Brassica Vegetables Inhibit the Onset of Hepatic Cancer Cells in Vitro

The liver is the largest internal organ found in the human which plays an essential role in filtering the blood from the digestive system before passing them to other parts of the body.

The liver also produces cholesterol, a waxy substance which aids digestion, builds cell membranes and produces vitamin D and steroid hormones.

Liver disease is a class of medical conditions characterized by reducing partly or completely the function of the liver, including liver failure.


Liver cancer is a medical condition characterized by cell growth irregularly in the liver tissue.

The causes of liver cancer are associated with the alternation of cells' DNA which normally begins in the cells on the surface of the inner lining.

Liver cancer at the early stage no not cause any symptoms. However, at the advanced stage, liver cancer cells can cause a wide range of symptoms including jaundice, abdominal swelling and pain, and dark urine and white stool accompanied by the general symptoms of cancers such as unintended weight loss, loss of appetite, chronic fatigue and tiredness and gastrointestinal discomforts.

The most common cause of liver cancer is infected by the hepatitis virus. However, in North America, due to the overexpression of the overweight and obese population, liver cancer may be slowly progressed from nonalcoholic fatty liver disease through cirrhosis to liver cancer.


In 2017, 2,500 Canadians were diagnosed with liver cancer and 1,200 Canadians died from liver cancer.

Compared to the early stage of other cancer, the 5 years survival rate in the early stage diagnosis is only 31%, and 43% of people with liver cancer diagnosed at stages 0 and 1.

Cabbage is a species of Brassica oleracea belongings to the family Brassicaceae (or Cruciferae), native to the Mediterranean region along the seacoast. The veggie has a short stem of which is crowded a mass of leaves, usually green but in some varieties, it may be red or purplish.

With an aim to find a natural food that inhibits cancer, researchers examined the bioactivity of synthetic and plant-derived 1-cyano-2,3-epithiopropane (CETP) - the predominant epithionitrile in Brassica vegetables in three human hepatocellular carcinomas (HCC) cell lines.

According to the formazan dye assays, the concentrations of 380-1500 nM CETP isolated from Brassica vegetables inhibited the mitochondrial dehydrogenase activity-induced cytotoxicity of human HCC cells without impairment of cell growth.

Furthermore, at 100-fold higher CETP concentrations, the bioactive induced cell death.

The presence of a plant matrix associated with oxidative stress increased CETP-based toxicity without exhibiting the epithionitriles in human health.


Taken altogether, Brassica vegetables may be considered probiotics for the promotion of digestive functioning, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Brassica epithionitrile 1-cyano-2,3-epithiopropane triggers cell death in human liver cancer cells in vitro by Hanschen FS1, Herz C2, Schlotz N2, Kupke F2,3, Bartolomé Rodríguez MM4, Schreiner M1, Rohn S3, Lamy E. (PubMed)