Women's health: Obesity and Hirsutism

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

A. Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.


B. How do calculate your BMI index
BMI= weight (kg)/ height (m2)

C. Hirsutism is defined as a condition of excessive hair growth in the places where are considered minimal or not at all.

D. How obesity associates with Hirsutism
1. In a study of Endocrinology of hirsutism" by Kopera D, Wehr E, Obermayer-Pietsch B., conducted by Department of Dermatology, Internal Medicine, Medical University, posted in PubMed, researchers indicated that Obesity associated reproductive and metabolic dysfunctions may aggravate the symptoms of PCOS. PCOS might be underdiagnosed in non obese women because lean PCOS phenotypes might be underestimated for the syndrome. Effective medical treatment of PCOS and associated hirsutism depends on the endocrinological expertise and experience of the therapist in each individual case. An algorithm for the treatment has not been established yet.

2. According to the study of "Endocrinology of hirsutism" by Kopera D, Wehr E, Obermayer-Pietsch B., posted in PubMed, researcher wrote that Hirsutismrepresents a primary clinical indicator of androgen excess. The most common endocrine condition causing hirsutism is polycystic ovary syndrome (PCOS). Diagnosing PCOS is not easy as the signs and symptoms are heterogenous. The newest diagnostic guideline made by the Androgen Excess and PCOS Society in 2006, claims the presence of hyperandrogenism, and ovarian dysfunction. Obesityassociated reproductive and metabolic dysfunctions may aggravate the symptoms of PCOS. PCOS might be underdiagnosed in non obese women because lean PCOS phenotypes might be underestimated for the syndrome.

3. In the study of "Comparison of clinical and laboratory characteristics of cases with polycystic ovarian syndrome based on Rotterdam's criteria and women whose only clinical signs are oligo/anovulation or hirsutism" by Hassa H, Tanir HM, Yildiz Z., posted in PubMed, researchers concluded that non-PCOS women with only sign or symptom of oligo/anovulation or hirsutism had a more favorable endocrine milieu. These cases should be followed in vigilance in an aim to confront the development of short- and long-term adverse effects of impending PCOS in the future. Furthermore, different phenotypes of PCOS cases were clinically or biochemically similar in characteristics.

4. According to the study of "Management of polycystic ovary syndrome in childhood and adolescence" by Ojaniemi M, Tapanainen P, Morin-Papunen L.,posted in PubMed, researchers indicated in the clinical feature that typical features in adolescence include irregular menstrual cycles, acne, hirsutism,obesity and signs of insulin resistance such as acanthosis nigricans. Biochemical hyperandrogenism and polycystic ovaries are often present. However, some adolescents have no evidence of clinical and biochemical hyperandrogenism despite dysfunctional polycystic ovaries.

5. In a study of "Polycystic ovary syndrome: challenges in adolescence" byOliveira A, Sampaio B, Teixeira A, Castro-Correia C, Fontoura M, Luís Medina J., posted PubMed, researchers filed in abstract that polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases in women of reproductive age. PCOS typically develops during adolescence and is a heterogeneous syndrome classically characterized by features of anovulation combined with signs of androgen excess (hirsutism, acne). Increasing obesity in adolescents probably exacerbates signs of PCOS, contributing to its earlier recognition.

6. Etc.

E. Treatments of Obesity and Hirsutism 

1. According to the study of Six studies were included with n=164 participants. Three studies compared physical activity to minimal dietary and behavioural advice or no advice. Three studies compared combined dietary, exercise and behavioural interventions to minimal intervention, conducted by School of Public Health and Preventive Medicine, Monash University, posted in PubMed, researchers concluded that Lifestyle intervention improves body composition, hyperandrogenism (high male hormones and clinical effects) and insulin resistance in women with PCOS. There was no evidence of effect for lifestyle intervention on improving glucose tolerance or lipid profiles and no literature assessing clinical reproductive outcomes, quality of life and treatment satisfaction.

2. In the study of 151 girls with various complete and incomplete forms of precocious puberty, 20 girls with congenital adrenal hyperplasia, 20 with hirsutism, 18 with obesity, and 133 age-matched normal girls, conducted by University of Bologna, Italy, posted in PubMed, researchers sttated that Ultrasound imaging allowed an easy distinction between true precocious puberty and premature thelarche or idiopathic premature adrenarche. It was also helpful in the diagnosis of transient sexual precocity, although in these cases the differential diagnosis of precocious puberty can be difficult. In postmenarcheal patients with congenital adrenal hyperplasia, ultrasound study showed a low uterine volume and, frequently, a macrocyst in the ovary. In hirsute girls and in a few obese patients, ovaries had an increased volume and a microcystic structure, similar to those in polycystic ovary syndrome. Pelvic ultrasonography can be useful not only in diagnosing disorders in sexual development but also for greater understanding of the pathogenesis of these and other disorders.

3. Etc.



Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Women's Health: Obesity's complication of Menstrual Irregularities

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

A. Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.


B. How do calculate your BMI index
BMI= weight (kg)/ height (m2)

C. Menstrual rregularities are defined as the abnormal menstrual cycle, including Amenorrhea (absence of period), Dysmenorrhea (painful menstrual period), irregular period, spotting, Menorrhagia (heavy period), etc.

D. How Obesity associates with Menstrual Irregularities
1. In the study of 136 adolescent girls from a cohort of 301 girls between 15 and 17 years of age with confirmed menstrual irregularity, with or without ultrasound diagnosed polycystic ovaries, were assessed in detail after a gap of 2 years, conducted by Child Development Centre, Medical College, Thiruvananthapuram, posted in PubMed, researchers concluded that The results of this study support screening for menstrual irregularity, obesity and signs of clinical hyperandrogenism for early diagnosis of PCOS in an effort to improve the reproductive health of adolescent girls.

2. According to the study of "Impact of obesity on gynecology" by Pandey S, Bhattacharya S., posted in PubMed, researchers indicated that Rising obesityrates around the world have had a profound impact on female reproductive health. Childhood obesity is associated with early onset of puberty, menstrual irregularitiesduring adolescence and polycystic ovary syndrome.

3. In a study of Heights, weights (at 7, 11, 16, 23 and 33y) and reproductive data were available for 5799 females in the 1958 British birth cohort study. Body mass index (BMI) was calculated as weight/height2. Age-specific cut-offs were used to define overweight and obesity. Reproductive outcomes reported at age 33 included: menstrual problems (also reported at 16y), hypertension in pregnancy and subfertility, conducted Department of Epidemiology & Biostatistics, Institute of Child Health, posted in PubMed, researchers concluded that Overweight andobesity in early adulthood appears to increase the risk of menstrual problems, hypertension in pregnancy and subfertility. Other than menstrual problems, childhood body mass index had little impact on the reproductive health of women.

4. According of the study of "The relationship between obesity and fecundity" by Yilmaz N, Kilic S, Kanat-Pektas M, Gulerman C, Mollamahmutoglu L., posted in PubMed, researchers concluded that Obesity was found to be associated with reduced fecundity for all weight-adjusted groups of women and persisted for women with regular cycles. Weight loss should be encouraged initially during the treatment of infertile overweight and obese women.

5. In the study of "Obesity and menstrual irregularity: associations with SHBG, testosterone, and insulin" by Wei S, Schmidt MD, Dwyer T, Norman RJ, Venn AJ., posted in PubMed, researchers concluded that both overall and centralobesity were significantly associated with having an irregular menstrual cycle. This association was substantially influenced by hormonal factors, particularly insulin and SHBG.

6. Etc.

E. Treatments of Obesity and Menstrual Irregularities
1. In the study of summarizing major factors affecting fertility in obesity, conducted by University Alma Mater Studiorum of Bologna, posted in PubMed, researchers indicated that Fertility can be negatively affected by obesity. In women, early onset of obesity favours the development of menses irregularities, chronic oligo-anovulation and infertility in the adult age. Obesity in women can also increase risk of miscarriages and impair the outcomes of assisted reproductive technologies and pregnancy, when the body mass index exceeds 30 kg/m.

2. According to the study of "Evaluation of irregular menses in perimenarcheal girls: a pilot study" by Browner-Elhanan KJ, Epstein J, Alderman EM., posted inPubMed, researchers found that Those perimenarcheal girls presenting with irregular menses and findings including obesity, acne, or pallor, were likely to have treatable causes of menstrual irregularities. In one of the four girls with a normal physical examination, hormonal testing indicated possible FOH, thus suggesting that hormonal evaluation of perimenarcheal girls with menstrual irregularities may be justified, as it may reveal previously unsuspected pathology.

3. Etc.



Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Women's Health: The Effect of Phytochemical Capsaicins on Women Health

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The effects of Phytochemicals - Capsaicin in Women's health 

Phytochemicals Capsaicin can be found abundant in chili peppers, which are genus Capsicum, belonging to the family Solanaceae and has been used in herbal medicine to relieve muscle and arthritic pain over thousand of year. It is type of an irritant which can cause burning sensation of burning in any tissue if comes to contact, effecting mammals, excluding bird. According to the study of Health benefits of herbs and spices: the past, the present, the future. by Tapsell LC, Hemphill I, Cobiac L, Patch CS, Sullivan DR, Fenech M, Roodenrys S, Keogh JB, Clifton PM, Williams PG, Fazio VA, Inge KE. from the Source of National Centre of Excellence in Functional Foods, University of Wollongong, NSW, posted in US National Library of Medicine National Institutes of Health, researchers found that these developments are well underway through evidence-based frameworks for substantiating health claims related to foods. At present, recommendations are warranted to support the consumption of foods rich in bioactive components, such as herbs and spices. With time, we can expect to see a greater body of scientific evidence supporting the benefits of herbs and spices in the overall maintenance of health and protection from disease.

Pharmacy In Vegetables
Use the science behind the health benefits of vegetables
to improve your health, delay aging and cure major diseases.

The effects of Phytochemicals - Capsaicin in Women's health 

1. Female reproduction function

In a study of Fifteen 21-day-old female Sprague-Dawley rats were divided randomly into three groups. The first group received no treatment, the second group received 0.5 mg/kg/day CAP dissolved in the vehicle, and the third group was treated with the vehicle only, conducted by University of Uludag, posted in PubMed, researchers found that CAP may lead to release of NO either directly from nerves or indirectly by evoking release from other cells via the action of neuropeptides that are released from afferent terminals and are involved in regulating female reproductive function.

2. Weight loss
Capsiate, a non-pungent capsaicin analog is considered as one of the best know chemical compounds of which can suppress body fat accumulation and reduce body weight by enhancing of energy expenditure. In a study of "Capsiate, a non-pungent capsaicin analog, reduces body fat without weight rebound like swimming exercise in mice" by Haramizu S, Kawabata F, Ohnuki K, Inoue N, Watanabe T, Yazawa S, Fushiki T., posted in PubMed, researchers found that the abdominal adipose tissue weight in capsiate and exercise groups was significantly lower than that of control group. These results indicate that suppressing body fat accumulation by capsiate intake is beneficial for maintaining an ideal body weight as exercise.

3. Breast cancer
Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or thelobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast. In 2010, over 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8. In a study of "Capsaicin may induce breast cancer cell death through apoptosis-inducing factor involving mitochondrial dysfunction" by Chang HC, Chen ST, Chien SY, Kuo SJ, Tsai HT, Chen DR., posted in PubMed, researchers wrote that capsaicin inhibited breast cancer cell growth through inducing cell apoptosis and cell cycle arrest in the S phase. This apoptotic effect could be induced through the mitochondrial pathway, and PARP-1 subsequently cleaved by activation of caspase-7. The application of capsaicin in clinical therapy could be useful for breast cancer patients.

4. Regulating reproductive function
In a study of Fifteen 21-day-old female Sprague-Dawley rats were divided randomly into three groups. The first group received no treatment, the second group received 0.5 mg/kg/day CAP dissolved in the vehicle, and the third group was treated with the vehicle only, conducted by Faculty of Veterinary Medicine, University of Uludag, posted in PubMed, researchers found that
CAP may lead to release of NO either directly from nerves or indirectly by evoking release from other cells via the action of neuropeptides that are released from afferent terminals and are involved in regulating female reproductive function.

5. Endometriotic cells
According to the study of "Capsaicin inhibits proliferation of endometriotic cells in vitro" by Wu Y, Starzinski-Powitz A, Guo SW, posted in PubMed, researchers found that treatment of immortalized stromal-like and epithelial-like endometriotic cells with capsaicin resulted in inhibition of proliferation in a concentration-dependent manner. In addition, endometriotic cells are more sensitive to capsaicintreatment than immortalized endometrial cells, suggesting that capsaicin may be an admissible drug candidate for treating endometriosis.

6. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Women's Health: The Effect of Phytochemicals Allyl sulfides on Women Health

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The Effect of  Phytochemicals Allyl sulfides on Women Health

Garlic has been used in traditional Chinese and herbal medicine over thousands of year as antibacterial, antiviral, and antifungal agent and in treating other conditions such as parasites, respiratory problems, poor digestion, low energy, etc. In many studies, researchers found that Allyl sulfides, a phytochemical in garlic has been demonstrated effectively in treating certain diseases.


The effects of Phytochemicals Allyl sulfides in Women's health
1. Bone health
Allyl sulfides can be beneficial in preventing bone loss for women with osteoporosis and in the stage of perimenopause, menopause and postmenopause.In a study of "Prevention of bone loss by oil extract of garlic (Allium sativum Linn.) in an ovariectomized rat model of osteoporosis." by Mukherjee M, Das AS, Mitra S, Mitra C. (Department of Physiology, Presidency College, Kolkata-700073, India.) posted in US National Library of Medicine National Institutes of Health, researchers found that Garlic oil extract supplementation, apart from its unique influence in lowering blood cholesterol, could also prevent ovariectomy-induced rise in all the above-mentioned marker changes. The results of this study emphasize that oil extract of garlic possibly has a positive role in suppressing ovariectomy-induced bone resorption.

2. Breast cancer
Allyl sulfides is one of many phytochemicials shown to suppress the proliferation of various tumor cells, according to the study of "Antiproliferative effect of natural tetrasulfides in human breast cancer cells is mediated through the inhibition of the cell division cycle 25 phosphatases" by Viry E, Anwar A, Kirsch G, Jacob C, Diederich M, Bagrel D., posted PubMed, researchers wrote that on the inhibitory activity of tetrasulfides occurring naturally in garlic and onion towards the human Cdc25 phosphatases. Diallyl- and dipropyltetrasulfides have emerged as interesting irreversible inhibitors of the Cdc25 isoforms A and C in vitro. Furthermore, growth of both sensitive (MCF-7) and resistant (Vcr-R) human breast carcinoma cells was significantly decreased by these tetrasulfides. The observed antiproliferative effect appeared to be associated with a G2-M cell cycle arrest.

3. Cervical cancer
According to the study of "Reversal of hypermethylation and reactivation of the RARβ2 gene by natural compounds in cervical cancer cell lines" by Jha AK, Nikbakht M, Parashar G, Shrivastava A, Capalash N, Kaur J., posted in PubMed, researchers found that allyl sulphide treatment (20 μM) did not cause the reversal of hypermethylation until 72 h of treatment in the SiHa cell line. This is the first report to show the reversal of hypermethylation of the RARβ2 gene by genistein and curcumin in cervical cancer cell lines. Furthermore, these compounds acted as doublepronged agents as they caused apoptosis in the treated cervical cancer cell lines in addition to reversal of promoter hypermethylation.

4. Vaginal infection
Allyl sulfides is considered by herbalist as a herb used to treat certain infections, including candidiasis cause of vaginal infection, according to the article of "Garlic: Herbal Remedies" by Jennifer Brett, N.D., posted in Discovery fit and health, the author wrote that Garlic is used to treat many types of infections: Use capsules internally for recurrent vaginal yeast infections, use a garlic infusion topically as a soak for athlete's foot, or add garlic to an oil to treat middle ear infections.

5. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity 
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

The Smoothie of Cooked Sweet Potato, Olive and Grape Juice for treatment of Chronic Kidney Diseases(CKD) in Autosomal recessive polycystic kidney disease

The smoothie for prevention and treatment of  Chronic Kidney Diseases(CKD)  in Autosomal recessive polycystic kidney disease 

Yield: 2 servings (about 8 ounces each)

1/2 cup olive

1 cup cooked sweet potato

1 cup organic grape juice

1. Place all ingredients in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.

3. Serve immediately

Autosomal recessive polycystic kidney disease is an inherited diseases(Mutations in the PKHD1)causing abnormal functions of liver and reno inducing morbidity and mortality in children.
Until today, there is no cure, treatment options for autosomal recessive polycystic kidney disease, depending to complications, such as Chronic Kidney Diseases(CKD).

The finding of a natural source for treatment of Chronic Kidney Diseases(CKD)  in Autosomal recessive polycystic kidney disease has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Cooked Sweet Potato, Olive and Grape Juice may be the next generation of natural ingredients for prevention and treatment of Chronic Kidney Diseases(CKD).

Chronic Kidney Diseases(CKD) in in Autosomal recessive polycystic kidney disease is a progressive loss of kidney function over period longer than 3 months through different stages, deepening to the GFR (Glomerular Filtration Rate). According to the Tri-Service General Hospital, Excessive oxidative stress increased oxidative nucleicacid damage and exagerated the development of complication of Chronic Kidney Diseases(1).

The Anti-Odxidant Therapy in Chronic Renal Insufficiency (ATIC) study suggested, combination of pravastatin, vitamin E, and homocysteine treatment in 18 months together with hypertension controlled  effectively attenuated expression of Chronic Kidney Diseases(CKD) through reduced oxidative stress against renal function(2).Vitamin E-coated membranes (VECMs) consist of a multilayer membrane with liposoluble vitamin E, used in dialysis significantly improved Hb levels and lower rHuEpo requirements in chronic HD patients(3).Dr. Rashid Khan M and colleagues insisted, vitamin E significantly reduced dyslipidemia and inhibited the development of CRD caused by atherogenic factors after six weeks. particular in hypolipidemic and nephroprotective activity against free radical-related diseases(4).

N-3 fatty acids found abundantly in olive may also contribute to the potential benefits of dietary fat

modification in CKD patients, according to the Karolinska Institutet(5).

Dr. Lee SM and Dr. An WS., professors at the Seoul National University Hospital, insisted, intake of Omega 3 fatty acid exhibited cardioprotective effects in chronic kidney disease, the main cause of death, through attenuated inflammation, dyslipidemia, malnutrition, atherosclerosis, and vascular calcification(6).

Dr. Friedman AN said, " Long-chain polyunsaturated omega-3 fatty acids (n-3 PUFA), which are obtained primarily from dietary sources such as coldwater fish, have diverse and potent mediating effects on the immune, inflammatory, and metabolic pathways, signal transduction, and cell membrane physiology" and "In the meantime, the current American Heart Association n-3 PUFA intake guidelines can be applied to CKD patients"(7).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in grape and blueberry, may also benefit in attenuated complications and treatment of Chronic Kidney Diseases(CKD), through its inflammation and oxidative stress modulation (8).

According to the joint study led by the The Catholic University of Korea, Bucheon, resveratrol expressed renoprotective effects by activating NRF2 signaling against against oxidative or electrophilic stress(9).Furthermore by suppressing the pro inflammatory cytokines, consumption of white wine and olive oil, significantly reduced plasma markers of chronic inflammation in CKD patients(10).

The effectiveness of Cooked Sweet Potato, Olive and Grape Juice may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Albuminuria with little or no adverse effects.

People who are at high risk of Chronic Kidney Diseases(CKD) in in Autosomal recessive polycystic kidney diseasedue to gene mutation of PKHD1, ...  should drink no more than 4 servings daily, depending to digestive toleration.
Life style and diet pattern change are necessary.

All Forms of Arthritis are Curable

You Can Eliminate Osteoarthritis

By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(1) Oxidative stress and nucleic acid oxidation in patients with chronic kidney disease by Sung CC1, Hsu YC, Chen CC, Lin YF, Wu CC.(PubMed)
(2) Effect of a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on carotid intima-media thickness, endothelial function, and renal function in patients with mild to moderate chronic kidney disease: results from the Anti-Oxidant Therapy in Chronic Renal Insufficiency (ATIC) Study by Nanayakkara PW1, van Guldener C, ter Wee PM, Scheffer PG, van Ittersum FJ, Twisk JW, Teerlink T, van Dorp W, Stehouwer CD.(PubMed)
(3) Effect of vitamin E-coated dialysis membranes on anemia in patients with chronic kidney disease: an Italian multicenter study by Cruz DN1, De Cal M, Garzotto F, Brendolan A, Nalesso D, Corradi V, Ronco C.(PubMed)
(4) Tocotrienols have a nephroprotective action against lipid-induced chronic renal dysfunction in rats by Rashid Khan M1, Ahsan H, Siddiqui S, Siddiqui WA.(PubMed)
(5) Dietary fat modification in patients with chronic kidney disease: n-3 fatty acids and beyond by Huang X1, Lindholm B, Stenvinkel P, Carrero JJ.(PubMed)
(6) Cardioprotective effects of ω -3 PUFAs in chronic kidney disease. by Lee SM1, An WS.(PubMed)
(7) Omega-3 fatty acid supplementation in advanced kidney disease by Friedman AN1.(PubMed)
(8) Resveratrol: why is it a promising therapy for chronic kidney disease patients?by Saldanha JF1, Leal Vde O2, Stenvinkel P3, Carraro-Eduardo JC4, Mafra D1.(PubMed)
(9) Effect of redox modulating NRF2 activators on chronic kidney disease.by Choi BH1, Kang KS2, Kwak MK3.(PubMed)

The Smoothie of Cooked mushroom, calcium acetate (Rx) and watercress juice for Prevention and Treatment of Chronic kidney disease-mineral and bone disorder CKD-MBD)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie at least prolong and prevention of Chronic kidney disease-mineral and bone disorder CKD-MBD)

Yield: 2 servings (about 8 ounces each)

1 1/2 cups cooked mushroom

2 capsules (1334 mg) calcium acetate (Rx)

1 cup of organic watercress juice

1. Place all ingredients in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.

3. Serve immediately

The finding of a natural source for treatment of Chronic kidney disease-mineral and bone disorder CKD-MBD) has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Sodium bicarbonate and Juar tea may be the next generation of natural ingredients for prevention and treatment of Chronic kidney disease-mineral and bone disorder CKD-MBD).

Chronic kidney disease-mineral and bone disorder(CKD-MBD) is a medical condition of abnormal levels of calcium and phosphorus in the blood, leading to abnormal bone hormone levels as a result of kidney dysfunction.

Vitamin D,  calcium, phosphate binders(1) may benefits for patients of Chronic kidney disease-mineral and bone disorder CKD-MBD)(6).

Vitamin D found abundantly in Mushrooms, according to Dr. Fujii H," vitamin D may prevent progression of Chronic Kidney Disease-Mineral and Bone Disorder) and cardiovascular disease. It has been reported that Vitamin D may attenuate renal injury and ameliorate renal function and proteinuria"(2).

The Paris Ile de France Ouest University study of the effects of vitamin D in chronic kidney disease-mineral bone disease (CKD-MBD) suggested that Vitamin D is of paramount importance to skeletal development, integrity and health. Vitamin D homeostatis is typically deranged in a number of chronic conditions(3). 

Calcium found abundantly in Watercress may also benefit patients with  Chronic kidney disease-mineral and bone disorder CKD-MBD), according to Guangdong Provincial Hospital of Chinese Medicine,dietary interventions (calcium-enriched bread or low phosphorus/protein intake) may positively affect CKD-MBD by increasing serum calcium(4).

Dr. Hirukawa T and colleagues in the study of better management of CKD-MBD during pre-dialysis and dialysis period insisted, phosphorus, calcium, 1,25-dihydroxyvitamin D, parathyroid hormone and fibroblast growth factor 23, gradually return toward acceptable levels following the re-establishment of kidney function after transplantation(5). of that reaffirm the importance of calciun and other minerals used for treatment of Chronic kidney disease-mineral and bone disorder CKD-MBD).

Calcium acetate is a chemical compound of calcium salt of acetic acid with function in binding the blood phosphate level. According to the Indiana University School of Medicine, phosphatebinders were effective in lowering urine phosphorus of which may be beneficiary for prevention and treatment of abnormalities in kidney, intestine, and bone in early CKD-MBD(7).

Dr. Cernaro V and professors at the University of Messina, said, "Starting phosphate binders when phosphatemia reaches values higher than normal may represent a late therapeutic approach. Serum phosphorus is not the ideal biomarker for the diagnosis and treatment of phosphate imbalance"(8).

This finding of the effectiveness of Cooked mushroom, calcium acetate (Rx) and watercress  juice  may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk and treatment of  Chronic kidney disease-mineral and bone disorder CKD-MBD) with little or no adverse effects.
People who are at high risk of  Chronic kidney disease-mineral and bone disorder CKD-MBD) due to family history, kidney disease,..... should drink at least one serving daily and people with Chronic kidney disease-mineral and bone disorder CKD-MBD) should drink the smoothie as much as they can, depending to digestive toleration.
Life style and dietary pattern change are recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) Cinacalcet: An oral calcimimetic agent for the management of hyperparathyroidism by Dong BJ1.(PubMed)(2) [CKD-MBD (Chronic Kidney Disease-Mineral and Bone Disorder). Effect of vitamin D on kidney and cardiovascular system].[Article in Japanese] by Fujii H1.(PubMed)
(3) The uses and abuses of Vitamin D compounds in chronic kidney disease-mineral bone disease (CKD-MBD). by Goldsmith DJ1, Massy ZA2, Brandenburg V3.(PubMed)
(4) Dietary interventions for mineral and bone disorder in people with chronic kidney disease by Liu Z1, Su G, Guo X, Wu Y, Liu X, Zou C, Zhang L, Yang Q, Xu Y, Ma W(PubMed)
(5) Mineral and bone disorders in kidney transplant recipients: reversible, irreversible, and de novo abnormalities by Hirukawa T1, Kakuta T, Nakamura M, Fukagawa M.(PubMed)
(6) Phosphate binders, vitamin D and calcimimetics in the management of chronic kidney disease-mineral bonedisorders (CKD-MBD) in children by Wesseling-Perry K1, Salusky IB.(PubMed)
(7) The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response tophosphate binders in the rat by Moe SM1, Radcliffe JS, White KE, Gattone VH 2nd, Seifert MF, Chen X, Aldridge B, Chen NX.(PubMed)
(8) The future of phosphate binders: a perspective on novel therapeutics by Cernaro V1, Santoro D, Lucisano S, Nicocia G, Lacquaniti A, Buemi M.(PubMed)

The Smoothie of Green Tea, Water and Coffee for Prevention and Treatment of Kidney stones in Adenine phosphoribosyltransferase deficiency

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Kidney stone in Adenine phosphoribosyltransferase deficiency

Yield: 2 servings (about 8 ounces each)

1/2 for mineral water
1/2 cup coffee
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute

2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.

3. Serve immediately

The finding of a natural source for treatment of Adenine phosphoribosyltransferase deficiency has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Adenine phosphoribosyltransferase deficiency is an inherited metabolic disorder associated to 
excessive production of 2,8-dihydroxyadenine (DHA), affecting the kidneys and urinary tract.
Kidney stone, a most complication of adenine phosphoribosyltransferase deficiency is a forming of minerals in urine due to reduced urinary volume or excessive collection of stone-forming substances in the urine.

Recent studies back by well known institutions proposed, Green tea, Olive and Blueberry may be the next generation of natural ingredients for prevention and treatment of Adenine phosphoribosyltransferase deficiency. According to the study led by the University of Iceland, Progressive chronic kidney disease (CKD) and acute kidney injury (AKI) episodes are major features of APRT deficiency, whereas kidney stone is the most common presentation(1).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to the Zhongnan Hospital of Wuhan University, regular intake of green tea drink and water is associated to reduce risk of kidney stone forming(2).

Dr. Ferraro PM and collesgues at the Catholic University of the Sacred Heart, suggested, consumption of green tea, coffee, ......is associated with a lower risk of forming of kidney stones(3).
The study of 553 081 person-years of follow-up over an 8-year period said, " increase in total fluid intake can reduce risk for kidney stones, and the choice of beverage may be meaningful(including green tea and coffee)"(4).

In deed, intake of water also exhibited anti kidney stone formation as the fluoride in water inhibited ethylenglycol induced calcification of the kidneys(5). In fact, strong evidence in epidemiological studies suggested that Water Intake and Effectively Decreases Urinary Calcium Oxalate, Calcium Phosphate and Uric Acid Supersaturations through increased urine volume and decreased urinary supersaturation in calcium stone formers(6)(7).

Coffee, a brewed drink prepared from roasted coffee beans from the Coffee plant, may be independently associated with a lower risk of incident kidney stones, according to the Catholic University of the Sacred Heart(8).

The effectiveness of Green Tea, Mineral Water and Coffee may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk, complications and treatment of Kidney stones in Adenine phosphoribosyltransferase deficiency with little or no adverse effects.

People who are at high risk of Kidney stones in Adenine phosphoribosyltransferase deficiency due to aging, weaken renal function... should drink at least one serving daily and People with Kidney stones in Adenine phosphoribosyltransferase deficiency should drink no more than 4 servings daily, depending to digestive toleration.
Life style and diet pattern change are necessary.

All Forms of Arthritis are Curable

You Can Eliminate Osteoarthritis

By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References

(1) Kidney Disease in Adenine Phosphoribosyltransferase Deficiency. by Runolfsdottir HL1, Palsson R2, Agustsdottir IM3, Indridason OS4, Edvardsson VO5.(PubMed)

(2) Self-Fluid Management in Prevention of Kidney Stones: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Observational Studies by Xu C1, Zhang C, Wang XL, Liu TZ, Zeng XT, Li S, Duan XW.(PubMed)

(3) Soda and other beverages and the risk of kidney stones by Ferraro PM1, Taylor EN, Gambaro G, Curhan GC.(PubMed)

(4) Beverage use and risk for kidney stones in women by Curhan GC1, Willett WC, Speizer FE, Stampfer MJ.(PubMed)

(5) Fluoridation of drinking water: effects on kidney stone formation by Hering F, Briellmann T, Seiler H, Rutishauser G.(PubMed)

(6) Short-Term Tolvaptan Increases Water Intake and Effectively Decreases Urinary Calcium Oxalate, Calcium Phosphate and Uric Acid Supersaturations by Cheungpasitporn W1, Erickson SB1, Rule AD2, Enders F3, Lieske JC4.(PubMed)

(7) Self-Fluid Management in Prevention of Kidney Stones: A PRISMA-Compliant Systematic Review and Dose-Response Meta-Analysis of Observational Studies by Xu C1, Zhang C, Wang XL, Liu TZ, Zeng XT, Li S, Duan XW.(PubMed)