Cruciferous Vegetables Inhibit the Onset of Glioblastoma, in Vitro

Glioblastoma or glioblastoma (also called GBM) caused mostly by the abnormal astrocytic cells and dead cells (necrosis) is considered one of the most aggressive cancers induced by the alternation of cells originated from the brain, including the cerebral hemispheres.


In other words, primary glioblastoma may arise as a Grade IV tumor with no evidence.

Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.

Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.

Most cases of GBM are diagnosed at an older age with a median age of 64. Some researchers suggested that aging with the change of body function may be one of the major risk factors that cause the incidence.

In the US, the median age of glioblastoma diagnosed is 64 years and the incidence of the disease onset is 1.6 times higher in males compared to females.

Furthermore, the condition is 2 times higher in Caucasians compared to Africans and Afro-Americans.

GBM is deadly, patients with GBM have a median survival of less than one year and less than 2% of patients survive three years or more.

According to statistics, most patients diagnosed with cancer die within 12 to 15 months. Less than 5% of patients are survived longer than five years.

If you are male you are at 1.5 higher risks of glioblastoma, compared to the female's counterpart.

The causes of glioblastoma are unknown, some researchers suggested that genetic preposition and environmental factors, previous radiotherapy, a weakened immune system may be some risk factors associated with the onset of the disease.

On finding a potential plant that process neuro-protective researchers compared the effects of
Sulforaphane (SFN), an isothiocyanate (ITC) derived from cruciferous vegetables on glioblastoma.

According to the differentiation,
* SFN can rapidly cross the BBB and accumulate in the CNS after i.p. administration [76,77] to exert its anti-cancer activity.


* Furthermore, the application of SFN induces apoptosis and inhibits both growth and invasion of GBM cells.

* SFN can overcome the chemoresistance of tumor cells.

More precisely, the effects of SFN inhibited the profession by focusing on pro-apoptotic, anti-invasion, anti-proliferative, and anti-chemo/radioresistance activities.

Taken altogether, cruciferous vegetables consisting of SFN may be considered a functional food for the prevention and treatment of atherothrombotic diseases, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment by Sita G1, Hrelia P2, Graziosi A3, Morroni F. (PubMed)