Black Bean, The Best in Reduced Risk and Treatment of Liver Fibrosis Naturally

Black or common bean may be potential function food used for reduced risk and treatment of liver
fibrosis, a research institute supposed.

Black bean, small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can be bought in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

Liver fibrosis is a condition of excessive accumulation of extracellular collagen caused by an abnormal liver response to injure.

According to the Tecnológico de Monterrey, School of Medicine, Basic Research Laboratory, oral administrated black bean extract exerted a significantly decreased type I and type IV collagen gene expression.


In eight weeks of carbon tetrachloride (CCl4)induced liver injury in rat model, black bean extract of 70 mg/kg treatment showed a reduced hepatic fibrosis index by 18% compared to positive controls.


The study also indicated that the efficacy of black bean extract in the ameliorated risk of liver fibrosis due to injuring may be attributed to legume strong antifibrotic compounds in the treatment of diseases with an increase in inflammation and oxidative burst in their pathogenesis, including liver fibrosis.

Furthermore in the application of 0.1 g of crude biomass obtained from seed coats of Perla black bean dissolved in 400 mL of H2 O, and 100 g of NaCl added in liver injure mice model, back bean treatment group expressed evidence of improvement of pathological changes, including interstitial fibrosis, inflammatory infiltration, collagen deposition and steatosis in compared to normal group.

Histological analysis showed that the test group presented a significant reduction of collagen deposition of which exhibited a reduced risk of developed liver scaring in the recovery phase.

The study also insisted that antioxidant effect against liver intoxication, a widely use laboratory application in induced lipid peroxidation and trichloromethyl radical (CCl3 ), to cause severe liver cell damage in an animal model, may represent a new perspective in liver injury and fibrosis prevention, the researcher concluded.

Taking together, black bean, contains various phytochemicals, such as naringenin, Nacetylcysteine, vitamin E, silymarin, quercetin in exhibited antioxidant activity, may be considered as an integrated form of diet therapy for reduced risk and treatment of liver fibrosis.

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Author Biography
Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) Black bean extract ameliorates liver fibrosis in rats with CCl4-induced injury by López-Reyes AG1, Arroyo-Curras N, Cano BG, Lara-Díaz VJ, Guajardo-Salinas GE, Islas JF, Morales-Oyarvide V, Morales-Garza LA, Galvez-Gastelum FJ, Grijalva G, Moreno-Cuevas JE.(PubMed)(Annals of Hepatology)