Navy Bean Protects Large Intestines Against Colitis

Colitis is medical a condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.

Depending on the causes, colitis can be classified into microscopic colitis, ischemic colitis, segmental colitis associated with diverticula, radiation colitis, diversion colitis, eosinophilic colitis, and Behcet's colitis, particularly in those associated with inflammatory bowel disease (IBD), such as ulcerative colitis (UC).

* Inflammatory bowel disease (IBD) is the inflammation of chronic inflammation of the digestive tract associated with symptoms of severe diarrhea, abdominal pain, fatigue, and weight loss.

* Microscopic colitis is a disease involved in the inflammation of the colon or large intestine, associated with symptoms of watery diarrhea and cramping. Microscopic colitis is much less severe than other types of inflammatory bowel disease.

* Ischemic colitis is an inflammation of the large intestine caused by the injury-induced inadequate blood supply to the colon, leading to pain on the left side of the abdomen.

* Segmental colitis associated with diverticula is an inflammation that affects colonic luminal mucosa in segments due to diverticulosis, causing symptoms of bloody stools, sometimes accompanied by abdominal pain, cramping discomfort, or diarrhea.

* Radiation colitis is an inflammation of the large intestines in patients with radiation therapy, leading to symptoms of diarrhea, nausea, vomiting and stomach cramps.

* Diversion colitis is an inflammation of the large intestines as a complication of ileostomy or colostomy. Most cases of diversion colitis often occur within the year following the surgery.


* Eosinophilic colitis is a rare disease associated with a type of white blood cell, due to injury and inflammation to the large intestine.

* Behcet's colitis is chronic immune-mediated, inflammatory disorders that only affect the intestines but also the joints, skin, eyes, and biliary tracts.

The small, white navy bean, also called pea bean or haricot, popular in both dry and green forms, is very popular in Britain and the US, native to Peru. It is now grown and consumed across the world, due to its numerous health benefits.

On finding a natural compound for the protection of digestive function, researchers examined the black and navy beans' effects within the colon that improve gut health and mitigate the severity of colitis-associated inflammatory pathology.

The study included C57Bl/6 mice pre-fed isocaloric 20% cooked navy bean (NB) or black bean (BB) diets for 3 weeks then switched to control basal diet (BD) 24 h prior to colitis induction via 5-day exposure to dextran sodium sulfate (2% w/v in drinking water)+3 days of freshwater.

According to the observation of the inflammatory transcription factors, such as NFκB, STAT3, black and navy beans pre-fed showed a significant effect on the reduced severity of the acute colitis phenotype.

The levels of inflammatory mediators levels in the colon such as IL-1β, IL-6, IL-18, and MCP-1 were also lowered in the black and navy bean pre-fed groups compared to control.

Furthermore, the levels of biomarkers that enhanced wound repair responses were increased by bean prefeeding groups.

Moreover, black and navy beans pre-fed group not only also normalized the colonic epithelial function but also promoted epithelial barrier integrity, defense and/or restitution and wound closure compared to the control.

Based on the findings, Dr. Monk JM, the lead scientist wrote, "Collectively, bean supplementation prior to colitis induction (i.e., mimicking disease relapse) primes the colonic microenvironment to attenuate the severity of the colitis inflammatory phenotype and maintain aspects of epithelial barrier function".

Taken altogether, the navy bean may be considered a remedy for the prevention and treatment of colitis, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Navy and black bean supplementation attenuates colitis-associated inflammation and colonic epithelial damage by Monk JM1, Wu W2, Hutchinson AL3, Pauls P4, Robinson LE3, Power KA. (PMC)
(2) Cooked navy and black bean diets improve biomarkers of colon health and reduce inflammation during colitis by Zhang C1, Monk JM1, Lu JT1, Zarepoor L1, Wu W1, Liu R1, Pauls KP2, Wood GA3, Robinson L4, Tsao R1, Power KA. (PubMed)