Navy Bean Promotes Colon Health through Modulating Microbiome Metabolism

The colon formed part of the digestive system plays a critical role to absorb water from the small bowel contents and break down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Colon health is the process to enhance the function of the colon through many mechanisms, particularly, in the improvement of the ratio of gut microbiota.

Gut microbiota is a community of bacteria found in the gut. In a healthy individual, the ratio of good and bad bacterias are balanced. However, if the bad bacteria are overgrowing compared to good bacteria, it may lead to dysbiosis which has been found to induce chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism.

Most common risk factors associated with the imbalanced ratio of gut microbiota include the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle.

In other words, if you follow a healthy diet with a high in vegetables and fruits and fewer in processed foods, saturated and trans fat and red meat accompanied by moderate exercise, you may have done a job to protect the balance of gut microbiota.
The impact of gut microbes can also have a strong influence on what the human host is able to extract from its diet, both nutritionally and energetically.

Epidemiological studies suggested overweight and obese people show a dysbiosis characterized by a lower diversity. Imbalanced gut microbiota dysbiosis promotes diet-induced obesity and metabolic complications.

Some researchers suggested that we can optimize our colon health by manipulating the gut microbiota through diet by increasing the intake fiber, prebiotic and probiotic foods.

Dr. Hall A, the lead scientist in the study of microbial metabolism in the mammalian gut, wrote, "Microbial dysbiosis, however, has been implicated in a number of human disorders, including obesity and inflammation. This dichotomy highlights the need to understand the factors that determine the composition and metabolic output of our resident and transient microbes".

And, " Throughout the human lifespan, we know that diet plays a major role in shaping gut microbial communities, as well as directing the types and amounts of metabolites produced. Understanding the factors that affect microbial metabolic output within the host may help identify the roles of microbes in health, as well as new targets for treatment in disease".

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.

On finding a natural compound for the improvement of colon health, researchers evaluated the effect of navy beans in the modulation of the host-microbiome metabolism.

The 4-week, randomized controlled trial with overweight and obese CRC survivors involved consumption of 1 meal and 1 snack daily, containing 35 g of cooked navy bean or macronutrient matched meals and snacks with 0 g of navy beans for the control group (n = 18).

According to the assessment of the impact on the human stool metabolome, which includes the presence of navy bean metabolites, * 26 significantly different metabolites were found at day 28 in navy bean group compared to the participants' baseline (p ≤ 0.05) and to the control group.

* Additionally, of the 560 total metabolites identified from the cooked navy beans, there were 237 possible navy bean-derived metabolites identified in the stool of participants consuming navy beans.

* Most importantly, the stool relative abundance of ophthalmic increased 5.25-fold for navy bean consumers strongly suggested that navy bean in the glutathione regulation and cancer control were attributed to detoxification of xenobiotics, antioxidant defense, proliferation, and apoptosis.

More precisely, navy-bean protects the colon cells' integrity by exciting detoxed, antioxidant, anti-proliferation, and anti-apoptotic activity.
Based on the findings, researchers said, "These metabolites and metabolic pathways represent an acute response to increased navy bean intake, which merits further investigation for improving colonic health after long-term consumption".

Taken altogether, navy-bean may be considered a remedy for the improvement of colon health, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors by Baxter BA1, Oppel RC2, Ryan EP. (PubMed)
(2) Dysbiosis of the gut microbiota in disease by Simon Carding,1,2 Kristin Verbeke,3 Daniel T. Vipond,1,2 Bernard M. Corfe,4,5,* andLauren J. Owen. (PMC)