Healthy Food Tomato, A Potential and Natural Prevention and Treatment of Cancer

Cancer is a class of chronic and medical condition caused by cell growth irregularly in the tissues of the body.

Cancer can be classified into
* Primary cancer or original cancer is a tumor at the original site where it first arose where tumor progression began and proceeded to yield a cancerous mass.

* Secondary metastasis is tumor spread from primary cancer.

Most cases of cancer begin in the cells on the surface of the inner lining of the organs' tissues. For example, breast cancer starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.

Under normal circumstance, cell growth is a natural process without even notice, every day millions of cell growth to replace millions of dead cells and to keep our body in balance and healthy.

Sometimes, acceleration of cell growth is necessary to prevent further damage to the body tissues and organs, such as cut, injure, etc., but after fulfilling their purposes, the growth of cells are back to a normal rate again due to our body growth inhibitors.

However, in cancer, mutated cells can grow indefinitely by accelerating cell division rates or inhibiting normal controls on the system, such as cell cycle arrest or programmed cell death, leading to the formation of cell mass or tumor.

The exact causes of cancer are unidentified. Researchers can not explain why people with the same health conditions and family history in the same family, some are prone to cancer development while others do not.

According to the statistic, In 2018, approximately 1,735,350 new cases of cancer were diagnosed in the United States. The diseases also cause the death of 609,640 Americans in the same year.

Believe it or not, cancer mortality is higher among men than women (196.8 per 100,000 men and 139.6 per 100,000 women), according to the National Cancer Institute.

Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

On finding a natural ingredient for the prevention and treatment of cancer with no side effects researchers examined several HDACi of natural and dietary origin such as tomatoes against cancer developing.

Where histone deacetylase inhibitors (HDACi) regulated the activity of histone deacetylase enzymes (HDACs) have been used in cancer treatment either alone or in combination with other chemotherapeutic drugs/radiotherapy.

According to the differential, HDACi exhibited antitumor effect by the activation of cell cycle arrest, induction of apoptosis and autophagy, angiogenesis inhibition.

Furthermore, the cancer inhibition of HDACi is also found in increased reactive oxygen species generation that causes oxidative stress, and mitotic cell death in cancer cells.


In order to reveal more information about tomatoes' anti-cancer property, scientists investigated lycopene loaded whey protein isolate nanoparticles (LYC-WPI-NPs) anti-cancer activity.

The percent lycopene entrapment of prepared LYC-WPI-NPs was estimated in the range to 50 and 65%.

The WPI-NPs was found to enhance the oral bioavailability and absorption of lycopene by controlling its release from nano-formulation and lymphatic pathways.

Moreover, lycopene improved the biopharmaceutical attributes of lycopene and demonstrated prophylactic anticancer activity, decrease tumor proliferation and increased the survival rate of treated animals, in the form of loaded protein nanoparticles.

Taken altogether, tomatoes processed high amounts of lycopene may be considered a functional food for the treatment of cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy by Singh AK1, Bishayee A2, Pandey AK. (PubMed)
(2) Lycopene loaded whey protein isolate nanoparticles: An innovative endeavor for enhanced bioavailability of lycopene and anti-cancer activity by Jain A1, Sharma G2, Ghoshal G3, Kesharwani P4, Singh B5, Shivhare US4, Katare OP. (PubMed)