Tomato Suppresses the Onset of Pulmonary Diseases

Pulmonary diseases are a class of diseases associated with the lungs, including asthma, COPD, influenza, pneumonia and tuberculosis, and lung cancer.

In other words, any diseases involved in breathing problems that reduce the function of the lung are pulmonary diseases.

The most common pulmonary diseases are

* Asthma

Asthma is a chronic inflammatory disease affecting the airway of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood.

* Pneumothorax

Pneumothorax is a condition of collection of air within the pleural cavity, from either the outside or from the lung.

* Bronchitis
Bronchitis is a condition of an inflammation of the mucous membranes of the bronchi, the larger and medium-sized airways that carry airflow from the trachea into the lung parenchyma.


* COPD (chronic obstructive pulmonary disease)** Emphysema is a type of COPD with a long-term and progressive condition that causes shortness of breath, depending on the stage of lung function associated with the damage of tissues of the air sacs (alveoli) in the lungs.

** Chronic bronchitis
Chronic bronchitis is a chronic inflammation of the lung’s bronchi that cause the increased production of mucus in the lung associated with the difficulty of breathing.


*Lung cancer a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancers are derived from epithelial cells


* PneumoniaPneumonia is a condition of the inflammation of the lung caused by bacteria, such as bacterial infection, Streptococcus pneumonia, or influenza viruses in most cases.


* Pulmonary edema
Pulmonary edema is a condition of fluid accumulation in the air spaces and parenchyma of the lungs that lead to difficulty of breathing and respiratory failure.



Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a potential ingredient for the treatment of pulmonary disease, researchers examined the dietary supplementation of tomato juice, TJ protection against the developing lung injury caused by breathing hyperoxic gas.

Neonatal mice (C57BL6/J) breathed either 65% O2 (hyperoxia) or room air from birth until postnatal day 7 (P7d)selected to the study underwent necropsy at P7d or raised in room air until adulthood (P56d). A subset of both groups, drinking water was replaced with TJ (diluted 50:50 in water) from late gestation to necropsy.

In P7d, TJ injection increased pulmonary total antioxidants (TAC) and COL1α1 expression associated with pulmonary fibrosis and attenuated the hyperoxia-induced increase in production ROS without affecting the changes in lung structure.


Furthermore, in P56d, TJ increased TAC, decreased oxidative stress, and reversed the hyperoxia-induced increase in bronchiolar smooth muscle by ameliorating the production of pro-inflammatory cytokines.


Based on the findings, researchers said, "TJ supplementation during and after neonatal exposure to hyperoxia protects the lung from some but not all aspects of hyperoxia-induced injury".


In other words, TJ protects the lung against injury by stimulating the expression of circulation of antioxidant concentration.

Taken altogether, tomatoes may be considered supplements for the prevention and treatment of pulmonary diseases, pending the confirmation of the larger sample size and multicenter human study.


Intake of lycopene in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Impact of Dietary Tomato Juice on Changes in Pulmonary Oxidative Stress, Inflammation and Structure Induced by Neonatal Hyperoxia in Mice (Mus musculus) by Bouch S1, Harding R1, O'Reilly M1, Wood LG2, Sozo F. (PubMed)
(2) Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression by Yan KH1, Lee LM, Yan SH, Huang HC, Li CC, Lin HT, Chen PS. (PubMed)