Lycopene Promotes Kidney Against Renal Disease

Kidneys, a pair of the bean-shaped organ in the human body not only filter out blood but also balances the body fluids by eliminating them and removes them through urinary secretion.

Additionally, the kidney accompanied by the liver and skin form also detox the toxins in the body.

Kidney disease is a medical condition associated with a gradually reduced function of the kidney.

Renal protection is a strategy that protect the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.

Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness

In severe cases, patients may also have symptoms of shortness of breath, confusion, and irregular heartbeat.

The worse cases of kidney damage can lead to renal failure, a condition that induces wastes and toxins accumulated in the blood. In this stage, dialysis and kidney transplant are the only options.

Believe it or not, most cases of kidney disease are found in the late stage. In other words, kidney disease can only be diagnosed, if your kidneys have less than 10% functioning capacity.

Most patients at the advanced stage of chronic kidney damage may experience more severe symptoms of swelling in the hands and feet, back pain and urinating more or less than normal, accompanied by other health problem associated with weakened kidney function

However, at the end-stage CKD with the GFR <15 mL/min, patients are considered very close to renal failure or renal failure.

Where eGFR is short for estimated glomerular filtration rate.


Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,

Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.

On finding a potent compound that processes kidney protective activity, researchers examined the effects of lycopene on kidney oxidative tissue damage.

According to the results in 2 pharmaceutical forms in methotrexate-induced kidney damage in rats, a single dose of methotrexate- showed a significant effect to induce severe functional and morphological alterations of kidneys observed by kidney cell skin peeling, tubular vacuolation, and focal necrosis.

Serum urea and creatinine increase associated with kidney damage and injury and reduced kidney tissue antioxidant enzymes were also found in the kidney in methotrexate-induced rats.

Application of both forms of lycopene concomitantly with methotrexate not only ameliorated changes in serum urea and creatinine and oxidative damage markers but also markedly reversed structural changes of kidney tissue.

In other words, lycopene protected the kidney tissue against oxidative stress-induced toxicity by increasing the levels of antioxidant enzymes produced by the host.

Interestingly, rats treated by lycopene in nanoliposome-encapsulated form showed a higher degree of recovery compared to those treated with free lycopene form.


Based on the findings, researchers wrote, "treatment with nanoliposome-encapsulated lycopene comparing to lycopene in the standard vehicle has an advantage as it more efficiently reduces methotrexate-induced kidney dysfunction".

Taken altogether, lycopene found in tomato may be considered supplements for the prevention and treatment of kidney disease, pending on the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Encapsulation of Lycopene in Nanoliposomes Enhances Its Protective Potential in Methotrexate-Induced Kidney Injury Model by Stojiljkovic N1, Ilic S1, Jakovljevic V2,3, Stojanovic N4, Stojnev S5, Kocic H6, Stojanovic M4, Kocic G. (PubMed)
(2) Effect of Lycopene and Rosmarinic Acid on Gentamicin Induced Renal Cortical Oxidative Stress, Apoptosis, and Autophagy in Adult Male Albino Rat by Bayomy NA1, Elbakary RH1, Ibrahim MAA1, Abdelaziz EZ. (PubMed)