rich diets are safe toxicological safety, incorporated with easy accessibility, low price, biodegradability, and potentially advantageous biological effects on health.
These results strongly suggested betalains may be used in food manufacturing and related industries to overcome current concerns over the health risks of artificial colors.
Dr. Rahimi P, the lead scientist wrote, "(Even with the efficacy), further studies using pure betalains are required to gain a deeper understanding of their precise biological functions".
Taken altogether, betaxanthins found abundantly in betalains and betalain-rich diets may be considered anti-atherosclerotic remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Betalains, the nature-inspired pigments, in health and diseases by Rahimi P1, Abedimanesh S1, Mesbah-Namin SA1, Ostadrahimi A. (PubMed)
Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.
Friday, November 1, 2019
Garbanzo beans(Chickpeas) increase function of Bowel health
Whole food(herbal medicine), linking health benefits in the prevention, management, and treatment of diseases has played an important role in human history over many centuries. The finding of whole food medication by renowned scientists all over the world to replace the single ingredient of Western medicine with little or no side effect has been difficult due to no commercial benefit and patent right to producers.
Garbanzo bean also known as chickpea is an edible legume of genus Cicer and the family Fabaceae, high in protein and minerals. It is one of the earliest cultivated vegetables, native to the Middle East.
With Nutrients of
1. Carbohydrates
2. Dietary fiber
3. Fat
4. Protein
5. Vitamin A
6. Thiamine (Vitamin B1)
7. Riboflavin (Vitamin B2)
8. Niacin (Vitamin B3)
9. Pantothenic acid (B5)
10. Vitamin B6
11. Folate (Vitamin B9)
12. Vitamin C
13. Vitamin E
14. Vitamin K
15. Iron
16. Magnesium
17. Phosphorus
18. Potassium
19. Zinc
20. Etc.
People who follow a typical American diet may express a certain problem in bowel movement, as a result of consuming high saturated fat, salt, sugar....... and less of fiber. According to the University of Tasmania, diet not only affects food choice, satiety but also have a profound influence of bowel health. 15 participants.who participated in the study tended to eat more processed snack foods (high energy, low fiber) after ceasing chickpea consumption(1).
In 27 free-living adults followed two randomized, crossover dietary interventions each of five weeks duration, Dr. Pittaway JK and the research team said,"... significant decrease in serum TC and LDL-C during the chickpea diet compared to the equivalent fiber wheat diet was partly due to unintentional changes in macronutrient intake occurring because of chickpea ingestion"(2).
The effect of chickpea in the promotion of bowel health may be the result of a high amount of dietary fiber found in the peas. The study of the effectiveness of probiotics, prebiotics, and dietary fiber in the treatment of FGD in the pediatric population, suggested that the administration of a fiber supplement is more effective than placebo for the treatment of childhood constipation(3).
In fact, Fiber undergoes partial or total fermentation after conscription in the distal small bowel and colon leading to the production of short-chain fatty acids and gas, thereby affecting gastrointestinal function and sensation, the University of Michigan Health System, insisted(4).
Taking all together, people who eat a portion of chickpea every day may improve the gastrointestinal function, regardless of the type of diet.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Chickpea supplementation in an Australian diet affects food choice, satiety and bowel health by Murty CM1, Pittaway JK, Ball MJ.(PubMed)
(2) Effects of a controlled diet supplemented with chickpeas on serum lipids, glucose tolerance, satiety and bowel function by Pittaway JK1, Ahuja KD, Robertson IK, Ball MJ.(PubMed)
(3) Probiotics, prebiotics, and dietary fiber in the management of functional gastrointestinal disorders by Horvath A1, Szajewska H.(PubMed)
(4) Fiber and functional gastrointestinal disorders by Eswaran S1, Muir J, Chey WD.(PubMed)
Black beans Protect Your Large Intestine Against Colon Cancer
Black bean may have a profound effect on reducing and treatment of colon cancer, some scientists suggested.
The colon also known as the large bowel or large intestine, is part of the digestive system in our body.
Colon cancer is a chronic condition caused by cell growth irregularly and disorderly in the colon due to the alternation of DNA.
Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. At this stage, patients may not experience any symptoms.
After penetrating deeper into the colon layer, the cancer cells may travel a distance away to infect other healthy tissue and organs through the fluids and blood circulation.
At this stage, the increased size of the tumor may suppress the nearby tissue, organs or nerve cells causing localized symptoms and severe pain.
Most common colon cancer metastasis are the lungs, liver.
According to the epidemiological studies, the most common risk factors of colon cancer are older
age, ethnicity, personal and family history of colorectal cancer or polyps, inflammatory intestinal conditions.
Particularly, people who follow the low-fiber, high-fat diet or have a sedentary lifestyle. are associated with the substantial risk for the onset of the disease.
Dr. Y J Cong, the lead author in the concerns of the sedentary behavior in risk of colon cancer in modern society, launched an investigation to examine the association of sedentary behavior with colon and rectal cancer.
The search of the databases of PubMed, Embase, and Google Scholar databases up to May 2013 to identify cohort and case-control studies that evaluated the association between sedentary behavior and colon or rectal cancer identified 23 studies with 63 reports included 4 324 462 participants.
After assessing the results of all the studies, the doctor team wrote. "Sedentary behavior is associated with an increased risk of colon cancer. Subgroup analyses suggest a positive association between sedentary behavior and risk of rectal cancer in cohort studies".
Black bean is a Small roughly ovoid legume with glossy black shells, genus Phaseolus, belonging to the family Fabaceae.
The bean can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.
The major chemical compounds of black bean include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.
On finding, natural whole food for the treatment of colon cancer, researchers at the Tecnológico de Monterrey-Campus Monterrey conducted an investigation to examine the black bean antioxidant capacity and antiproliferative activity against cancer cell lines.
Flavonoids extracted from seed coats exerted a potential effect against colon cancer cell line'
The extracts obtained from seed coats after 3 and 5 germination days inhibited all cancer cell lines proliferation, including the tested colon cancer with no cytotoxicity against control cells.
Further analysis also suggested that flavonols and group B saponins isolated from the seed coat were more related to hepatic and colon cancers.
These results indicated that not all chemical compounds found in black bean have a potential effect in the inhibition of colon cancer. However, the intake of the black bean as a whole food may have significant effects in reducing the risk of colon cancer.
Additionally, in finding evidence to suggest an inverse relationship between bean consumption and colon cancer, researchers at the Food Science program at Michigan State University conducted a study to determine whether consumption of black beans and/or navy beans would reduce colon carcinogenesis in rats.
Selected rat group were fed a modified AIN-93G diet (control) or diets containing 75% black beans or 75% navy beans for 4 wk, and then colon cancer was initiated by the administration of two injections of azoxymethane 1 wk apart.
At 31 wk after the second injection, the incidence of colon adenocarcinomas was significantly lower in rats fed the black bean (9%) than in rats fed the control diet (36%).
Total tumor multiplicity was also significantly lower in rats fed the black bean diet than in rats fed the control diet.
After taking into account co and confounders, Dr. Hangen L, the lead author said, "The 44-75% reduction in colon carcinogenesis in rats fed beans was attributed to 1) more controlled appetites, leading to significantly less body fat, and 2) much greater concentrations of butyrate in the distal colon".
These results suggested black beans only have a potential effect in lowering the risk of colon cancer. but also stop cell multiplicity in the case of colon cancer.
However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of black bean anti-colon cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Differential accumulation of polyphenolics in black bean genotypes grown in four environments.
Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Evaluation of the antioxidant and antiproliferative activities of extracted saponins and flavonols from germinated black beans (Phaseolus vulgaris L.).
Guajardo-Flores D, Serna-Saldívar SO, Gutiérrez-Uribe JA(PubMed)
(3) Consumption of black beans and navy beans (Phaseolus vulgaris) reduced azoxymethane-induced colon cancer in rats. by Hangen L, Bennink MR. (PubMed)
(4) Association of sedentary behavior with colon and rectal cancer: a meta-analysis of observational studies by bY J Cong,1 Y Gan,1 HL Sun,1 J Deng,1 S Y Cao,1 X Xu,1,2 and Z X Lu. (PubMed)
The colon also known as the large bowel or large intestine, is part of the digestive system in our body.
Colon cancer is a chronic condition caused by cell growth irregularly and disorderly in the colon due to the alternation of DNA.
Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. At this stage, patients may not experience any symptoms.
After penetrating deeper into the colon layer, the cancer cells may travel a distance away to infect other healthy tissue and organs through the fluids and blood circulation.
At this stage, the increased size of the tumor may suppress the nearby tissue, organs or nerve cells causing localized symptoms and severe pain.
Most common colon cancer metastasis are the lungs, liver.
According to the epidemiological studies, the most common risk factors of colon cancer are older
age, ethnicity, personal and family history of colorectal cancer or polyps, inflammatory intestinal conditions.
Particularly, people who follow the low-fiber, high-fat diet or have a sedentary lifestyle. are associated with the substantial risk for the onset of the disease.
Dr. Y J Cong, the lead author in the concerns of the sedentary behavior in risk of colon cancer in modern society, launched an investigation to examine the association of sedentary behavior with colon and rectal cancer.
The search of the databases of PubMed, Embase, and Google Scholar databases up to May 2013 to identify cohort and case-control studies that evaluated the association between sedentary behavior and colon or rectal cancer identified 23 studies with 63 reports included 4 324 462 participants.
After assessing the results of all the studies, the doctor team wrote. "Sedentary behavior is associated with an increased risk of colon cancer. Subgroup analyses suggest a positive association between sedentary behavior and risk of rectal cancer in cohort studies".
Black bean is a Small roughly ovoid legume with glossy black shells, genus Phaseolus, belonging to the family Fabaceae.
The bean can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.
The major chemical compounds of black bean include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.
On finding, natural whole food for the treatment of colon cancer, researchers at the Tecnológico de Monterrey-Campus Monterrey conducted an investigation to examine the black bean antioxidant capacity and antiproliferative activity against cancer cell lines.
Flavonoids extracted from seed coats exerted a potential effect against colon cancer cell line'
The extracts obtained from seed coats after 3 and 5 germination days inhibited all cancer cell lines proliferation, including the tested colon cancer with no cytotoxicity against control cells.
Further analysis also suggested that flavonols and group B saponins isolated from the seed coat were more related to hepatic and colon cancers.
These results indicated that not all chemical compounds found in black bean have a potential effect in the inhibition of colon cancer. However, the intake of the black bean as a whole food may have significant effects in reducing the risk of colon cancer.
Additionally, in finding evidence to suggest an inverse relationship between bean consumption and colon cancer, researchers at the Food Science program at Michigan State University conducted a study to determine whether consumption of black beans and/or navy beans would reduce colon carcinogenesis in rats.
Selected rat group were fed a modified AIN-93G diet (control) or diets containing 75% black beans or 75% navy beans for 4 wk, and then colon cancer was initiated by the administration of two injections of azoxymethane 1 wk apart.
At 31 wk after the second injection, the incidence of colon adenocarcinomas was significantly lower in rats fed the black bean (9%) than in rats fed the control diet (36%).
Total tumor multiplicity was also significantly lower in rats fed the black bean diet than in rats fed the control diet.
After taking into account co and confounders, Dr. Hangen L, the lead author said, "The 44-75% reduction in colon carcinogenesis in rats fed beans was attributed to 1) more controlled appetites, leading to significantly less body fat, and 2) much greater concentrations of butyrate in the distal colon".
These results suggested black beans only have a potential effect in lowering the risk of colon cancer. but also stop cell multiplicity in the case of colon cancer.
However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of black bean anti-colon cancer possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Differential accumulation of polyphenolics in black bean genotypes grown in four environments.
Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Evaluation of the antioxidant and antiproliferative activities of extracted saponins and flavonols from germinated black beans (Phaseolus vulgaris L.).
Guajardo-Flores D, Serna-Saldívar SO, Gutiérrez-Uribe JA(PubMed)
(3) Consumption of black beans and navy beans (Phaseolus vulgaris) reduced azoxymethane-induced colon cancer in rats. by Hangen L, Bennink MR. (PubMed)
(4) Association of sedentary behavior with colon and rectal cancer: a meta-analysis of observational studies by bY J Cong,1 Y Gan,1 HL Sun,1 J Deng,1 S Y Cao,1 X Xu,1,2 and Z X Lu. (PubMed)
Tualang Honey the Best to Boosts Memory
Honey may have a profound and positive effect in boosting human memory, some scientists suggested
Memory is a process of the minds in learning and storing information.
Memory impairment is a condition of not remembering the new and current event which may be recalled in a short period of time, affecting mostly the older population.
Memory impairment is an early symptom associated with late-life neurodegenerative diseases.
In contrast to general belief, memory impairment not only is associated with the progression of neurodegenerative diseases but also can be caused by other factors such as medical conditions including stroke and brain injury.
Long-term use of certain medications such as antidepressants, antihistamines, anti-anxiety medications, excessive alcohol drinking, substance abuse, and tobacco are some major risk factors associated with the onset of memory loss.
Some researchers suggested that people who are living under long-term stress and anxiety or follow a nutritionally deficient diet are most vulnerable to the condition develops.
According to the article "Stress might lead to memory loss and brain shrinkage, study says" By Sandee LaMotte, CNN wrote, "If you live a high-stress life, you could have memory loss and brain shrinkage before you turn 50, according to a study published Wednesday in the journal Neurology".
"Higher levels of cortisol, a stress hormone, seem to predict brain function, brain size and performance on cognitive tests," said study author Dr. Sudha Seshadri, professor of neurology at UT Health San Antonio.
"We found memory loss and brain shrinkage in relatively young people long before any symptoms could be seen," Seshadri said. "It's never too early to be mindful of reducing stress."
In other words, long-term stress can induce the production of certain hormones such as cortisol which have strong implications on the brain in the induction of memory loss.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid It is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
On finding the correlation and association with the aging and stress exposure and memory impairment, researchers examined the potential protective effects of Tualang honey supplementation on memory performance in aged rats exposed to noise stress.
Tested rats were given orally, 200 mg/kg body weight of Tualang honey supplementation for 28 days, before exposing to the loud noise, 100 dB(A), 4 hours daily for 14 days.
Rats subjected to noise stress exhibited significantly lower memory performance and higher oxidative stress, through the increased expression of oxidative stress markers, the elevated malondialdehyde, and protein carbonyl levels.
The stress rats also exhibited a reduction of the levels of antioxidant enzymes compared to the nonstressed rats.
Tualang honey supplementation applied to the stress rats showed a significant improvement of the memory performance, by decreasing oxidative stress levels and increasing the brain-derived neurotrophic factor (BDNF) concentration, which was reduced due to stress.
Furthermore, Tualang honey also normalized the ratio of free radicals and antioxidants in the stress rats' body and enhanced neuronal proliferation in the medial prefrontal cortex (mPFC) and hippocampus associated with the memory, particularly, in long-term memory.
Dr. Azman KF, the lead scientist at the final report wrote, "Tualang honey protects against memory decline due to stress exposure and/or aging via enhancement of mPFC and hippocampal morphology possibly secondary to a reduction in brain oxidative stress and/or upregulation of BDNF concentration and cholinergic system".
The results underlined the effects of the Tualang honey effect in boosting the short and long-term memory which was significantly reduced by stress exposure and/or aging.
Moreover, in the study of the total of forty-eight adult male rats randomly divided into the following four groups: i) nonstressed with vehicle, ii) nonstressed with Tualang honey, iii) stressed with vehicle, and iv) stressed with honey with supplement was given once daily via oral gavage at 0.2 g/kg body weight, researchers found that
* The rats subjected to noise stress were found to process higher levels of depressive-like behavior and lower memory functions compared to the unexposed control rats.
* Tuatang honey supplementation regimen successfully counteracted the effects of noise stress.
* Tualng honey also increased the climbing and swimming and mobility times significantly.
These results suggested that Tualang honey normalizes the cognitive function of the rats exposed to noise stress, similar to those of the first study.
Taken altogether, Tualang honey may be considered a functional food for the prevention and combined with the primary therapy for the treatment of cognitive impairment, pending to the larger and multi center's human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats by Azman KF1, Zakaria R1, Abdul Aziz CB1, Othman Z2. (PubMed)
(2) Tualang honey improves memory performance and decreases depressive-like behavior in rats exposed to loud noise stress by Azman KF1, Zakaria R, AbdAziz C, Othman Z, Al-Rahbi B. (PubMed)
(3) Potential Role of Honey in Learning and Memory by Othman Z1, Zakaria R2, Hussain NHN3, Hassan A4, Shafin N5, Al-Rahbi B6, Ahmad AH. (PubMed)
Turmeric, a Natural Prevention and Treatment of Inflammation
Inflammation is a systematic immune response associated with the production of proinflammatory cytokine activated by the white blood cells in the first line of defense.
In the early phase of bodily injury and damage, the reaction of the immune system also encompasses a wide range of pathophysiological responses to minimize tissue damage while enhancing the repair process.
Inflammation also can be caused by viruses and bacteria, some of the most common stimuli of inflammation. However, overproduction of pro-inflammatory cytokines initiated by the immune system for a prolonged period of time may lead to cell damage and sometimes death of the healthy cells in the infectious site and nearby cells.
Badly enough, some proteins process the duo functions of pro and anti-inflammation. Under abnormal conditions, they can switch from their original action of anti-inflammatory cytokines to pro-inflammatory cytokines.
The complications involved in overproduction of pro-inflammatory cytokines induced improper healing for the forming of scars and damage to the tissue of the organ can also affect and limit the organs functioning, such as liver scars caused by hepatitis virus infection.
Malfunctioning immunological responses attack the body tissue can incite inappropriate and chronic inflammation
Believe it or not, tissues die from a lack of oxygen or nutrients associated with oxidative stress overload can also cause inflammation.
Chronic inflammation in the hand, caused by the immune response that can not kill off all infectious agents in the acute phase of infection.
Some researchers argued that the evolution of the immune system is to kill off all infectious stimuli or pathogens within 3 - 8 weeks, otherwise, the immune system will adapt to their existence, in other words, chronic inflammation.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound for the treatment of diseases associated with inflammation, researchers examined the efficacy of a hot water extract of C. longa (WEC) or bisacurone, a component of turmeric extract antioxidant and anti-inflammatory activity.
On C57BL/6 mice-induced liver injury by acute ethanol, administration of WEC (20 mg/kg body weight; BW) or bisacurone (60 µg/kg BW) at 30 min before a single dose of ethanol(3·0 g/kg BW), researchers found that plasma levels of aspartate aminotransferase and alanine aminotransferase elevated in ethanol-treated mice was significantly suppressed by WEC and bisacurone.
Furthermore, mice treated by WEC also protected the hepatic tissue by increasing the levels of antioxidants superoxide dismutase and glutathione.
Moreover, hepatic tissue levels of thiobarbituric acid-reactive substances. and associated with reduced levels of oxidation, proteins TNF-α protein and IL-6 mRNA involved in the production of pro-inflammatory cytokines was also inhibited by WEC and bisacurone, compared to control mice.
In other words, WEC and bisacurone protect the liver cell by inhibiting the parameters against the induction of oxidative stress.
Conclusively, researchers said, " oral administration of WEC may have a protective effect against ethanol-induced liver injury by suppressing hepatic oxidation and inflammation, at least partly through the effects of bisacurone".
Taken altogether, turmeric processed abundantly bioactive compound bisacurone may be considered supplements for the prevention and treatment of diseases associated with inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hot water extract of turmeric (Curcuma longa) prevents non-alcoholic steatohepatitis in mice by inhibiting hepatic oxidative stress and inflammation by Uchio R1, Murosaki S2, Ichikawa H. (PubMed)
(2) A hot water extract of turmeric (Curcuma longa) suppresses acute ethanol-induced liver injury in mice by inhibiting hepatic oxidative stress and inflammatory cytokine production by Uchio R1, Higashi Y1, Kohama Y2, Kawasaki K1, Hirao T2, Muroyama K1, Murosaki S. (PubMed)
In the early phase of bodily injury and damage, the reaction of the immune system also encompasses a wide range of pathophysiological responses to minimize tissue damage while enhancing the repair process.
Inflammation also can be caused by viruses and bacteria, some of the most common stimuli of inflammation. However, overproduction of pro-inflammatory cytokines initiated by the immune system for a prolonged period of time may lead to cell damage and sometimes death of the healthy cells in the infectious site and nearby cells.
Badly enough, some proteins process the duo functions of pro and anti-inflammation. Under abnormal conditions, they can switch from their original action of anti-inflammatory cytokines to pro-inflammatory cytokines.
The complications involved in overproduction of pro-inflammatory cytokines induced improper healing for the forming of scars and damage to the tissue of the organ can also affect and limit the organs functioning, such as liver scars caused by hepatitis virus infection.
Malfunctioning immunological responses attack the body tissue can incite inappropriate and chronic inflammation
Believe it or not, tissues die from a lack of oxygen or nutrients associated with oxidative stress overload can also cause inflammation.
Chronic inflammation in the hand, caused by the immune response that can not kill off all infectious agents in the acute phase of infection.
Some researchers argued that the evolution of the immune system is to kill off all infectious stimuli or pathogens within 3 - 8 weeks, otherwise, the immune system will adapt to their existence, in other words, chronic inflammation.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound for the treatment of diseases associated with inflammation, researchers examined the efficacy of a hot water extract of C. longa (WEC) or bisacurone, a component of turmeric extract antioxidant and anti-inflammatory activity.
On C57BL/6 mice-induced liver injury by acute ethanol, administration of WEC (20 mg/kg body weight; BW) or bisacurone (60 µg/kg BW) at 30 min before a single dose of ethanol(3·0 g/kg BW), researchers found that plasma levels of aspartate aminotransferase and alanine aminotransferase elevated in ethanol-treated mice was significantly suppressed by WEC and bisacurone.
Furthermore, mice treated by WEC also protected the hepatic tissue by increasing the levels of antioxidants superoxide dismutase and glutathione.
Moreover, hepatic tissue levels of thiobarbituric acid-reactive substances. and associated with reduced levels of oxidation, proteins TNF-α protein and IL-6 mRNA involved in the production of pro-inflammatory cytokines was also inhibited by WEC and bisacurone, compared to control mice.
In other words, WEC and bisacurone protect the liver cell by inhibiting the parameters against the induction of oxidative stress.
Conclusively, researchers said, " oral administration of WEC may have a protective effect against ethanol-induced liver injury by suppressing hepatic oxidation and inflammation, at least partly through the effects of bisacurone".
Taken altogether, turmeric processed abundantly bioactive compound bisacurone may be considered supplements for the prevention and treatment of diseases associated with inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Hot water extract of turmeric (Curcuma longa) prevents non-alcoholic steatohepatitis in mice by inhibiting hepatic oxidative stress and inflammation by Uchio R1, Murosaki S2, Ichikawa H. (PubMed)
(2) A hot water extract of turmeric (Curcuma longa) suppresses acute ethanol-induced liver injury in mice by inhibiting hepatic oxidative stress and inflammatory cytokine production by Uchio R1, Higashi Y1, Kohama Y2, Kawasaki K1, Hirao T2, Muroyama K1, Murosaki S. (PubMed)
Kidney Bean, The Anti Obesity Complications Natural functional Food
Intake of kidney bean regularly may reduce the risk of complication in obese patients, a study conducted by renowned institute insisted.
Kidney bean is popular because of its kidney shape, strong flavor and color of reddish-brown in nature, genus Phaseolus, belonging to the family Fabaceae. The bean is often an excellent dietary selection with no cholesterol, but a good source of protein and minerals.
Obesity is a medical condition of excess body fat that has accumulated over time. According to the Body Mass Index(BMI), a BMI of over 30 is an indication of obesity. Unfortunately, 68% of the American population is either overweight or obese.
According to the Instituto Tecnológico de Durango,, kidney bean may have potential effects as natural alternative treatments of some metabolic alterations associated with obesity.
The efficacy may involve the regulation of many aspects, including a lipid profile, and lipid and carbohydrates metabolisms, in addition to anti-inflammatory and antioxidant activities.
The study also found that kidney beans exerted a similar anti obese effect of that of green tea and its active principles, in both in vitro (cell cultures) and in vivo (animal models).
In fact, the test of different levels of lectin of kidney bean (Phaseolus vulgaris) content (27 g/kg meal) in a high-quality (lactalbumin) control diet in obese Zucker (FFA) rats and their lean littermates, phytochemical compound, bean lectin as a dietary adjunct or therapeutic agent expressed a stimulated gut function and ameliorated obesity, in doses depended manner. The result also indicated that a safe and effective dose-range of bean lectin can be established for human subjects.
Furthermore, standardised and purified P. vulgaris extract (PVE), when employed as a supplement in a mixed balanced meal (60 % carbohydrates, 25 % lipids and 15 % protein), in a randomised, double-blind, placebo-controlled of 12 volunteers, exerted a significant on hypometabolic and appetite control affecting satiety sensations and lower desire to eat.
But further studies are needed to prove the concept of Kidney Bean as a supplement used as a functional food in balanced meals in obese, glucose-intolerant and diabetic subjects.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Plants with potential use on obesity and its complications by Gamboa-Gómez CI1, Rocha-Guzmán NE1, Gallegos-Infante JA1, Moreno-Jiménez MR1, Vázquez-Cabral BD1, González-Laredo RF1.(PubMed)
(1) Lipid accumulation in obese Zucker rats is reduced by inclusion of raw kidney bean (Phaseolus vulgaris) in the diet by Pusztai A1, Grant G, Buchan WC, Bardocz S, de Carvalho AF, Ewen SW.(PubMed)
(3) Phaseolus vulgaris extract affects glycometabolic and appetite control in healthy human subjects by Spadafranca A1, Rinelli S, Riva A, Morazzoni P, Magni P, Bertoli S, Battezzati A.(PubMed)
Kidney bean is popular because of its kidney shape, strong flavor and color of reddish-brown in nature, genus Phaseolus, belonging to the family Fabaceae. The bean is often an excellent dietary selection with no cholesterol, but a good source of protein and minerals.
Obesity is a medical condition of excess body fat that has accumulated over time. According to the Body Mass Index(BMI), a BMI of over 30 is an indication of obesity. Unfortunately, 68% of the American population is either overweight or obese.
According to the Instituto Tecnológico de Durango,, kidney bean may have potential effects as natural alternative treatments of some metabolic alterations associated with obesity.
The efficacy may involve the regulation of many aspects, including a lipid profile, and lipid and carbohydrates metabolisms, in addition to anti-inflammatory and antioxidant activities.
The study also found that kidney beans exerted a similar anti obese effect of that of green tea and its active principles, in both in vitro (cell cultures) and in vivo (animal models).
In fact, the test of different levels of lectin of kidney bean (Phaseolus vulgaris) content (27 g/kg meal) in a high-quality (lactalbumin) control diet in obese Zucker (FFA) rats and their lean littermates, phytochemical compound, bean lectin as a dietary adjunct or therapeutic agent expressed a stimulated gut function and ameliorated obesity, in doses depended manner. The result also indicated that a safe and effective dose-range of bean lectin can be established for human subjects.
Furthermore, standardised and purified P. vulgaris extract (PVE), when employed as a supplement in a mixed balanced meal (60 % carbohydrates, 25 % lipids and 15 % protein), in a randomised, double-blind, placebo-controlled of 12 volunteers, exerted a significant on hypometabolic and appetite control affecting satiety sensations and lower desire to eat.
But further studies are needed to prove the concept of Kidney Bean as a supplement used as a functional food in balanced meals in obese, glucose-intolerant and diabetic subjects.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Plants with potential use on obesity and its complications by Gamboa-Gómez CI1, Rocha-Guzmán NE1, Gallegos-Infante JA1, Moreno-Jiménez MR1, Vázquez-Cabral BD1, González-Laredo RF1.(PubMed)
(1) Lipid accumulation in obese Zucker rats is reduced by inclusion of raw kidney bean (Phaseolus vulgaris) in the diet by Pusztai A1, Grant G, Buchan WC, Bardocz S, de Carvalho AF, Ewen SW.(PubMed)
(3) Phaseolus vulgaris extract affects glycometabolic and appetite control in healthy human subjects by Spadafranca A1, Rinelli S, Riva A, Morazzoni P, Magni P, Bertoli S, Battezzati A.(PubMed)
Thursday, October 31, 2019
Cucumber's Bioactive Compound Cucurbitacin B (CuB) Exerts Anti-Hyperglycemic Effect in Diabetics
Hypoglycemia is abnormally high blood glucose levels in the bloodstream in diabetes.
Most cases of hyperglycemia are associated with poor management of blood sugar levels as a result of poor diet and poor practice of medicine intake and insulin injection.
Hyperglycemia is a hallmark of diabetes caused by the inability of the body to convert glucose to energy or make the hormone insulin.
Most common and early signs of hyperglycemia are increased thirst and/or hunger, frequent urination, sugar in your urine, fatigue.
In severe cases, patients with hyperglycemia may also experience symptoms of headache and blurred vision.
Long-term untreated hyperglycemia may induce complications that affect the eyes, kidneys, ner, es and heart.
In severe cases, hyperglycemia can also lead to serious complications that require emergency care, such as a diabetic coma.
Women who are nondiabetics before pregnancy and experience gestation hyperglycemia are likely to develop diabetes in the latter days.
Believe it or not, hyperglycemia can also occur in people without diabetes due to stress. According to the study, people who are nondiabetics and experience abnormally high blood glucose are most likely to develop diabetes later in life.
According to the statistics, In 2015, approximately 30.3 million Americans, or 9.4% of the population, had diabetes. Approximately 1.25 million American children and adults have type 1 diabetes.
Some researchers suggested that by changing lifestyle with moderate exercise, hyperglycemia can be manageable in type II diabetes.
Dr. Salwa W. Rizkalla wrote, " Only 4 weeks of a (low GI diet) LGI diet was able to improve glycemic control, glucose utilization, some lipid profiles, and the capacity for fibrinolysis in type 2 diabetes. Even if changes in glycemic control were modest during the 4-week period, the use of an LGI diet in a longer-term manner might play an important role in the treatment and prevention of diabetes and related disorders"
The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural ingredient for the prevention of hyperglycemia in patients with diabetes, researchers examined the effect of Cucurbitacin B (CuB) isolated from cucumber induced hypoglycemic effect in an animal model.
On mice, induced diabetes, administration of Cucurbitacin B (CuB) composed of triterpenoid structure stimulated AMP-activated protein kinase (AMPK) pathway which has been found to contribute to the correction of insulin resistance overexpression in hyperglycemia.
CuB also ameliorated hyperglycemia not only by activating intestinal AMPK levels and also by inducing production of plasma GLP-1 associated with the improvement of insulin-releasing by pancreatic β-cells.
However, GLP-1 mimetic medicines although exerted a similar effect compared to that of natural GLP-1, it induced clinical side effects, such as autoimmune hepatitis, acute kidney injury, pancreatitis, and pancreatic cancer.
Interestingly, the efficacy of hypoglycemic activity of CuB decreased significantly in dorsomorphin- (a selective inhibitor of the BMP pathway involved in the expression of cytokines) injected mice and α-gustducin null mice.
In differentiated NCI-H716 cell line, CuB inhibited hyperglycemia involved in activation of AMPK through α-gustducin and Gβγ-signaling of taste receptors in signaling secretion of incretin hormones such as glucagon-like peptide-1 (GLP-1).
Where taste receptors are found in several organs including tongue to colon and have the diverse functions dependent on specific cell types.
In enteroendocrine L cells, stimulated taste receptor signaling plays a critical role in inducing incretin hormones, including GLP-1.
Based on the findings, researchers said, "CuB represents novel hypoglycemic agents by activation of AMPK and stimulation of GLP-1 in differentiated enteroendocrine L-cells".
Taken altogether, cucumber processed high levels of CuB may be used for the treatment of hyperglycemia in diabetics, pending to the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling by Kim KH1,2, Lee IS1,2, Park JY1,2, Kim Y1,2, An EJ1,2, Jang HJ. (PubMed)
(2) Improved Plasma Glucose Control, Whole-Body Glucose Utilization, and Lipid Profile on a Low-Glycemic Index Diet in Type 2 Diabetic Men by
Salwa W. Rizkalla, MD, PHD12,
Laika Taghrid, MD1,
Muriel Laromiguiere, PharmD, PHD3,
Dorothée Huet, MD1,
Josette Boillot, PHD1,
Aude Rigoir, RN1,
Fabienne Elgrably, MD1 and
Gerard Slama, MD. (the American Diabetes Association)
Most cases of hyperglycemia are associated with poor management of blood sugar levels as a result of poor diet and poor practice of medicine intake and insulin injection.
Hyperglycemia is a hallmark of diabetes caused by the inability of the body to convert glucose to energy or make the hormone insulin.
Most common and early signs of hyperglycemia are increased thirst and/or hunger, frequent urination, sugar in your urine, fatigue.
In severe cases, patients with hyperglycemia may also experience symptoms of headache and blurred vision.
Long-term untreated hyperglycemia may induce complications that affect the eyes, kidneys, ner, es and heart.
In severe cases, hyperglycemia can also lead to serious complications that require emergency care, such as a diabetic coma.
Women who are nondiabetics before pregnancy and experience gestation hyperglycemia are likely to develop diabetes in the latter days.
Believe it or not, hyperglycemia can also occur in people without diabetes due to stress. According to the study, people who are nondiabetics and experience abnormally high blood glucose are most likely to develop diabetes later in life.
According to the statistics, In 2015, approximately 30.3 million Americans, or 9.4% of the population, had diabetes. Approximately 1.25 million American children and adults have type 1 diabetes.
Some researchers suggested that by changing lifestyle with moderate exercise, hyperglycemia can be manageable in type II diabetes.
Dr. Salwa W. Rizkalla wrote, " Only 4 weeks of a (low GI diet) LGI diet was able to improve glycemic control, glucose utilization, some lipid profiles, and the capacity for fibrinolysis in type 2 diabetes. Even if changes in glycemic control were modest during the 4-week period, the use of an LGI diet in a longer-term manner might play an important role in the treatment and prevention of diabetes and related disorders"
The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural ingredient for the prevention of hyperglycemia in patients with diabetes, researchers examined the effect of Cucurbitacin B (CuB) isolated from cucumber induced hypoglycemic effect in an animal model.
On mice, induced diabetes, administration of Cucurbitacin B (CuB) composed of triterpenoid structure stimulated AMP-activated protein kinase (AMPK) pathway which has been found to contribute to the correction of insulin resistance overexpression in hyperglycemia.
CuB also ameliorated hyperglycemia not only by activating intestinal AMPK levels and also by inducing production of plasma GLP-1 associated with the improvement of insulin-releasing by pancreatic β-cells.
However, GLP-1 mimetic medicines although exerted a similar effect compared to that of natural GLP-1, it induced clinical side effects, such as autoimmune hepatitis, acute kidney injury, pancreatitis, and pancreatic cancer.
Interestingly, the efficacy of hypoglycemic activity of CuB decreased significantly in dorsomorphin- (a selective inhibitor of the BMP pathway involved in the expression of cytokines) injected mice and α-gustducin null mice.
In differentiated NCI-H716 cell line, CuB inhibited hyperglycemia involved in activation of AMPK through α-gustducin and Gβγ-signaling of taste receptors in signaling secretion of incretin hormones such as glucagon-like peptide-1 (GLP-1).
Where taste receptors are found in several organs including tongue to colon and have the diverse functions dependent on specific cell types.
In enteroendocrine L cells, stimulated taste receptor signaling plays a critical role in inducing incretin hormones, including GLP-1.
Based on the findings, researchers said, "CuB represents novel hypoglycemic agents by activation of AMPK and stimulation of GLP-1 in differentiated enteroendocrine L-cells".
Taken altogether, cucumber processed high levels of CuB may be used for the treatment of hyperglycemia in diabetics, pending to the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling by Kim KH1,2, Lee IS1,2, Park JY1,2, Kim Y1,2, An EJ1,2, Jang HJ. (PubMed)
(2) Improved Plasma Glucose Control, Whole-Body Glucose Utilization, and Lipid Profile on a Low-Glycemic Index Diet in Type 2 Diabetic Men by
Salwa W. Rizkalla, MD, PHD12,
Laika Taghrid, MD1,
Muriel Laromiguiere, PharmD, PHD3,
Dorothée Huet, MD1,
Josette Boillot, PHD1,
Aude Rigoir, RN1,
Fabienne Elgrably, MD1 and
Gerard Slama, MD. (the American Diabetes Association)
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