Antioxidants Betanin Protect the Digestive Tract Against the Onset of Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a class of chronic conditions associated with the inflammation of the gastrointestinal tract, including

* Ulcerative colitis is a chronic inflammation and ulcers found in the innermost lining of the colon and rectum.

* Crohn's disease. is a type of IBD that causes inflammation of the lining of the digestive tract, other than the colon and rectum.

Most common symptoms of IBD are severe diarrhea, abdominal pain, fatigue, and weight loss. Long-term persistent symptoms such as weight loss may be life-threatening.

If you have experienced some of the aforementioned symptoms, please make sure to check with your doctor to rule out the possibility.

The causes of IBD are unknown. However, some researchers suggested that the promotion of a high-fat diet over the past few decades that cause the alternation of the ration of gut microbiota may be the major culprit in facilitating the onset of IBD.

The research of Case Western Reserve University, wrote, "A high-fat diet may lead to specific changes in gut bacteria that could fight harmful inflammation -- a major discovery for patients suffering from Crohn's disease, research indicates. Crohn's disease, a type of inflammatory bowel syndrome, causes debilitating intestinal swelling, cramping, and diarrhea".

Betanin is phytochemicals in the class of red and yellow indole-derived pigments of betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.

With an aim to find a treatment of inflammatory bowel disease (IBS), researchers examined the effect of beetroot (Beta vulgaris var. Rubra) products and their major component betanin on the reactive oxygen species (ROS) production and DNA damage in vitro.

In neutrophils isolated from the blood of patients with inflammatory bowel disease--ulcerative colitis (UC) and Crohn's disease (CD), injection of betanin at 100 μM for 24 h increased DNA damage, according to the comet assay.

However, in Caco-2 cells.injection of betanin at 100 μM for 24 h showed a lesser pronounced stimulation of DNA damage.

Treatment of Caco-2 cells with H2O2 caused a 4-fold increase of DNA strand breaks in comparison to untreated cells, but pre-treatment with betanin reduced DNA damage in these cells.

In other words, betanin exerted a cytotoxic effect against the DNA alternated cells but inhibited the free radical expression in the induction of DNA damage of normal cells.

More precisely, betanin led to the release of ROS and apoptotic cell death.

Based on the findings, researchers wrote, " betanin may exert anti-inflammatory and potentially cancer-preventive activity".

Taken altogether, betanin may be considered supplements for the prevention and treatment of inflammatory bowel disease, pending to the confirmation of larger sample size and multicenter human study.
Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) DNA damage and apoptosis in blood neutrophils of inflammatory bowel diseasepatients and in Caco-2 cells in vitro exposed to betanin by Zielińska-Przyjemska M1, Olejnik A2, Dobrowolska-Zachwieja A3, Łuczak M4, Baer-Dubowska W. (PubMed)
(2) High fat diet reduces gut bacteria, Crohn's disease symptoms by Case Western Reserve University. (Science Daily)