Cruciferous Vegetables, the Best Natural Whole Food Medicine for Reduced risk and Treatment of Cancers

Intake of Cruciferous Vegetables may reduce the risk of cancers.
According to the recent study, Indole-3-carbinol (I3C), a substance present in cruciferous vegetables suppressed the proliferation of different tumor cells, including those isolated from breast, prostate, endometrium, and colon cancers, in vitro.

Dr. Popolo A, the lead author suggested, the effect of the chemical compound in the treatment of various cancers may attribute to the interference of cancer cell cycle division and expression of a diverse set of genes involved cell differentiation.

Cruciferous vegetables are the group of vegetables belonging to the family Brassicaceae, including cauliflower, cabbage, cress, bok choy, broccoli, etc.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.

Indole-3-carbinol (I3C), according to Dr. Aggarwal BB and Dr. Ichikawa H., also inhibited DNA-carcinogen abducted formation, and suppressed free-radical production, stimulated 2-hydroxylation of estradiol in reduced cell proliferative and estrogenic activity and formation of blood vessels involved cancer cell survival.

Furthermore, indole-3-carbinol and its derivatives in the other studies not only expressed the anti-cancer effects through gene formation but also inhibited free radicals production, ... but also interfered with the cancer cell cycle division phase to induce apoptosis.

Other chemical compounds found in cruciferous vegetables, showed to possess potent antitumor and chemopreventive activity including sulforaphane (SFN), an isothiocyanate and Allyl nitrile (3-butenenitrile).

Taking together, there is no doubt, cruciferous vegetables have exhibited anti-cancer activities, through many aspects. Intake of cruciferous vegetables regularly is associated with reduced risk and treatment of various types of cancer.


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Sources
(1) Two likely targets for the anti-cancer effect of indole derivatives from cruciferous vegetables: PI3K/Akt/mTOR signalling pathway and the aryl hydrocarbon receptor by Popolo A1, Pinto A1, Daglia M2, Nabavi SF3, Farooqi AA4, Rastrelli L5.(PubMed)
(2) Molecular targets and anticancer potential of indole-3-carbinol and its derivatives by Aggarwal BB1, Ichikawa H.(PubMed)
(3) Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells by Liu KC1, Shih TY1, Kuo CL2, Ma YS3,4, Yang JL2, Wu PP5, Huang YP6, Lai KC7,8, Chung JG9,10.(PubMed)
(4) Allyl nitrile: Toxicity and health effects by Tanii H1.(PubMed)