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Saturday, July 2, 2016

The Smoothie of Cooked mushroom, calcium acetate (Rx) and watercress juice for Prevention and Treatment of Chronic kidney disease-mineral and bone disorder CKD-MBD)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie at least prolong and prevention of Chronic kidney disease-mineral and bone disorder CKD-MBD)
Yield: 2 servings (about 8 ounces each)
1 1/2 cups cooked mushroom
2 capsules (1334 mg) calcium acetate (Rx)
1 cup of organic watercress juice

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Chronic kidney disease-mineral and bone disorder CKD-MBD) has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Recent studies back by well known institutions proposed, Sodium bicarbonate and Juar tea may be the next generation of natural ingredients for prevention and treatment of Chronic kidney disease-mineral and bone disorder CKD-MBD).

Chronic kidney disease-mineral and bone disorder(CKD-MBD) is a medical condition of abnormal levels of calcium and phosphorus in the blood, leading to abnormal bone hormone levels as a result of kidney dysfunction.

Vitamin D,  calcium, phosphate binders(1) may benefits for patients of Chronic kidney disease-mineral and bone disorder CKD-MBD)(6).

Vitamin D found abundantly in Mushrooms, according to Dr. Fujii H," vitamin D may prevent progression of Chronic Kidney Disease-Mineral and Bone Disorder) and cardiovascular disease. It has been reported that Vitamin D may attenuate renal injury and ameliorate renal function and proteinuria"(2).
The Paris Ile de France Ouest University study of the effects of vitamin D in chronic kidney disease-mineral bone disease (CKD-MBD) suggested that Vitamin D is of paramount importance to skeletal development, integrity and health. Vitamin D homeostatis is typically deranged in a number of chronic conditions(3). 

Calcium found abundantly in Watercress may also benefit patients with  Chronic kidney disease-mineral and bone disorder CKD-MBD), according to Guangdong Provincial Hospital of Chinese Medicine,dietary interventions (calcium-enriched bread or low phosphorus/protein intake) may positively affect CKD-MBD by increasing serum calcium(4).
Dr. Hirukawa T and colleagues in the study of better management of CKD-MBD during pre-dialysis and dialysis period insisted, phosphorus, calcium, 1,25-dihydroxyvitamin D, parathyroid hormone and fibroblast growth factor 23, gradually return toward acceptable levels following the re-establishment of kidney function after transplantation(5). of that reaffirm the importance of calciun and other minerals used for treatment of Chronic kidney disease-mineral and bone disorder CKD-MBD).

Calcium acetate is a chemical compound of calcium salt of acetic acid with function in binding the blood phosphate level. According to the Indiana University School of Medicine, phosphatebinders were effective in lowering urine phosphorus of which may be beneficiary for prevention and treatment of abnormalities in kidney, intestine, and bone in early CKD-MBD(7).
Dr. Cernaro V and professors at the University of Messina, said, "Starting phosphate binders when phosphatemia reaches values higher than normal may represent a late therapeutic approach. Serum phosphorus is not the ideal biomarker for the diagnosis and treatment of phosphate imbalance"(8).

This finding of the effectiveness of Cooked mushroom, calcium acetate (Rx) and watercress  juice  may serve as cornerstones of pharmaceutical target for further studies in production of a potential medication for reduced risk and treatment of  Chronic kidney disease-mineral and bone disorder CKD-MBD) with little or no adverse effects.
People who are at high risk of  Chronic kidney disease-mineral and bone disorder CKD-MBD) due to family history, kidney disease,..... should drink at least one serving daily and people with Chronic kidney disease-mineral and bone disorder CKD-MBD) should drink the smoothie as much as they can, depending to digestive toleration.
Life style and dietary pattern change are recommended.

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(1) Cinacalcet: An oral calcimimetic agent for the management of hyperparathyroidism by Dong BJ1.(PubMed)(2) [CKD-MBD (Chronic Kidney Disease-Mineral and Bone Disorder). Effect of vitamin D on kidney and cardiovascular system].[Article in Japanese] by Fujii H1.(PubMed)
(3) The uses and abuses of Vitamin D compounds in chronic kidney disease-mineral bone disease (CKD-MBD). by Goldsmith DJ1, Massy ZA2, Brandenburg V3.(PubMed)
(4) Dietary interventions for mineral and bone disorder in people with chronic kidney disease by Liu Z1, Su G, Guo X, Wu Y, Liu X, Zou C, Zhang L, Yang Q, Xu Y, Ma W(PubMed)
(5) Mineral and bone disorders in kidney transplant recipients: reversible, irreversible, and de novo abnormalities by Hirukawa T1, Kakuta T, Nakamura M, Fukagawa M.(PubMed)
(6) Phosphate binders, vitamin D and calcimimetics in the management of chronic kidney disease-mineral bonedisorders (CKD-MBD) in children by Wesseling-Perry K1, Salusky IB.(PubMed)
(7) The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response tophosphate binders in the rat by Moe SM1, Radcliffe JS, White KE, Gattone VH 2nd, Seifert MF, Chen X, Aldridge B, Chen NX.(PubMed)
(8) The future of phosphate binders: a perspective on novel therapeutics by Cernaro V1, Santoro D, Lucisano S, Nicocia G, Lacquaniti A, Buemi M.(PubMed)

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