Adding a portion of beet in your daily diet may have a significant effect in improved blood circulation through anti platelet aggregation and anti hypertension activities, a recent and renowned study suggested.
Platelet aggregation is natural reaction of wound healing process of blood clotting in damage and injure of our body, to prevent infection and inflammation.
Beet, best known as the beetroot or garden beet and belongings to the amaranth family, is a perennial plant with leafy stems growing to 1–2 m tall.
According to the Barts & the London School of Medicine and Dentistry, dietary rich of nitrate vegetable or fruit, such as beet showed to exhibited vascular function in promotion of blood vessel and blood circulation function, thus reducing risk CVD.
In healthy volunteers, ingestion of a dietary nitrate load (beetroot juice 500 mL), approximately 3 hours after, correlated with peak increases in plasma nitrite concentration showed a significant effect in attenuated platelet aggregation in response to collagen and adenosine diphosphate (ADP), in cell energy metabolism. And decreased plasma nitrite, may block the decrease in blood pressure and abolished the inhibitory effects on platelet aggregation.
This findings suggested that regular drinking of dietary nitrate from food sources is necessary for maintenance of a healthy heart through decreased platelet aggregation and reduced blood pressure.
In 2 randomised crossover studies each in 24 (12 of each sex) healthy subjects with oral administrated dietary nitrate (250 ml beetroot juice) or potassium nitrate capsules (KNO3, 8 mmol) vs placebo control on platelet reactivity, researchers found that group treated with nitrate component shows a strong inhibition of platelet aggregation.
The study also demonstrated that inorganic nitrate ingestion, whether via the diet or through supplementation, may have a gender preference in decreased platelet reactivity in healthy males but not females counterpart.
Dr. Velmurugan S, the lead author said, " dietary nitrate (may be benefit) as an adjunct to current antiplatelet therapies to prevent atherothrombotic complications".
Furthermore, according to the review of the National Heart and Lung Institute, in vitro and in vivo, dietary nitrite exhibited cGMP in mediated the levels of platelet aggregation through expression of nitric oxide actions,
And, in a model of thromboembolic radiolabeled platelet aggregation, injection of dietary nitrate or supplement showed a significantly inhibited platelet function in eNOS(-/-) mice.
Cyclic guanosine monophosphate (cGMP), a cyclic nucleotide plays both a stimulatory and an inhibitory role in platelet activation depending on concentration and timing.
NO also are best known for its function in regulating blood pressure and that impaired NO bioactivity is an important component of hypertension
Collectively, beet with high amount of dietary nitrate may be used as functional food combined conventional treatment in reduced risk of platelet aggregation and htpertension in induction of CVD.
People who are taking anti platelet aggregation medicine should consult with their doctors before applying large amount beet juice or juice with high concentration of nitrate.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299
(1) Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite by Webb AJ1, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ, Ahluwalia A.(PubMed)
(2) Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex by Velmurugan S1, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ, Poole A, Ahluwalia A.(PubMed)
(3) Role of inorganic nitrate and nitrite in driving nitric oxide-cGMP-mediated inhibition of platelet aggregation in vitro and in vivo by Apostoli GL1, Solomon A, Smallwood MJ, Winyard PG, Emerson M.(PubMed)