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Monday, April 1, 2019

Phytochemicals Phytic Acid Anti Cancers Potency

Cancer is a class of chronic diseases associated with the irregular cells growth that starts in the cells of the inner lining of a tissue or organ caused by DNA alternation.

At the advanced stage, cells of the invasive tumor may travel a distance away from the primary site to infect other healthy tissue of the organs, through lymph and blood, leading to secondary metastasis.

Some cancers can be slow-growth such as prostate and colon cancer.

Primary cancer at stage 0 and 1 do not induce any symptoms. However, at the later stage, a larger size tumor can suppress the nearby tissue and nerve cells leading to localized and severe symptoms and pain, depending on the types of cancer.

According to the statistics, in the US, the number of new cases of cancer(cancer incidence) is 439.2 per 100,000 men and women per year (based on 2011–2015 cases). The number of cancer deaths (cancer mortality) is 163.5 per 100,000 men and women per year (based on 2011–2015 deaths).

Cancers which are diagnosed in the early stage have a 5 years survival rate closed to 100%. Therefore, the annual examination may be necessary for people who are classified to have a higher risk of cancer development.

The causes of cancer are unknown. researchers cannot explain why people with the same healthy condition, family history in the same family, some are susceptible to the onset of the disease while others do not.

Either they can explain why people who carry some of the risk factors associated with the development of cancer never have cancer, while others having no risk factor are diagnosed with cancer.

Conventionally, treatment of cancers completely depends on the types and grade of cancer. Some people with cancer at an early stage may only need one treatment. But most people with cancer in the later stage have a combination of treatments, including surgery with chemotherapy and/or radiation therapy.

Phytic acids (Inositol hexaphosphate) are phytochemicals of the organic acid found abundantly in nuts, sesame seeds, soybeans, wheat, pumpkin, beans, almonds, etc.

With an aim to find a natural ingredient for the p[revention and treatment of cancers without inducing side effects, researchers examine the anticancer effects of phytic acid (IP6).

In vitro and in vivo phytic acid (IP6) exerted a strong anticancer activity by inhibiting the tumor growth and cell proliferation in a series of cancer cell lines, including colon, nipple, breast, prostate, cervix, liver, pancreas, melanoma and glioblastoma.

The efficacy of IP6 was probably associated with the promoted antioxidant production, improved signal transduction, enhance functions of the NK-cells and exhibited cell cycle arrest and activated proteins associated with cell death programming.

Furthermore, in the finding, the proper role for the treatment of cancer researchers looked into the concentration of IP6 and its lower phosphorylated forms (IP(1-5)),

At the 10 microM to 1 mM concentrations, IP6 and its lower phosphorylated forms (IP(1-5)) showed a potential activity in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation, similar to those of the previous study.

In vivo and in vitro, exogenously administered IP6 and internalized, IP6 and IP(1-5) inhibited cell growth.

Moreover, researchers found that application of IP6 not only decreased cellular proliferation but also causes differentiation of malignant cells often resulting in a reversion to normal phenotype.

The results strongly indicated that IP6 inhibits the cancer cell lines through a number of mechanisms, including cell cycle regulatory genes, differentiation genes, and tumor suppressor genes.

Taken all together, phytic acid (IP6) may be considered an anti-cancer bioactive compound for the prevention and treatment of cancer with no side effects, pending to the confirmation of large sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) [Phytic acid--anticancer nutriceutic].[Article in Polish] by Nawrocka-MusiaƂ D, Latocha M.(PubMed)
(2) IP6: a novel anti-cancer agent by Shamsuddin AM, Vucenik I, Cole KE.(PubMed)

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