Skin, a large organ of the body protects our tissue and organs against the invasion of pathogens and fluid loss.
There are many causes of skin damage. Sun exposure is the most common cause of skin damage. Other causes of skin damage include smoking cigarettes, drinking too much alcohol, extreme temperatures, and exposure to toxic chemicals and pollutants in the air outside.
Some researchers suggested that free radicals bombard our body daily are also associated with skin damage in the modern world.
Free radicals are unstable molecules with the unpaired electron on the outer ring. In order for them to become balanced, free radical either donates or intercept an electron from another stable molecule, leading to a chain reaction that can not be stopped until the outer ring election is paired or inhibited by antioxidant.
In fact, free radical formation occurs continuously in the cells as a consequence of both enzymatic and nonenzymatic reactions, they can be generated by our bodies such as the process of metabolism and exogenous sources such as pollution, alcohol, tobacco smoke.
Free radicals can affect our skin in different ways, including the alternation of the DNA, damage of lipid membrane, collagen structures, and inducing photoaging and cancer.
Dr. Borut Poljšak, in the study "Free Radicals and Extrinsic Skin Aging" wrote, "Extrinsic skin damage develops due to several factors: ionizing radiation, severe physical and psychological stress, alcohol intake, poor nutrition, overeating, environmental pollution, and exposure to UV radiation (UVR)". and
"The only protection of our skin is in its endogenous protection (melanin and enzymatic antioxidants) and antioxidants we consume from the food (vitamin A, C, E, etc.)".
These results suggested that although free radical can induce the early onset of skin damage and aging, providing our body with enough antioxidants from the food sources is the best way to counter the process.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
On finding a natural ingredient or essential oil which has a potential effect on skin health without inducing any side effects, researchers explored the effects of various avocado oils on collagen metabolism.
In skin rats fed diets containing 10% (w/w) of the tested oils, researchers found the akin protective effects were totally depended on the types of avocado oil.
Rats fed the unrefined avocado oil extracted with hexane from the intact fruit, including unsaponifiables or the avocado seed oil, showed a significant increase in soluble collagen content in skin, though total collagen content was not affected.
The increased soluble collagen content was attributed to the inhibition of lysyl oxidase activity whose increment is associated with the oxidative stress induced by chronic exposure to skin harmful substances.
The active factor which protects the skin health was found to be present in the unrefined avocado oil and probably originated from the avocado seed, observed by the collagen metabolism which is affected only by fractions containing lipids fraction from the seed.
In order to illustrate the effects of avocado oil on skin health, researchers evaluated the wound-healing activity of a semisolid formulation of avocado oil, SSFAO 50%, or avocado oil in natural, on incisional and excisional cutaneous wound models in Wistar rats.
On the 14 days of application on the wound, 50% SSFAO or avocado oil demonstrate a significant increase in percentage wound contraction and reepithelialization, compared to the petroleum jelly control.
The treatment group also displayed an increase in anti-inflammatory activity, density of collagen, and tensile strength, compared to control groups.
This efficacy of the 50% SSFAO or avocado oil was attributed to the contents of the bioactive compounds, oleic fatty acid (47.20%), followed by palmitic (23.66%), linoleic (13.46%) docosadienoic (8.88%), palmitoleic (3.58%), linolenic (1.60%), eicosenoic (1.29%), and myristic acids (0.33%).
Dr. de Oliveira AP, the lead scientist wrote in the final report, "When used in natural or in pharmaceutical formulations for topical use, avocado oil can promote increased collagen synthesis and decreased numbers of inflammatory cells during the wound-healing process".
In skin exposure to ultraviolet (UV) radiation, unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, reduced significantly UV-induced cellular damage, through increasing cell viability, decreased the secretion of IL-6, a pro-inflammatory cytokine, and PGE(2) in mediated the inflammation process.
Taken altogether, avocado processed abundantly bioactive compounds may be considered a functional food for the promotion of skin health without inducing any side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The effect of various avocado oils on skin collagen metabolism by Werman MJ1, Mokady S, Nimni ME, Neeman I.(PubMed)
(2) Effect of semisolid formulation of persea americana mill (avocado) oil on wound healing in rats by de Oliveira AP1, Franco Ede S, Rodrigues Barreto R, Cordeiro DP, de Melo RG, de Aquino CM, E Silva AA, de Medeiros PL, da Silva TG, Góes AJ, Maia MB.(PubMed)
(3) Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells by Rosenblat G1, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M.(PubMed)
(4) Free Radicals and Extrinsic Skin Aging by Borut Poljšak 1 and Raja Dahmane. (PMC)
Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.
Thursday, April 4, 2019
Phytochemical Isothiocyanates as Antioxidants
Scientists may have found a bioactive compound Dithiolthiones isolated from the cruciferous vegetables for the prevention and treatment of oxidative stress-related diseases, according to the studies.
According to the oxidative stress theory, aging and cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancers are the most common conditions associated with oxidative stress.
Antioxidants are stable molecules which play a critic role to protect our body against oxidation.
There are 2 types of antioxidants, antioxidants produced by the host are called antioxidant enzymes and antioxidant came from dietary intake.
Under normal conditions, antioxidants produced by the host are good enough to keep the levels of free radicals in check.
Oxidative stress, a major cause of many chronic ailments is a result of overexpression of free radical in the body that overwhelms the levels of antioxidants enzymes. In other words, free radicals have started a chain oxidative reaction that has not been stopped, leading to oxidative stress.
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction.
They may have positive, negative or zero charges. The unpaired electrons cause free radicals to be highly chemically reactive to induce oxidative stress that damage the cell structures, protein and lipid and the alternation of DNA.
According to the study by the Heinrich-Heine-Universität Düsseldorf, Universitätsstr in the examination of the risk oxidative stress in Alzheimer disease, "The protective role of antioxidants against the development of several diseases and conditions recognized as risk factors for Alzheimer's disease (AD)" and "A variety of health behaviors, including an adequate supply of antioxidant micronutrients with the diet might help preventing AD directly, or indirectly through the mitigation of pathologic conditions associated with AD, such as vascular disease and diabetes".
Therefore, by enhancing antioxidant status in the body through regular physical activity and intake of fruits and vegetables which contain a high amount of dietary antioxidant to offset the free radical toxic effects, the risk of oxidative stress can be reduced substantially
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
In the concern of oxidative stress disorder that leads to age-related and gradual loss of corneal endothelial cells resulting in corneal edema and loss of vision. researchers at the Harvard Medical School, Boston investigated the antioxidant activity of sulforaphane (SFN) and D3T by targeting Nrf2-ARE in Fuchs endothelial corneal dystrophy (FECD).
Where Nuclear factor-like 2 (Nrf2-ARE) is a transcription factor which regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.
In human corneal endothelial cell lines (CEC) induced oxidative stress with tert-Butyl hydroperoxide (tBHP), injection of SFN decreased CEC apoptosis by 55% in the control group and by 43% in tBHP-treated specimens.
SFN enhanced nuclear translocation of Nrf2 in FECD specimens and decreased p53 gene in the cancer cells line under oxidative stress.
Where p53 is a protein that regulates the cell cycle and hence functions as a tumor suppression.
Futhermore, the application of SFN protected the cell integrity and viability against injection of tert-Butyl hydroperoxide (tBHP), causing overexpression of free radicals in the initiation of oxidative stress.
These results clearly suggested SFN significantly promoted major ARE-dependent antioxidants and ameliorated oxidative stress-induced apoptosis in FECD.
Dr. Ziaei A said, " targeting Nrf2-ARE pathway may arrest degenerative cell loss seen in FECD".
Most importantly, in the review the anti-oxidant properties of isothiocyanates (ITCs), researchers found that The ITCs induces Phase II enzymes related to detoxification processes of chemical carcinogens to prevent the start of carcinogenesis and exhibits antitumor activity at post-initiation phase,
In other words, ITCs inhibited the substances which can cause cancers and cancers in the early and late stages.
In a dose-dependent manner, ITCs inhibit the cell viability of human cancer cell lines through its antioxidant activity.
The review showed support to the use of isothiocyanates such as sulforaphane for cancer and cardiovascular diseases treatments.
Taken altogether, there is no doubt that bioactive compound Isothiocyanates processed a significant antioxidant property may be used for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.Reference
(1) Sulforaphane decreases endothelial cell apoptosis in fuchs endothelial corneal dystrophy: a novel treatment by Ziaei A1, Schmedt T, Chen Y, Jurkunas UV.(PubMed)
(2) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB.(PubMed)
(3) Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression by Prawan A1, Keum YS, Khor TO, Yu S, Nair S, Li W, Hu L, Kong AN.(PubMed)
(4) Oxidative stress and risk factors for Alzheimer's disease: clues to prevention and therapy by Polidori MC. (PubMed)
According to the oxidative stress theory, aging and cardiovascular diseases [CVDs], chronic obstructive pulmonary disease, chronic kidney disease, neurodegenerative diseases, and cancers are the most common conditions associated with oxidative stress.
Antioxidants are stable molecules which play a critic role to protect our body against oxidation.
There are 2 types of antioxidants, antioxidants produced by the host are called antioxidant enzymes and antioxidant came from dietary intake.
Under normal conditions, antioxidants produced by the host are good enough to keep the levels of free radicals in check.
Oxidative stress, a major cause of many chronic ailments is a result of overexpression of free radical in the body that overwhelms the levels of antioxidants enzymes. In other words, free radicals have started a chain oxidative reaction that has not been stopped, leading to oxidative stress.
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction.
They may have positive, negative or zero charges. The unpaired electrons cause free radicals to be highly chemically reactive to induce oxidative stress that damage the cell structures, protein and lipid and the alternation of DNA.
According to the study by the Heinrich-Heine-Universität Düsseldorf, Universitätsstr in the examination of the risk oxidative stress in Alzheimer disease, "The protective role of antioxidants against the development of several diseases and conditions recognized as risk factors for Alzheimer's disease (AD)" and "A variety of health behaviors, including an adequate supply of antioxidant micronutrients with the diet might help preventing AD directly, or indirectly through the mitigation of pathologic conditions associated with AD, such as vascular disease and diabetes".
Therefore, by enhancing antioxidant status in the body through regular physical activity and intake of fruits and vegetables which contain a high amount of dietary antioxidant to offset the free radical toxic effects, the risk of oxidative stress can be reduced substantially
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
In the concern of oxidative stress disorder that leads to age-related and gradual loss of corneal endothelial cells resulting in corneal edema and loss of vision. researchers at the Harvard Medical School, Boston investigated the antioxidant activity of sulforaphane (SFN) and D3T by targeting Nrf2-ARE in Fuchs endothelial corneal dystrophy (FECD).
Where Nuclear factor-like 2 (Nrf2-ARE) is a transcription factor which regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation.
In human corneal endothelial cell lines (CEC) induced oxidative stress with tert-Butyl hydroperoxide (tBHP), injection of SFN decreased CEC apoptosis by 55% in the control group and by 43% in tBHP-treated specimens.
SFN enhanced nuclear translocation of Nrf2 in FECD specimens and decreased p53 gene in the cancer cells line under oxidative stress.
Where p53 is a protein that regulates the cell cycle and hence functions as a tumor suppression.
Futhermore, the application of SFN protected the cell integrity and viability against injection of tert-Butyl hydroperoxide (tBHP), causing overexpression of free radicals in the initiation of oxidative stress.
These results clearly suggested SFN significantly promoted major ARE-dependent antioxidants and ameliorated oxidative stress-induced apoptosis in FECD.
Dr. Ziaei A said, " targeting Nrf2-ARE pathway may arrest degenerative cell loss seen in FECD".
Most importantly, in the review the anti-oxidant properties of isothiocyanates (ITCs), researchers found that The ITCs induces Phase II enzymes related to detoxification processes of chemical carcinogens to prevent the start of carcinogenesis and exhibits antitumor activity at post-initiation phase,
In other words, ITCs inhibited the substances which can cause cancers and cancers in the early and late stages.
In a dose-dependent manner, ITCs inhibit the cell viability of human cancer cell lines through its antioxidant activity.
The review showed support to the use of isothiocyanates such as sulforaphane for cancer and cardiovascular diseases treatments.
Taken altogether, there is no doubt that bioactive compound Isothiocyanates processed a significant antioxidant property may be used for the prevention and treatment of diseases associated with oxidative stress, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.Reference
(1) Sulforaphane decreases endothelial cell apoptosis in fuchs endothelial corneal dystrophy: a novel treatment by Ziaei A1, Schmedt T, Chen Y, Jurkunas UV.(PubMed)
(2) The anti-oxidant properties of isothiocyanates: a review by de Figueiredo SM1, Filho SA, Nogueira-Machado JA, Caligiorne RB.(PubMed)
(3) Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression by Prawan A1, Keum YS, Khor TO, Yu S, Nair S, Li W, Hu L, Kong AN.(PubMed)
(4) Oxidative stress and risk factors for Alzheimer's disease: clues to prevention and therapy by Polidori MC. (PubMed)
Wednesday, April 3, 2019
Phytochemical Allicin, Gobbles Up Endometrial Cancer Cells in Vitro
Scientists may have found a natural ingredient for the prevention and treatment of endometrial cancer with no side effects, according to studies.
The endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particularly to the menstrual cycle.
Endometrial cancer is a late adulthood cancer characterized by the cell growth irregularly and uncontrollably in the endometrial tissue.
The cause of endometrial cancer is an alternation of call DNA in the endometrium.
Most cases of endometrial cancer start in the cells on the surface of the inner lining of the endometrium. After penetrating deeper into the organ tissue, the cancerous cell may induce secondary metastasis through lymph and blood.
Endometrial cancer is the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer. The average age diagnosed with endometrial cancer is 60.
According to the statistic provided by the American Cancer Society, every year, approximately,
63,000 new cases of cancer of the body of the uterus (uterine body or corpus) will be diagnosed.
Endometrial cancer causes the death of 11,350 women,, every year.
The 5-year survival rate for women with uterine cancer is 81%. However, the 5 years mortality rate in black women is substantially higher, compared to white women.
Most common risk factors of endometrial cancer are associated with hormone change due to menopause, use of birth control pills, and tamoxifen pregnancy, ovarian tumors, and polycystic ovarian syndrome.
Some researchers suggested that obesity is one major cause of hormone change associated with the onset of endometrial cancer.
Dt. Evan L. Busch, the lead scientists analyzed the endometrial cancer risk factors, said, " Compared with not being obese, obesity increased the odds of having an ER-positive tumor at cut points of 0% to 20% [maximum OR, 2.92; 95% confidence interval (CI), 1.34–6.33] as well as the odds of having a PR-positive tumor at cut points of 70% to 90% (maximum OR, 2.53; 95% CI, 1.36–4.68)".
And, " Obesity may be associated with greater endometrial tumor expression of ER and PR. Adding either marker does not appear to improve mortality prediction beyond the standard predictors".
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
With an aim to find the ingredient for the treatment of endometrial cancer, researchers determined whether pure allicin exhibits the antiproliferative effect reported for garlic in vitro models.
Treatment of allicin, but not its precursor alliin, inhibited proliferation of human endometrial (Ishikawa) cancer cells (50% inhibitory concentration = 10-25 microM).
Furthermore, the pure allicin and water extract of garlic powder with equivalent allicin concentrations displayed a similar potency.
The result strongly suggested that allicin is responsible for the antiproliferative effect of the extract.
Allicin treatments inhibited the levels of antioxidants produced by the cancer cell line and the extent of the decrease in glutathione (GSH) levels correlated well (r = 0.75) with the growth inhibitory activity of allicin.
However, the magnitude and kinetics of which significantly varied depending on cancer cell type.
Dr. Hirsch K, the lead scientist said, allicin plays a major role in the antiproliferative effect of water-soluble garlic preparations and that this effect may be attributed to the ability of allicin to transiently deplete the intracellular GSH level.
Moreover, treatment of allicin also induces cancer cell death through activating proteins associated with cell apoptosis and cell death programming.
Also, the efficacy of allicin also was attributed to the function of bioactive compound stimulating the protein involved "on" or "off" switch of cell apoptosis, as well as inhibiting the antioxidant enzymes produced by the cancer cells.
Taken altogether, phytochemical allicin may be considered a bioactive compound for reducing risk and combined with the primary medicine for the treatment of endometrial cancer.
However, intake of allicin in the form of supplement should be taken with extreme care as acute toxicity was reported in a number of cases.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation by Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M, Mirelman D, Levy J, Sharoni Y. (PubMed)
(2) Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway by Cha JH, Choi YJ, Cha SH, Choi CH, Cho WH. (PubMed)
(3) Endometrial Cancer Risk Factors, Hormone Receptors, and Mortality Prediction by Evan L. Busch, Marta Crous-Bou, Jennifer Prescott, Maxine M. Chen, Michael J. Downing, Bernard A. Rosner, George L. Mutter and Immaculata De Vivo. (AACR)
Phytochemical 3,3'-Diindolylmethane May Be the Potent Anti Breast Cancer Bioactive Ingredient, According to Studies
3,3'-Diindolylmethane or DIM may be the next bioactive compound used for the treatment of breast cancer, according to studies.
Breast cancer is a chronic and a medical condition characterized cell growth irregularly in the breast tissue.
Breast cancer is the most common cancer in American women, besides skin cancers. Most cases of breast cancer begin in the cells of the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone, leading to the death of over 41,000 women.
The risk of getting invasive breast cancer during the lifetime of a woman is 1/8. As of today, there are more than 3.1 million breast cancer survivors in the US.
The 5 years of the survival rate of localized breast cancer is closed to 100%.
The risk factors of breast cancer can be divided into 2 groups
* Preventable risk factors include exposure to ionizing radiation, hormone replacement therapy, use of oral contraceptives, alcohol, being obese and physical inactivity.
* Unpreventable risk factors include family and personal history, age, race, genetic preposition, dense breast, and reproductive history.
If you are at the higher risk of breast cancer, please make sure you self check your breast every month for preventive measure.
Since breast cancer is so sensitive to levels of the hormone, some scientists suggested that hormonal changes may have a critical impact on the disease.
Dr. Hindle WH in the examination of the hormonal changes in the risk of breast cancer wrote, "Nearly a dozen hormonal hypotheses of breast cancer causes have been proposed -- among them estrogen excess, low luteal-phase progestational activity, adrenal androgen deficiency, ovarian androgen excess, melatonin deficiency, prolactin excess, and thyroid insufficiency".
And, The androgen deficiency hypotheses, however, may have some bearing on premenopausal breast cancer, and the ovarian dysfunction hypothesis may have some bearing on postmenopausal breast cancer".
The results strongly indicated that the risk of breast cancer is associated with the decline production of hormones due to aging.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding a natural compound for the treatment of cancer without the development of toxic side effects and resistance to chemotherapy examined the effect of 3,3'-Diindolylmethane (DIM) on the enhancement of docetaxel (DOC) on breast cancer.
The study included the selected MDA-MB231 and Sk-BR-3 cells treated with and without 25 or 50 µM of DIM and 1 nM of DOC for 48 and 72 h.
Combining 25 µM of DIM with 1 nM DOC showed a significantly decreased cell survival by 42% in MDA-MB231 cells and 59% in Sk-BR-3 cells compared to control and the use of DIM or DOC alone.
The combination treatment increased apoptosis over 20% (p ≤ 0.01) in both cell lines, associated with decreased of proteins involved cell proliferation and survival and activation of JNK involved in the cancer cells apoptosis.
ROS production induced cancer cells cytotoxicity were increased by 46.5% in the MDA-MB231 and 29.3% in Sk-BR-3 cells with the combination compared to DIM or DOC alone.
The overexpression of ROS was correlated with a 54% decrease in antioxidant MnSOD and 47% increase of free radicals NOX2 protein compared to the other groups.
Dr. Lanza-Jacoby S, the lead scientist concluded, "DIM enhances the sensitivity of breast cancer cells to DOC treatment by increasing ROS, which led to decreased cell survival and apoptosis".
Furthermore, in order to reveal more information about the DIM, researchers investigated the bioactive compound against HER2/neu positive breast tumors.
The differentiation included MDA-MB-435eB1 human Her2/neu breast cancer cells treated with varying concentrations of DIM and paclitaxel.
Both DIM and paclitaxel exhibited time and concentration-dependent inhibition of cell proliferation.
The combination also increased the number of apoptotic cells more than either agent alone, according to tested assays.
Moreover, the combined treatment exerted breast cancer cells apoptosis by inhibiting the proteins associated with cancer cell proliferation and survival and exhibiting the function of enzymes associated with cell death programming.
Additionally, DIM alone inhibited the cancer expression by decreasing the activation of the Her2/neu receptor and the combination decreased the activation of ERK1/ERK2 associated with cancer cell proliferation.
The results suggested that DIM enhanced the function of chemo medicine against the development and progression of breast cancer.
Taken altogether, DIM used alone may be considered a supplement for the prevention and combined with primary therapy for treatment of breast cancer with reduced side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane enhances apoptosis in docetaxel-treated breast cancercells by generation of reactive oxygen species by Lanza-Jacoby S1, Cheng G. (PubMed)
(2) 3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells by McGuire KP1, Ngoubilly N, Neavyn M, Lanza-Jacoby S. (PubMed)
(3) Hormone alterations in breast cancer: examining the hypotheses by Hindle WH. (PubMed)
Breast cancer is a chronic and a medical condition characterized cell growth irregularly in the breast tissue.
Breast cancer is the most common cancer in American women, besides skin cancers. Most cases of breast cancer begin in the cells of the surface of the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
In 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone, leading to the death of over 41,000 women.
The risk of getting invasive breast cancer during the lifetime of a woman is 1/8. As of today, there are more than 3.1 million breast cancer survivors in the US.
The 5 years of the survival rate of localized breast cancer is closed to 100%.
The risk factors of breast cancer can be divided into 2 groups
* Preventable risk factors include exposure to ionizing radiation, hormone replacement therapy, use of oral contraceptives, alcohol, being obese and physical inactivity.
* Unpreventable risk factors include family and personal history, age, race, genetic preposition, dense breast, and reproductive history.
If you are at the higher risk of breast cancer, please make sure you self check your breast every month for preventive measure.
Since breast cancer is so sensitive to levels of the hormone, some scientists suggested that hormonal changes may have a critical impact on the disease.
Dr. Hindle WH in the examination of the hormonal changes in the risk of breast cancer wrote, "Nearly a dozen hormonal hypotheses of breast cancer causes have been proposed -- among them estrogen excess, low luteal-phase progestational activity, adrenal androgen deficiency, ovarian androgen excess, melatonin deficiency, prolactin excess, and thyroid insufficiency".
And, The androgen deficiency hypotheses, however, may have some bearing on premenopausal breast cancer, and the ovarian dysfunction hypothesis may have some bearing on postmenopausal breast cancer".
The results strongly indicated that the risk of breast cancer is associated with the decline production of hormones due to aging.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
Researchers on finding a natural compound for the treatment of cancer without the development of toxic side effects and resistance to chemotherapy examined the effect of 3,3'-Diindolylmethane (DIM) on the enhancement of docetaxel (DOC) on breast cancer.
The study included the selected MDA-MB231 and Sk-BR-3 cells treated with and without 25 or 50 µM of DIM and 1 nM of DOC for 48 and 72 h.
Combining 25 µM of DIM with 1 nM DOC showed a significantly decreased cell survival by 42% in MDA-MB231 cells and 59% in Sk-BR-3 cells compared to control and the use of DIM or DOC alone.
The combination treatment increased apoptosis over 20% (p ≤ 0.01) in both cell lines, associated with decreased of proteins involved cell proliferation and survival and activation of JNK involved in the cancer cells apoptosis.
ROS production induced cancer cells cytotoxicity were increased by 46.5% in the MDA-MB231 and 29.3% in Sk-BR-3 cells with the combination compared to DIM or DOC alone.
The overexpression of ROS was correlated with a 54% decrease in antioxidant MnSOD and 47% increase of free radicals NOX2 protein compared to the other groups.
Dr. Lanza-Jacoby S, the lead scientist concluded, "DIM enhances the sensitivity of breast cancer cells to DOC treatment by increasing ROS, which led to decreased cell survival and apoptosis".
Furthermore, in order to reveal more information about the DIM, researchers investigated the bioactive compound against HER2/neu positive breast tumors.
The differentiation included MDA-MB-435eB1 human Her2/neu breast cancer cells treated with varying concentrations of DIM and paclitaxel.
Both DIM and paclitaxel exhibited time and concentration-dependent inhibition of cell proliferation.
The combination also increased the number of apoptotic cells more than either agent alone, according to tested assays.
Moreover, the combined treatment exerted breast cancer cells apoptosis by inhibiting the proteins associated with cancer cell proliferation and survival and exhibiting the function of enzymes associated with cell death programming.
Additionally, DIM alone inhibited the cancer expression by decreasing the activation of the Her2/neu receptor and the combination decreased the activation of ERK1/ERK2 associated with cancer cell proliferation.
The results suggested that DIM enhanced the function of chemo medicine against the development and progression of breast cancer.
Taken altogether, DIM used alone may be considered a supplement for the prevention and combined with primary therapy for treatment of breast cancer with reduced side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) 3,3'-Diindolylmethane enhances apoptosis in docetaxel-treated breast cancercells by generation of reactive oxygen species by Lanza-Jacoby S1, Cheng G. (PubMed)
(2) 3,3'-diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2/Neu human breast cancer cells by McGuire KP1, Ngoubilly N, Neavyn M, Lanza-Jacoby S. (PubMed)
(3) Hormone alterations in breast cancer: examining the hypotheses by Hindle WH. (PubMed)
Monday, April 1, 2019
Phytochemicals Phytic Acid Anti Cancers Potency
Cancer is a class of chronic diseases associated with the irregular cells growth that starts in the cells of the inner lining of a tissue or organ caused by DNA alternation.
At the advanced stage, cells of the invasive tumor may travel a distance away from the primary site to infect other healthy tissue of the organs, through lymph and blood, leading to secondary metastasis.
Some cancers can be slow-growth such as prostate and colon cancer.
Primary cancer at stage 0 and 1 do not induce any symptoms. However, at the later stage, a larger size tumor can suppress the nearby tissue and nerve cells leading to localized and severe symptoms and pain, depending on the types of cancer.
According to the statistics, in the US, the number of new cases of cancer(cancer incidence) is 439.2 per 100,000 men and women per year (based on 2011–2015 cases). The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year (based on 2011–2015 deaths).
Cancers which are diagnosed in the early stage have a 5 years survival rate closed to 100%. Therefore, the annual examination may be necessary for people who are classified to have a higher risk of cancer development.
The causes of cancer are unknown. researchers cannot explain why people with the same healthy condition, family history in the same family, some are susceptible to the onset of the disease while others do not.
Either they can explain why people who carry some of the risk factors associated with the development of cancer never have cancer, while others having no risk factor are diagnosed with cancer.
Conventionally, treatment of cancers completely depends on the types and grade of cancer. Some people with cancer at an early stage may only need one treatment. But most people with cancer in the later stage have a combination of treatments, including surgery with chemotherapy and/or radiation therapy.
Phytic acids (Inositol hexaphosphate) are phytochemicals of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.
With an aim to find a natural ingredient for the p[revention and treatment of cancers without inducing side effects, researchers examine the anticancer effects of phytic acid (IP6).
In vitro and in vivo phytic acid (IP6) exerted a strong anticancer activity by inhibiting the tumor growth and cell proliferation in a series of cancer cell lines, including colon, nipple, breast, prostate, cervix, liver, pancreas, melanoma and glioblastoma.
The efficacy of IP6 was probably associated with the promoted antioxidant production, improved signal transduction, enhance functions of the NK-cells and exhibited cell cycle arrest and activated proteins associated with cell death programming.
Furthermore, in the finding, the proper role for the treatment of cancer researchers looked into the concentration of IP6 and its lower phosphorylated forms (IP(1-5)),
At the 10 microM to 1 mM concentrations, IP6 and its lower phosphorylated forms (IP(1-5)) showed a potential activity in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation, similar to those of the previous study.
In vivo and in vitro, exogenously administered IP6 and internalized, IP6 and IP(1-5) inhibited cell growth.
Moreover, researchers found that application of IP6 not only decreased cellular proliferation but also causes differentiation of malignant cells often resulting in a reversion to normal phenotype.
The results strongly indicated that IP6 inhibits the cancer cell lines through a number of mechanisms, including cell cycle regulatory genes, differentiation genes, and tumor suppressor genes.
Taken all together, phytic acid (IP6) may be considered an anti-cancer bioactive compound for the prevention and treatment of cancer with no side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Reference
(1) [Phytic acid--anticancer nutriceutic].[Article in Polish] by Nawrocka-Musiał D, Latocha M.(PubMed)
(2) IP6: a novel anti-cancer agent by Shamsuddin AM, Vucenik I, Cole KE.(PubMed)
Phytochemical Allicin, the Anti Malaria bioactive Compound, Scientists Say
Scientists may have found a natural ingredient with a similar effect as that of antibiotics for the treatment of malaria with no side effects, according to studies.
Malaria, a mosquito-borne infectious disease caused by parasitic protozoans.
According to the statistic, malaria is one of the most common diseases in Nigeria, affecting over 97% of Nigeria's population. There are an estimated 100 million malaria cases with over 300,000 deaths per year.
Symptoms of malaria tend to occur in cycles, which correspond to the life cycle of the parasite. Most common symptoms include headaches, fatigue, muscle aches, and gastrointestinal discomforts including diarrhea.
In severe cases, patients with malaria may also experience symptoms of shortness of breath caused by fluid in the lungs and expanded abdomen caused by enlarged spleen hypoglycemia and liver diseases such as jaundice and low blood glucose.
Immune deficiency, pregnant women, newborn baby are prone to the disease if they are bitten by an infected mosquito.
However, some researchers suggested that where you live may be one of the major risks for the disease onset.
Dr. Wulung Hanandita, the lead scientists in the concern of geography and social distribution of malaria in Indonesian, wrote, "rural Papuans, as well as those who live in poor, densely forested, lowland districts, are at a higher risk of infection than their counterparts. We also find age and gender differentials in malaria prevalence, if only to a small degree".
These results clearly suggested that if you are poor, and live in densely forested, lowland districts (away from the urban world), you are at the increased risk of malaria.
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
In the concern of widespread malaria infection in the third world where antibiotics are scarce, researchers urgently looked into allicin, the major biologically active component of garlic which has been found to exert a similar effect as that of the Western medicine with no side effects.
On protozoan parasites including Plasmodium, injection of allicin reduced parasitemia and prolonged survival of the host in a dose-dependent manner by improving the host immune responses.
During the experiment, researchers discovered the efficacy of allicin against the tested parasites was attributed to the bioactive compound in stimulating the production of pro-inflammatory cytokines.
The numbers of white blood cells such as macrophages were significantly higher in allicin-treated mice.
The promotion of proinflammatory cytokine and immune response by allicin did reduce the function of anti-inflammatory cytokines during the course of the test.
In other words, allicin protects the host against P. yoelii 17XL through enhancement of the host innate and adaptive immune responses.
Furthermore, examining the effect of allicin on sporozoites, researchers found that at low concentrations, allicin was not toxic to either sporozoites or mammalian cells.
In vitro, at these low concentrations, allicin inhibited the circumsporozoite protein (CSP) processing and prevented sporozoite invasion of host cells.
Mice injected with allicin had decreased Plasmodium infections and prevented malaria infection compared to controls.
Moreover, a 4-day regimen of allicin administered either orally or intravenously significantly decreased parasitemias and increased the survival of infected mice by 10 days.
Dr. Coppi A the lead scientist on the final reports said, "these experiments demonstrate that the same cysteine protease inhibitor can target two different life cycle stages in the vertebrate host".
Taken altogether, the results strongly suggested that phytochemical allicin may be considered an alternative antibiotic for the prevention and combined with the primary medicine for the treatment of malaria induced by parasite infection.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection by Feng Y, Zhu X, Wang Q, Jiang Y, Shang H, Cui L, Cao Y.(PubMed)
(2) Antimalarial activity of allicin, a biologically active compound from garlic cloves by Coppi A, Cabinian M, Mirelman D, Sinnis P.(PubMed)
(3) Geography and social distribution of malaria in Indonesian Papua: a cross-sectional study by Wulung Hanandita
and Gindo Tampubolon. (PMC)
Malaria, a mosquito-borne infectious disease caused by parasitic protozoans.
According to the statistic, malaria is one of the most common diseases in Nigeria, affecting over 97% of Nigeria's population. There are an estimated 100 million malaria cases with over 300,000 deaths per year.
Symptoms of malaria tend to occur in cycles, which correspond to the life cycle of the parasite. Most common symptoms include headaches, fatigue, muscle aches, and gastrointestinal discomforts including diarrhea.
In severe cases, patients with malaria may also experience symptoms of shortness of breath caused by fluid in the lungs and expanded abdomen caused by enlarged spleen hypoglycemia and liver diseases such as jaundice and low blood glucose.
Immune deficiency, pregnant women, newborn baby are prone to the disease if they are bitten by an infected mosquito.
However, some researchers suggested that where you live may be one of the major risks for the disease onset.
Dr. Wulung Hanandita, the lead scientists in the concern of geography and social distribution of malaria in Indonesian, wrote, "rural Papuans, as well as those who live in poor, densely forested, lowland districts, are at a higher risk of infection than their counterparts. We also find age and gender differentials in malaria prevalence, if only to a small degree".
These results clearly suggested that if you are poor, and live in densely forested, lowland districts (away from the urban world), you are at the increased risk of malaria.
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
In the concern of widespread malaria infection in the third world where antibiotics are scarce, researchers urgently looked into allicin, the major biologically active component of garlic which has been found to exert a similar effect as that of the Western medicine with no side effects.
On protozoan parasites including Plasmodium, injection of allicin reduced parasitemia and prolonged survival of the host in a dose-dependent manner by improving the host immune responses.
During the experiment, researchers discovered the efficacy of allicin against the tested parasites was attributed to the bioactive compound in stimulating the production of pro-inflammatory cytokines.
The numbers of white blood cells such as macrophages were significantly higher in allicin-treated mice.
The promotion of proinflammatory cytokine and immune response by allicin did reduce the function of anti-inflammatory cytokines during the course of the test.
In other words, allicin protects the host against P. yoelii 17XL through enhancement of the host innate and adaptive immune responses.
Furthermore, examining the effect of allicin on sporozoites, researchers found that at low concentrations, allicin was not toxic to either sporozoites or mammalian cells.
In vitro, at these low concentrations, allicin inhibited the circumsporozoite protein (CSP) processing and prevented sporozoite invasion of host cells.
Mice injected with allicin had decreased Plasmodium infections and prevented malaria infection compared to controls.
Moreover, a 4-day regimen of allicin administered either orally or intravenously significantly decreased parasitemias and increased the survival of infected mice by 10 days.
Dr. Coppi A the lead scientist on the final reports said, "these experiments demonstrate that the same cysteine protease inhibitor can target two different life cycle stages in the vertebrate host".
Taken altogether, the results strongly suggested that phytochemical allicin may be considered an alternative antibiotic for the prevention and combined with the primary medicine for the treatment of malaria induced by parasite infection.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection by Feng Y, Zhu X, Wang Q, Jiang Y, Shang H, Cui L, Cao Y.(PubMed)
(2) Antimalarial activity of allicin, a biologically active compound from garlic cloves by Coppi A, Cabinian M, Mirelman D, Sinnis P.(PubMed)
(3) Geography and social distribution of malaria in Indonesian Papua: a cross-sectional study by Wulung Hanandita
and Gindo Tampubolon. (PMC)
Sunday, March 31, 2019
Phytochemical Sinigrin, Inhibits the Risk and Progress of Aberrant Crypt Foci Against Colon Cancer, Researchers Find
The bioactive compound Sinigrin may be used for the prevention and treatment of aberrant crypt foci (ACF) in the lining of the colon and rectum, according to studies.
Aberrant crypt foci is a condition of clusters of abnormal tube-like glands in the lining of the colon and rectum. The condition can be subclassified into dysplastic, nondysplastic or mixed type.
Crypt cells of the colon renew the lining of the intestine and produce mucus.
Epidemiological studies suggested that aberrant crypt foci have been found to form before colorectal polyps, the main cause of colon cancer.
According to the high magnification chromoendoscopy, aberrant cryptic foci are stained darker than normal crypts.
And, dysplastic ACF is found in 25- 30% of all patients with colon cancer due to genetic preposition of mutation of KRAS.
Where KRAS protein is associated with the regulation of cell proliferation under normal condition.
Dr. Takayama T and colleagues in the investigation of aberrant crypt foci in gene abnormalities and risk of colon cancer, wrote, "ACF, particularly dysplastic ACF, are precursor lesions of the adenoma-carcinoma sequence in humans. In most sporadic ACF, K-ras mutations were positive, but APC mutations were negative irrespective of nondysplastic or dysplastic features".
And, "In most sporadic ACF, K-ras mutations were positive, but APC mutations were negative irrespective of nondysplastic or dysplastic features. Conversely, in most ACF from familial adenomatous polyposis patients, APC mutations were positive but K-ras mutations were negative".
The results strongly support the genetic mutation of gene KRAS involved in the initiation of dysplastic crypt foci.
Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Scientists on finding a bioactive compound for the protection of colonic mucosal crypts against the aberrant crypt foci investigated the effect of oral administration of the isolated glucosinolate sinigrin in the suppression of aberrant crypt foci in the colonic mucosa of rats treated with 1,2-dimethylhydrazine (DMH).
During the experiment, glucosinolate sinigrin found in Brussels sprout modulated crypt cell apoptosis and mitosis, and the frequency of aberrant crypt foci in the colon.
Oral administration of uncooked Brussels sprouts, whether as a juice or as a freeze-dried powder, was associated with significantly enhanced levels of apoptosis and reduced mitosis in the colonic crypts.
The findings strongly suggested that the inhibition of colonic mucosal crypts was attributed to other chemical compounds found in freeze-dried raw, microwave-cooked Brussels sprouts and sprout juice.
In-depth analysis of the activity, researchers found that the efficacy was attributed to the glucosinolate breakdown products derived from Brassica vegetables on the balance of colorectal cell proliferation and death in an animal model of precancerous colon polyp.
Additionally, in order to reveal more information about the sinigrin effects on the colonic mucosal crypts, researchers examined the sinigrin on the intestinal mucosa of rats treated with dimethylhydrazine (DMH).
Sinigrin showed to inhibit the aberrant crypt foci at 18, 24, 38, 48 and 72 h after injection, compared to control groups were given DMH only, or a sham injection.
Before injection of sinigrin, tested rats showed higher numbers of aberrant crypt foci in colonic tissue from both groups of DMH-treated rats and the controls.
Moreover, the experiment of rats given sinigrin (400 microg/g diet) 22 h after the second of two injections of DMH, showed that sinigrin reduced numbers of ACF by increasing the levels of apoptosis compared to those of higher in DMH-and controls.
The findings clearly support the use of sinigrin for the protection of colonic mucosal crypts.
Taken altogether, sinigrin in forms of glucosinolates, the sulfur compounds may be considered a supplement for the prevention and treatment of aberrant crypt foci, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of Brassica vegetable juice on the induction of apoptosis and aberrant crypt foci in rat colonic mucosal crypts in vivo by Smith TK1, Mithen R, Johnson IT. (PubMed)
(2) Inhibition of dimethylhydrazine-induced aberrant crypt foci and induction of apoptosis in rat colon following oral administration of the glucosinolate sinigrin by Smith TK1, Lund EK, Johnson IT. (PubMed)
(3) Aberrant crypt foci: detection, gene abnormalities, and clinical usefulness by Takayama T1, Miyanishi K, Hayashi T, Kukitsu T, Takanashi K, Ishiwatari H, Kogawa T, Abe T, Niitsu Y. (PubMed)
Aberrant crypt foci is a condition of clusters of abnormal tube-like glands in the lining of the colon and rectum. The condition can be subclassified into dysplastic, nondysplastic or mixed type.
Crypt cells of the colon renew the lining of the intestine and produce mucus.
Epidemiological studies suggested that aberrant crypt foci have been found to form before colorectal polyps, the main cause of colon cancer.
According to the high magnification chromoendoscopy, aberrant cryptic foci are stained darker than normal crypts.
And, dysplastic ACF is found in 25- 30% of all patients with colon cancer due to genetic preposition of mutation of KRAS.
Where KRAS protein is associated with the regulation of cell proliferation under normal condition.
Dr. Takayama T and colleagues in the investigation of aberrant crypt foci in gene abnormalities and risk of colon cancer, wrote, "ACF, particularly dysplastic ACF, are precursor lesions of the adenoma-carcinoma sequence in humans. In most sporadic ACF, K-ras mutations were positive, but APC mutations were negative irrespective of nondysplastic or dysplastic features".
And, "In most sporadic ACF, K-ras mutations were positive, but APC mutations were negative irrespective of nondysplastic or dysplastic features. Conversely, in most ACF from familial adenomatous polyposis patients, APC mutations were positive but K-ras mutations were negative".
The results strongly support the genetic mutation of gene KRAS involved in the initiation of dysplastic crypt foci.
Sinigrin is a phytochemical glucosinolate, belongs to the family of glucosides found abundantly in Brussels sprouts, broccoli, the seeds of black mustard, etc.
Scientists on finding a bioactive compound for the protection of colonic mucosal crypts against the aberrant crypt foci investigated the effect of oral administration of the isolated glucosinolate sinigrin in the suppression of aberrant crypt foci in the colonic mucosa of rats treated with 1,2-dimethylhydrazine (DMH).
During the experiment, glucosinolate sinigrin found in Brussels sprout modulated crypt cell apoptosis and mitosis, and the frequency of aberrant crypt foci in the colon.
Oral administration of uncooked Brussels sprouts, whether as a juice or as a freeze-dried powder, was associated with significantly enhanced levels of apoptosis and reduced mitosis in the colonic crypts.
The findings strongly suggested that the inhibition of colonic mucosal crypts was attributed to other chemical compounds found in freeze-dried raw, microwave-cooked Brussels sprouts and sprout juice.
In-depth analysis of the activity, researchers found that the efficacy was attributed to the glucosinolate breakdown products derived from Brassica vegetables on the balance of colorectal cell proliferation and death in an animal model of precancerous colon polyp.
Additionally, in order to reveal more information about the sinigrin effects on the colonic mucosal crypts, researchers examined the sinigrin on the intestinal mucosa of rats treated with dimethylhydrazine (DMH).
Sinigrin showed to inhibit the aberrant crypt foci at 18, 24, 38, 48 and 72 h after injection, compared to control groups were given DMH only, or a sham injection.
Before injection of sinigrin, tested rats showed higher numbers of aberrant crypt foci in colonic tissue from both groups of DMH-treated rats and the controls.
Moreover, the experiment of rats given sinigrin (400 microg/g diet) 22 h after the second of two injections of DMH, showed that sinigrin reduced numbers of ACF by increasing the levels of apoptosis compared to those of higher in DMH-and controls.
The findings clearly support the use of sinigrin for the protection of colonic mucosal crypts.
Taken altogether, sinigrin in forms of glucosinolates, the sulfur compounds may be considered a supplement for the prevention and treatment of aberrant crypt foci, pending to the confirmation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of Brassica vegetable juice on the induction of apoptosis and aberrant crypt foci in rat colonic mucosal crypts in vivo by Smith TK1, Mithen R, Johnson IT. (PubMed)
(2) Inhibition of dimethylhydrazine-induced aberrant crypt foci and induction of apoptosis in rat colon following oral administration of the glucosinolate sinigrin by Smith TK1, Lund EK, Johnson IT. (PubMed)
(3) Aberrant crypt foci: detection, gene abnormalities, and clinical usefulness by Takayama T1, Miyanishi K, Hayashi T, Kukitsu T, Takanashi K, Ishiwatari H, Kogawa T, Abe T, Niitsu Y. (PubMed)
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