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Biography
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome(PCOs)
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).
The prevention and management
Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
The Antioxidants
1. Bilirubin
Bilirubin is a prosthetic group helped to break down molecules into smaller units in releasing energy, excreted in bile and urine. It is a cellular antioxidant(511), by reverting to biliverdin, a green tetrapyrrolic bile pigment, once again when oxidized, it inhibits the effects of mutagens(512). The antioxidant showed to inhibit digestive proteases like trypsin and chymotrypsin(504), benefit heart health(505) and nonalcoholic fatty liver disease(507), reduce risk of diabetes(506). Recent studies also found that the antioxidant exhibits its anti inflammatory effects(511) against certain chronic inflammatory diseases, including psoriasis(508), chronic obstructive pulmonary disease(509), .... and enhances immunity activities(510)
2. Carotenoids
Carotenoids are organic pigments, occurring in the chloroplasts and chromoplasts(513) of plants and some photosynthetic organisms like algae and bacteria(514).
a. Beta-carotene
Beta-carotene, an organic compound classified as a terpenoid, is a strongly-coloured red-orange pigment in plants and fruits, stored in liver for the production of vitamin A. Epidemiological evidences sugested that beta-carotene neutralizes singlet oxygen before giving rise of free radicals(515) which can damage of DNA, leading to improper cell DNA replication(516)(517), causing irregual cells growth, such as cancers(518)(519)(520). The phytochemical also promotes immunity(521)(522) against foreign invasion and symptoms of chronic inflammatory disease(523)(524) and improve low-density lipoprotein cholesterol resistance to oxidation causes of cardiovascular disease related to atherosclerosis(527) through its antioxidant anti inflammatory activities(525)(526).....
b. Alpha-carotene
Alpha-carotene, one of the most abundant carotenoids in the North American diet, is a form of carotene with a β-ring at one end and an ε-ring at the other, not only protects cells from the damaging effects of free radicals(526) and enhances the immune system(528) in fighting against bacteria and virus infection and inflammation(529)(530), but also inhibits irregular cell growth(531)(532) cause of benign tumors(531) and cancers(532).
c. Beta-cryptoxanthin
Chemically Beta-cryptoxanthin is a xanthophyll which protects our cells from oxidation(538) and provides a source of vitamin A. The phytochemical showed to enhances the immune system functioning(533)(534) against infectious(537) and inflammatory diseases(535)(536) and reduces insulin resistance(536) and cancers(539)(540) risks
d. Lycopene
Lycopene is a red carotene of the carotenoids group found in tomatoes, watermelons, and grapefruits. This antioxidant is believed to be a powerful fighter against irregular growth(543), such as prostate cancer(541)(542), breast cancer(544)(545) and liver diseases(546)(547). Lycopene has many anti-aging(549) capabilities as well as enhancing immune function(548) against oxidative stress(550)(551) and inflammatory diseases(551)(552).
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine
References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women WithPolycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(266) [Immunopathological responses in women with chronic inflammatorydiseases of the uterus and appendages and their therapeutic correction].[Article in Russian] by Medvedev BI1, Kazachkova EA, Kazachkov EL.(PubMed)
(267) Cross Talk Between ER Stress, Oxidative Stress, and Inflammation in Health and Disease by Dandekar A1, Mendez R, Zhang K.(PubMed)
(268) New dog and new tricks: evolving roles for IL-33 in type 2 immunity by Lott JM1, Sumpter TL1, Turnquist HR2.(PubMed)
(507) Serum bilirubin levels are inversely associated with nonalcoholic fatty liver disease by Kwak MS1, Kim D, Chung GE, Kang SJ, Park MJ, Kim YJ, Yoon JH, Lee HS.(PubMed)
(508) Antioxidant status in patients with psoriasis by Nemati H, Khodarahmi R, Sadeghi M, Ebrahimi A, Rezaei M, Vaisi-Raygani A.(PubMed)
(509) Serum Bilirubin and Disease Progression in Mild Chronic Obstructive Pulmonary Disease by Apperley S, Park HY, Holmes DT, Man SF, Tashkin D, Wise RA, Connett JE, Sin DD.(PubMed)(510) Cellular-mediated immune responses in the liver tissue of patients with severe Plasmodiumfalciparum malaria by Punsawadl C, Setthapramote C, Viriyavejakul P.(PubMed)
(511) Bile pigment pharmacokinetics and absorption in the rat: therapeutic potential for enteral administration by Bulmer AC1, Coombes JS, Blanchfield JT, Toth I, Fassett RG, Taylor SM.(PubMed)
(512) Bilirubin and related tetrapyrroles inhibit food-borne mutagenesis: a mechanism for antigenotoxic action against a model epoxide by Mölzer C1, Huber H, Steyrer A, Ziesel GV, Wallner M, Hong HT, Blanchfield JT, Bulmer AC, Wagner KH.(PubMed)
(513) Confocal laser scanning microscopy detection of chlorophylls and carotenoids in chloroplasts and chromoplasts of tomato fruit by D'Andrea L1, Amenós M, Rodríguez-Concepción M.(PubMed)
(514) Carotenoids(Wikipedia)
(515) Lycopene Inhibits the Isomerization of β-Carotene during Quenching of Singlet Oxygen and Free Radicals by Heymann T1, Heinz P1, Glomb MA1.(PubMed)
(516) Wood smoke particles generate free radicals and cause lipid peroxidation, DNA damage, NFkappaB activation and TNF-alpha release in macrophages by Leonard SS1, Wang S, Shi X, Jordan BS, Castranova V, Dubick MA.(PubMed)
(517) The Effects of Babesiosis on Oxidative Stress and DNA Damage in Anatolian Black Goats Naturally Infected with Babesia ovis by Kucukkurt I1, Cigerci IH2, Ince S3, Kozan E4, Aytekin I5, Eryavuz A6, Fidan AF1.(PubMed)
(518) Beta-carotene and lung cancer in smokers: review of hypotheses and status of research by Goralczyk R1.(PubMed)
(519) Beta-carotene in multivitamins and the possible risk of lung canceramong smokers versus former smokers: a meta-analysis and evaluation of national brands by Tanvetyanon T1, Bepler G.(PubMed)
(520) Dietary Risk Reduction Factors for the Barrett's Esophagus-Esophageal Adenocarcinoma Continuum: A Review of the Recent Literature by Petrick JL1, Li N1, McClain KM1, Steck SE2, Gammon MD3.(PubMed)
(521) Short- and long-term beta-carotene supplementation do not influence T cell-mediated immunity in healthy elderly persons by Santos MS1, Leka LS, Ribaya-Mercado JD, Russell RM, Meydani M, Hennekens CH, Gaziano JM, Meydani SN.(PubMed)
(522) A and beta-carotene concentrations in adults with HIV/AIDS on highly active antiretroviral therapy by Kaio DJ1, Rondó PH, Souza JM, Firmino AV, Luzia LA, Segurado AA.(PubMed)
(523) Plasma antioxidant levels in chronic cholestatic liver diseases by Floreani A1, Baragiotta A, Martines D, Naccarato R, D'odorico A.(PubMed)
(524) Use of antioxidants to treat pain in chronic pancreatitis.[Article in English, Spanish by De las Heras Castaño G1, García de la Paz A, Fernández MD, Fernández Forcelledo JL.(PubMed)
(525) Functional nutraceutical profiling of wild edible and medicinal mushrooms consumed by ethnic tribes in India by Khaund P1, Joshi SR1.(PubMed)
(526)Dietary intake of carotenoids and their antioxidant and anti-inflammatory effects in cardiovascular cares. by Ciccone MM1, Cortese F1, Gesualdo M1, Carbonara S1, Zito A1, Ricci G1, De Pascalis F1, Scicchitano P1, Riccioni G2.(PubMed)
(527) Carotenoids and cardiovascular risk by Giordano P1, Scicchitano P, Locorotondo M, Mandurino C, Ricci G, Carbonara S, Gesualdo M, Zito A, Dachille A, Caputo P, Riccardi R, Frasso G, Lassandro G, Di Mauro A, Ciccone MM.(PubMed)
(528) Supplementation of a low-carotenoid diet with tomato or carrot juice modulates immune functions in healthy men by Watzl B1, Bub A, Briviba K, Rechkemmer G.(PubMed)
(529) Nutritional biomarkers associated with gynecological conditions among US women with or at risk of HIV infection by Tohill BC1, Heilig CM, Klein RS, Rompalo A, Cu-Uvin S, Piwoz EG, Jamieson DJ, Duerr A.(PubMed)
(530) Low levels of plasma carotenoids are associated with an increased risk of atrial fibrillation by Karppi J1, Kurl S, Mäkikallio TH, Ronkainen K, Laukkanen JA.(PubMed)
(531)Adolescent carotenoid intake and benign breast disease by Boeke CE1, Tamimi RM2, Berkey CS3, Colditz GA4, Eliassen AH2, Malspeis S5, Willett WC6, Frazier AL7.(PubMed)
(532) Dietary carotenoids and risk of breast cancer in Chinese women by Huang JP1, Zhang M, Holman CD, Xie X.(PubMed)
(533) Effect of carotenoid β-cryptoxanthin on cellular and humoral immune response in rabbit by Ghodratizadeh S1, Kanbak G, Beyramzadeh M, Dikmen ZG, Memarzadeh S, Habibian R.(PubMed)
(534) beta-Carotene and beta-cryptoxanthin but not lutein evoke redox and immune changes in RAW264 murine macrophages by Katsuura S1, Imamura T, Bando N, Yamanishi R.(PubMed)
(535) β-Cryptoxanthin alleviates diet-induced nonalcoholic steatohepatitis by suppressing inflammatory gene expression in mice by Kobori M1, Ni Y2, Takahashi Y1, Watanabe N1, Sugiura M3, Ogawa K4, Nagashimada M5, Kaneko S6, Naito S1, Ota T2.(PubMed)
(536) Prevention and reversal of lipotoxicity-induced hepatic insulin resistance and steatohepatitis in mice by an antioxidant carotenoid, β-cryptoxanthin by Ni Y1, Nagashimada M, Zhan L, Nagata N, Kobori M, Sugiura M, Ogawa K, Kaneko S, Ota T.(PubMed)
(537) The role of diet and nutrition in cervical carcinogenesis: a review of recent evidence by García-Closas R1, Castellsagué X, Bosch X, González CA.(PubMed)
(538) The carotenoid beta-cryptoxanthin stimulates the repair of DNA oxidation damage in addition to acting as an antioxidant in human cells by Lorenzo Y1, Azqueta A, Luna L, Bonilla F, Domínguez G, Collins AR.(PubMed)
(539) Antiproliferative activity of Cyanophora paradoxa pigments in melanoma, breast and lung cancer cells by Baudelet PH1, Gagez AL, Bérard JB, Juin C, Bridiau N, Kaas R, Thiéry V, Cadoret JP, Picot L.(PubMed)
(540) Dietary carotenoids and risk of breast cancer in Chinese women by Huang JP1, Zhang M, Holman CD, Xie X.(PubMed)
(541) Lycopene/tomato consumption and the risk of prostate cancer: a systematic review and meta-analysis of prospective studies by Chen J1, Song Y, Zhang L.(PubMed)
(542) The role of tomato products and lycopene in the prevention of prostate cancer: a meta-analysis of observational studies by Etminan M1, Takkouche B, Caamaño-Isorna F.(PubMed)
(543) The anti-cancer effects of carotenoids and other phytonutrients resides in their combined activity by Linnewiel-Hermoni K1, Khanin M1, Danilenko M1, Zango G1, Amosi Y1, Levy J1, Sharoni Y2.(PubMed)
(544) Inhibitory effects of combination of lycopene and genistein on 7,12- dimethyl benz(a)anthracene-induced breast cancer in rats by Sahin K1, Tuzcu M, Sahin N, Akdemir F, Ozercan I, Bayraktar S, Kucuk O.(PubMed)
(545) Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines by Gloria NF1, Soares N, Brand C, Oliveira FL, Borojevic R, Teodoro AJ.(PubMed)
(546) Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention by Ip BC1, Wang XD2.(PubMed)
(547) Lipid biomarkers and metabolic effects of lycopene from tomato juice on liver of rats with induced hepatic steatosis by Bernal C1, Martín-Pozuelo G, Lozano AB, Sevilla A, García-Alonso J, Canovas M, Periago MJ.(PubMed)
(548) Lycopene enhances antioxidant enzyme activities and immunityfunction in N-methyl-N'-nitro-N-nitrosoguanidine-enduced gastric cancer rats by Luo C1, Wu XG.(PubMed)
(549) Anti-aging effect of Blakeslea trispora powder on adult mice by Hu W1, Dai D, Li W.(PubMed)
(550) The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats by Boyacioglu M1, Kum C2, Sekkin S2, Yalinkilinc HS2, Avci H3, Epikmen ET3, Karademir U2.(PubMed)
(551) Beneficial effect of lycopene on anti-diabetic nephropathy through diminishing inflammatory response and oxidative stress by Guo Y1, Liu Y, Wang Y.(PubMed)
(552) Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors by Pall ML1, Levine S2.(PubMed)
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