Cruciferous Vegetables Induce the Death of Bladder Cancer Cells

The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.

Bladder cancer is a medical condition characterized by irregular cell growth in the bladder tissue due to the alternation of DNA.

Most cases of primary bladder cancer start on the cell on the surface of the inner lining. However, after growing large enough, the cancerous call can spread to other regions in the body through the circulation of fluids and blood.

According to the statistic. 90% of bladder cancer were diagnosed in people who are older than 55. and the average age of people diagnosed with bladder cancer is 73.

Every year, the disease causes over 17,000 deaths and bladder cancer is the eighth most common cause of cancer death in men.


Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women.

Usually, it starts from the lining of the bladder caused by several types of malignant growths of the urinary bladder cells.
Although there are many risk factors associated with the onset of bladder cancer, long-term cigarette smoking use is considered a significant cause of the disease. Smokers are 4 to 7 times more likely to develop bladder cancer than nonsmokers.

However, most of the cigarette smoker has never developed bladder cancer.


On finding a potential plant that processes anti-cancer activity researchers evaluated the diets rich in cruciferous vegetables, particularly broccoli on bladder cancer risk.

In vitro studies, isothiocyanates, the major chemical compound of cruciferous vegetables inhibited bladder cancer cell lines, induced cell cycle arrest, and apoptosis.


Furthermore, isothiocyanates demonstrated many mechanisms of anticancer activity at the steps of cancer initiation, promotion, and progression.

Moreover, isothiocyanates induced cancer cell death by targeting multiple pathways including the adaptive stress response, phase I/II enzyme modulation, pro-growth, pro-survival, pro-inflammatory signaling, angiogenesis, and even epigenetic modulation, according to multiple in vivo studies.

Collectively, researchers said, "Overall, both cell and animal studies support a potential role for isothiocyanates in bladder cancer prevention and treatment. Future studies are necessary to examine clinically relevant outcomes and define guidelines on ameliorating the bladder cancer burden".

Taken altogether, collard green consisting of isothiocyanates that may be considered a functional food for the prevention and treatment of bladder cancer pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention by Abbaoui B1,2,3, Lucas CR3,4,5, Riedl KM2,5, Clinton SK5,6, Mortazavi A. (PubMed)