Black Bean, A Potent Anti Liver Cancer Legume

Intake of black bean regularly may have a profound effect in reduced risk and treatment of liver cancer, a renowned institute study proposed.

Liver cancer is a condition of the abnormal growth of the cells in the liver's tissue. According to statistics approximated 40,710 adults (29,200 men and 11,510 women) in the United States will be diagnosed with primary liver cancer this year.



Black bean, small roughly ovoid legumes with glossy black shells, genus Phaseolus, belongings to the family Fabaceae can buy in most grocery stores all around the year in dried and canned forms. It is believed that black bean was first domesticated growth in South America.

According to the Stocking Hall, Cornell University, phytochemicals isolated from black beans such as triterpenoids, flavonoids, and other compounds exhibited antiproliferative activities against the HepG2 cells, the human liver cancer cell line.


The efficacy of black bean in ameliorated growth of liver cancer may be attributed to the presence of some potent antioxidants in the expression of apoptosis.


Furthermore, consumption of bean not only played a prominent role in gene expression involved the regulation of gene Hspa8 in reduced risk of liver disease developed, but also addressed the important issue of attenuated hepatic stress or toxicity in a rat model.


In fact, increased bean consumption in rats exhibits changes indicative of hepatic damage, Dr. Daniell EL, the lead author said, "Dry bean (Phaseolus vulgaris L.) consumption is associated with reduced risk for a number of chronic diseases", such as liver cancer.
More interestingly, dietary bean concentrations.is found to associate with the cholesterol 7α hydoxylase and UDP-glucuronosyltransferase genes increased with connection to the development of liver cancer, in a dose-dependent manner.

These findings suggested that dietary black(dried) bean may have a potential effect in reduced risk and treatment of liver cancer through antioxidant activity and regulated genes involved the early onset of the disease.


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Sources
(1) Phytochemicals of black bean seed coats: isolation, structure elucidation, and their antiproliferative and antioxidative activities by Dong M1, He X, Liu RH.(PubMed)
(2) Dietary dry bean effects on hepatic expression of stress and toxicity-related genes in rats by Daniell EL1, Ryan EP, Brick MA, Thompson HJ.(PubMed)