Broccoli Protects the Pancreatic Tissue Damage Induced by Oxidative Stress

Oxidative stress is a condition characterized by a chain reaction of the overexpression of free radicals that cannot be stopped.

In other words, overexpression of free radicals and depletion of antioxidants are the major cause of oxidative stress.

More precisely, oxidative stress is a result of a long-term imbalance of the ratio of free radicals and antioxidants produced by the host.

Free radicals are highly reactive atoms with a single unpaired electron in an outermost shell with a function to donate or intercepts an electron from other stable atoms, leading to a chain reaction that induces oxidative damage to the enzymes, other proteins, unsaturated fatty acid, phospholipids, DNA and RNA,..,

Antioxidants are stable atoms that inhibit oxidation.

Oxidative stress may be preventable if antioxidants in the body can pair all electrons in the outermost ring.

Overexpression of free radicals is harmful to the human body. However, free radicals in a moderate amount generated from cell metabolism may play a critical role in the synthesis of energy and essential molecules and boosting the immune system.

In a healthy individual, antioxidants produced by the body are good enough to prevent the onset of oxidative stress. However, people with a weakened immune system, intake of dietary antioxidants such as supplements of antioxidant-rich food may be necessary.

Dr. Biller-Takahashi JD, the lead scientist at the joint study led by the UNESP Univ Estadual Paulista wrote, "short-term supplementation with 0.6 mg Se-yeast kg(-1) reestablished the antioxidative status, allowing the production of innate components which can boost immunity without the risk of oxidative stress".

Broccoli is a species of Brassica Oleracea, belongings to the family Brassicaceae with unknown origin. Today, the plant is cultivated commercially for its thick, slightly bitter edible leaves.


On finding a potent and natural compound to prevention pancreatic tissue damage in diabetes, scientists investigated the potential hypoglycaemic and antioxidant properties of aqueous broccoli extracts (BEs) in diabetic rats.

Rats selected to the study induced diabetes by a single intraperitoneal injection dose of 50 mg/kg body weight of Streptozotocin (STZ) drug were co-administration with or without BEs.


After 8 weeks, based on the blood analysis, diabetic rats without co-administration with BEs showed significantly higher levels of pancreatic cells DNA damage, depletion of levels of antioxidant GSH and impaired antioxidant capacity (TAC) levels, compared to non-diabetics.


Furthermore, diabetes rats without co-administration with BEs also demonstrated significant pancreatic tissue damage.

Diabetes rats with BEs co-administration not only reduced all parameters expression but also protected the pancreatic tissue against histopathological changes.

In other words, BEs reduced the damage of pancreas tissue caused by STZ induced hyperglycemia and oxidative injury by enhancing the production of antioxidant enzymes in the tested rats.

Based on the findings, researchers said, "The used in vivo model confirmed the efficacy of BE as an anti-diabetic herbal medicine and provided insights into the capacity of BE to be used for phytoremediation purposes for human type 2 diabetes".

Taken altogether, broccoli may be considered a functional food for the prevention of oxidative stress-induced pancreatic tissue damage, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Broccoli (Brassica oleracea) Reduces Oxidative Damage to Pancreatic Tissue and Combats Hyperglycaemia in Diabetic Rats by Suresh S1, Waly MI1, Rahman MS1, Guizani N1, Al-Kindi MAB2, Al-Issaei HKA2, Al-Maskari SNM3, Al-Ruqaishi BRS3, Al-Salami A. (PubMed)
(2) The immune system is limited by oxidative stress: Dietary selenium promotes optimal antioxidative status and greatest immune defense in pacu Piaractus mesopotamicus by Biller-Takahashi JD1, Takahashi LS2, Mingatto FE3, Urbinati EC. (PubMed)