Kidney(Common) Bean, The Whole Food in Reduced Risk and Treatment of Colon Cancer

Intake of thoroughly cooked kidney bean may reduce risk and inhibit the progression of colon cancer, the recent study suggested.

Kidney bean is popular food, with kidney shape, strong flavor and color in reddish-brown in nature used often as an excellent dietary selection because of enormous health benefits with a good source of protein and minerals.

Colon cancer is a condition of the abnormal proliferation of cells in the colon.

According to the Hannam University Daedeok Valley Campus, Korean kidney bean husk extract, ameliorated risk of colon cancer through the ability to control the messenger initiated chemical reactions of intracellular signaling responsible for inducing antitumor activities in colon cancer cells.


The anti preoperative effect of the extract also exhibited the protein is responsible in inducing cell death by interfering phases of tumor cell cycle division.

Dr.Lee YK, the lead author in the study said, " the ability of carcinogenesis control by Korean kidney bean husk extract with high potency suggests its value as an antitumor agent in colon cancer therapy."

Furthermore, in the evaluated composition and chemopreventive effect of a polysaccharide extract (PE) from cooked common beans ( P. Vulgaris L), including kidney bean, in Negro 8025 with azoxymethane (AOM) induced colon cancer, rats group fed with polysaccharide extract (PE) showed a significantly decreased clusters of abnormal tissues in the lining of the colon and rectum.


The study also insisted the anti colon cancer activity can also be attributed to cell apoptotic expression and action of butyrate concentration found in the beans.


In support to the above differentiation, the Querétaro State University study concluded that the efficacy of common bean in treatment of colon cancer is a result of chemoprevention against aberrant crypt foci, clusters of abnormal tube-like glands in the lining of the colon and rectum through a combination of cell-cycle arrest in phase I and II.

Additionally, the study also suggested that through modulation of gene expression profiles in the colon tissue, a non-digestible fraction (NDF) of cooked bean (cultivar Bayo Madero) may contribute to the chemoprotective effect on early-stage colon cancer.

Taking together, intake of kidney bean regularly may have a potential effect in reduced risk and treatment of early stage of colon cancer.


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Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources
(1) Kidney bean husk extracts exert antitumor effect by inducing apoptosis involving AMP-activated protein kinase signaling pathway by Lee YK1, Hwang JT, Lee MS, Kim YM, Park OJ.(PubMed)
(2) Composition and chemopreventive effect of polysaccharides from common beans(Phaseolus vulgaris L.) on azoxymethane-induced colon cancer by Feregrino-Pérez AA1, Berumen LC, García-Alcocer G, Guevara-Gonzalez RG, Ramos-Gomez M, Reynoso-Camacho R, Acosta-Gallegos JA, Loarca-Piña G.(PubMed)
(3) Non-digestible fraction of beans (Phaseolus vulgaris L.) modulates signalling pathway genes at an early stage of colon cancer in Sprague-Dawley rats by Haydé VC1, Ramón GG, Lorenzo GO, Dave OB, Rosalía RC, Paul W, Guadalupe LP.(PubMed)