Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Fructooligosaccharides (FOS), are oligosaccharide, a molecule made up of a small group of these sugar,
Due to its nature as a natural source of sugar and low in calories, FOS may be used as an alternative sweetener as intake of FOS does not cause a spike in blood sugar.
FOS are considered prebiotics. Intake of FOS can increase the levels of good bacteria in the intestine, leading to a healthy ratio of gut microbiota.
Digestively, FOS contains high levels of soluble fiber which has been found to improve bowel function. Consumption of FOS also increased fecal bolus and the frequency of depositions, while a dose of 4-15 g/day given to healthy subjects has been found to reduce constipation.
According to the study, FOS also showed anti toxicity, carcinogenicity, and genotoxic effects.
FOS improved mineral absorption by decreasing levels of pH in the colon, thus facilitating the absorption of mineral ions from the intestine, mainly calcium and magnesium
Furthermore, FOS also found in studies decrease levels of serum cholesterol, triacylglycerols, the lead causes of cardiovascular diseases.
By modulating the levels of phospholipids, FOS lower the risk of coronary heart disease, inflammation or cancer, particularly in colon cancer.
In foods, FOS are increasingly included in food products and infant formulas for their prebiotic effect in stimulating the growth of nonpathogenic intestinal microflora.
In the examined the effects of chronic ingestion of short-chain fructooligosaccharides (FOS), an indigestible carbohydrate, on hepatic glucose production, insulin-mediated glucose metabolism, erythrocyte insulin binding, and blood lipids in 12 healthy volunteers selected received either 20 g FOS/d or sucrose for 4 wk in a double-blind crossover design, researchers found that the mean (+/- SEM) basal hepatic glucose production was lower after FOS than after sucrose consumption, through the effects on insulin-stimulated glucose metabolism in healthy subjects.
Taken altogether, artichoke processed many health benefits may be used as a functional remedy for diseases prevention in healthy subjects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Dietary fructooligosaccharides and potential benefits on health by Sabater-Molina M1, Larqué E, Torrella F, Zamora S. (PubMed)
(2) Chronic consumption of short-chain fructooligosaccharides by healthy subjects decreased basal hepatic glucose production but had no effect on insulin-stimulated glucose metabolism by Luo J1, Rizkalla SW, Alamowitch C, Boussairi A, Blayo A, Barry JL, Laffitte A, Guyon F, Bornet FR, Slama G. (PubMed)
(3) Fructooligosaccharides: a review by Fishbein L1, Kaplan M, Gough M. (PubMed)
(4) Fructooligosaccharides: Applications and Health benefits- a review by SHUBHANGI S. KHANVILKAR, Shalini S. Arya*
Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.
Friday, May 3, 2019
Cucumber (Cucumis sativus) Cucurbitacin B (CuB) The Potential and Natural Anti Chronic Myeloid Leukaemia Functional Food
Chronic myeloid leukemia (CML) also known as chronic myelogenous leukemia is a type of leukemia associated with certain blood-forming cells of the bone marrow.
Chronic myeloid leukemia (CML) is a slow growing cancer compared to the acute forms of leukemia.
In the US, most cases of chronic myelogenous leukemia are found in adults age of 65 and older.
According to the American Cancer Society, approximately, 8,990 new cases will be diagnosed with CML (5,250 in men and 3,740 in women) in 2019. CML also will cause the death of 1,140 patients (660 men and 480 women) in the same years.
The lifetime risk of CML is 1 in 526 in the United States.
CML besides sharing the common of symptoms of other types of cancer, the condition also induce symptoms of easy bleeding, pain or fullness below the ribs on the left side, pale skin and sweating excessively during sleep (night sweats).
If you are experiencing some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
Today, due to new drug discovery and improvement of technology, the 5-year survival rate for CML is 68% compared to only 31% in the early 1990s.
Out of many risk factors such as radiotherapy, gender, and aging, some researchers suggested that obesity may be one of the main factors that elevated the risk of the disease.
Dr. Strom SS, the lead researchers in the cancer team at the University of Texas M. D. Anderson Cancer Center wrote, " Obesity, measured as body mass index, has been identified as a possible risk factor for several solid tumors as well as some adult hematopoietic malignancies".
And, "Obesity at all ages was found to be an independent risk factor, with a significant dose-response effect. Among participants > or =45 years, cases gained significantly more weight each year between ages 25 and 40 compared with controls (0.78 versus 0.44 kg/y, P < 0.001) with the association strongest among those who gained >1 kg/y between 25 and 40 years of age (OR, 3.63; 95% CI, 1.46-9.04). Our results suggest that obesity and adulthood weight gain play important roles in CML risk".
The findings strongly suggested that obese are more likely to develop CML, compared to those with normal weight.
Cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
On finding a natural and potential compound for the treatment of chronic myeloid leukemia, researchers examined the Cucurbitacin B (CuB) antiproliferative effects on various leukemia cell lines.
Administration of CuB showed strong inhibition against various leukemia, lymphoma cell lines, primary mononuclear bone marrow cells derived from patients with acute myeloid leukemia or myelodysplastic syndrome.
CuB induced myeloid leukemic cells apoptosis through S-phase cell cycle arrest, enlarged cell size, multinucleation, and enhanced expression of a monocytic- and granulocytic-specific CD11b involved in numerous adhesion-related associations between cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes.
Furthermore, CuB prominently altered the cytoskeletal network of leukemic cells, leading to cell death.
In order to obtain additional information about cucurbitacin B (CuB) anti myeloid leukemia activity, researchers explored the antitumor effect and action mechanism of cucurbitacin B (CuB) on human T-cell leukemia Jurkat cells.
According to the tested assays, CuB inhibited the proliferation of Jurkat cells in a dose-dependent manner and induced G 2 /M phase arrest.
CuB induced around 10% of cells undergoing apoptosis, after treatment for 24 h.
Moreover, CuB induced cancer cell autophagy observed by the accumulation of LC3-II, an indication of cleaning out damaged cells and regenerating new ones.
The results of autophagy were found to be activated by the protein associated with a significantly increased rate of recurrence and deaths.
Taken altogether, cucumber processed a higher number of CuB may be used for the treatment of leukemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells by Haritunians T1, Gueller S, Zhang L, Badr R, Yin D, Xing H, Fung MC, Koeffler HP. (PubMed)
(2) Cucurbitacin B induces cell cycle arrest, apoptosis and autophagy associated with G actin reduction and persistent activation of cofilin in Jurkat cells by Zhu JS1, Ouyang DY, Shi ZJ, Xu LH, Zhang YT, He XH. (PubMed)
(3) Obesity, weight gain, and risk of chronic myeloid leukemia by Strom SS1, Yamamura Y, Kantarijian HM, Cortes-Franco JE. (PubMeb)
Chronic myeloid leukemia (CML) is a slow growing cancer compared to the acute forms of leukemia.
In the US, most cases of chronic myelogenous leukemia are found in adults age of 65 and older.
According to the American Cancer Society, approximately, 8,990 new cases will be diagnosed with CML (5,250 in men and 3,740 in women) in 2019. CML also will cause the death of 1,140 patients (660 men and 480 women) in the same years.
The lifetime risk of CML is 1 in 526 in the United States.
CML besides sharing the common of symptoms of other types of cancer, the condition also induce symptoms of easy bleeding, pain or fullness below the ribs on the left side, pale skin and sweating excessively during sleep (night sweats).
If you are experiencing some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
Today, due to new drug discovery and improvement of technology, the 5-year survival rate for CML is 68% compared to only 31% in the early 1990s.
Out of many risk factors such as radiotherapy, gender, and aging, some researchers suggested that obesity may be one of the main factors that elevated the risk of the disease.
Dr. Strom SS, the lead researchers in the cancer team at the University of Texas M. D. Anderson Cancer Center wrote, " Obesity, measured as body mass index, has been identified as a possible risk factor for several solid tumors as well as some adult hematopoietic malignancies".
And, "Obesity at all ages was found to be an independent risk factor, with a significant dose-response effect. Among participants > or =45 years, cases gained significantly more weight each year between ages 25 and 40 compared with controls (0.78 versus 0.44 kg/y, P < 0.001) with the association strongest among those who gained >1 kg/y between 25 and 40 years of age (OR, 3.63; 95% CI, 1.46-9.04). Our results suggest that obesity and adulthood weight gain play important roles in CML risk".
The findings strongly suggested that obese are more likely to develop CML, compared to those with normal weight.
Cucumber plant is a species of Cucumis Sativus, belonging to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
On finding a natural and potential compound for the treatment of chronic myeloid leukemia, researchers examined the Cucurbitacin B (CuB) antiproliferative effects on various leukemia cell lines.
Administration of CuB showed strong inhibition against various leukemia, lymphoma cell lines, primary mononuclear bone marrow cells derived from patients with acute myeloid leukemia or myelodysplastic syndrome.
CuB induced myeloid leukemic cells apoptosis through S-phase cell cycle arrest, enlarged cell size, multinucleation, and enhanced expression of a monocytic- and granulocytic-specific CD11b involved in numerous adhesion-related associations between cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes.
Furthermore, CuB prominently altered the cytoskeletal network of leukemic cells, leading to cell death.
In order to obtain additional information about cucurbitacin B (CuB) anti myeloid leukemia activity, researchers explored the antitumor effect and action mechanism of cucurbitacin B (CuB) on human T-cell leukemia Jurkat cells.
According to the tested assays, CuB inhibited the proliferation of Jurkat cells in a dose-dependent manner and induced G 2 /M phase arrest.
CuB induced around 10% of cells undergoing apoptosis, after treatment for 24 h.
Moreover, CuB induced cancer cell autophagy observed by the accumulation of LC3-II, an indication of cleaning out damaged cells and regenerating new ones.
The results of autophagy were found to be activated by the protein associated with a significantly increased rate of recurrence and deaths.
Taken altogether, cucumber processed a higher number of CuB may be used for the treatment of leukemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of CuB in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells by Haritunians T1, Gueller S, Zhang L, Badr R, Yin D, Xing H, Fung MC, Koeffler HP. (PubMed)
(2) Cucurbitacin B induces cell cycle arrest, apoptosis and autophagy associated with G actin reduction and persistent activation of cofilin in Jurkat cells by Zhu JS1, Ouyang DY, Shi ZJ, Xu LH, Zhang YT, He XH. (PubMed)
(3) Obesity, weight gain, and risk of chronic myeloid leukemia by Strom SS1, Yamamura Y, Kantarijian HM, Cortes-Franco JE. (PubMeb)
Thursday, May 2, 2019
Phytochemical Alliin Balances the Gut Microbiota and Proinflammatory Cytokines for Optimal Immunity
Gut microbiota refers to the population of microbes living in the gut. The community contains tens of trillions of microorganisms with over 1000 different species of bacterias.
The gut microbiota plays a vital role in human health, including the key processes of nutrition-enhancing the digestive functioning, lipid, and energy metabolism by inducing the production of short chain fatty acids (SCFAs), phenolics, and other molecules, and pathogen resistance by promoting the immune function.
In a healthy individual, the levels of gut microbiota are balanced that allow the body to function in an optimal way.
Furthermore, gut microbiota also is found to stimulate the production of some vitamins (B and K), digest certain foods that the stomach and small intestine have not been able to digest, particularly in the combat against the aggression of other bad microorganisms.
However, alterations in gut microbiota composition have been found in patients with a low-grade inflammatory state, leading to an increased risk of several diseases, including type 2 diabetes mellitus and cardiovascular disease.
Although the digestive tract can adapt to change, the loss of balance in gut microbiota may induce dysbiosis., leading to health problems of functional bowel disorders, inflammatory bowel disease, allergies, obesity, and diabetes.
The are many risk factors associated with gut microbiota imbalance. Some researchers suggested that the major causes of the condition may be a result of the promotion of a high-fat diet over the past few decades.
Dr. Duo Li, at the Institute of Nutrition and Health at Qingdao University in China, and colleagues wrote, "“Western-type diet has a strong effect on the genetic composition and metabolic activity of gut microbiota,” they wrote. “Evidence has shown that in humans gut microbiota diversity and richness are reduced when comparing such high-fat diets with more traditional diets with relatively higher proportions of carbohydrate. Such diet-induced ‘dysbiosis’ in gut-associated microbial communities has been postulated as a major trigger of metabolic impairments associated with obesity".
Alliin (S-allyl-L-cysteine-S-oxour intestinal chemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a natural ingredient with immunomodulatory activity, researchers examined the effect of the garlic derivative alliin, on the mitogen-induced peripheral blood mononuclear cell (PBMC) proliferation and cytokine production in vitro.
Before treated with garlic derivative alliin, pokeweed mitogen (PWM) injection induced cell proliferation, production of proinflammatory cytokines, including IL-1beta and TNF-alpha.
Furthermore, pokeweed mitogen (PWM) treated group also showed the reduced levels of both percentage of phagocyting cells and number of latex particles associated with the immune functions of phagocytosis.
Administration of garlic derivative alliin not decreased only the production of proinflammatory cytokines induced by pokeweed mitogen (PWM) but also improved the levels of antioxidant enzymes.
In other words, alliin exerted an immunomodulatory effect on the peripheral blood cells in vitro.
On finding a natural compound for the improvement of the ratio of gut microbiota, researchers examined whether different plant-derived components with similar anti-oxidative and anti-inflammatory function such as quercetin and alliin in traditional Asian diet on the status of the gut microbiota and colonic epithelial immunity.
Traditional Asian diet significantly increased reshaped the gut microbiota composition by significantly increased the relative abundance of fecal Firmicutes and Cyanobacteria but decreased that of Bacteroidetes (P < 0.05) and increased the relative abundance of Candidatus Arthromitus, Lactococcus, Geobacillus, and Ruminococcus at the genus level that benefits the host's health.
In other words, the traditional Asian diet reduced the expression of bad bacteria and increased the good bacteria in the gut.
The consumption of quercetin and alliin also altered 13 genes expression involved in the KEGG pathways immunomodulatory effect in improving the gut immunity through their anti-inflammatory and anti-free radical activities.
In other words, the alternate consumption of quercetin and alliin can contribute beneficial metabolic effects by optimizing gut microbiota by improving the immunologic function of colonic epithelial cells associated with the innate immune defense.
Taken altogether, alliin may be considered supplements for improvement of gut microbiota inducing immunologic function of colonic epithelial cells associated with the innate immune defense, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The Alternate Consumption of Quercetin and Alliin in the Traditional Asian Diet Reshaped Microbiota and Altered Gene Expression of Colonic Epithelial Cells in Rats by Yu J1, Guo H1, Xie J1, Luo J1, Li Y1, Liu L1, Ou S1, Zhang G1, Peng X. (PubMed)
(2) High-fat diet linked to unfavorable gut microbiota changes by Wan Y. (Healio Gastroenterology)
The gut microbiota plays a vital role in human health, including the key processes of nutrition-enhancing the digestive functioning, lipid, and energy metabolism by inducing the production of short chain fatty acids (SCFAs), phenolics, and other molecules, and pathogen resistance by promoting the immune function.
In a healthy individual, the levels of gut microbiota are balanced that allow the body to function in an optimal way.
Furthermore, gut microbiota also is found to stimulate the production of some vitamins (B and K), digest certain foods that the stomach and small intestine have not been able to digest, particularly in the combat against the aggression of other bad microorganisms.
However, alterations in gut microbiota composition have been found in patients with a low-grade inflammatory state, leading to an increased risk of several diseases, including type 2 diabetes mellitus and cardiovascular disease.
Although the digestive tract can adapt to change, the loss of balance in gut microbiota may induce dysbiosis., leading to health problems of functional bowel disorders, inflammatory bowel disease, allergies, obesity, and diabetes.
The are many risk factors associated with gut microbiota imbalance. Some researchers suggested that the major causes of the condition may be a result of the promotion of a high-fat diet over the past few decades.
Dr. Duo Li, at the Institute of Nutrition and Health at Qingdao University in China, and colleagues wrote, "“Western-type diet has a strong effect on the genetic composition and metabolic activity of gut microbiota,” they wrote. “Evidence has shown that in humans gut microbiota diversity and richness are reduced when comparing such high-fat diets with more traditional diets with relatively higher proportions of carbohydrate. Such diet-induced ‘dysbiosis’ in gut-associated microbial communities has been postulated as a major trigger of metabolic impairments associated with obesity".
Alliin (S-allyl-L-cysteine-S-oxour intestinal chemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find a natural ingredient with immunomodulatory activity, researchers examined the effect of the garlic derivative alliin, on the mitogen-induced peripheral blood mononuclear cell (PBMC) proliferation and cytokine production in vitro.
Before treated with garlic derivative alliin, pokeweed mitogen (PWM) injection induced cell proliferation, production of proinflammatory cytokines, including IL-1beta and TNF-alpha.
Furthermore, pokeweed mitogen (PWM) treated group also showed the reduced levels of both percentage of phagocyting cells and number of latex particles associated with the immune functions of phagocytosis.
Administration of garlic derivative alliin not decreased only the production of proinflammatory cytokines induced by pokeweed mitogen (PWM) but also improved the levels of antioxidant enzymes.
In other words, alliin exerted an immunomodulatory effect on the peripheral blood cells in vitro.
On finding a natural compound for the improvement of the ratio of gut microbiota, researchers examined whether different plant-derived components with similar anti-oxidative and anti-inflammatory function such as quercetin and alliin in traditional Asian diet on the status of the gut microbiota and colonic epithelial immunity.
Traditional Asian diet significantly increased reshaped the gut microbiota composition by significantly increased the relative abundance of fecal Firmicutes and Cyanobacteria but decreased that of Bacteroidetes (P < 0.05) and increased the relative abundance of Candidatus Arthromitus, Lactococcus, Geobacillus, and Ruminococcus at the genus level that benefits the host's health.
In other words, the traditional Asian diet reduced the expression of bad bacteria and increased the good bacteria in the gut.
The consumption of quercetin and alliin also altered 13 genes expression involved in the KEGG pathways immunomodulatory effect in improving the gut immunity through their anti-inflammatory and anti-free radical activities.
In other words, the alternate consumption of quercetin and alliin can contribute beneficial metabolic effects by optimizing gut microbiota by improving the immunologic function of colonic epithelial cells associated with the innate immune defense.
Taken altogether, alliin may be considered supplements for improvement of gut microbiota inducing immunologic function of colonic epithelial cells associated with the innate immune defense, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The Alternate Consumption of Quercetin and Alliin in the Traditional Asian Diet Reshaped Microbiota and Altered Gene Expression of Colonic Epithelial Cells in Rats by Yu J1, Guo H1, Xie J1, Luo J1, Li Y1, Liu L1, Ou S1, Zhang G1, Peng X. (PubMed)
(2) High-fat diet linked to unfavorable gut microbiota changes by Wan Y. (Healio Gastroenterology)
Herbal Turmeric Protects the Bone Cells Integrity Against Osteoporosis
Osteoporosis is a medical condition characterized by the loss of bone density.
In other words, the bone disease is a result of overexpression of bone loss due to bone resorption compared to bone made by the body, leading to risk bone fracture and breaking.
In a severe case, bones of patients with osteoporosis may become so weak, they can break from a fall or even from sneezing or minor bumps.
Microscopy, healthy bone processed a high density (fewer spaces and small holes in the honeycomb) compared to low density ( large spaces and holes in a honeycomb) in the patients with osteoporosis.
In the US, due to the widespread osteoporosis in the elderly, the disease has become a concern of the scientist community. Believe it or not, according to the statistics, osteoporosis is responsible for two million broken bones and $19 billion in related costs every year.
As the condition continues to worsen, by 2025, osteoporosis will be responsible for approximately three million fractures and $25.3 billion in costs annually.
According to the statistics, in Canada, osteoporosis affects approximately 1.4 million Canadians, mainly in the postmenopausal women and the elderly.
Additionally, 1 in 4 women and more than 1 in 8 men over the age of 50 years, with 1 in 4 men and women are having evidence of a vertebral fracture.
Out of many risk factors associated with the onset of osteoporosis, some researchers suggested that the disease may be correlated to the promotion of Western diet over the past few decades.
Dr. Seon-Joo Park, the lead scientist wrote, "(In the comparison of ) "Three major dietary patterns,... using factor analysis based on baseline intake data: traditional (high intake of rice, kimchi, and vegetables), dairy (high intake of milk, dairy products, and green tea), and western (high intake of sugar, fat, and bread).".
And, "..., western dietary pattern (p-trend = 0.043 in radius) demonstrated a higher risk of osteoporosis incidence than those in the lowest quintile".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of osteoporosis, researchers evaluated the efficacy, in term of changes in bone density, and safety of an oral formulation based on turmeric phytosome (Meriva®), in subjects suffering from low bone density.
The study included a total of 57 otherwise healthy subjects with low bone density who freely decided to follow either standard management (SM) to control low bone density (control group=28) or SM associated with a curcumin-based oral supplementation (supplement group=29).
Meriva®-supplemented group remarkably improved in the bone density of the heel measured by the Sahara densitometer accompanied by a significant decrease of ultrasounds transmission values at week 12 (-18.4%) and at week 24 (-21.0%), compared with baseline.
Furthermore, Meriva®-supplemented group also improved the bone densities of small finger and upper jaw with no adverse effects.
Based on the results researchers said, "This preliminary study suggests that a curcumin-based supplementation in combination with an appropriate lifestyle could be beneficial in the prevention and management of osteopenia".
In order to know more information about turmeric anti-osteoporosis activity, researchers examined the effects of curcumin on oxidative stress-induced osteoblast apoptosis.
The study included an osteoblastic cell line (Saos-2) exposed to various concentrations of H2O2 with or without curcumin treatment.
Injection of curcumin protected the viability of Saos-2 cells against the exposure to H2O2 and attenuated H2O2-induced apoptosis.
Furthermore, curcumin also improved the cellular function by preserving the mitochondrial redox potential, decreasing the mitochondrial oxidative status, through its antioxidants activity.
Moreover, curcumin treatment markedly increased levels of phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3β (GSK3β) that have been found to induced bone loss in low levels.
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of osteoporosis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of curcumin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of a curcumin-based supplementation in asymptomatic subjects with low bone density: a preliminary 24-week supplement study by Riva A1, Togni S, Giacomelli L, Franceschi F, Eggenhoffner R, Feragalli B, Belcaro G, Cacchio M, Shu H, Dugall M. (PubMed)
(2) Attenuation of Oxidative Stress-Induced Osteoblast Apoptosis by Curcumin is Associated with Preservation of Mitochondrial Functions and Increased Akt-GSK3β Signaling by Dai P, Mao Y, Sun X, Li X, Muhammad I, Gu W, Zhang D, Zhou Y, Ni Z, Ma J, Huang S. (PubMed)
(3) Dietary Patterns and Osteoporosis Risk in Postmenopausal Korean Women by Seon-Joo Park, Seong-Eun Joo, Haesook Min, Jae Kyung Park, Yeonjung Kim, Sung Soo Kim, and Younjhin Ahn. (PMC)
In other words, the bone disease is a result of overexpression of bone loss due to bone resorption compared to bone made by the body, leading to risk bone fracture and breaking.
In a severe case, bones of patients with osteoporosis may become so weak, they can break from a fall or even from sneezing or minor bumps.
Microscopy, healthy bone processed a high density (fewer spaces and small holes in the honeycomb) compared to low density ( large spaces and holes in a honeycomb) in the patients with osteoporosis.
In the US, due to the widespread osteoporosis in the elderly, the disease has become a concern of the scientist community. Believe it or not, according to the statistics, osteoporosis is responsible for two million broken bones and $19 billion in related costs every year.
As the condition continues to worsen, by 2025, osteoporosis will be responsible for approximately three million fractures and $25.3 billion in costs annually.
According to the statistics, in Canada, osteoporosis affects approximately 1.4 million Canadians, mainly in the postmenopausal women and the elderly.
Additionally, 1 in 4 women and more than 1 in 8 men over the age of 50 years, with 1 in 4 men and women are having evidence of a vertebral fracture.
Out of many risk factors associated with the onset of osteoporosis, some researchers suggested that the disease may be correlated to the promotion of Western diet over the past few decades.
Dr. Seon-Joo Park, the lead scientist wrote, "(In the comparison of ) "Three major dietary patterns,... using factor analysis based on baseline intake data: traditional (high intake of rice, kimchi, and vegetables), dairy (high intake of milk, dairy products, and green tea), and western (high intake of sugar, fat, and bread).".
And, "..., western dietary pattern (p-trend = 0.043 in radius) demonstrated a higher risk of osteoporosis incidence than those in the lowest quintile".
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of osteoporosis, researchers evaluated the efficacy, in term of changes in bone density, and safety of an oral formulation based on turmeric phytosome (Meriva®), in subjects suffering from low bone density.
The study included a total of 57 otherwise healthy subjects with low bone density who freely decided to follow either standard management (SM) to control low bone density (control group=28) or SM associated with a curcumin-based oral supplementation (supplement group=29).
Meriva®-supplemented group remarkably improved in the bone density of the heel measured by the Sahara densitometer accompanied by a significant decrease of ultrasounds transmission values at week 12 (-18.4%) and at week 24 (-21.0%), compared with baseline.
Furthermore, Meriva®-supplemented group also improved the bone densities of small finger and upper jaw with no adverse effects.
Based on the results researchers said, "This preliminary study suggests that a curcumin-based supplementation in combination with an appropriate lifestyle could be beneficial in the prevention and management of osteopenia".
In order to know more information about turmeric anti-osteoporosis activity, researchers examined the effects of curcumin on oxidative stress-induced osteoblast apoptosis.
The study included an osteoblastic cell line (Saos-2) exposed to various concentrations of H2O2 with or without curcumin treatment.
Injection of curcumin protected the viability of Saos-2 cells against the exposure to H2O2 and attenuated H2O2-induced apoptosis.
Furthermore, curcumin also improved the cellular function by preserving the mitochondrial redox potential, decreasing the mitochondrial oxidative status, through its antioxidants activity.
Moreover, curcumin treatment markedly increased levels of phosphorylated protein kinase B (Akt) and phosphorylated glycogen synthase kinase-3β (GSK3β) that have been found to induced bone loss in low levels.
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention and treatment of osteoporosis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of curcumin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of a curcumin-based supplementation in asymptomatic subjects with low bone density: a preliminary 24-week supplement study by Riva A1, Togni S, Giacomelli L, Franceschi F, Eggenhoffner R, Feragalli B, Belcaro G, Cacchio M, Shu H, Dugall M. (PubMed)
(2) Attenuation of Oxidative Stress-Induced Osteoblast Apoptosis by Curcumin is Associated with Preservation of Mitochondrial Functions and Increased Akt-GSK3β Signaling by Dai P, Mao Y, Sun X, Li X, Muhammad I, Gu W, Zhang D, Zhou Y, Ni Z, Ma J, Huang S. (PubMed)
(3) Dietary Patterns and Osteoporosis Risk in Postmenopausal Korean Women by Seon-Joo Park, Seong-Eun Joo, Haesook Min, Jae Kyung Park, Yeonjung Kim, Sung Soo Kim, and Younjhin Ahn. (PMC)
Wednesday, May 1, 2019
Bilberry, the Best Neuro-Protective Functional Remedy, According to Medical Literature
Scientists may have found a herbal remedy which processes a neuron-protective effect against brain diseases, according to studies.
Neurological disorders are diseases associated with the brain, spine, and nerves. In other words, they are diseases of the central nervous system.
There are many risk factors involved in the incidence of neurological disorders, including unhealthy lifestyle, infections, genetics preposition, and physical injury.
Oxidative stress is a result of an imbalance of the ratio of levels of free radicals and antioxidant caused either by overexpression of free radicals or depletion of antioxidants enzymes or both.
Free radicals can be produced internally by normal cellular metabolism or from the external sources such as the air we breathe, smoking. Free radicals are unstable molecules with unpaired electrons on the outer ring.
In order for them to maintain stable, free radicals must either donate an electron or intercept an electron from other atoms, leading to a chain reaction that can not stop[ed until the outer ring electron is paired or inhibited by antioxidants.
Oxidative stress has been found to be a major risk for the onset of the neurological disorder in the Western world, particularly in North American.
Dr. Carvalho AN, the lead scientist in the assessment of oxidative stress and antioxidants in neurological diseases, said, "Oxidative stress is a pathological feature common to a multitude of neurological diseases. The production of reactive oxygen species (ROS) is the main mechanism underlying this cellular redox imbalance".
And, "overview of the main players in oxidative stress and outline evidence of their involvement in Parkinson's disease, Alzheimer's disease, Huntington's disease, and multiple sclerosis".
The results clearly suggested the impact of oxidative stress in the facilitation of the onset of neurodegenerative diseases.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Scientists on finding a natural ingredient which processes neuroprotective effects evaluated the activity of Vaccinium myrtillus (bilberry) anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) against retinal damage.
According to the assays, in the retinal ganglion cells (RGCs) induced cell damage and radical activation by 3-(4-morpholinyl) sydnonimine hydrochloride (SIN-1), injection of VMA and all three anthocyanidins significantly inhibited SIN-1-induced neurotoxicity and free radical activation.
Furthermore, VMA also significantly inhibited the N-methyl-D-aspartic acid (NMDA)-induced morphological retinal damage compared to other derivatives. and increased apoptosis of the damage cells in the ganglion cell layer.
Moreover, VMA at a concentration-dependently inhibited lipid peroxidation in mouse forebrain homogenates. In other words, VMA prevented the accumulation of lipid peroxidation in the neurons, the major cause of the neuron damage.
The findings suggested that VMA and its anthocyanidins process neuroprotective effects via an anti-oxidation mechanism in vitro and in vivo models of retinal diseases.
Additionally, in order to reveal more information about bilberry neuroprotective activity, researchers examined the antioxidants richly present in bilberry fruits effects on diabetes-related brain dysfunctions.
αCaMKII in hippocampal neurons from non-diabetic, diabetic and diabetic rats before fed with an extract of bilberry fruit showed a reduction of swollen and the lengths of the neuronal fibers.
Interestingly, diabetic rats fed with bilberry fruit showed a αCaMKII-positive nerve fiber significantly longer compared to the groups of diabetic and control rats.
The results strongly suggested that bilberry fruits influence the morphology of and possibly exhibit beneficial and neuroprotective effects on hippocampal neurons during diabetes through the expression of antioxidants.
Taken altogether, bilberry processed abundantly bioactive compound such as anthocyanidin and its constituents cyanidin, delphinidin, and malvidin may be considered a functional remedy for the prevention and treatment of neuro-diseases, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H. (PubMed)
(2) Effect of feeding with bilberry fruit on the expression pattern of αCaMKII in hippocampal neurons in normal and diabetic rats by Matysek M1, Mozel S1, Szalak R1, Zacharko-Siembida A1, Obszańska K1, Arciszewski MB. (PubMed)
(3) Oxidative Stress and Antioxidants in Neurological Diseases: Is There Still Hope? by Carvalho AN1, Firuzi O2, Gama MJ3, Horssen JV4, Saso L. (PubMed)
Neurological disorders are diseases associated with the brain, spine, and nerves. In other words, they are diseases of the central nervous system.
There are many risk factors involved in the incidence of neurological disorders, including unhealthy lifestyle, infections, genetics preposition, and physical injury.
Oxidative stress is a result of an imbalance of the ratio of levels of free radicals and antioxidant caused either by overexpression of free radicals or depletion of antioxidants enzymes or both.
Free radicals can be produced internally by normal cellular metabolism or from the external sources such as the air we breathe, smoking. Free radicals are unstable molecules with unpaired electrons on the outer ring.
In order for them to maintain stable, free radicals must either donate an electron or intercept an electron from other atoms, leading to a chain reaction that can not stop[ed until the outer ring electron is paired or inhibited by antioxidants.
Oxidative stress has been found to be a major risk for the onset of the neurological disorder in the Western world, particularly in North American.
Dr. Carvalho AN, the lead scientist in the assessment of oxidative stress and antioxidants in neurological diseases, said, "Oxidative stress is a pathological feature common to a multitude of neurological diseases. The production of reactive oxygen species (ROS) is the main mechanism underlying this cellular redox imbalance".
And, "overview of the main players in oxidative stress and outline evidence of their involvement in Parkinson's disease, Alzheimer's disease, Huntington's disease, and multiple sclerosis".
The results clearly suggested the impact of oxidative stress in the facilitation of the onset of neurodegenerative diseases.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Scientists on finding a natural ingredient which processes neuroprotective effects evaluated the activity of Vaccinium myrtillus (bilberry) anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) against retinal damage.
According to the assays, in the retinal ganglion cells (RGCs) induced cell damage and radical activation by 3-(4-morpholinyl) sydnonimine hydrochloride (SIN-1), injection of VMA and all three anthocyanidins significantly inhibited SIN-1-induced neurotoxicity and free radical activation.
Furthermore, VMA also significantly inhibited the N-methyl-D-aspartic acid (NMDA)-induced morphological retinal damage compared to other derivatives. and increased apoptosis of the damage cells in the ganglion cell layer.
Moreover, VMA at a concentration-dependently inhibited lipid peroxidation in mouse forebrain homogenates. In other words, VMA prevented the accumulation of lipid peroxidation in the neurons, the major cause of the neuron damage.
The findings suggested that VMA and its anthocyanidins process neuroprotective effects via an anti-oxidation mechanism in vitro and in vivo models of retinal diseases.
Additionally, in order to reveal more information about bilberry neuroprotective activity, researchers examined the antioxidants richly present in bilberry fruits effects on diabetes-related brain dysfunctions.
αCaMKII in hippocampal neurons from non-diabetic, diabetic and diabetic rats before fed with an extract of bilberry fruit showed a reduction of swollen and the lengths of the neuronal fibers.
Interestingly, diabetic rats fed with bilberry fruit showed a αCaMKII-positive nerve fiber significantly longer compared to the groups of diabetic and control rats.
The results strongly suggested that bilberry fruits influence the morphology of and possibly exhibit beneficial and neuroprotective effects on hippocampal neurons during diabetes through the expression of antioxidants.
Taken altogether, bilberry processed abundantly bioactive compound such as anthocyanidin and its constituents cyanidin, delphinidin, and malvidin may be considered a functional remedy for the prevention and treatment of neuro-diseases, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H. (PubMed)
(2) Effect of feeding with bilberry fruit on the expression pattern of αCaMKII in hippocampal neurons in normal and diabetic rats by Matysek M1, Mozel S1, Szalak R1, Zacharko-Siembida A1, Obszańska K1, Arciszewski MB. (PubMed)
(3) Oxidative Stress and Antioxidants in Neurological Diseases: Is There Still Hope? by Carvalho AN1, Firuzi O2, Gama MJ3, Horssen JV4, Saso L. (PubMed)
Phytochemical 3,3'-Diindolylmethane, the Potential Anti Prostate Cancer Bioactive Compound, According to Researchers
Prostate cancer is a medical condition caused by cell growth disorderly in the tissue of the prostate glands. Prostate cancer is one of the most slow-growing cancers that take years to develop.
The disease often is discovered during the rectum examine annually. Most cases of prostate cancer start in the cells on the surface of the inner lining of prostate tissue.
In the early stage, patients may not experience any symptoms. However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine and semen, disruption of urinary passing, frequent and urged urinary.
In severe cases, prostate cancer can also cause erectile dysfunction.
According to statistic, 1 man in 9 will be diagnosed with prostate cancer during his lifetime.
Most cases ( about 60%) of prostate cancer are found in older men, particularly in the African-American. The 5-year survival rate of local or regional prostate cancer is nearly 100.
Out of many risk factors, unhealthy diet may be one of the major risk factors associated with the onset of the disease.
Some researchers in the study of the preventive diet against prostate cancer wrote, " Although the available data are not entirely consistent, possible preventative behavioral factors include increased physical activity, intakes of tomatoes, cruciferous vegetables, and soy. Factors that may enhance prostate cancer risk include frequent consumption of dairy products and, possibly, meat".
" By comparison, alcohol probably exerts no important influence on prostate cancer development. Similarly, dietary supplements are unlikely to protect against the onset of prostate cancer in healthy men".
"Several factors, such as smoking and obesity, show a weak association with prostate cancer incidence but a positive relation with prostate cancer mortality. Other factors, such as fish intake, also appear to be unassociated with incident prostate cancer but show an inverse relation with fatal prostate cancer".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding a natural compound for the treatment of prostate cancer examined the effect of 3,3'-Diindolylmethane (DIM) as tumor inhibitors in multiple malignant tumors on microRNAs (miRNAs).
Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) application showed a significant effect in the inhibition of proliferation and invasion of prostate cancer cells.
Furthermore, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment induced cancer death by inhibiting the expression level of CYP1A1, an enzyme associated with the activation of the compounds with carcinogenic properties.
In other words, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment activated the expression of MAP3K12 in the promotion of cancer cell by targeting the mRNA of miR-150-5p in prostate cancer cells.
Moreover, in order to reveal more information of DIM anti-prostate cancer activity, researchers examine the modulation of the immune system by cancer protective food bioactives, indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM).
Injection of indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), exerted prostate cell protective effect by the regulation of inflammatory responses in monocytes and macrophages of the immune system.
In other words, I3C and DIM inhibited the lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria in the induction of IL-1β mRNA associated with the immune response to infection and protein in the monocyte form of the white blood cells.
I3C and DIM also exerted anti-inflammatory activity by inhibiting the expression of gene CD84 mRNA in signaling T-cell activation by regulating the proteins associated with the expression of the gene.
Dr. Wang TTY and colleagues after taking into account co and confounders, wrote, "cross-talk between AHR(protein associated with regulating gene expression) and inflammation-mediated pathways, but not CD84-mediated pathways, in monocytes but not macrophages may contribute to the modulation of tumor environments by I3C and DIM in prostate cancer'.
The results strongly suggested that DIM modulated the immune function against the process of prostate cancer development and progression.
Taken altogether, DIM may be considered a supplement for the prevention and combined with primary medicine for the treatment of prostate cancer, pending to the confirmation of larger sample size and multicenter human study.
Intake of DIM in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12 by Yu J1, Feng Y1, Wang Y1, An R. (PubMed)
(2) Elucidating the Role of CD84 and AHR in Modulation of LPS-Induced Cytokines Production by Cruciferous Vegetable-Derived Compounds Indole-3-Carbinol and 3,3'-Diindolylmethane by Wang TTY1, Pham Q2, Kim YS. (PubMed)
(3) Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates by Michael F Leitzmann1 and Sabine Rohrmann. (PMC)
The disease often is discovered during the rectum examine annually. Most cases of prostate cancer start in the cells on the surface of the inner lining of prostate tissue.
In the early stage, patients may not experience any symptoms. However, at the advanced stage, prostate cancer can induce symptoms of blood in the urine and semen, disruption of urinary passing, frequent and urged urinary.
In severe cases, prostate cancer can also cause erectile dysfunction.
According to statistic, 1 man in 9 will be diagnosed with prostate cancer during his lifetime.
Most cases ( about 60%) of prostate cancer are found in older men, particularly in the African-American. The 5-year survival rate of local or regional prostate cancer is nearly 100.
Out of many risk factors, unhealthy diet may be one of the major risk factors associated with the onset of the disease.
Some researchers in the study of the preventive diet against prostate cancer wrote, " Although the available data are not entirely consistent, possible preventative behavioral factors include increased physical activity, intakes of tomatoes, cruciferous vegetables, and soy. Factors that may enhance prostate cancer risk include frequent consumption of dairy products and, possibly, meat".
" By comparison, alcohol probably exerts no important influence on prostate cancer development. Similarly, dietary supplements are unlikely to protect against the onset of prostate cancer in healthy men".
"Several factors, such as smoking and obesity, show a weak association with prostate cancer incidence but a positive relation with prostate cancer mortality. Other factors, such as fish intake, also appear to be unassociated with incident prostate cancer but show an inverse relation with fatal prostate cancer".
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding a natural compound for the treatment of prostate cancer examined the effect of 3,3'-Diindolylmethane (DIM) as tumor inhibitors in multiple malignant tumors on microRNAs (miRNAs).
Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) application showed a significant effect in the inhibition of proliferation and invasion of prostate cancer cells.
Furthermore, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment induced cancer death by inhibiting the expression level of CYP1A1, an enzyme associated with the activation of the compounds with carcinogenic properties.
In other words, Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3'-Diindolylmethane (DIM) treatment activated the expression of MAP3K12 in the promotion of cancer cell by targeting the mRNA of miR-150-5p in prostate cancer cells.
Moreover, in order to reveal more information of DIM anti-prostate cancer activity, researchers examine the modulation of the immune system by cancer protective food bioactives, indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM).
Injection of indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), exerted prostate cell protective effect by the regulation of inflammatory responses in monocytes and macrophages of the immune system.
In other words, I3C and DIM inhibited the lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria in the induction of IL-1β mRNA associated with the immune response to infection and protein in the monocyte form of the white blood cells.
I3C and DIM also exerted anti-inflammatory activity by inhibiting the expression of gene CD84 mRNA in signaling T-cell activation by regulating the proteins associated with the expression of the gene.
Dr. Wang TTY and colleagues after taking into account co and confounders, wrote, "cross-talk between AHR(protein associated with regulating gene expression) and inflammation-mediated pathways, but not CD84-mediated pathways, in monocytes but not macrophages may contribute to the modulation of tumor environments by I3C and DIM in prostate cancer'.
The results strongly suggested that DIM modulated the immune function against the process of prostate cancer development and progression.
Taken altogether, DIM may be considered a supplement for the prevention and combined with primary medicine for the treatment of prostate cancer, pending to the confirmation of larger sample size and multicenter human study.
Intake of DIM in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Aryl hydrocarbon receptor enhances the expression of miR-150-5p to suppress in prostate cancer progression by regulating MAP3K12 by Yu J1, Feng Y1, Wang Y1, An R. (PubMed)
(2) Elucidating the Role of CD84 and AHR in Modulation of LPS-Induced Cytokines Production by Cruciferous Vegetable-Derived Compounds Indole-3-Carbinol and 3,3'-Diindolylmethane by Wang TTY1, Pham Q2, Kim YS. (PubMed)
(3) Risk factors for the onset of prostatic cancer: age, location, and behavioral correlates by Michael F Leitzmann1 and Sabine Rohrmann. (PMC)
Tuesday, April 30, 2019
The 61 Incredible Health Benefits of Honey & Counting
Honey is the miraculous product made by bees using nectar from flowers.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
1. Honey, The Rich Golden Liquid May Process Anti Prostate Cancer Potency
2, Honey, Protects the Breast Cells integrity Against the Onset of Breast Cancer
3. Honey Protects Our Skin Pigment Against the Onset of Melanoma Skin Cancer
4. Honey, the Potential Anti-Colon Cancer Functional Food
5. Honey, the Potential Chemo Replacement for the Treatment Cancers, Scientists Say
6. Tualang Honey Which Kills Leukemia Cancer Cells In Vivo and Vitro, Scientists Say
7. Manaku Honey, the Potential Cartilage Repair Functional Food
8. Manuka Honey, the Best for Tissue Regeneration
9. Tualang Honey May Process a Potential for the Prevention and Treatment of Osteosarcoma
10. Tualang Honey Protects the Oral Cells Against Cancer With No Side Effects
11. Honey, The Functional Food Which Kills Bladder Cancer Cells in Vivo and Vitro, Scientists
Find
12. Honey, The Best to Inhibits Chemo-toxicity and ImprovesChemotherapy For Treatment of Cancers
13. Manuka Honey, the Best for the Prevention and Treatment of Acute and Chronic Inflammatory Diseases
14. Manuka Honey (MH) and Tualang Honey (TH), the Potential Natural Antibiotics Alternative with No Side Effects
15. Manuka Honey, The Anti Antioxidants Functional Sweety
16. Honey, the Natural Whole Food for Prevention and Treatment of Dandruff
17. Manuka Honey, the Best Anti-influenza Functional Food
18. Honey, the Anti Varicella Zoster Virus (VZV) Functional Food, According to Studies
19. Honey, Better Than Over the Counter Medicine for Treatment of Acute Cough in Children
20. Thyme Honey, the Potential Anti-Endometrial Cancer Functional Food
21. Monofloral Honey, the Potential Anti- Human immunodeficiency virus HIV-1 Functional Foods
22. Localized Honey, the Best for the Treatment of Allergies with No Side Effects, According to Studies
23. Tualang Honey the Best to Boosts Memory
24. Honey, the Natural Ingredient that Normalizes Your Blood Pressure with No Side Effects
25. Honey, the Heart Friendly Natural Remedy
26. Honey Relives Hangover, Scientists Reveal
27. Manuka Honey, the Best Natural Liquid for Treatment Atopic Dermatitis, Researchers Reveal
28. Tualang Honey, The Potential Anti-Cervical Cancer Functional Food
29. Honey In the Controlling of Obesity
30. Honey Detoxes the Liver Against Toxicity in Vivo, According to Scientists
31. Honey, the Natural Remedy for Influenza with No Side Effects
32. Honey Speeds Up Wound Healing with Anti-infection Activity
33. Honey, the Best for the Treatment of Ocular Demodex and Dry-Eye with No Side Effects
34. Honey, the Natural Treatment of Anxiety Disorder with No Side Effects, According to Studies
35. Honey, the Best Remedy for the treatment of Asthma with No Side Effects
36. Honey Improves the sleep Quality Naturally with No Side Effects, Scientists Say
37. Honey, Eliminates the Bad Breath Instantly
38. Honey, the Best Remedy for Depression with No Side Effects
39. Honey, the Natural Pain Reliever with No Side Effects
40. Honey, the Best for the Treatment of Chronic Cough with No Side Effects
41. Honey, the Best to inhibit the Expression of Oxidative Stress with No Side Effects
42. The Best Remedy for Prevention and Treatment of Stomach Ulcers, According to Studies
43. Honey, the Best Remedy for the Prevention and Treatment of Diarrhea
44. Honey Normalizes the Levels of Blood Cholesterol with No Side Effects
45. Honey, the Best Remedy for the Prevention and Treatment of Reflux Esophagitis
46. Honey, the Herbal Remedy Which Suppresses Osteoarthritis
47. Honey the Magic Cure Gastroenteritis (Stomach Flu)
48. Honey the Best Natural Treatment of High Blood Pressure with No Side Effects, Scientists Say
49. Honey, the Best Natural Remedy for Chronic Otitis Externa With No Side Effects
50. Honey, the Best for treatment of First and Second Degrees of Burns
51. Honey Promotes Drainage of Bile and Pancreatic Duct Against Obstructive Jaundice
52. Honey, the Best Remedy In the Modulation of the Immune System for the Body Needs
53. Honey Protects the Bone Mass with No Side Effect, According to Studies
54. Honey, Antidepressant Functional and Natural Remedy
55. Honey, the Anti Obesity Functional Food
56. Tualang Honey Protects the Neuron Integrity Against Memory Deficits
57. Honey, the Best for the Treatment of Acute and Chronic Infection
58. Honey Improves Sexual Behavior and Fertility In Male Smokers in Vivo
59. 1015. Honey Improved the Digestive Functioning
60. Whole Food Honey, the Best to Speed Up Wound Healing
61. Whole Food Honey, the Best to Inhibit Oxidative Stress-Related Disease-
To Be Continued
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
The rich golden liquid is considered one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people.
1. Honey, The Rich Golden Liquid May Process Anti Prostate Cancer Potency
2, Honey, Protects the Breast Cells integrity Against the Onset of Breast Cancer
3. Honey Protects Our Skin Pigment Against the Onset of Melanoma Skin Cancer
4. Honey, the Potential Anti-Colon Cancer Functional Food
5. Honey, the Potential Chemo Replacement for the Treatment Cancers, Scientists Say
6. Tualang Honey Which Kills Leukemia Cancer Cells In Vivo and Vitro, Scientists Say
7. Manaku Honey, the Potential Cartilage Repair Functional Food
8. Manuka Honey, the Best for Tissue Regeneration
9. Tualang Honey May Process a Potential for the Prevention and Treatment of Osteosarcoma
10. Tualang Honey Protects the Oral Cells Against Cancer With No Side Effects
11. Honey, The Functional Food Which Kills Bladder Cancer Cells in Vivo and Vitro, Scientists
Find
12. Honey, The Best to Inhibits Chemo-toxicity and ImprovesChemotherapy For Treatment of Cancers
13. Manuka Honey, the Best for the Prevention and Treatment of Acute and Chronic Inflammatory Diseases
14. Manuka Honey (MH) and Tualang Honey (TH), the Potential Natural Antibiotics Alternative with No Side Effects
15. Manuka Honey, The Anti Antioxidants Functional Sweety
16. Honey, the Natural Whole Food for Prevention and Treatment of Dandruff
17. Manuka Honey, the Best Anti-influenza Functional Food
18. Honey, the Anti Varicella Zoster Virus (VZV) Functional Food, According to Studies
19. Honey, Better Than Over the Counter Medicine for Treatment of Acute Cough in Children
20. Thyme Honey, the Potential Anti-Endometrial Cancer Functional Food
21. Monofloral Honey, the Potential Anti- Human immunodeficiency virus HIV-1 Functional Foods
22. Localized Honey, the Best for the Treatment of Allergies with No Side Effects, According to Studies
23. Tualang Honey the Best to Boosts Memory
24. Honey, the Natural Ingredient that Normalizes Your Blood Pressure with No Side Effects
25. Honey, the Heart Friendly Natural Remedy
26. Honey Relives Hangover, Scientists Reveal
27. Manuka Honey, the Best Natural Liquid for Treatment Atopic Dermatitis, Researchers Reveal
28. Tualang Honey, The Potential Anti-Cervical Cancer Functional Food
29. Honey In the Controlling of Obesity
30. Honey Detoxes the Liver Against Toxicity in Vivo, According to Scientists
31. Honey, the Natural Remedy for Influenza with No Side Effects
32. Honey Speeds Up Wound Healing with Anti-infection Activity
33. Honey, the Best for the Treatment of Ocular Demodex and Dry-Eye with No Side Effects
34. Honey, the Natural Treatment of Anxiety Disorder with No Side Effects, According to Studies
35. Honey, the Best Remedy for the treatment of Asthma with No Side Effects
36. Honey Improves the sleep Quality Naturally with No Side Effects, Scientists Say
37. Honey, Eliminates the Bad Breath Instantly
38. Honey, the Best Remedy for Depression with No Side Effects
39. Honey, the Natural Pain Reliever with No Side Effects
40. Honey, the Best for the Treatment of Chronic Cough with No Side Effects
41. Honey, the Best to inhibit the Expression of Oxidative Stress with No Side Effects
42. The Best Remedy for Prevention and Treatment of Stomach Ulcers, According to Studies
43. Honey, the Best Remedy for the Prevention and Treatment of Diarrhea
44. Honey Normalizes the Levels of Blood Cholesterol with No Side Effects
45. Honey, the Best Remedy for the Prevention and Treatment of Reflux Esophagitis
46. Honey, the Herbal Remedy Which Suppresses Osteoarthritis
47. Honey the Magic Cure Gastroenteritis (Stomach Flu)
48. Honey the Best Natural Treatment of High Blood Pressure with No Side Effects, Scientists Say
49. Honey, the Best Natural Remedy for Chronic Otitis Externa With No Side Effects
50. Honey, the Best for treatment of First and Second Degrees of Burns
51. Honey Promotes Drainage of Bile and Pancreatic Duct Against Obstructive Jaundice
52. Honey, the Best Remedy In the Modulation of the Immune System for the Body Needs
53. Honey Protects the Bone Mass with No Side Effect, According to Studies
54. Honey, Antidepressant Functional and Natural Remedy
55. Honey, the Anti Obesity Functional Food
56. Tualang Honey Protects the Neuron Integrity Against Memory Deficits
57. Honey, the Best for the Treatment of Acute and Chronic Infection
58. Honey Improves Sexual Behavior and Fertility In Male Smokers in Vivo
59. 1015. Honey Improved the Digestive Functioning
60. Whole Food Honey, the Best to Speed Up Wound Healing
61. Whole Food Honey, the Best to Inhibit Oxidative Stress-Related Disease-
To Be Continued
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
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