Glioblastoma or glioblastoma (also called GBM) caused mostly by the abnormal astrocytic cells and dead cells (necrosis) is considered one of the most aggressive cancers induced by the alternation of cells originated from the brain, including the cerebral hemispheres.
In other words, primary glioblastoma may arise as a Grade IV tumor with no evidence.
Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.
Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.
Most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change of body function may be one of the major risk factors that cause the incidence.
In the US, the median age of glioblastoma diagnosed is 64 years and the incidence of the disease onset is 1.6 times higher in males compared to females.
Furthermore, the condition is 2 times higher in Caucasians compared to Africans and Afro-Americans.
GBM is deadly, patients with GBM have a median survival of less than one year and less than 2% of patients survive three years or more.
According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients are survived longer than five years.
If you are male you are at 1.5 higher risks of glioblastoma, compared to the female's counterpart.
The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, a weakened immune system may be some risk factors associated with the onset of the disease.
On finding a potential plant that process neuro-protective researchers compared the effects of
Sulforaphane (SFN), an isothiocyanate (ITC) derived from cruciferous vegetables on glioblastoma.
According to the differentiation,
* SFN can rapidly cross the BBB and accumulate in the CNS after i.p. administration [76,77] to exert its anti-cancer activity.
* Furthermore, the application of SFN induces apoptosis and inhibits both growth and invasion of GBM cells.
* SFN can overcome the chemoresistance of tumor cells.
More precisely, the effects of SFN inhibited the profession by focusing on pro-apoptotic, anti-invasion, anti-proliferative, and anti-chemo/radioresistance activities.
Taken altogether, cruciferous vegetables consisting of SFN may be considered a functional food for the prevention and treatment of atherothrombotic diseases, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment by Sita G1, Hrelia P2, Graziosi A3, Morroni F. (PubMed)
Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.
Tuesday, April 14, 2020
Monday, April 13, 2020
Whole Food Tomato Inhibits Gene and Factors Associated with Obesity Complications in Vivo
Obesity is a medical condition characterized by fat accumulated in the body over time.
In other words, obesity is a progressive disease similar to those of diabetes and high blood pressure and lipid, leading to the impairment of health in many aspects, including heart disease, diabetes, and high blood pressure.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.
According to the statistic, 68% of the American population is either overweight or obese.
The causes of obesity are the results overconsumption of food that produces energy, compared to energy expenditure (physical inactivity) over the period of time.
Most common physical symptoms of obesity are breathlessness. increased sweating, snoring, tiredness, back, and joint pains accompanied by psychological symptoms of low confidence and self-esteem.
Some researchers in the evaluation of the risk factors that cause widespread obesity in the US population suggested that the incidence may correlate to the promotion of the Western diet over the past few decades.
Dr. Farah Naja, the lead scientist wrote, "The Western pattern was characterized by high consumption of red meat, eggs, and fast-food sandwiches".
And, "After adjustment, subjects belonging to the 3rd tertile of the Western pattern scores had significantly higher odds of overweight compared with those belonging to the 1st tertile (OR 2·3; 95 % CI 1·12, 4·73)".
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of obesity, scientists evaluated and compared the effect of lycopene and tomato powder on obesity-associated disorders.
Selected male C57BL/J6 mice included in the study were assigned into four groups to receive: control diet (CD), high-fat diet (HFD), high-fat diet supplemented with lycopene or with tomato powder (TP) for 12 weeks.
According to the tested assays, both lycopene and TP supplementation significantly reduced adiposity index, organ, and relative organ weights, serum triglycerides, free fatty acids, 8-iso-prostaglandin GF2α induced by inflammation and improved glucose homeostasis, but did not affect total body weight.
Furthermore, both lycopene and TP supplementation prevented HFD-induced hepatosteatosis and hypertrophy of adipocytes associated with induced obesity.
Moreover, both lycopene and TP decreased HFD-induced proinflammatory cytokine mRNA expression in the liver and in the epididymal adipose tissue.
In other words, lycopene and TP inhibited the expression of hepatosteatosis involved in liver disease and hypertrophy of adipocytes in obese.
Lycopene and TP protected the adipocytes dysfunction in the onset of obese complications by inhibiting the overexpression of pro-inflammatory cytokines in the tissues.
Based on the results, researchers said, " lycopene or TP supplementation display similar beneficial health effects that could be particularly relevant in the context of nutritional approaches to fight obesity-associated pathologies".
In order to reveal more information about tomato effects on obese complications, researchers examined the Mediterranean tomato-based sofrito sauce against obese fibroblast growth factor 21 (FGF21)-resistant state.
In obese Zucker rats (OZR) fed with a sofrito-supplemented diet or control diet, researchers found that the sofrito-supplemented diet improved insulin and FGF21 sensitivity in OZR, by exhibiting the effect on glucose metabolism.
The sofrito-fed rats also showed a strong effect on the protection of the UCP1 gene associated with reduced obesity and improved insulin sensitivity.
Taken altogether, tomatoes processed abundantly bioactive compound lycopene may be considered functional food for the prevention of obese complications, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders by Fenni S1,2, Hammou H2, Astier J1, Bonnet L1, Karkeni E1, Couturier C1, Tourniaire F1, Landrier JF. (PubMed)
(2) Mediterranean Tomato-Based Sofrito Sauce Improves Fibroblast Growth Factor 21 (FGF21) Signaling in White Adipose Tissue of Obese ZUCKER Rats by Sandoval V1,2, Rodríguez-Rodríguez R3, Martínez-Garza Ú1,2, Rosell-Cardona C1, Lamuela-Raventós RM1,2,4, Marrero PF1,5, Haro D1,5, Relat J. (PubMed)
(3) A Western dietary pattern is associated with overweight and obesity in a national sample of Lebanese adolescents (13–19 years): a cross-sectional study by Farah Naja,1 Nahla Hwalla,1 Leila Itani,2 Sabine Karam,1 Abla Mehio Sibai,3 andLara Nasreddine. (PMC)
In other words, obesity is a progressive disease similar to those of diabetes and high blood pressure and lipid, leading to the impairment of health in many aspects, including heart disease, diabetes, and high blood pressure.
According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered overweight, while a BMI of over 30 is an indication of obesity.
According to the statistic, 68% of the American population is either overweight or obese.
The causes of obesity are the results overconsumption of food that produces energy, compared to energy expenditure (physical inactivity) over the period of time.
Most common physical symptoms of obesity are breathlessness. increased sweating, snoring, tiredness, back, and joint pains accompanied by psychological symptoms of low confidence and self-esteem.
Some researchers in the evaluation of the risk factors that cause widespread obesity in the US population suggested that the incidence may correlate to the promotion of the Western diet over the past few decades.
Dr. Farah Naja, the lead scientist wrote, "The Western pattern was characterized by high consumption of red meat, eggs, and fast-food sandwiches".
And, "After adjustment, subjects belonging to the 3rd tertile of the Western pattern scores had significantly higher odds of overweight compared with those belonging to the 1st tertile (OR 2·3; 95 % CI 1·12, 4·73)".
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to find a potential compound for the treatment of obesity, scientists evaluated and compared the effect of lycopene and tomato powder on obesity-associated disorders.
Selected male C57BL/J6 mice included in the study were assigned into four groups to receive: control diet (CD), high-fat diet (HFD), high-fat diet supplemented with lycopene or with tomato powder (TP) for 12 weeks.
According to the tested assays, both lycopene and TP supplementation significantly reduced adiposity index, organ, and relative organ weights, serum triglycerides, free fatty acids, 8-iso-prostaglandin GF2α induced by inflammation and improved glucose homeostasis, but did not affect total body weight.
Furthermore, both lycopene and TP supplementation prevented HFD-induced hepatosteatosis and hypertrophy of adipocytes associated with induced obesity.
Moreover, both lycopene and TP decreased HFD-induced proinflammatory cytokine mRNA expression in the liver and in the epididymal adipose tissue.
In other words, lycopene and TP inhibited the expression of hepatosteatosis involved in liver disease and hypertrophy of adipocytes in obese.
Lycopene and TP protected the adipocytes dysfunction in the onset of obese complications by inhibiting the overexpression of pro-inflammatory cytokines in the tissues.
Based on the results, researchers said, " lycopene or TP supplementation display similar beneficial health effects that could be particularly relevant in the context of nutritional approaches to fight obesity-associated pathologies".
In order to reveal more information about tomato effects on obese complications, researchers examined the Mediterranean tomato-based sofrito sauce against obese fibroblast growth factor 21 (FGF21)-resistant state.
In obese Zucker rats (OZR) fed with a sofrito-supplemented diet or control diet, researchers found that the sofrito-supplemented diet improved insulin and FGF21 sensitivity in OZR, by exhibiting the effect on glucose metabolism.
The sofrito-fed rats also showed a strong effect on the protection of the UCP1 gene associated with reduced obesity and improved insulin sensitivity.
Taken altogether, tomatoes processed abundantly bioactive compound lycopene may be considered functional food for the prevention of obese complications, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene and tomato powder supplementation similarly inhibit high-fat diet induced obesity, inflammatory response, and associated metabolic disorders by Fenni S1,2, Hammou H2, Astier J1, Bonnet L1, Karkeni E1, Couturier C1, Tourniaire F1, Landrier JF. (PubMed)
(2) Mediterranean Tomato-Based Sofrito Sauce Improves Fibroblast Growth Factor 21 (FGF21) Signaling in White Adipose Tissue of Obese ZUCKER Rats by Sandoval V1,2, Rodríguez-Rodríguez R3, Martínez-Garza Ú1,2, Rosell-Cardona C1, Lamuela-Raventós RM1,2,4, Marrero PF1,5, Haro D1,5, Relat J. (PubMed)
(3) A Western dietary pattern is associated with overweight and obesity in a national sample of Lebanese adolescents (13–19 years): a cross-sectional study by Farah Naja,1 Nahla Hwalla,1 Leila Itani,2 Sabine Karam,1 Abla Mehio Sibai,3 andLara Nasreddine. (PMC)
Sunday, April 12, 2020
Ginger and Shell Ginger in the Promotion of Healthy Longevity, According to Studies
Scientists may have a pungent spice that processes the potential for the promotion of healthy longevity, according to the study.
Compared to life expectancy which the average number of years remaining of a given age or living of a certain group's people, longevity is a long life out of the boundary of life expectancy.
Truly, we all dream to live healthy longevity. However how many of us can maintain health and prevent the onset of chronic disease?
Some researchers suggested that by following a healthy lifestyle and moderate exercise healthy longevity can be achieved.
Dr. Mehta N in the study of the healthy lifestyle impact of life expectancy wrote, "Compared to the whole US population, those with such a favorable behavioral profile had a life expectancy at age fifty that was seven years longer, and they experienced a delay in the onset of disability of up to six years".
The results clearly suggested the massively damaging effects caused by unhealthy behavioral risks on health at older ages.
Furthermore, Dr. Vincent Gremeaux and colleagues on the differentiation of exercise and longevity said, "As the number of older individuals continues to increase, it is important to develop interventions that can be easily implemented and contribute to “successful aging".
And, " In addition to a healthy diet and psychosocial well-being, the benefits of regular exercise on mortality, and the prevention and control of chronic disease affecting both life expectancy and quality of life are well established".
Regularly moderate exercise has been found to have partially reverse effects on the aging process on physiological functions and preserve functional capability in the elderly.
Epidemiological studies strongly suggested that healthy longevity can be achieved by maintaining a minimum quantity and quality of exercise, preventing the development of certain cancers, lowering the risk of osteoporosis.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a bioactive compound for the healthy longevity examined the shell ginger (Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm) of the ginger family (Zingiberaceae) activity in the population in the Okinawa Islands of Japan.
According to the review of the literature, culinary shell ginger may contribute to longevity among the population in Okinawa probably due to the procession of phytochemical content with antioxidants and its effects on anti-obesity properties.
Some researchers suggested that the longevity of the population may also be attributed to the shell ginger in the promotion of health in the reduced diseases by exhibiting anti-inflammatory, fungistatic, and antibacterial activities against Escherichia coli, Bacillus subtilis, and Bacillus cereus activity.
Shell ginger also is proven to have a positive effect neuraminidase enzyme and inhibition of human immunodeficiency virus (HIV-1).
Dr. Rolf Teschke in the examination of the mortality rate of Japan general public compared to the population on the island wrote, "cardiovascular disease as the top cause of death for both sexes, and neoplasms as the second leading cause of death in Japan nationally, with major variations among the prefectures"
And, " Comparing Japan overall with Okinawa, the mean mortality rates from ischaemic heart disease, Alzheimer’s disease, breast cancer, and oesophageal cancer were not remarkably different. However, for Okinawa, four death categories were significantly lower, including ischaemic stroke, stomach cancer, pancreatic cancer, and liver cancer due to hepatitis C.
The finding clearly suggested that intake of shell ginger which was not found in other areas in Japan may contribute to the healthy longevity of the population in the Okinawa Islands of Japan.
In the joint study led by the Woosuk University, the Korean scientists evaluated the compound 6-gingerol longevity-promoting activity.isolated from the most active ethyl acetate soluble fraction on Caenorhabditis Elegans (C. elegans).
Injection od 6 gingerol elevated the survival rate of worms against stressful environments including thermal, osmotic, and oxidative conditions.
The bioactive compound elevated the antioxidant enzyme activities of C. elegans and showed a dose-depend reduction of intracellular reactive oxygen species (ROS) accumulation in worms.
Furthermore, 6 gingerols also demonstrated increased stress tolerance, leading to the promotion of stress resistance proteins.
The findings strongly suggest that 6-gingerol exerted longevity-promoting activities independently of these factors and could extend the human lifespan.
Taken altogether, ginger and shell ginger may be considered functional foods for the promotion of healthy longevity with no side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Longevity and Stress Resistant Property of 6-Gingerol from Zingiber officinale Roscoe in Caenorhabditis elegans by Eun Byeol Lee,1 Jun Hyeong Kim,1 Chang Wan An,1 Yeong Jee Kim,1 Yun Jeong Noh,1Su Jin Kim,1 Ju-Eun Kim,1 Abinash Chandra Shrestha,1 Ha-Neul Ham,1 Jae-Yoon Leem,1Hyung-Kwon Jo,2 Dae-Sung Kim,2 Kwang Hyun Moon,3 Jeong Ho Lee,3 Kyung Ok Jeong,3 andDae Keun Kim. (PubMed)
(2) Viewpoint: A Contributory Role of Shell Ginger (Alpinia zerumbet) for Human Longevity in Okinawa, Japan? by Rolf Teschke1,* and Tran Dang Xuan. (PMC)
(3) The Population Health Benefits Of A Healthy Lifestyle: Life Expectancy Increased And Onset Of Disability Delayed by Mehta N1, Myrskylä M. (PubMed)
(4) Exercise and longevity by Vincent Gremeaux, Duxabcdef, MathieuGay, RomualdLeperse, Philippe Sosneraghi, MartinJuneau, AnilNigam. (Science Direct)
Compared to life expectancy which the average number of years remaining of a given age or living of a certain group's people, longevity is a long life out of the boundary of life expectancy.
Truly, we all dream to live healthy longevity. However how many of us can maintain health and prevent the onset of chronic disease?
Some researchers suggested that by following a healthy lifestyle and moderate exercise healthy longevity can be achieved.
Dr. Mehta N in the study of the healthy lifestyle impact of life expectancy wrote, "Compared to the whole US population, those with such a favorable behavioral profile had a life expectancy at age fifty that was seven years longer, and they experienced a delay in the onset of disability of up to six years".
The results clearly suggested the massively damaging effects caused by unhealthy behavioral risks on health at older ages.
Furthermore, Dr. Vincent Gremeaux and colleagues on the differentiation of exercise and longevity said, "As the number of older individuals continues to increase, it is important to develop interventions that can be easily implemented and contribute to “successful aging".
And, " In addition to a healthy diet and psychosocial well-being, the benefits of regular exercise on mortality, and the prevention and control of chronic disease affecting both life expectancy and quality of life are well established".
Regularly moderate exercise has been found to have partially reverse effects on the aging process on physiological functions and preserve functional capability in the elderly.
Epidemiological studies strongly suggested that healthy longevity can be achieved by maintaining a minimum quantity and quality of exercise, preventing the development of certain cancers, lowering the risk of osteoporosis.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a bioactive compound for the healthy longevity examined the shell ginger (Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm) of the ginger family (Zingiberaceae) activity in the population in the Okinawa Islands of Japan.
According to the review of the literature, culinary shell ginger may contribute to longevity among the population in Okinawa probably due to the procession of phytochemical content with antioxidants and its effects on anti-obesity properties.
Some researchers suggested that the longevity of the population may also be attributed to the shell ginger in the promotion of health in the reduced diseases by exhibiting anti-inflammatory, fungistatic, and antibacterial activities against Escherichia coli, Bacillus subtilis, and Bacillus cereus activity.
Shell ginger also is proven to have a positive effect neuraminidase enzyme and inhibition of human immunodeficiency virus (HIV-1).
Dr. Rolf Teschke in the examination of the mortality rate of Japan general public compared to the population on the island wrote, "cardiovascular disease as the top cause of death for both sexes, and neoplasms as the second leading cause of death in Japan nationally, with major variations among the prefectures"
And, " Comparing Japan overall with Okinawa, the mean mortality rates from ischaemic heart disease, Alzheimer’s disease, breast cancer, and oesophageal cancer were not remarkably different. However, for Okinawa, four death categories were significantly lower, including ischaemic stroke, stomach cancer, pancreatic cancer, and liver cancer due to hepatitis C.
The finding clearly suggested that intake of shell ginger which was not found in other areas in Japan may contribute to the healthy longevity of the population in the Okinawa Islands of Japan.
In the joint study led by the Woosuk University, the Korean scientists evaluated the compound 6-gingerol longevity-promoting activity.isolated from the most active ethyl acetate soluble fraction on Caenorhabditis Elegans (C. elegans).
Injection od 6 gingerol elevated the survival rate of worms against stressful environments including thermal, osmotic, and oxidative conditions.
The bioactive compound elevated the antioxidant enzyme activities of C. elegans and showed a dose-depend reduction of intracellular reactive oxygen species (ROS) accumulation in worms.
Furthermore, 6 gingerols also demonstrated increased stress tolerance, leading to the promotion of stress resistance proteins.
The findings strongly suggest that 6-gingerol exerted longevity-promoting activities independently of these factors and could extend the human lifespan.
Taken altogether, ginger and shell ginger may be considered functional foods for the promotion of healthy longevity with no side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Longevity and Stress Resistant Property of 6-Gingerol from Zingiber officinale Roscoe in Caenorhabditis elegans by Eun Byeol Lee,1 Jun Hyeong Kim,1 Chang Wan An,1 Yeong Jee Kim,1 Yun Jeong Noh,1Su Jin Kim,1 Ju-Eun Kim,1 Abinash Chandra Shrestha,1 Ha-Neul Ham,1 Jae-Yoon Leem,1Hyung-Kwon Jo,2 Dae-Sung Kim,2 Kwang Hyun Moon,3 Jeong Ho Lee,3 Kyung Ok Jeong,3 andDae Keun Kim. (PubMed)
(2) Viewpoint: A Contributory Role of Shell Ginger (Alpinia zerumbet) for Human Longevity in Okinawa, Japan? by Rolf Teschke1,* and Tran Dang Xuan. (PMC)
(3) The Population Health Benefits Of A Healthy Lifestyle: Life Expectancy Increased And Onset Of Disability Delayed by Mehta N1, Myrskylä M. (PubMed)
(4) Exercise and longevity by Vincent Gremeaux, Duxabcdef, MathieuGay, RomualdLeperse, Philippe Sosneraghi, MartinJuneau, AnilNigam. (Science Direct)
Saturday, April 11, 2020
Tomatoes Protect the Liver Against Non-alcoholic Steatohepatitis in Vivo
Nonalcoholic steatohepatitis (NASH) is a type of inflammatory non-alcoholic fatty liver disease caused by excessive fat accumulated in the liver.
Nonalcoholic steatohepatitis (NASH) is asymptomatic until the condition is developed into cirrhosis, the condition that causes advanced liver scars and reduced the performance of the liver.
In other words, if more than 5% – 10% percent of your liver’s weight is fat, you have a fatty liver (steatosis).
According to the statistics, non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of liver disease affecting 100 million people in the US. Out of that number, approximately 20% of people have NASH.
Medical conditions such as obesity, metabolic syndrome, and type 2 diabetes are some of the metabolic risk factors that have been found to induce the development of NASH.
As of today, there is no effective treatment of NASH. Depending on the condition people with overweight or obese are recommended to lose weight. The aim of medical treatment is to reduce the symptoms and delay the progression of the condition and improve the quality of life.
Out of many prevalent factors that cause the onset of NASH, some researchers suggested that the promotion of a high-fat diet over the past few decades induced a high percentage of the overweight and obese population may be the major culprit associated with the rise of NASH.
Dr. Jensen VS, the lead scientist wrote, "Hepatic dysfunction and inflammation was confirmed in HFD-fed rats by elevated levels of hepatic MCP-1 (p < 0.0001), TNF-alpha (p < 0.001) and plasma β-hydroxybutyrate (p < 0.0001), and in NASH-fed rats by elevated levels of hepatic MCP-1 (p < 0.01), increased hepatic macrophage infiltration (p < 0.001), and higher plasma levels of alanine aminotransferase (p < 0.0001) aspartate aminotransferase (p < 0.05), haptoglobin (p < 0.001) and TIMP-1 (p < 0.01) compared to Control".
And, " dietary fat and cholesterol are the primary drivers of NAFLD development and progression in rats, while fructose mostly exerts its effect on the circulating lipid pool".
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to discover a potential and natural compound for the treatment of liver cancer, researchers in the cancer team at the First Affiliated Hospital of Harbin Medical University examined the hepatoprotective effect of lycopene (Ly) on the non-alcoholic fatty liver disease (NAFLD) in an animal model.
65 rats selected to the study were randomly divided into the normal group, model group, and lycopene (Ly) treatment groups, with model rats induced NAFLD by feeding a high-fat diet for 14 wks.
Pretreatment of lycopene at the dose of 20 mg/kg showed a significant decrease in the levels of serum AST (2.07-fold), ALT (2.95-fold), and the blood lipid TG (2.34-fold) and TC (1.66-fold) compared to the model group.
Furthermore, pretreatment with 5, 10 and 20 mg/kg of Ly significantly raised the levels of antioxidant enzyme SOD in a dose-dependent manner compared to the model group.
Additional differentiation of the lycopene liver protective property, researchers found that Ly not only significantly decreased levels of lipid products LDL-C and improved HDL-C level but also significantly decreased the content of liver free fatty acid (FFA), also compared to the model group.
Moreover, in the doses of pretreatment with 5, 10 and 20 mg/kg of Ly also significantly reduced MDA amount, a marker of liver oxidative stress by 30.87, 45.51 and 54.49% in the liver homogenates, respectively
Levels of CYP2E1 expression associated with the metabolism of xenobiotics in the liver, proinflammatory cytokines, infiltration of liver fats and reversed histopathological changes in the model group also were reduced by the injection of Ly.
Based on the results, researchers said, "Ly has a protective effect on NAFLD, down-regulates expression of TNF-α, and that CYP2E1 may be one of the action mechanisms for Ly".
Taken altogether, tomatoes processed abundantly bioactive compound Ly may be considered supplements for the prevention and treatment of non-alcoholic steatohepatitis through its liver protective, anti-inflammatory, and antioxidant properties, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
non-alcoholic steatohepatitis
(1) Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liverdisease in rat by Jiang W1, Guo MH1, Hai X. (PubMed)
(2) Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation by Aizawa K1,2, Liu C1, Tang S1, Veeramachaneni S1, Hu KQ1, Smith DE3, Wang XD. (PubMed)
(3) Dietary fat stimulates development of NAFLD more potently than dietary fructose in Sprague-Dawley rats by Jensen VS1,2, Hvid H2, Damgaard J2, Nygaard H2, Ingvorsen C3, Wulff EM4, Lykkesfeldt J1, Fledelius C. (PubMed)
Nonalcoholic steatohepatitis (NASH) is asymptomatic until the condition is developed into cirrhosis, the condition that causes advanced liver scars and reduced the performance of the liver.
In other words, if more than 5% – 10% percent of your liver’s weight is fat, you have a fatty liver (steatosis).
According to the statistics, non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of liver disease affecting 100 million people in the US. Out of that number, approximately 20% of people have NASH.
Medical conditions such as obesity, metabolic syndrome, and type 2 diabetes are some of the metabolic risk factors that have been found to induce the development of NASH.
As of today, there is no effective treatment of NASH. Depending on the condition people with overweight or obese are recommended to lose weight. The aim of medical treatment is to reduce the symptoms and delay the progression of the condition and improve the quality of life.
Out of many prevalent factors that cause the onset of NASH, some researchers suggested that the promotion of a high-fat diet over the past few decades induced a high percentage of the overweight and obese population may be the major culprit associated with the rise of NASH.
Dr. Jensen VS, the lead scientist wrote, "Hepatic dysfunction and inflammation was confirmed in HFD-fed rats by elevated levels of hepatic MCP-1 (p < 0.0001), TNF-alpha (p < 0.001) and plasma β-hydroxybutyrate (p < 0.0001), and in NASH-fed rats by elevated levels of hepatic MCP-1 (p < 0.01), increased hepatic macrophage infiltration (p < 0.001), and higher plasma levels of alanine aminotransferase (p < 0.0001) aspartate aminotransferase (p < 0.05), haptoglobin (p < 0.001) and TIMP-1 (p < 0.01) compared to Control".
And, " dietary fat and cholesterol are the primary drivers of NAFLD development and progression in rats, while fructose mostly exerts its effect on the circulating lipid pool".
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
With an aim to discover a potential and natural compound for the treatment of liver cancer, researchers in the cancer team at the First Affiliated Hospital of Harbin Medical University examined the hepatoprotective effect of lycopene (Ly) on the non-alcoholic fatty liver disease (NAFLD) in an animal model.
65 rats selected to the study were randomly divided into the normal group, model group, and lycopene (Ly) treatment groups, with model rats induced NAFLD by feeding a high-fat diet for 14 wks.
Pretreatment of lycopene at the dose of 20 mg/kg showed a significant decrease in the levels of serum AST (2.07-fold), ALT (2.95-fold), and the blood lipid TG (2.34-fold) and TC (1.66-fold) compared to the model group.
Furthermore, pretreatment with 5, 10 and 20 mg/kg of Ly significantly raised the levels of antioxidant enzyme SOD in a dose-dependent manner compared to the model group.
Additional differentiation of the lycopene liver protective property, researchers found that Ly not only significantly decreased levels of lipid products LDL-C and improved HDL-C level but also significantly decreased the content of liver free fatty acid (FFA), also compared to the model group.
Moreover, in the doses of pretreatment with 5, 10 and 20 mg/kg of Ly also significantly reduced MDA amount, a marker of liver oxidative stress by 30.87, 45.51 and 54.49% in the liver homogenates, respectively
Levels of CYP2E1 expression associated with the metabolism of xenobiotics in the liver, proinflammatory cytokines, infiltration of liver fats and reversed histopathological changes in the model group also were reduced by the injection of Ly.
Based on the results, researchers said, "Ly has a protective effect on NAFLD, down-regulates expression of TNF-α, and that CYP2E1 may be one of the action mechanisms for Ly".
Taken altogether, tomatoes processed abundantly bioactive compound Ly may be considered supplements for the prevention and treatment of non-alcoholic steatohepatitis through its liver protective, anti-inflammatory, and antioxidant properties, pending to the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
non-alcoholic steatohepatitis
(1) Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liverdisease in rat by Jiang W1, Guo MH1, Hai X. (PubMed)
(2) Tobacco carcinogen induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation by Aizawa K1,2, Liu C1, Tang S1, Veeramachaneni S1, Hu KQ1, Smith DE3, Wang XD. (PubMed)
(3) Dietary fat stimulates development of NAFLD more potently than dietary fructose in Sprague-Dawley rats by Jensen VS1,2, Hvid H2, Damgaard J2, Nygaard H2, Ingvorsen C3, Wulff EM4, Lykkesfeldt J1, Fledelius C. (PubMed)
Friday, April 10, 2020
Ginger, The Potential Anti Ulcerative Colitis Functional Spice
Ginger may be considered a natural whole food for the treatment of acute ulcerative colitis (UC) with no side effects, some scientists suggested.
Ulcerative colitis (UC) can be an acute or chronic inflammation of the membrane-lined the colon or the large intestine. People with UC are at higher risk for developing colorectal cancer, compared to the general population.
Acute inflammation is a process of inflammation in response to tissue injury, that occurs over a short period of time and can be resolved within a time frame.
Most people with acute inflammation experience the symptoms of pain, redness, swelling, and heat.
According to the American Family Physician, between 250,000 and 500,000 people in the United States were affected by ulcerative colitis.
The exact causes of ulcerative colitis. are debatable. Researchers do not know why people with the same health conditions in the family, some members are susceptible to the onset of the condition, while others do not
However, according to the epidemiological studies genetic mutation, environment, and weakened immune system may be the prevalent risk factors associated with ulcerative colitis.
Dr. Yuan Huang, the lead scientist, in the concern of the weakened immune system in the risk of inflammatory bowel disease, including ulcerative colitis (UC) and Crohn’s disease (CD) said, " after environmental factors act on individuals with genetic susceptibility, and abnormal intestinal immune response is launched under stimulation of intestinal flora".
The team explained, "Inflammatory bowel disease-related immune disorders. The innate immune abnormalities of inflammatory bowel disease leading to adaptive immune disorders,... The inflammatory cytokines, in turn, increase the innate immune damages,.... abate the intestinal barrier function, and aggravate inflammation. Therefore a vicious circle forms.
The immune disorder caused by the inability to kill off all the invader pathogens in the acute phase of inflammation at the colon can lead to immune compromise of the host in facilitating chronic low-grade inflammation disease, such as chronic ulcerative colitis (UC).
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to reaffirm the traditional use of ginger for the treatment of ulcerative colitis, one of the most common types of inflammatory bowel disease, researchers evaluated the 6-Gingerol, a component of gingerols extracted from ginger (Zingiber officinale) anti ulcerative colitis effect.
In the selected rat model, colitis was induced in rats through consumption of 5% (cw/v) dextran sulfate sodium drinking water for 7 consecutive days before 6-Gingerol, 8-gingerol, and 10-gingerol were given intraperitoneally at doses of 30 mg kg-1 d-1 for another 7 days,
At the end of the experiment, researchers found that all three gingerols attenuated colitic symptoms evoked by dextran sulfate sodium
Application of 6-Gingerol, 8-gingerol, and 10-gingerol significantly elevated superoxide dismutase activity, decreased malondialdehyde levels and myeloperoxidase activity in the colon tissue.
The applications also strongly decrease the expression of proinflammatory cytokines expression.
All three gingerols obviously accelerated mucosal damage healing.
Dr. Zhang F, the lead author said, "6-gingerol, 8-gingerol, and 10-gingerol, the three analogs, have a strong and relatively equal efficacy in the treatment of colitis".
Further investigation of the gingerols, the phenolic compounds in ginger (Zingiber officinale) anti-inflammatory and antioxidant effects, researchers examined the gingers activity against a mouse model of dextran sulfate sodium (DSS)-induced ulcerative colitis.
Adult male selected mice were either exposed to DSS in drinking water alone or co-treated with 6-gingerol orally at 50, 100, and 200 mg/kg for 7 days.
Mice co-treated with 6 gingerols significantly reversed the DSS-mediated reduction in body weight, diarrhea, rectal bleeding, and restored the colon shrinkage back to near normal.
Application of 6-gingerol significantly suppressed the circulating concentrations of proinflammatory cytokines caused by injection DSS and reactivity the systematic immune response through increasing the myeloperoxidase activity.
Moreover, 6-gingerol also restored the function of the colon in response to waste material.
The efficacy of 6-gingerol in the inhibition of ulcerative colitis was attributed to the stimulation of the increasing activities of antioxidant enzymes and glutathione content, decreasing the hydrogen peroxide and malondialdehyde levels.
In other words, 6-gingerol restored the balanced ratio of free radicals and antioxidants in the tested mice injected by DSS.
Dr. Ajayi BO, the lead scientist said, " 6-Gingerol suppressed the induction of ulcerative colitis in mice via and anti-inflammatory activities, and may thus represent a potential anti-colitis drug candidate".
Taken altogether, ginger processed a high amount of bioactive gingerols may be considered a functional food for the prevention and combined with other primary therapy for the treatment of ulcerative colitis with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Therapeutic Effects of 6-Gingerol, 8-Gingerol, and 10-Gingerol on Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Rats by Zhang F1, Ma N1, Gao YF1, Sun LL1, Zhang JG. (PubMed)
(2) Pharmacological activity of 6-gingerol in dextran sulphate sodium-induced ulcerative colitis in BALB/c mice by Ajayi BO1, Adedara IA, Farombi EO. (PubMed)
(3) Modulating effect of ginger extract on rats with ulcerative colitis by El-Abhar HS1, Hammad LN, Gawad HS. (PubMed)
(4) Inflammatory bowel disease related innate immunity and adaptive immunity by Yuan Huang1,* and Zhonge Chen2. (PubMed)
Ulcerative colitis (UC) can be an acute or chronic inflammation of the membrane-lined the colon or the large intestine. People with UC are at higher risk for developing colorectal cancer, compared to the general population.
Acute inflammation is a process of inflammation in response to tissue injury, that occurs over a short period of time and can be resolved within a time frame.
Most people with acute inflammation experience the symptoms of pain, redness, swelling, and heat.
According to the American Family Physician, between 250,000 and 500,000 people in the United States were affected by ulcerative colitis.
The exact causes of ulcerative colitis. are debatable. Researchers do not know why people with the same health conditions in the family, some members are susceptible to the onset of the condition, while others do not
However, according to the epidemiological studies genetic mutation, environment, and weakened immune system may be the prevalent risk factors associated with ulcerative colitis.
Dr. Yuan Huang, the lead scientist, in the concern of the weakened immune system in the risk of inflammatory bowel disease, including ulcerative colitis (UC) and Crohn’s disease (CD) said, " after environmental factors act on individuals with genetic susceptibility, and abnormal intestinal immune response is launched under stimulation of intestinal flora".
The team explained, "Inflammatory bowel disease-related immune disorders. The innate immune abnormalities of inflammatory bowel disease leading to adaptive immune disorders,... The inflammatory cytokines, in turn, increase the innate immune damages,.... abate the intestinal barrier function, and aggravate inflammation. Therefore a vicious circle forms.
The immune disorder caused by the inability to kill off all the invader pathogens in the acute phase of inflammation at the colon can lead to immune compromise of the host in facilitating chronic low-grade inflammation disease, such as chronic ulcerative colitis (UC).
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to reaffirm the traditional use of ginger for the treatment of ulcerative colitis, one of the most common types of inflammatory bowel disease, researchers evaluated the 6-Gingerol, a component of gingerols extracted from ginger (Zingiber officinale) anti ulcerative colitis effect.
In the selected rat model, colitis was induced in rats through consumption of 5% (cw/v) dextran sulfate sodium drinking water for 7 consecutive days before 6-Gingerol, 8-gingerol, and 10-gingerol were given intraperitoneally at doses of 30 mg kg-1 d-1 for another 7 days,
At the end of the experiment, researchers found that all three gingerols attenuated colitic symptoms evoked by dextran sulfate sodium
Application of 6-Gingerol, 8-gingerol, and 10-gingerol significantly elevated superoxide dismutase activity, decreased malondialdehyde levels and myeloperoxidase activity in the colon tissue.
The applications also strongly decrease the expression of proinflammatory cytokines expression.
All three gingerols obviously accelerated mucosal damage healing.
Dr. Zhang F, the lead author said, "6-gingerol, 8-gingerol, and 10-gingerol, the three analogs, have a strong and relatively equal efficacy in the treatment of colitis".
Further investigation of the gingerols, the phenolic compounds in ginger (Zingiber officinale) anti-inflammatory and antioxidant effects, researchers examined the gingers activity against a mouse model of dextran sulfate sodium (DSS)-induced ulcerative colitis.
Adult male selected mice were either exposed to DSS in drinking water alone or co-treated with 6-gingerol orally at 50, 100, and 200 mg/kg for 7 days.
Mice co-treated with 6 gingerols significantly reversed the DSS-mediated reduction in body weight, diarrhea, rectal bleeding, and restored the colon shrinkage back to near normal.
Application of 6-gingerol significantly suppressed the circulating concentrations of proinflammatory cytokines caused by injection DSS and reactivity the systematic immune response through increasing the myeloperoxidase activity.
Moreover, 6-gingerol also restored the function of the colon in response to waste material.
The efficacy of 6-gingerol in the inhibition of ulcerative colitis was attributed to the stimulation of the increasing activities of antioxidant enzymes and glutathione content, decreasing the hydrogen peroxide and malondialdehyde levels.
In other words, 6-gingerol restored the balanced ratio of free radicals and antioxidants in the tested mice injected by DSS.
Dr. Ajayi BO, the lead scientist said, " 6-Gingerol suppressed the induction of ulcerative colitis in mice via and anti-inflammatory activities, and may thus represent a potential anti-colitis drug candidate".
Taken altogether, ginger processed a high amount of bioactive gingerols may be considered a functional food for the prevention and combined with other primary therapy for the treatment of ulcerative colitis with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Therapeutic Effects of 6-Gingerol, 8-Gingerol, and 10-Gingerol on Dextran Sulfate Sodium-Induced Acute Ulcerative Colitis in Rats by Zhang F1, Ma N1, Gao YF1, Sun LL1, Zhang JG. (PubMed)
(2) Pharmacological activity of 6-gingerol in dextran sulphate sodium-induced ulcerative colitis in BALB/c mice by Ajayi BO1, Adedara IA, Farombi EO. (PubMed)
(3) Modulating effect of ginger extract on rats with ulcerative colitis by El-Abhar HS1, Hammad LN, Gawad HS. (PubMed)
(4) Inflammatory bowel disease related innate immunity and adaptive immunity by Yuan Huang1,* and Zhonge Chen2. (PubMed)
Thursday, April 9, 2020
Fennel, the Functional Herb Which Processes Anti-antispasmodic Activity, Scientists Find
Fennel may have a potential and positive effect in reducing pain through its anti antispasmodic property, some scientists suggested.
Anti-antispasmodic activity is an action that relieves, prevents, or lowers the incidence of muscle spasms, especially those of adnominal muscle in the uterus and smooth muscle such as in the bowel wall.
Certain hormones that have the function in controlling muscle contraction and relaxation are found to associate with the intensity of muscle spasms, if overexpressed.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the findings, the natural antispasmodic ingredients with little or no side effects, Dr. Shamkant B. Badgujar, and colleagues launched an investigation to compare doses of 2.5 and 10.0 mL/L of an alcoholic extract with other Germanic medicinal plants, including Melissa officinalis, Rosmarinus officinalis, Mentha piperita, Matricaria chamomilla, Carum carvi, and Citrus aurantium.
The experiment was carried out on guinea pig ileum by using acetylcholine and histamine as spasmogens.
After taking into all account co and confounders account, researchers found that application tested doses of alcoholic extract of the fruits of Foeniculum vulgare exert a significant anti antispasmodic activity by inhibiting the acetylcholine and histamine-induced guinea pig ileal contractions.
Further analysis of the effects of n essential oil obtained from the fruits of Foeniculum vulgare at the doses of 25 μg/ and 10 μg/mL, researchers discovered that the injections also demonstrated the similar as of the extract but through the inhibition of hormone oxytocin and prostaglandin activities.
Oxytocin and prostaglandin are hormones with a function that causes contraction of the muscles of the uterus. Over contraction of muscles of the uterus is a major cause of the abdominal pain in women.
Additionally, the comparison of the antispasmodic property of 4 different herbal medicine that has been used in traditional medicine for the treatment of abdominal pain in Swiss mice, including fennel according to the guidelines of the Organization for Economic Co-operation and Development (OECD) also found that all herbs used in the testing display a substantial reduction of abdominal pain without inducing any adverse effects.
In the experiment carried out in the guinea pig, the application of fennel also showed significant relaxation in different agonists like histamine and acetylcholine-induced contractions in guinea-pig ileum.
Interestingly, in the study to investigate whether oral fennel drop has any effects in primary dysmenorrhea, the occurrence of painful menstrual cramps of the uterus, researchers conducted an experiment on sixty college students who suffer from primary dysmenorrhea.
The participants were randomly assigned to two groups and followed up for two cycles. The treatment group was given fennel drop and the control group was given non-steroidal anti-inflammatory drugs (NSAIDs) or oral contraceptive pills.
After assessing the final report, researchers suggested that both groups exert a clinic significant effect in reducing pain. However, a comparison of bleeding severity in the study group before and after the intervention on the first day, second day, the third day, the fourth day, and fifth day was 0.948, 0.330, 0.508, 0.583, 0.890, respectively.
Dr. Bokaie M, the lead scientist said, "fennel can be effective in reducing the severity of dysmenorrhea, but it has an unpleasant taste in view of most of the volunteers".
Taken all together, fennel may be considered a secondary and therapeutical form of treatment in reducing pain caused by overexpression of hormones that control the muscle contraction through its antispasmodic activity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Spasmolytic effect of traditional herbal formulation on guinea pig ileum by Kumar D1, Ganguly K1, Hegde HV1, Patil PA2, Kholkute SD1(PubMed)
(3) Oral fennel (Foeniculum vulgare) drop effect on primary dysmenorrhea: Effectiveness of herbal drug by Bokaie M1, Farajkhoda T, Enjezab B, Khoshbin A, Karimi-Zarchi M(PubMed)
Anti-antispasmodic activity is an action that relieves, prevents, or lowers the incidence of muscle spasms, especially those of adnominal muscle in the uterus and smooth muscle such as in the bowel wall.
Certain hormones that have the function in controlling muscle contraction and relaxation are found to associate with the intensity of muscle spasms, if overexpressed.
Fennel (Foeniculum vulgare) is a plant species of the genus, belonging to Apiaceae (Umbelliferae), native to the Mediterranean.
The herb has been used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
In the findings, the natural antispasmodic ingredients with little or no side effects, Dr. Shamkant B. Badgujar, and colleagues launched an investigation to compare doses of 2.5 and 10.0 mL/L of an alcoholic extract with other Germanic medicinal plants, including Melissa officinalis, Rosmarinus officinalis, Mentha piperita, Matricaria chamomilla, Carum carvi, and Citrus aurantium.
The experiment was carried out on guinea pig ileum by using acetylcholine and histamine as spasmogens.
After taking into all account co and confounders account, researchers found that application tested doses of alcoholic extract of the fruits of Foeniculum vulgare exert a significant anti antispasmodic activity by inhibiting the acetylcholine and histamine-induced guinea pig ileal contractions.
Further analysis of the effects of n essential oil obtained from the fruits of Foeniculum vulgare at the doses of 25 μg/ and 10 μg/mL, researchers discovered that the injections also demonstrated the similar as of the extract but through the inhibition of hormone oxytocin and prostaglandin activities.
Oxytocin and prostaglandin are hormones with a function that causes contraction of the muscles of the uterus. Over contraction of muscles of the uterus is a major cause of the abdominal pain in women.
Additionally, the comparison of the antispasmodic property of 4 different herbal medicine that has been used in traditional medicine for the treatment of abdominal pain in Swiss mice, including fennel according to the guidelines of the Organization for Economic Co-operation and Development (OECD) also found that all herbs used in the testing display a substantial reduction of abdominal pain without inducing any adverse effects.
In the experiment carried out in the guinea pig, the application of fennel also showed significant relaxation in different agonists like histamine and acetylcholine-induced contractions in guinea-pig ileum.
Interestingly, in the study to investigate whether oral fennel drop has any effects in primary dysmenorrhea, the occurrence of painful menstrual cramps of the uterus, researchers conducted an experiment on sixty college students who suffer from primary dysmenorrhea.
The participants were randomly assigned to two groups and followed up for two cycles. The treatment group was given fennel drop and the control group was given non-steroidal anti-inflammatory drugs (NSAIDs) or oral contraceptive pills.
After assessing the final report, researchers suggested that both groups exert a clinic significant effect in reducing pain. However, a comparison of bleeding severity in the study group before and after the intervention on the first day, second day, the third day, the fourth day, and fifth day was 0.948, 0.330, 0.508, 0.583, 0.890, respectively.
Dr. Bokaie M, the lead scientist said, "fennel can be effective in reducing the severity of dysmenorrhea, but it has an unpleasant taste in view of most of the volunteers".
Taken all together, fennel may be considered a secondary and therapeutical form of treatment in reducing pain caused by overexpression of hormones that control the muscle contraction through its antispasmodic activity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PMC)
(2) Spasmolytic effect of traditional herbal formulation on guinea pig ileum by Kumar D1, Ganguly K1, Hegde HV1, Patil PA2, Kholkute SD1(PubMed)
(3) Oral fennel (Foeniculum vulgare) drop effect on primary dysmenorrhea: Effectiveness of herbal drug by Bokaie M1, Farajkhoda T, Enjezab B, Khoshbin A, Karimi-Zarchi M(PubMed)
Wednesday, April 8, 2020
Ginger, the Natural Antibiotics Alternative Functional Spice
Ginger may be considered a natural antibiotics alternative for the treatment of Candida albicans overgrowth without inducing any side effects, some scientists suggested.
Candida albicans is an opportunistic pathogenic yeast formed part of the commensal gastrointestinal mycobiota.
Candida albicans overgrowth is the most prevalent cause of fungal infections in humans.
Epidemiological studies strongly suggested that long-term users of antibiotics that cause an imbalance of the gut microbiome, weakened the immune system, unhealthy diet, and women who are pregnant and hormone imbalance of hormone near menstruation are susceptible to the onset of the condition.
If you experience symptoms of oral thrush, recurring genital or urinary tract infections, persistently digestive issues, joint pain. particularly, in the skin and nail fungal infections, you may have a yeast infection.
Please check with your doctor to rule the Candida albicans overgrowth possibility.
Dr. Carol A. Kumamoto in the research team of infectious diseases in the study "Inflammation and gastrointestinal Candida colonization" suggested that a Candida albicans overgrowth can be caused by other medical conditions, associated to a digestive disorder.
In the study, the doctor wrote, "Recent studies, however, show that high-level Candida colonization is associated with several diseases of the gastrointestinal tract. Further, results from animal models argue that Candida colonization delays healing of inflammatory lesions and that inflammation promotes colonization".
And, "Both inflammatory bowel disease and gastrointestinal Candida colonization are associated with elevated levels of the pro-inflammatory cytokine IL-17. Therefore, effects on IL-17 levels may underlie the ability of Candida colonization to enhance inflammation".
These results strongly suggested, inflammation flames the overgrowth of Candida colonization in return, the overgrowth of Candida albicans induces persistently low-grade inflammation.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find the natural ingredient or whole food for the replacement of the conventional antibiotics without inducing any effects, researchers at the Teikyo University Institute of Medical Mycology, investigated the effect of ginger against infection caused by Candida albicans.
4 preparations of the essential oils of young and mature rhizomes, air-dried and steamed rhizomes, and seed rhizomes of Zingiber officinale Roscoe (ginger) were compared in the study.
* All ginger essential oils processed a significant anti-Candida albicans activity.
* Essential oil from the seed and air-dried rhizomes, exerted the highest effect compared to other preparations.
* The seed and air-dried rhizomes essential oils also had a potent inhibitory activity compared to ginger oleoresins obtained by ethanol and hypercritical carbon dioxide extraction and essential oils of 5 other plants in the family Zingiberaceae.
According to the chemical constituents assay, [6]-shogaol was most active against filament formation and growth of C. Albicans, followed by citral and [6]-gingerol.
Furthermore, ginger oleoresin, especially that obtained by ethanol extraction, with a high [6]-gingerol content exhibited potent anti the growth of C. Albicans compared to essential oils of ginger and other Zingiberaceae plants.
Moreover, in a vitro joint study by the Institute of Science and Technology, researchers launched an investigation to evaluate the antimicrobial activity of 2% chlorhexidine gel (CHX) isolated from the ginger as auxiliary chemical substance and intracanal medications on Candida albicans.
The study included 48 single-rooted human teeth randomly divided into fourr groups (n = 12), according to intracanal medications used: (1) Calcium hydroxide + apyrogenic saline solution (Ca(OH)2 + SS), (2) 20% ginger glycolic extract (GEN), (3) calcium hydroxide + 20% ginger glycolic extract (Ca(OH)2 + GEN), (4) apyrogenic SS (control).
At the end of the experiment, researchers found that
* CHX was effective in the complete elimination of E. coli and C. albicans.
* ChX also significantly reduced and then completely eliminated E. faecalis after intracanal medication.
* All other applications also revealed a reduction of endotoxins, the outer membrane of the cell wall of Gram-negative bacteria.
In the final report, the research team concluded, "CHX and intracanal medication used were able to eliminate the microorganisms from the root canal; the endotoxins were reduced, yet not completely eliminated".
These results strongly suggested that ginger bioactive compound processes a significant antibacterial activity, particularly in those of C. albicans.
Taken all together, there is no doubt that ginger may be considered a functional food for the prevention and combined with primary medicine for the treatment of yeast infection with no side effects.
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Candida and radical scavenging activities of essential oils and oleoresins of Zingiber officinale Roscoe and essential oils of other plants belonging to the family Zingiberaceae by Takahashi M1, Inouye S, Abe S.(PubMed)
(2) Action of Chlorhexidine, Zingiber officinale, and Calcium Hydroxide on Candidaalbicans, Enterococcus faecalis, Escherichia coli, and Endotoxin in the Root Canals by Valera MC1, Oliveira SA2, Maekawa LE2, Cardoso FG3, Chung A2, Silva SF2, Carvalho CA2. (PubMed)
(3) Inflammation and gastrointestinal Candida colonization by Carol A. Kumamoto. (PMC)
Candida albicans is an opportunistic pathogenic yeast formed part of the commensal gastrointestinal mycobiota.
Candida albicans overgrowth is the most prevalent cause of fungal infections in humans.
Epidemiological studies strongly suggested that long-term users of antibiotics that cause an imbalance of the gut microbiome, weakened the immune system, unhealthy diet, and women who are pregnant and hormone imbalance of hormone near menstruation are susceptible to the onset of the condition.
If you experience symptoms of oral thrush, recurring genital or urinary tract infections, persistently digestive issues, joint pain. particularly, in the skin and nail fungal infections, you may have a yeast infection.
Please check with your doctor to rule the Candida albicans overgrowth possibility.
Dr. Carol A. Kumamoto in the research team of infectious diseases in the study "Inflammation and gastrointestinal Candida colonization" suggested that a Candida albicans overgrowth can be caused by other medical conditions, associated to a digestive disorder.
In the study, the doctor wrote, "Recent studies, however, show that high-level Candida colonization is associated with several diseases of the gastrointestinal tract. Further, results from animal models argue that Candida colonization delays healing of inflammatory lesions and that inflammation promotes colonization".
And, "Both inflammatory bowel disease and gastrointestinal Candida colonization are associated with elevated levels of the pro-inflammatory cytokine IL-17. Therefore, effects on IL-17 levels may underlie the ability of Candida colonization to enhance inflammation".
These results strongly suggested, inflammation flames the overgrowth of Candida colonization in return, the overgrowth of Candida albicans induces persistently low-grade inflammation.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find the natural ingredient or whole food for the replacement of the conventional antibiotics without inducing any effects, researchers at the Teikyo University Institute of Medical Mycology, investigated the effect of ginger against infection caused by Candida albicans.
4 preparations of the essential oils of young and mature rhizomes, air-dried and steamed rhizomes, and seed rhizomes of Zingiber officinale Roscoe (ginger) were compared in the study.
* All ginger essential oils processed a significant anti-Candida albicans activity.
* Essential oil from the seed and air-dried rhizomes, exerted the highest effect compared to other preparations.
* The seed and air-dried rhizomes essential oils also had a potent inhibitory activity compared to ginger oleoresins obtained by ethanol and hypercritical carbon dioxide extraction and essential oils of 5 other plants in the family Zingiberaceae.
According to the chemical constituents assay, [6]-shogaol was most active against filament formation and growth of C. Albicans, followed by citral and [6]-gingerol.
Furthermore, ginger oleoresin, especially that obtained by ethanol extraction, with a high [6]-gingerol content exhibited potent anti the growth of C. Albicans compared to essential oils of ginger and other Zingiberaceae plants.
Moreover, in a vitro joint study by the Institute of Science and Technology, researchers launched an investigation to evaluate the antimicrobial activity of 2% chlorhexidine gel (CHX) isolated from the ginger as auxiliary chemical substance and intracanal medications on Candida albicans.
The study included 48 single-rooted human teeth randomly divided into fourr groups (n = 12), according to intracanal medications used: (1) Calcium hydroxide + apyrogenic saline solution (Ca(OH)2 + SS), (2) 20% ginger glycolic extract (GEN), (3) calcium hydroxide + 20% ginger glycolic extract (Ca(OH)2 + GEN), (4) apyrogenic SS (control).
At the end of the experiment, researchers found that
* CHX was effective in the complete elimination of E. coli and C. albicans.
* ChX also significantly reduced and then completely eliminated E. faecalis after intracanal medication.
* All other applications also revealed a reduction of endotoxins, the outer membrane of the cell wall of Gram-negative bacteria.
In the final report, the research team concluded, "CHX and intracanal medication used were able to eliminate the microorganisms from the root canal; the endotoxins were reduced, yet not completely eliminated".
These results strongly suggested that ginger bioactive compound processes a significant antibacterial activity, particularly in those of C. albicans.
Taken all together, there is no doubt that ginger may be considered a functional food for the prevention and combined with primary medicine for the treatment of yeast infection with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Anti-Candida and radical scavenging activities of essential oils and oleoresins of Zingiber officinale Roscoe and essential oils of other plants belonging to the family Zingiberaceae by Takahashi M1, Inouye S, Abe S.(PubMed)
(2) Action of Chlorhexidine, Zingiber officinale, and Calcium Hydroxide on Candidaalbicans, Enterococcus faecalis, Escherichia coli, and Endotoxin in the Root Canals by Valera MC1, Oliveira SA2, Maekawa LE2, Cardoso FG3, Chung A2, Silva SF2, Carvalho CA2. (PubMed)
(3) Inflammation and gastrointestinal Candida colonization by Carol A. Kumamoto. (PMC)
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