Healthy Food Cucumber' Cucurbitacin B Protects the Heart Against the Risk of Cardiac Hypertrophy

Cardiac hypertrophy (CH) is a medical condition characterized by the abnormal enlargement or thickening of the heart muscle, affecting the heart function in pumping blood.

Cardiac hypertrophy induced reduced blood flow to the body may cause symptoms of shortness of breath, chest pain, particularly during exercise.

In some serious cases, CH can disrupt the heart's electrical system, leading to life-threatening abnormal heart rhythms (arrhythmias).

The most common types of CH include
*Ventricular hypertrophy due to intense sports activities, particularly in people with intensive exercise

* Ventricular hypertrophy due to hypertension-induced ventricular pressure overload.

and
* Ventricular hypertrophy due to tricuspid regurgitation induced ventricular volume overload.


Although there are various causes associated with the onset of CH, the most common cause of CH is associated with plaque accumulated on the arterial wall resulting in a blockage that causes damage to the heart muscle.

Dr. Joa˜o Carlos Hueb, the lead scientist in the article "Association Between Atherosclerotic Aortic Plaques and Left Ventricular Hypertrophy in Patients With Cerebrovascular Events" wrote, "Almost half of the patients (43.1%) presented atherosclerotic lesions in the aorta. LVH was present in 90.0% of patients with a plaque and in only 30.3% of patients without plaque. Using high blood pressure as a covariate, the risk of patients with LVH presenting atherosclerotic plaque in the aorta was 18.23-fold greater than the risk for patients without LVH (95% CI, 5.68 to 58.54; P0.0001)"

And, "Adding age into the model, the risk increased to 26.36 (95% CI, 7.14 to 97.30; P0.0001). Conclusions—LVH detected by conventional echocardiogram is associated with a high risk of atherosclerotic plaque in the aorta and would be used as a criterion for an indication of transesophageal".

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

In the urgency to find a natural treatment that processes anti-cardiac hypertrophy associated with the prevalence of heart failure, researchers evaluated the anti-hypertrophy and anti-fibrosis potential of a natural plant triterpenoid, Cucurbitacin B in vivo.

The study included mice induced cardiac hypertrophy by aortic banding (AB) received cucurbitacin B treatment (Gavage, 0.2 mg/kg body weight/2 day) after 1 week of surgery.

Observation after 4 weeks of AB, cucurbitacin B (CuB) demonstrated a strong anti-hypertrophy and -fibrosis ability by decreasing heart weight, myocardial cell cross-sectional area, and interstitial fibrosis.

Furthermore, CuB also protected the heart by ameliorating systolic and diastolic abnormalities, normalized the gene expression of hypertrophic and fibrotic markers induced by aortic banding (AB).

Moreover, cucurbitacin B also showed significant hypertrophy inhibitory effect in phenylephrine that stimulates cardiac muscle cells.


The efficacy of CuB in the inhibition of abnormal enlargement, or thickening, of the heart muscle, was attributed to the increasing level of autophagy involved in the orderly degradation and recycling of cellular components by blocking signaling pathways associated with inhibited autophagy.

Taken altogether, cucumber processed a major compound cucurbitacin B (CuB) may be used for the treatment of cardiac hypertrophy, pending to the confirmation of the larger sample size and multicenter human study.

Intake of CuB in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy by Xiao Y1,2,3, Yang Z1,2,3, Wu QQ1,2,3, Jiang XH1,2,3, Yuan Y1,2,3, Chang W1,2,3, Bian ZY1,2,3, Zhu JX1,2,3, Tang QZ. (PubMed)
(2) Association Between Atherosclerotic Aortic Plaques and Left Ventricular Hypertrophy in Patients With Cerebrovascular Events" by Joa˜o Carlos Hueb, MD, PhD; Silme´ia G. Zanati, MD; Katashi Okoshi, MD, PhD; Ce´sar N. Raffin, MD, PhD; Liciana Vaz de Arruda Silveira, PhD; Beatriz B. Matsubara, MD, PhD. (AHA journals)