Asparagus, the Natural Whole Food for Neuroprotective Effects

Asparagus may be a potential whole food medicine for reduced risk and treatment of neurodegenerative disease, a renowned institution suggested.

Methanol extract from Asparagus cochinchinensi, in vivo and in vitro is found to exhibit neuroprotective effects through activation of the Shp-2, antibody and ErK1/2 Akt and Akt involved the cell apoptosis, cell proliferation.


Asparagus is a flowering plant belongs to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and western Asia. Asparagus has been used from early times as a vegetable and medicine, because of its delicate flavor and diuretic properties.

In animal study of neurodegenerative disorders involved Alzheimer's disease (AD) , biological stresses, such as oxidative and inflammatory stress, induced neural cell damage, asparagus extract (ETAS) exerted anti neuroprotective effects, through expression of mRNAs in information transfer of DNA factors in exerted cytoprotective and anti-apoptotic functions against death of neuronal cells and early cognitive impairment.
Dr. Sakurai T, the lead researcher in the study insisted, this efficacy may be contributed by the extract in attenuated neuro-cell damage through improved hippocampus function in the expression of memory.


Furthermore, other chemical compound isolated roots of Asparagus cochinchinensis may be also effective in treating cognitive impairment by ameliorated neuroinflammation through decreased production of free radical NO and suppressed microglia cell activation cause of neuronal cell death.


Taking all together, there is no doubt that asparagus extract may be a potential agent for delay neurodegenerative disease through the improved function of hippocampal regions associated with the learning and memory functions, increased neurotransmitter activity, attenuated neuroinflammatory expression and inhibited oxidative stress-induced free radical in damage of neurons.


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Sources
(1) The neuroprotective effects and possible mechanism of action of a methanol extract from Asparagus cochinchinensis: In vitro and in vivo studies by Jalsrai A1, Numakawa T2, Kunugi H2, Dieterich DC3, Becker A4.(PubMed)
(2) Enzyme-treated Asparagus officinalis extract shows neuroprotective effects and attenuates cognitive impairment in senescence-accelerated mice by Sakurai T, Ito T, Wakame K, Kitadate K, Arai T, Ogasawara J, Kizaki T, Sato S, Ishibashi Y, Fujiwara T, Akagawa K, Ishida H, Ohno H.(PubMed)
(3) Anti-neuroinflammatory constituents from Asparagus cochinchinensis by Jian R1, Zeng KW, Li J, Li N, Jiang Y, Tu P.(PubMed)
(4) Effect of Convolvulus pluricaulis Choisy and Asparagus racemosus Willd on learning and memory in young and old mice: a comparative evaluation by Sharma K1, Bhatnagar M, Kulkarni SK.(PubMed)