Scientists may have found a whole vegetable for the prevention and treatment of high blood cholesterol comparable to that of conventional medicine without inducing any side effects, according to studies.
High blood cholesterol is a medical condition of abnormally high levels of cholesterol in the blood.
There are 2 types of cholesterols in the human body, the low-density lipoproteins, and high-density lipoproteins.
The low-density cholesterol plays an important role in building cell membranes, inducing the production of bile, steroid hormones and vitamin. However, long-term accumulation of cholesterol in the bloodstream not only impedes the blood flow of the arteries but also increases the risk of plaque built up on the arterial walls.
The high-density lipoprotein removes cholesterol from the blood and returns them to the liver. However, if the low-density lipoprotein in the bloodstream was found in high amounts, compared to high-density lipoprotein, then some bad cholesterols may be left in the arteries, causing the onset of high blood cholesterol.
The healthy ratio of blood cholesterol is lower than 4 (levels of low-density lipoprotein)/ 1(levels of high-density cholesterol).
What causes high blood cholesterol? Epidemiological studies suggested that a poor diet with rich in saturated and trans fat, red meat and processed foods and few in fruits and vegetables are the most common risk factors that cause the onset of high blood cholesterol in the Western world.
According to the statistic, in Australia, over 1 million of the population have high blood cholesterol. The highest prevalent group is those between 55 to 64 year age group.
Sadly, one in five Australians aged 18 to 34 also has high total cholesterol.
Dr. Henry N. Ginsberg, the lead scientist in the cardiovascular disease team in examining the risk of high blood cholesterol and diet cholesterol in young and healthy men said, "Fasting plasma total cholesterol concentrations increased by 1.47 mg/dL (0.038 mmol/L) for every 100 mg dietary cholesterol added to the diet (P <.001). Low-density lipoprotein (LDL) cholesterol increased in parallel." and " increases in dietary cholesterol resulted in linear increases in fasting total and LDL cholesterol in young, healthy men".
These results suggested that short-term intake of high cholesterol diet does not have an effect on postprandial plasma lipids or an increased atherogenic potential of postprandial serum. In other words, high blood cholesterol is a condition caused by long-term high cholesterol diet that takes years to develop.
Celery is a species of Apium graveolens, belonging to the family Apiaceae. It is cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.
With an aim to find a natural ingredient or whole food which processes anti-high blood cholesterol activity with no side effects, researchers at the National University of Singapore looked into the antihyperlipidemic property of aqueous celery extract.
The study included 2 groups of Wistar rats fed a high-fat diet for eight weeks to induce hyperlipidemia. One group was supplemented with aqueous celery extract in the diet while the other group served as control.
At the end of the experiment, treatment group exerted a significant reduction in the serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) concentrations, compared to control.
The concentration of hepatic TG was significantly higher in the celery-treated group than in the control group. However, the hepatic triacylglycerol lipase (HL) activity was found to be significantly lower in the celery-treated rats observed for the hepatic microsomal P450 content which is an indication of individual hepatic clearance.
Surprisingly, researchers discovered that aqueous extract of celery does not contain 3-n-butylphthalide (BuPh), a unique compound in celery. This result suggested that the efficacy of celery probably is associated with other major unknown compound compounds.
Futhermore, in the examining other compounds processed the anti-high blood cholesterol activity, researchers explored the antihyperlipidemic effect of ethanolic extract of seeds of Apium graveolens L. (celery) and its chloroform and aqueous basic fraction in olive oil induced hyperlipidemic rats.
The antihyperlipidemic activity of Apium graveolens has been found in the previous study was effective as of those of standard drug Atorvastatin (50mg/kg).
The study included the ethanolic extract and its fractions administered orally at doses of 200 and 400 mg/kg body weight in rats following by the Olive oil (5ml/kg oral dose) administered 30 min after treatment.
The ethanolic extract and its fractions of celery at a dose-dependently inhibited the total cholesterol (TC) triglycerides (TG), low-density lipoproteins (LDL) level, and significantly increased high density lipoprotein (HDL) level.
The inhibition of high blood cholesterol was attributed to the major compounds terpenoid, tannin, alkaloid, glycoside, flavonoid, and sterols.
Taken altogether, celery containing high amounts of bioactive compounds may be considered a functional food for the prevention and treatment of high blood cholesterol with no side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effects of aqueous celery (Apium graveolens) extract on lipid parameters of rats fed a high fat diet by Tsi D1, Das NP, Tan BK.(PubMed)
(2) Effect of chloroform and an aqueous basic fraction of ethanolic extract from Apium graveolens L. in experimentally-induced hyperlipidemia in ratsm by Iyer D1, Patil UK(PubMed)
(3) Hypolipidemic and antioxidant activity of mountain celery (Cryptotaenia japonica Hassk) seed essential oils by Cheng MC1, Lin LY, Yu TH, Peng RY.(PubMed)
(4) The mechanism underlying the hypocholesterolaemic activity of aqueous celery extract, its butanol and aqueous fractions in genetically hypercholesterolaemic RICO rats by Tsi D1, Tan BK.(PubMed)
(5) Effects of celery extract and 3-N-butylphthalide on lipid levels in genetically hypercholesterolaemic (RICO) rats by Tsi D1, Tan BK.(PubMed)
(6) A Dose-Response Study of the Effects of Dietary Cholesterol on Fasting and Postprandial Lipid and Lipoprotein Metabolism in Healthy Young Men by Henry N. Ginsberg, Wahida Karmally, Maliha Siddiqui, Steve Holleran, Alan R. Tall, Steven C. Rumsey, Richard J. Deckelbaum, William S. Blaner, and Rajasekhar Ramakrishnan. (PMC)
Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.
Wednesday, April 10, 2019
Herbal Cascara Sagrada (Rhamnus purshiana) and type 2 diabetes
Herbal Cascara sagrada may process a strong and positive effect on reducing the risk and treatment of type 2 diabetes, according to studies.
Diabetes is a condition characterized by insulin resistance and abnormally high blood glucose. Most cases of type 2 diabetes are associated with the insufficient insulin entering the bloodstream to regulate the glucose, caused by either cell in pancreas died off or receptor sites clogged up by fat and cholesterol.
Family history, ethnicity, impaired glucose tolerance or impaired fasting glucose, high blood cholesterol and fasting glucose overweight or obese are some prevalent risk factors of the disease, according to the epidemiological studies.
Women, having gestational diabetes and polycystic ovary syndrome are also at a higher risk of diabetes.
Some researchers also suggested that aging also plays a critical role in inducing the onset of the disease, therefore, anyone over the age of 40 should be tested for diabetes every three years.
The Diabetes Society of Canada went one step further to suggest that anyone who has one or more risk factors should be tested more frequently and/or start regular screening earlier.
Truly, the clinical features of elderly diabetes are significant differences, compared to that of younger age population. Dr. Katarzyna Mordarska, the lead scientist said, "The prevalence of both type 2 diabetes and prediabetes increases with advancing age. The most important factors leading to hyperglycemia as follows deficiency of insulin secretion developing with age, and growing insulin resistance caused by a change in body composition and sarcopenia".
And, "Diabetes in elderly people is often diagnosed with a delay due to atypical symptoms (dementia, urinary incontinence) and occurrence of mainly postprandial hyperglycemia. Elderly people are more exposed to diabetes complications, have more risk of myocardial infarction and end-stage renal disease, and are hospitalized more often due to hypoglycemia than are younger patients"
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, it's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.,
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on finding natural products for the treatment of type 2 diabetes investigated the effect of emodin, a bioactive ingredient isolated from herbal Cascara Sagrada.
Emodin enhanced GLUT4 translocation and [(14)C] function in facilitating the transport of glucose across the plasma membrane of the myotube in an AMPK-dependent manner.
Where 5' AMP-activated protein kinase or AMPK is an enzyme (EC 2.7.11.31) which plays a role in activating the glucose and fatty acid uptake.
Futhermore, emodin also inhibited glucose production by suppressing the expression genes associated with key gluconeogenesis in generating glucose through sources other than carbohydrates, such as lactate, glycerol, and glucogenic amino acids.
In C57Bl/6J mice, a single dose of emodin significantly decreased the fasting plasma glucose levels and improved glucose tolerance.
According to the insulin tolerance test, administration of emodin also increased insulin sensitivity after daily injection for 8 days.
Dr. the lead scientists said, "emodin regulates glucose homeostasis in vivo by AMPK activation and that this may represent a novel therapeutic principle in the treatment of type 2 diabetic models".
In order to reveal more information about the anti-diabetes of emodin, researchers investigated the effects of emodin on 11beta-HSD1 and its ability to ameliorate metabolic disorders in diet-induced obese (DIO) mice.
Where 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an attractive therapeutic target of type 2 diabetes and metabolic syndrome.
Emodin exerted its potency as an 11beta-HSD1 inhibitor with the IC(50) of 186 and 86 nM for human and mouse 11beta-HSD1, respectively.
Single oral administration of emodin inhibited the 11beta-HSD1 activity of liver and fat significantly in mice.
Emodin reversed prednisone-induced insulin resistance in mice, without affecting the effect of dexamethasone-induced insulin resistance, by inhibiting the 11beta-HSD1 in vivo.
In DIO mice, oral administration of emodin improved insulin sensitivity and lipid metabolism and lowered blood glucose.
The findings suggested that emodin processes the potential value for the treatment of metabolic syndrome or type 2 diabetes.
Taken altogether, herbal Cascara Sagrada with a high amount of emodin may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of type 2 diabetes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
References
(1) Emodin regulates glucose utilization by activating AMP-activated protein kinase by Song P, Kim JH, Ghim J, Yoon JH, Lee A, Kwon Y, Hyun H, Moon HY, Choi HS, Berggren PO, Suh PG, Ryu SH.(PubMed)
(2) Promotion of adiponectin multimerization by emodin: a novel AMPK activator with PPARγ-agonist activity by Chen Z, Zhang L, Yi J, Yang Z, Zhang Z, Li Z. (PubMed)
(3) Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice by Feng Y, Huang SL, Dou W, Zhang S, Chen JH, Shen Y, Shen JH, Leng Y. (PubMed)
(4) Diabetes in the elderly by Katarzyna Mordarska
1 and Małgorzata Godziejewska-Zawada. (PMC)
Tuesday, April 9, 2019
Honey, The Best Remedy for Prevention and Treatment of Stomach Ulcers, According to Studies
Scientists may have found natural alternative antibiotics for the treatment of stomach ulcer caused by a bacterial infection, some studies found.
Stomach/Gastric ulcer is a condition characterized by the breaking in the tissue lining of the stomach.
Most cases of stomach ulcer are caused by the infection with the Helicobacter pylori bacterium or long-term intake of anti-inflammatory medication.
Most common symptoms of stomach ulcer include dull pain in the stomach, gastrointestinal discomforts such as nausea or vomiting. bloating, burping or burning sensation in the chest.
If you are experiencing some of the above symptoms persistently, please check with your doctor to rule out the possibility of stomach ulcer.
Unless the disease is caused by medication, most stomach ulcer can be treated successfully with the use of antibiotics and medications that reduce the overproduction of stomach acid.
Some researchers suggested that people who are obese are also susceptible to the onset of stomach ulcer due to the following reasons
* Epidemiological findings suggested that obesity is associated with the inflammation in the gut, leading to the weakness of gut cells that prone to the ulcer formation.
* Obesity has been found to have an unhealthy ratio of gut bacterias.
* Overexpression gut harmful bacterias increased the risk of toxin accumulation in the lining of the gut.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on finding a natural compound for the treatment of stomach ulcers investigated the Manuka honey antiulcer activity in gastric rats.
Ethanol-induced gastric ulcers in rats selected to the study were divided into control, ethanol (ulcer), omeprazole, and manuka honey group.
Injection of Manuka honey significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein through the increased the expression gastric mucosal levels of nitric oxide (NO) in the inhibition of leukocyte adherence to the endothelium, and antioxidant enzymes glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD).
Furthermore, Manuka honey also decreased gastric mucosal MDA, the oxidative stress marker and proinflammatory expression in the stomach caused by the injection of ethanol (ulcer), omeprazole.
Dr. the lead scientist wrote, "Manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels".
The findings clearly suggested Manuka honey inhibited stomach ulcer by modulating the oxidative stress, proinflammatory cytokines, and antioxidant expression.
In order to reveal more information about honey antiulcer activity, researchers evaluated the use of Manuka honey in the treatment of acetic acid-induced chronic gastric ulcers in rats.
The study included rats treated with three different concentrations of honey. Treatment with manuka honey was found to significantly reduce the ulcer index and maintain the glycoprotein content.
Manuka injection also reduced the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF-α, IL-1β, and IL-6) as compared to the untreated control group.
Honey-treated groups showed a significant increase in enzymatic (GPx and SOD) and nonenzymatic (GSH) antioxidants besides levels of the anti-inflammatory cytokine IL-10, similar to that of the previous study.
More importantly, manuka honey treated animals not only normalized cell cycle distribution but also significantly lowered apoptosis in gastric mucosa.
The results indicated that manuka honey is effective for the treatment of chronic ulcer through many mechanisms.
Taken altogether, Manuka honey may be considered a function remedy for the prevention and combined with primary medicine for the treatment of stomach ulcer with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Saad B. Almasaudi, 1 Nagla A. El-Shitany, 2 , 3 Aymn T. Abbas, 4 , 5 Umama A. Abdel-dayem, 6Soad S. Ali, 7 Soad K. Al Jaouni, 8 and Steve Harakeh. (PMC)
(2) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
(3) Association of peptic ulcer disease with obesity, nutritional components, and blood parameters in the Korean population by Jihye Kim, Keun Ho Kim, and Bum Ju Lee. (PMC)
Stomach/Gastric ulcer is a condition characterized by the breaking in the tissue lining of the stomach.
Most cases of stomach ulcer are caused by the infection with the Helicobacter pylori bacterium or long-term intake of anti-inflammatory medication.
Most common symptoms of stomach ulcer include dull pain in the stomach, gastrointestinal discomforts such as nausea or vomiting. bloating, burping or burning sensation in the chest.
If you are experiencing some of the above symptoms persistently, please check with your doctor to rule out the possibility of stomach ulcer.
Unless the disease is caused by medication, most stomach ulcer can be treated successfully with the use of antibiotics and medications that reduce the overproduction of stomach acid.
Some researchers suggested that people who are obese are also susceptible to the onset of stomach ulcer due to the following reasons
* Epidemiological findings suggested that obesity is associated with the inflammation in the gut, leading to the weakness of gut cells that prone to the ulcer formation.
* Obesity has been found to have an unhealthy ratio of gut bacterias.
* Overexpression gut harmful bacterias increased the risk of toxin accumulation in the lining of the gut.
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
Researchers on finding a natural compound for the treatment of stomach ulcers investigated the Manuka honey antiulcer activity in gastric rats.
Ethanol-induced gastric ulcers in rats selected to the study were divided into control, ethanol (ulcer), omeprazole, and manuka honey group.
Injection of Manuka honey significantly decreased the ulcer index, completely protected the mucosa from lesions, and preserved gastric mucosal glycoprotein through the increased the expression gastric mucosal levels of nitric oxide (NO) in the inhibition of leukocyte adherence to the endothelium, and antioxidant enzymes glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD).
Furthermore, Manuka honey also decreased gastric mucosal MDA, the oxidative stress marker and proinflammatory expression in the stomach caused by the injection of ethanol (ulcer), omeprazole.
Dr. the lead scientist wrote, "Manuka honey likely exerted its antiulcer, effect by keeping enzymatic (GPx and SOD) and nonenzymatic (GSH and NO) antioxidants as well as inflammatory cytokines (TNF-α, IL-1β, and IL-6) in a reduced form, inhibited lipid peroxidation (MDA), and preserved mucous glycoproteins levels".
The findings clearly suggested Manuka honey inhibited stomach ulcer by modulating the oxidative stress, proinflammatory cytokines, and antioxidant expression.
In order to reveal more information about honey antiulcer activity, researchers evaluated the use of Manuka honey in the treatment of acetic acid-induced chronic gastric ulcers in rats.
The study included rats treated with three different concentrations of honey. Treatment with manuka honey was found to significantly reduce the ulcer index and maintain the glycoprotein content.
Manuka injection also reduced the mucosal myeloperoxidase activity, lipid peroxidation (MDA), and the inflammatory cytokines (TNF-α, IL-1β, and IL-6) as compared to the untreated control group.
Honey-treated groups showed a significant increase in enzymatic (GPx and SOD) and nonenzymatic (GSH) antioxidants besides levels of the anti-inflammatory cytokine IL-10, similar to that of the previous study.
More importantly, manuka honey treated animals not only normalized cell cycle distribution but also significantly lowered apoptosis in gastric mucosa.
The results indicated that manuka honey is effective for the treatment of chronic ulcer through many mechanisms.
Taken altogether, Manuka honey may be considered a function remedy for the prevention and combined with primary medicine for the treatment of stomach ulcer with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Antioxidant, Anti-inflammatory, and Antiulcer Potential of Manuka Honey against Gastric Ulcer in Rats by Saad B. Almasaudi, 1 Nagla A. El-Shitany, 2 , 3 Aymn T. Abbas, 4 , 5 Umama A. Abdel-dayem, 6Soad S. Ali, 7 Soad K. Al Jaouni, 8 and Steve Harakeh. (PMC)
(2) Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats by Almasaudi SB1, Abbas AT2, Al-Hindi RR1, El-Shitany NA3, Abdel-Dayem UA4, Ali SS5, Saleh RM6, Al Jaouni SK7, Kamal MA8, Harakeh SM. (PubMed)
(3) Association of peptic ulcer disease with obesity, nutritional components, and blood parameters in the Korean population by Jihye Kim, Keun Ho Kim, and Bum Ju Lee. (PMC)
Herbal Cascara Sagrada (Rhamnus purshiana)The Natural Laxative for Acute and Chronic Constipation with No Side Effects, Scientists Discover
Herbal Cascara Sagrada may have a potential and positive effect in reducing risks and treatment of constipation, according to studies.
Constipation is a condition of infrequent bowel movements caused by hard and dry stool.
Without bowel movement that lasts longer than 3 days is considered having a condition of constipation
Chronic constipation can lead to symptoms of abdominal pain, bloating, and feeling as if one has not completely passed the bowel movement.
In severe cases, chronic constipation can cause the complications of formation of hemorrhoids, anal fissure or fecal impaction.
According to the statistic, constipation most often affects women, adults ages 65 and older. Constipation is highly prevalent, with approximately 12 million general practitioner prescriptions for laxatives in England in 2001.
Most common risk factors for the onset of the condition including, a poor diet with less fiber, overuse of laxatives, certain medical conditions such as irritable bowel syndrome, colon cancer, long-term use of certain medications, such as narcotics, antidepressants and resisting the urge to poop.
Some researchers suggested that atypical defecation habits are one of the most risk factor associated with the risk of constipation that is harder to treat.
Ms. Isabelle Beaudry-Bellefeuille in the examine the risk chronic constipation with atypical defecation habits in children, wrote, "Atypical defecation habits are common and distressing for children and families and can have a major impact on quality of life. Often, no underlying factor can be identified, and the defecation disorder is considered functional".
And, "Current interventions are not successful for up to 50% of children. We suggest this high failure rate may be caused by a lack of consistency in the descriptors of behavioral indicators for functional defecation problems. Most investigations and descriptors focus on general behavior. There are fewer reports concerning defecation-specific behaviors".
More investigations are necessary before a strategy can be found for the treatment of chronic constipation with atypical defecation habits in children.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America. The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers in the concerns of the high prevalence of constipation used of laxatives, a colon addictive substance, examined the effects of cascara sagrada accompanied by the infection of ear mushroom.
A total of 34 patients diagnosed with functional constipation according to the definition of the modified Rome II criteria. divided into 3 groups (placebo, ear mushrooms alone, and ear mushrooms with additives including cascara sagrada, etc.).
Numbers of bowel movement, straining, sense of incomplete evacuation, stool consistency, satisfactory relief, abdominal pain/discomfort and colon transit time were evaluated and analyzed before, during and after the treatment.
Both ear mushrooms alone and ear mushrooms with additives significantly improved a number of bowel movement, straining, sense of incomplete evacuation.
Furthermore, both applications also improved stool consistency and satisfactory relief in the participants.
Compared to the use of ear mushrooms alone, adding herbal Cascara Sagrada was found to be more effective on the improvement of constipation.
However, compared to no side effects on the use of ear mushroom, adding herbal Cascara Sagrada may induce mild gastrointestinal discomforts in some patients.
The results clearly suggested that ear mushroom combined with herbal Cascara Sagrada and fiber may have a strong inhibition against the development and chronic constipation with no serious effects.
Taken altogether, herbal Cascara Sagrada may be used alone or combined with other anti constipation functional foods for the prevention and treatment of chronic constipation with little or no side effects.
However, due to the limitation of the small sample size, we suggested that the confirmation by a large sample and multicenter human study is necessary before declaring the effective use of herbal Cascara Sagrada and its combination for the treatment of constipation.
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Rhamnus purshiana (Cascara)
(2) Constipation in adults. by Mueller-Lissner SA, Wald A.(PubMed)
(3) [Effect of ear mushroom (Auricularia) on functional constipation].[Article in Korean] by Kim TI, Park SJ, Choi CH, Lee SK, Kim WH.(PubMed)
(4) Defecation-Specific Behavior in Children with Functional Defecation Issues: A Systematic Review by Isabelle Beaudry-Bellefeuille, MSc. (PMC)
Constipation is a condition of infrequent bowel movements caused by hard and dry stool.
Without bowel movement that lasts longer than 3 days is considered having a condition of constipation
Chronic constipation can lead to symptoms of abdominal pain, bloating, and feeling as if one has not completely passed the bowel movement.
In severe cases, chronic constipation can cause the complications of formation of hemorrhoids, anal fissure or fecal impaction.
According to the statistic, constipation most often affects women, adults ages 65 and older. Constipation is highly prevalent, with approximately 12 million general practitioner prescriptions for laxatives in England in 2001.
Most common risk factors for the onset of the condition including, a poor diet with less fiber, overuse of laxatives, certain medical conditions such as irritable bowel syndrome, colon cancer, long-term use of certain medications, such as narcotics, antidepressants and resisting the urge to poop.
Some researchers suggested that atypical defecation habits are one of the most risk factor associated with the risk of constipation that is harder to treat.
Ms. Isabelle Beaudry-Bellefeuille in the examine the risk chronic constipation with atypical defecation habits in children, wrote, "Atypical defecation habits are common and distressing for children and families and can have a major impact on quality of life. Often, no underlying factor can be identified, and the defecation disorder is considered functional".
And, "Current interventions are not successful for up to 50% of children. We suggest this high failure rate may be caused by a lack of consistency in the descriptors of behavioral indicators for functional defecation problems. Most investigations and descriptors focus on general behavior. There are fewer reports concerning defecation-specific behaviors".
More investigations are necessary before a strategy can be found for the treatment of chronic constipation with atypical defecation habits in children.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America. The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers in the concerns of the high prevalence of constipation used of laxatives, a colon addictive substance, examined the effects of cascara sagrada accompanied by the infection of ear mushroom.
A total of 34 patients diagnosed with functional constipation according to the definition of the modified Rome II criteria. divided into 3 groups (placebo, ear mushrooms alone, and ear mushrooms with additives including cascara sagrada, etc.).
Numbers of bowel movement, straining, sense of incomplete evacuation, stool consistency, satisfactory relief, abdominal pain/discomfort and colon transit time were evaluated and analyzed before, during and after the treatment.
Both ear mushrooms alone and ear mushrooms with additives significantly improved a number of bowel movement, straining, sense of incomplete evacuation.
Furthermore, both applications also improved stool consistency and satisfactory relief in the participants.
Compared to the use of ear mushrooms alone, adding herbal Cascara Sagrada was found to be more effective on the improvement of constipation.
However, compared to no side effects on the use of ear mushroom, adding herbal Cascara Sagrada may induce mild gastrointestinal discomforts in some patients.
The results clearly suggested that ear mushroom combined with herbal Cascara Sagrada and fiber may have a strong inhibition against the development and chronic constipation with no serious effects.
Taken altogether, herbal Cascara Sagrada may be used alone or combined with other anti constipation functional foods for the prevention and treatment of chronic constipation with little or no side effects.
However, due to the limitation of the small sample size, we suggested that the confirmation by a large sample and multicenter human study is necessary before declaring the effective use of herbal Cascara Sagrada and its combination for the treatment of constipation.
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Rhamnus purshiana (Cascara)
(2) Constipation in adults. by Mueller-Lissner SA, Wald A.(PubMed)
(3) [Effect of ear mushroom (Auricularia) on functional constipation].[Article in Korean] by Kim TI, Park SJ, Choi CH, Lee SK, Kim WH.(PubMed)
(4) Defecation-Specific Behavior in Children with Functional Defecation Issues: A Systematic Review by Isabelle Beaudry-Bellefeuille, MSc. (PMC)
Monday, April 8, 2019
Ginger Combined with Other Herbal Medicines for The Treatment of Erectile Dysfunction
Scientists may have found a natural ingredient for the treatment of erectile dysfunction with no side effects, according to study.
Erectile dysfunction is a condition in which a man can not get or keep an erection to have sexual intercourse, affecting the self-confidence and contributing to relationship problems.
According to the statistics provided by the Massachusetts Male Aging Study, erectile dysfunction increased with age, affecting 40% and 70% of men in the age group of 40 and 70, respectively.
In other words, the prevalence of complete ED increased from 5% at age 40 to 15% at age 70. 150 million men worldwide have ED.
Age, hypertension, use of anti-hypertensive drugs, diabetes mellitus, heart disease and daily stress at home and work have been found to associate with the prevalent risk of ED.
Some researchers suggested the prevalence of ED may be correlated to widespread obesity in the Western world.
Dr. Skrypnik D, the lead scientist said, "In The United States it (obesity) causes more than 300 000 deaths per year. It leads to many complications, such as ischemic heart disease, hypertension, dyslipidemia, atherosclerosis, and abnormal carbohydrate metabolism".
And, " obesity is also an independent risk factor for erectile dysfunction in men. 79% of men presenting erectile disorders have a BMI of 25 kg/m2 or greater. BMI in the range 25-30 kg/m2 is associated with 1,5 times, and in the range of over 30 kg/m2 with a 3 times greater risk of sexual dysfunction".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural treatment for patients with erectile dysfunction with no side effects, researchers examined the effects of oral administration of Revactin twice daily (total daily dose of 500 mg of ginger root, Muira puama, and Paullinia cupana and 1,600 mg of L-citrulline in 54 middle-aged men with erectile dysfunction.
Based on the results from the complete IIEF-15 questionnaire [domains: erectile function (EF), orgasmic function (OF), sexual desire (SD), intercourse satisfaction (IS), overall satisfaction (OS)] at baseline (B), 1 month (M1), 2 months (M2) and 3 months (M3) and report any side effects, Revactin exerted a strong effect on the increase in median domain scores of OF, SD, IS, OS over 3 months compared to baseline median scores.
However, after taking other factors into account, statistical significance was found only in the EF, IS, and OS median domain scores.
5 patients in the study showed the reporting treatment side effects (e.g., dyspepsia, heartburn, migraine) and none considered severe.
Overall, approximately 50% of the patients reported a significant improvement in EF (P<0.05), compared to baseline.
Dr. Nguyen S, the lead scientist said, "Revactin®, a combination of 3 nutraceuticals packaged with L-citrulline, appears to have the same excellent safety profile known for each of its individual four components".
Take all together, ginger combined with other herbal medicines may be considered functional alternatives for the treatment of erectile dysfunction, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Safety and efficacy of daily Revactin® in men with erectile dysfunction: a 3-month pilot study by Nguyen S1, Rajfer J2, Shaheen M. (PubMed)
(2) Effect of ginger, Paullinia cupana, muira puama and l- citrulline, singly or in combination, on modulation of the inducible nitric oxide- NO-cGMP pathway in rat penile smooth muscle cells by Ferrini MG1, Garcia E2, Abraham A2, Artaza JN3, Nguyen S2, Rajfer J4. (PubMed)
(3) [Obesity--significant risk factor for erectile dysfunction in men].[Article in Polish] by Skrypnik D, Bogdański P, Musialik K. (PubMed)
Erectile dysfunction is a condition in which a man can not get or keep an erection to have sexual intercourse, affecting the self-confidence and contributing to relationship problems.
According to the statistics provided by the Massachusetts Male Aging Study, erectile dysfunction increased with age, affecting 40% and 70% of men in the age group of 40 and 70, respectively.
In other words, the prevalence of complete ED increased from 5% at age 40 to 15% at age 70. 150 million men worldwide have ED.
Age, hypertension, use of anti-hypertensive drugs, diabetes mellitus, heart disease and daily stress at home and work have been found to associate with the prevalent risk of ED.
Some researchers suggested the prevalence of ED may be correlated to widespread obesity in the Western world.
Dr. Skrypnik D, the lead scientist said, "In The United States it (obesity) causes more than 300 000 deaths per year. It leads to many complications, such as ischemic heart disease, hypertension, dyslipidemia, atherosclerosis, and abnormal carbohydrate metabolism".
And, " obesity is also an independent risk factor for erectile dysfunction in men. 79% of men presenting erectile disorders have a BMI of 25 kg/m2 or greater. BMI in the range 25-30 kg/m2 is associated with 1,5 times, and in the range of over 30 kg/m2 with a 3 times greater risk of sexual dysfunction".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural treatment for patients with erectile dysfunction with no side effects, researchers examined the effects of oral administration of Revactin twice daily (total daily dose of 500 mg of ginger root, Muira puama, and Paullinia cupana and 1,600 mg of L-citrulline in 54 middle-aged men with erectile dysfunction.
Based on the results from the complete IIEF-15 questionnaire [domains: erectile function (EF), orgasmic function (OF), sexual desire (SD), intercourse satisfaction (IS), overall satisfaction (OS)] at baseline (B), 1 month (M1), 2 months (M2) and 3 months (M3) and report any side effects, Revactin exerted a strong effect on the increase in median domain scores of OF, SD, IS, OS over 3 months compared to baseline median scores.
However, after taking other factors into account, statistical significance was found only in the EF, IS, and OS median domain scores.
5 patients in the study showed the reporting treatment side effects (e.g., dyspepsia, heartburn, migraine) and none considered severe.
Overall, approximately 50% of the patients reported a significant improvement in EF (P<0.05), compared to baseline.
Dr. Nguyen S, the lead scientist said, "Revactin®, a combination of 3 nutraceuticals packaged with L-citrulline, appears to have the same excellent safety profile known for each of its individual four components".
Take all together, ginger combined with other herbal medicines may be considered functional alternatives for the treatment of erectile dysfunction, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Safety and efficacy of daily Revactin® in men with erectile dysfunction: a 3-month pilot study by Nguyen S1, Rajfer J2, Shaheen M. (PubMed)
(2) Effect of ginger, Paullinia cupana, muira puama and l- citrulline, singly or in combination, on modulation of the inducible nitric oxide- NO-cGMP pathway in rat penile smooth muscle cells by Ferrini MG1, Garcia E2, Abraham A2, Artaza JN3, Nguyen S2, Rajfer J4. (PubMed)
(3) [Obesity--significant risk factor for erectile dysfunction in men].[Article in Polish] by Skrypnik D, Bogdański P, Musialik K. (PubMed)
Herbal Cascara Sagrada (Rhamnus purshiana), the Natural Antibiotic Alternative
Herbal Cascara sagrada processed a bioactive compound emodin may have a potential and profound effect on reducing the risk and treatment of bacterial infection, according to studies.
According to the statistic, infectious diseases caused the death of 9.2 million deaths in 2013 worldwide, represented 17% of all deaths.
Bacterial infection is a result of the battle of the immune system against the multiplication of bacteria in some selected tissue or organ by the pathogens after scaping the assault of white blood cell in the first line of immune defense.
Bacterial infection can be caused by the spread through infected person coughing and sneezing and contact with infected people or contaminated surfaces, food, and water.
However, the most common risk factors of bacterial infection are tissue damage or injury. Believe or not, most bacteria tries to enter the body through wound are killed off during the acute phase of infection.
At the early phase, immune not only stimulates the blood vessels constriction to produce palette to cover the wound but also activates the production of proinflammatory cytokines to the site of the damage with an aim to kill off all the micro-invaders.
Most common conventional medicine for the treatment of bacterial infection is an injection of antibiotics.
Due to overuse of such medication, some bacteria have development antibiotics resistances, such as Staphylococcus aureus ('golden staph' or MRSA) and Neisseria gonorrhoeae are now resistant to benzylpenicillin.
New antibiotics may be effective, however, they can induce some side effects. Please make sure you discuss the adverse effects with your doctor if you are currently taking some antibiotic for the treatment of infection.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America. The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on finding a natural ingredient to treat bacterial infection examined the effects of emodin against Methicillin-resistant Staphylococcus aureus (MRSA), a substantial contributor to morbidity and mortality.
In 17 different strains of the bacterium selected to the study, the combined activity of EM and two antimicrobial agents (AM, OX) against all strains resulted in a fractional inhibitory concentrations index (FICI) ranging from 0.37-0.5 and from 0.37-0.75, respectively.
The effect of EM with AM and OX was found to be synergistic or partially synergistic.
Furthermore, EM reduced the minimum inhibitory concentrations of AM and OX. EM against MRSA infection.
In the comparison of the antibacterial effects of aloe- emodin and aloe and its contents of anthraquinone compounds, researchers evaluated the antibacterial activities of the extracts from the outer leaf of Aloe saponaria Haw, aloin and aloe-emodin against three Gram-negative and two Gram-positive bacteria
Anthraquinone, aloin exhibited higher antibacterial activity [inhibition diameter > (7. 1 +/- 0.15) mm] than Aloe-emodin.
The antibacterial activity of Aloe was attributed to the concentration of anthraquinone, aloin in a dose-dependent manner.
The results clearly suggested that Aloe-emodin exerts a significant antibacterial effect to a lesser extent compared to levels of anthraquinone, aloin.
Taken altogether, herbal Cascara Sagrada processed a high amounts emodin may be considered an alternative antibiotic for the treatment of bacterial infection, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References(1) Synergistic effect of emodin in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus.by Lee YS, Kang OH, Choi JG, Oh YC, Keum JH, Kim SB, Jeong GS, Kim YC, Shin DW, Kwon DY.(PubMed)
(2) [Relationship between antibacterial activity of aloe and its anthaquinone compounds].[Article in Chinese] by Tian B, Hua YJ, Ma XQ, Wang GL.(PubMed)
According to the statistic, infectious diseases caused the death of 9.2 million deaths in 2013 worldwide, represented 17% of all deaths.
Bacterial infection is a result of the battle of the immune system against the multiplication of bacteria in some selected tissue or organ by the pathogens after scaping the assault of white blood cell in the first line of immune defense.
Bacterial infection can be caused by the spread through infected person coughing and sneezing and contact with infected people or contaminated surfaces, food, and water.
However, the most common risk factors of bacterial infection are tissue damage or injury. Believe or not, most bacteria tries to enter the body through wound are killed off during the acute phase of infection.
At the early phase, immune not only stimulates the blood vessels constriction to produce palette to cover the wound but also activates the production of proinflammatory cytokines to the site of the damage with an aim to kill off all the micro-invaders.
Most common conventional medicine for the treatment of bacterial infection is an injection of antibiotics.
Due to overuse of such medication, some bacteria have development antibiotics resistances, such as Staphylococcus aureus ('golden staph' or MRSA) and Neisseria gonorrhoeae are now resistant to benzylpenicillin.
New antibiotics may be effective, however, they can induce some side effects. Please make sure you discuss the adverse effects with your doctor if you are currently taking some antibiotic for the treatment of infection.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America. The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on finding a natural ingredient to treat bacterial infection examined the effects of emodin against Methicillin-resistant Staphylococcus aureus (MRSA), a substantial contributor to morbidity and mortality.
In 17 different strains of the bacterium selected to the study, the combined activity of EM and two antimicrobial agents (AM, OX) against all strains resulted in a fractional inhibitory concentrations index (FICI) ranging from 0.37-0.5 and from 0.37-0.75, respectively.
The effect of EM with AM and OX was found to be synergistic or partially synergistic.
Furthermore, EM reduced the minimum inhibitory concentrations of AM and OX. EM against MRSA infection.
In the comparison of the antibacterial effects of aloe- emodin and aloe and its contents of anthraquinone compounds, researchers evaluated the antibacterial activities of the extracts from the outer leaf of Aloe saponaria Haw, aloin and aloe-emodin against three Gram-negative and two Gram-positive bacteria
Anthraquinone, aloin exhibited higher antibacterial activity [inhibition diameter > (7. 1 +/- 0.15) mm] than Aloe-emodin.
The antibacterial activity of Aloe was attributed to the concentration of anthraquinone, aloin in a dose-dependent manner.
The results clearly suggested that Aloe-emodin exerts a significant antibacterial effect to a lesser extent compared to levels of anthraquinone, aloin.
Taken altogether, herbal Cascara Sagrada processed a high amounts emodin may be considered an alternative antibiotic for the treatment of bacterial infection, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References(1) Synergistic effect of emodin in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus.by Lee YS, Kang OH, Choi JG, Oh YC, Keum JH, Kim SB, Jeong GS, Kim YC, Shin DW, Kwon DY.(PubMed)
(2) [Relationship between antibacterial activity of aloe and its anthaquinone compounds].[Article in Chinese] by Tian B, Hua YJ, Ma XQ, Wang GL.(PubMed)
Sunday, April 7, 2019
Ginger, The Natural Anti Oral Cancer Herbal Remedy with No Side Effects
Oral cancer also known as mouth cancer is a medical condition characterized by irregular cell growth in the tissue of the oral cavity, due to the alternation of cell DNA.
Most cases of oral cancer begin in the cells on the surface of the inner lining of oral tissue.
However, at the advanced stage, oral cancer cells can travel a distance away to infect other healthy tissue and organs, leading to the secondary metastasis.
According to the statistic provided by the American Cancer Society, in 2018, approximately 51,540 people were diagnosed with oral cavity or oropharyngeal cancer. The disease causes the death of an estimated 10,030 people.
The 5-year survival rate of oral cancer is 66%, including all stages.
Family history, smoking, alcohol drinking, infected by HPV virus, poor hygiene and genetic preposition are some of the risk factors associated with the disease.
Some researchers suggested that oral sex may be one of the major prevalent risk factors involved in the development of oral cancer. Dr. Rajiv Saini in the examination of the connection of oral sex and oral cancer, wrote, "The diverse conduit in the oral cavity that provides as a gateway of exposure of infection from the oral cavity to bloodstream include any open sores, cuts, abrasions, or bleeding gum disease such as gingivitis and periodontitis".
"Accumulating molecular and pathologic evidence has strengthened the hypothesis that HPV infection could play a role in the etiology of some oral squamous cell carcinomas.
And, "To reduce the risk of infection during unprotected oral sex, limit exposure to sexual fluids and ensure that no cuts or lesions are present in the mouth or on the genitals. Good oral health, free from bleeding gums, lip sores, cuts, broken skin, and oral epithelium, enormously reduces the chances of transmission of infection among the partners indulging in oral sex".
These results strongly suggested people who perform oral sex before, during and after sexual intercourse may be at risk of oral cancer due to infected by the HPV virus.
Researchers on finding a natural compound for the inhibition of oral cancer examined the [6]-Shogaol ([6]-SHO), a major constituent of ginger anti-tumor activity.
[6]-SHO showed a significant effect in preventing oral squamous cell carcinoma by activating proapoptotic factors in vitro and in vivo experimental model.
In the inflammation and cell proliferation assays, injection of [6]-SHO inhibited the oral cancer cell line through cytotoxicity induced by the expression of proinflammatory cytokines, proteins associated with cell apoptosis and anti-cell survival mechanisms.
Furthermore, in the oral cancer cells, oral administration of [6]-SHO strongly inhibited phosphorylation in stimulating the enzymes which carry energy the cancer cells and enzymes in the degradation of cellular response to inflammation.
Dr. Annamalai G, the lead scientist said, " [6]-SHO is a novel functional agent capable of preventing DMBA induced inflammation and cell proliferation associated tumorigenesis by modulating multiple signaling molecules".
Additionally, in order to reveal more information about 6-Gingerol anti-oral cancer properties, researchers investigated the compound in human oral (SCC4, KB) with or without wortmannin, rapamycin, and cisplatin.
6-Gingerol showed dose-dependent cytotoxicity in the oral cell line.
Combinations of 6-gingerol with wortmannin and cisplatin showed additive effects, while with rapamycin, it showed 50% cytotoxicity equivalent to that of IC50 of 6-gingerol alone.
Treatment with 6-gingerol exhibited S-phase arrest in SCC4 cells. But 6-Gingerol, wortmannin, and rapamycin treatment showed almost two-fold higher expression of proteins associated with cancer cells apoptosis.
Dr. in the final report wrote," 6-gingerol appears to be a safe and potent chemotherapeutic/chemopreventive compound acting through cell cycle arrest and induction of apoptosis in human oral....cells".
Taken altogether, ginger processed bioactive ingredient 6-gingerol and [6]-Shogaol may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of oral cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) [6]-Shogaol attenuates inflammation, cell proliferation via modulate NF-κB and AP-1 oncogenic signaling in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis by Annamalai G1, Suresh K. (PubMed)
(2) 6-Gingerol Mediates its Anti Tumor Activities in Human Oral and Cervical Cancer Cell Lines through Apoptosis and Cell Cycle Arrest by Kapoor V1, Aggarwal S1, Das SN. (PubMed)
(3) Oral sex and oral cancer: A virus link by Rajiv Saini. (PMC)
Most cases of oral cancer begin in the cells on the surface of the inner lining of oral tissue.
However, at the advanced stage, oral cancer cells can travel a distance away to infect other healthy tissue and organs, leading to the secondary metastasis.
According to the statistic provided by the American Cancer Society, in 2018, approximately 51,540 people were diagnosed with oral cavity or oropharyngeal cancer. The disease causes the death of an estimated 10,030 people.
The 5-year survival rate of oral cancer is 66%, including all stages.
Family history, smoking, alcohol drinking, infected by HPV virus, poor hygiene and genetic preposition are some of the risk factors associated with the disease.
Some researchers suggested that oral sex may be one of the major prevalent risk factors involved in the development of oral cancer. Dr. Rajiv Saini in the examination of the connection of oral sex and oral cancer, wrote, "The diverse conduit in the oral cavity that provides as a gateway of exposure of infection from the oral cavity to bloodstream include any open sores, cuts, abrasions, or bleeding gum disease such as gingivitis and periodontitis".
"Accumulating molecular and pathologic evidence has strengthened the hypothesis that HPV infection could play a role in the etiology of some oral squamous cell carcinomas.
And, "To reduce the risk of infection during unprotected oral sex, limit exposure to sexual fluids and ensure that no cuts or lesions are present in the mouth or on the genitals. Good oral health, free from bleeding gums, lip sores, cuts, broken skin, and oral epithelium, enormously reduces the chances of transmission of infection among the partners indulging in oral sex".
These results strongly suggested people who perform oral sex before, during and after sexual intercourse may be at risk of oral cancer due to infected by the HPV virus.
Researchers on finding a natural compound for the inhibition of oral cancer examined the [6]-Shogaol ([6]-SHO), a major constituent of ginger anti-tumor activity.
[6]-SHO showed a significant effect in preventing oral squamous cell carcinoma by activating proapoptotic factors in vitro and in vivo experimental model.
In the inflammation and cell proliferation assays, injection of [6]-SHO inhibited the oral cancer cell line through cytotoxicity induced by the expression of proinflammatory cytokines, proteins associated with cell apoptosis and anti-cell survival mechanisms.
Furthermore, in the oral cancer cells, oral administration of [6]-SHO strongly inhibited phosphorylation in stimulating the enzymes which carry energy the cancer cells and enzymes in the degradation of cellular response to inflammation.
Dr. Annamalai G, the lead scientist said, " [6]-SHO is a novel functional agent capable of preventing DMBA induced inflammation and cell proliferation associated tumorigenesis by modulating multiple signaling molecules".
Additionally, in order to reveal more information about 6-Gingerol anti-oral cancer properties, researchers investigated the compound in human oral (SCC4, KB) with or without wortmannin, rapamycin, and cisplatin.
6-Gingerol showed dose-dependent cytotoxicity in the oral cell line.
Combinations of 6-gingerol with wortmannin and cisplatin showed additive effects, while with rapamycin, it showed 50% cytotoxicity equivalent to that of IC50 of 6-gingerol alone.
Treatment with 6-gingerol exhibited S-phase arrest in SCC4 cells. But 6-Gingerol, wortmannin, and rapamycin treatment showed almost two-fold higher expression of proteins associated with cancer cells apoptosis.
Dr. in the final report wrote," 6-gingerol appears to be a safe and potent chemotherapeutic/chemopreventive compound acting through cell cycle arrest and induction of apoptosis in human oral....cells".
Taken altogether, ginger processed bioactive ingredient 6-gingerol and [6]-Shogaol may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of oral cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) [6]-Shogaol attenuates inflammation, cell proliferation via modulate NF-κB and AP-1 oncogenic signaling in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis by Annamalai G1, Suresh K. (PubMed)
(2) 6-Gingerol Mediates its Anti Tumor Activities in Human Oral and Cervical Cancer Cell Lines through Apoptosis and Cell Cycle Arrest by Kapoor V1, Aggarwal S1, Das SN. (PubMed)
(3) Oral sex and oral cancer: A virus link by Rajiv Saini. (PMC)
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