Black beans Protect Your Large Intestine Against Colon Cancer

Black bean may have a profound effect on reducing and treatment of colon cancer, some scientists suggested.

The colon also known as the large bowel or large intestine, is part of the digestive system in our body.

Colon cancer is a chronic condition caused by cell growth irregularly and disorderly in the colon due to the alternation of DNA.

Most cases of colon cancer start in the cells on the surface of the inner lining of the colon. At this stage, patients may not experience any symptoms.

After penetrating deeper into the colon layer, the cancer cells may travel a distance away to infect other healthy tissue and organs through the fluids and blood circulation.

At this stage, the increased size of the tumor may suppress the nearby tissue, organs or nerve cells causing localized symptoms and severe pain.

Most common colon cancer metastasis are the lungs, liver.

According to the epidemiological studies, the most common risk factors of colon cancer are older

age, ethnicity, personal and family history of colorectal cancer or polyps, inflammatory intestinal conditions.


Particularly, people who follow the low-fiber, high-fat diet or have a sedentary lifestyle. are associated with the substantial risk for the onset of the disease.


Dr. Y J Cong, the lead author in the concerns of the sedentary behavior in risk of colon cancer in modern society, launched an investigation to examine the association of sedentary behavior with colon and rectal cancer.


The search of the databases of PubMed, Embase, and Google Scholar databases up to May 2013 to identify cohort and case-control studies that evaluated the association between sedentary behavior and colon or rectal cancer identified 23 studies with 63 reports included 4 324 462 participants.

After assessing the results of all the studies, the doctor team wrote. "Sedentary behavior is associated with an increased risk of colon cancer. Subgroup analyses suggest a positive association between sedentary behavior and risk of rectal cancer in cohort studies".

Black bean is a Small roughly ovoid legume with glossy black shells, genus Phaseolus, belonging to the family Fabaceae.

The bean can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

The major chemical compounds of black bean include anthocyanin, (-)-epicatechin, delphinidin, petunidin, flavonols, and malvidin.

On finding, natural whole food for the treatment of colon cancer, researchers at the Tecnológico de Monterrey-Campus Monterrey conducted an investigation to examine the black bean antioxidant capacity and antiproliferative activity against cancer cell lines.

Flavonoids extracted from seed coats exerted a potential effect against colon cancer cell line'

The extracts obtained from seed coats after 3 and 5 germination days inhibited all cancer cell lines proliferation, including the tested colon cancer with no cytotoxicity against control cells.

Further analysis also suggested that flavonols and group B saponins isolated from the seed coat were more related to hepatic and colon cancers.


These results indicated that not all chemical compounds found in black bean have a potential effect in the inhibition of colon cancer. However, the intake of the black bean as a whole food may have significant effects in reducing the risk of colon cancer.

Additionally, in finding evidence to suggest an inverse relationship between bean consumption and colon cancer, researchers at the Food Science program at Michigan State University conducted a study to determine whether consumption of black beans and/or navy beans would reduce colon carcinogenesis in rats.

Selected rat group were fed a modified AIN-93G diet (control) or diets containing 75% black beans or 75% navy beans for 4 wk, and then colon cancer was initiated by the administration of two injections of azoxymethane 1 wk apart.

At 31 wk after the second injection, the incidence of colon adenocarcinomas was significantly lower in rats fed the black bean (9%) than in rats fed the control diet (36%).

Total tumor multiplicity was also significantly lower in rats fed the black bean diet than in rats fed the control diet.

After taking into account co and confounders, Dr. Hangen L, the lead author said, "The 44-75% reduction in colon carcinogenesis in rats fed beans was attributed to 1) more controlled appetites, leading to significantly less body fat, and 2) much greater concentrations of butyrate in the distal colon".

These results suggested black beans only have a potential effect in lowering the risk of colon cancer. but also stop cell multiplicity in the case of colon cancer.

However, further data collection large example size and multi-centers studies performed with human consumption of the whole food or its bioactive compounds during the course of the disease will be necessary to complete the picture of black bean anti-colon cancer possibilities.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.



References
(1) Differential accumulation of polyphenolics in black bean genotypes grown in four environments.
Marles MA, Balasubramanian P, Bett KE. (PubMed)
(2) Evaluation of the antioxidant and antiproliferative activities of extracted saponins and flavonols from germinated black beans (Phaseolus vulgaris L.).
Guajardo-Flores D, Serna-Saldívar SO, Gutiérrez-Uribe JA(PubMed)
(3) Consumption of black beans and navy beans (Phaseolus vulgaris) reduced azoxymethane-induced colon cancer in rats. by Hangen L, Bennink MR. (PubMed)
(4) Association of sedentary behavior with colon and rectal cancer: a meta-analysis of observational studies by bY J Cong,1 Y Gan,1 HL Sun,1 J Deng,1 S Y Cao,1 X Xu,1,2 and Z X Lu. (PubMed)