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Monday, November 30, 2015

The Holistic Clinical Trials and Studies of Polycystic Ovarian Syndrome: The Stress Response and Management herbal Rhodiola (Rhodiola rosea)

By Kyle J. Norton
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                    Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).


  The prevention and management In Herbal Medicine

                  The stress management herbal Medicine 

Stress in a natural reaction of human fight or fight response induced by pressure due to environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).

                                       Rhodiola (Rhodiola rosea)

Rhodiola Rosea, one of the perennial plant grows in coldest region in the world, including the Arctic, is a genus Rhodiola, belongings to the family Crassulaceae, used in traditional medicine as an antiaging(1167) agent, and to treat fatigue(1168)(1169), depression(1170)(1171), anemia(1172), impotence(1173), inflammation(1174), infections(1175), nervous system disorders(1176)(1177), enhance physical endurance(1178), and increase an organism's resistance to stress(1167)(1179).etc.

Phytochemicals(1165)(1166)
1 .Salidroside
2. Sosavin
3. Rosin
4. Sosarin
5. Tyrosol
6. Lignan major compounds in the
7. Heterodontoside,
8. Viridoside
9. Mongrhoside
10. Cyanogenic glucoside rhodiocyanoside A
11. Epigallocatechin and gallate
12 . Epiga
13. Etc.

In an evaluating anti-stress effects, rhodiola rosea, exhibited positive effects on mental and physical performance under stress(1180)(1181), improved attention and cognitive function associated with its antidepressant activity(1180)(1182) and stress-protective effect of adaptogen(1181), through regulation of nitric oxide (NO) and cortisol levels(1180)(1181).
According to Gesundheitsbezirk Bozen,, rhodiola rosea active substance phenylpropanoide also processed sedative, anti-depressive(1180) and stress-modulated properties through stimulating the distribution of dopamine and serotonin(1182).
In animal model, the herb showed to display antidepressant(1181)(1182)(1184), adaptogenic(1181)(1184), anxiolytic(1184)(1186), nociceptive(1183)(1185) and locomotor activities(1186) induced by intense physical and psychological stress(1183).
In oxidative stress induced animal models, rhodiola is effective in the empowerment of performance(1187), modulation of the immune system(1187) against oxidative damage(1187).
Salidroside (SAL), an active component of Rhodiola rosea protect endothelium(1189) against H2O2-induced endothelial dysfunction(1188)(1189) and oxidative-stress-associated cardiovascular dysfunction(1189) through preventing the overactivation of oxidative stress-related downstream signaling pathways(1188).

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References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed) (1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)
(1165) Phylogenetic and Phytochemical Characteristics of Plant Species with Adaptogenic Properties by Robyn KLein. CHAPTER 6
(1166) Phytochemical characterization of an adaptogenic preparation from Rhodiola heterodonta by Grace MH1, Yousef GG, Kurmukov AG, Raskin I, Lila MA.(PubMed)
(1167) Rhodiola: a promising anti-aging Chinese herb. by Jafari M1, Felgner JS, Bussel II, Hutchili T, Khodayari B, Rose MR, Vince-Cruz C, Mueller LD.(PubMed)
(1168) Anti-Fatigue Effects of Fermented Rhodiola rosea Extract in Mice by Kang DZ1, Hong HD2, Kim KI3, Choi SY4.(PubMed)
(1169) Rhodiola rosea for mental and physical fatigue in nursing students: a randomized controlled trial by Punja S1, Shamseer L2, Olson K3, Vohra S4.(PubMed)
(1170) Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial by Mao JJ1, Xie SX2, Zee J2, Soeller I3, Li QS3, Rockwell K4, Amsterdam JD5.(PubMed)
(1171) Rhodiola rosea therapy for major depressive disorder: a study protocol for a randomized, double-blind, placebo- controlled trial by Mao JJ1, Li QS2, Soeller I2, Xie SX3, Amsterdam JD4.(PubMed)
(1172) [Effect of salidroside on bone marrow cell cycle and expression of apoptosis-related proteins in bone marrow cells of bone marrow depressed anemia mice]. [Article in Chinese] by Zhang XS1, Zhu BD, Hung XQ, Chen YF.(PubMed)
(1173) Panax ginseng, Rhodiola rosea and Schisandra chinensis by Chan SW1.(PubMed)
(1174) Rhodiola inhibits dengue virus multiplication by inducing innate immune response genes RIG-I, MDA5 and ISG in human monocytes by Diwaker D1, Mishra KP, Ganju L, Singh SB.(PubMed)
(1175) Sambucus nigra extracts inhibit infectious bronchitis virus at an early point during replication by Chen C, Zuckerman DM, Brantley S, Sharpe M, Childress K, Hoiczyk E, Pendleton AR1.(PubMed)
(1176) [Advance in studies on pharmacological effect of salidroside on nervous system diseases]. [Article in Chinese] by Xie H1, Zhu DH.(PubMed)
(1177) Protective effects of a Rhodiola crenulata extract and salidroside on hippocampal neurogenesis against streptozotocin-induced neural injury in the rat by Qu ZQ1, Zhou Y, Zeng YS, Lin YK, Li Y, Zhong ZQ, Chan WY.(PubMed)
(1178) The effects of an acute dose of Rhodiola rosea on endurance exercise performance by Noreen EE1, Buckley JG, Lewis SL, Brandauer J, Stuempfle KJ.(PubMed)
(1179) Effects of plant extracts on the reversal of glucose-induced impairment of stress-resistance in Caenorhabditis elegans by Fitzenberger E1, Deusing DJ, Wittkop A, Kler A, Kriesl E, Bonnländer B, Wenzel U.(PubMed)
(1180) The adaptogens rhodiola and schizandra modify the response to immobilization stress in rabbits by suppressing the increase of phosphorylated stress-activated protein kinase, nitric oxide and cortisol by Panossian A1, Hambardzumyan M, Hovhanissyan A, Wikman G.(PubMed)
(1182) [The interaction of Rhodiola rosea and antidepressants. A case report]. [Article in German] by Maniscalco I1, Toffol E, Giupponi G, Conca A.(PubMed)
(1183) Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice by Perfumi M1, Mattioli L.(PubMed)
(1184) Characterization of the anxiolytic activity of Nunavik Rhodiola rosea by Cayer C1, Ahmed F, Filion V, Saleem A, Cuerrier A, Allard M, Rochefort G, Merali Z, Arnason JT.(PubMed)
(1185) Synergistic interactions between the antinociceptive effect of Rhodiola rosea extract and B vitamins in the mouse formalin test by Montiel-Ruiz RM1, González-Trujano ME, Déciga-Campos M.(PubMed)
(1186) Pharmacological evaluation of Potentilla alba L. in mice: adaptogenic and central nervous system effects by Shikov AN1, Lazukina MA, Pozharitskaya ON, Makarova MN, Golubeva OV, Makarov VG, Djachuk GI.(PubMed)
(1187) Effects of herbal supplements on the immune system in relation to exercise by Megna M1, Amico AP, Cristella G, Saggini R, Jirillo E, Ranieri M.(PubMed)
(1188) Salidroside stimulates mitochondrial biogenesis and protects against H₂O₂-induced endothelial dysfunction by Xing S1, Yang X1, Li W1, Bian F1, Wu D1, Chi J1, Xu G1, Zhang Y1, Jin S1.(PubMed)
(1189) Salidroside improves homocysteine-induced endothelial dysfunction by reducing oxidative stress by Leung SB1, Zhang H, Lau CW, Huang Y, Lin Z.(PubMed)

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