Phytochemical Sinigrin Speeds Up Wound Healing

Wound healing is a natural process of immune systematic response to protect our body against the harmful pathogenic invasion.

After receiving the message from the neurons in the brain, the immune first line of defense including the macrophages stimulating the blood palettes to the site of infection to cover the injury and production of pro-inflammatory cytokines to kill off the stimuli and pathogens which try to enter the body through the wound.

Some anti-inflammatory cytokines under normal condition also switch to pro-inflammatory cytokines depending on the severity of the injury.

In some cases, overproduction of pro-inflammatory cytokines can cause damage or death of the nearby cells, leading to the formation of irreversible scars, such as hepatitis infection.

Even worse, if the immune system can not kill off all pathogens in the acute phase of infection, it will compromise to the new change, leading to chronic low-grade inflammation.


Bacterial pathogens often cause infection in specific areas of the body by overgrowth the numbers of bacteria in the site, including the gut.

According to the epidemiological studies, some bacteria are opportunistic pathogens, people with a weakened immune system are particularly prone to their invasion.


Dr. Dennis W. Metzger, the lead scientist wrote, " While it has been commonly thought that viral-induced epithelial cell damage allows bacterial invasiveness, recent studies by several groups have now implicated dysfunctional innate immune defenses following influenza as the primary culprit for enhanced susceptibility to secondary bacterial infections".


The results strongly indicated the increased risk of bacterial infection in people with a weakened immune system.

Researchers on finding a natural compound for speeding up wound healing explored on wound healing effect of sinigrin on HaCaT cells.


In the phytosome with sinigrin with an average particle size of 153 ± 39 nm, the zeta potential of 10.09 ± 0.98 mV and complex efficiency of 69.5 ± 5%.

The formulated sinigrin-phytosome complex significantly exhibited a greater wound healing effect compared to the use of sinigrin alone.

Compared to only 71% wound closer of sinigrin after 42 hours, the phytosome complex completely healed the wound.


At a lower concentration of 0.07 mg/mL, the sinigrin–phytosome complex displayed 79%, whilst sinigrin showed only 50% of wound closure.


At the higher concentration 0.14 mg/mL the sinigrin–phytosome complex completely cured the wound (100%), compared to only 71% wound healing of sinigrin.


Furthermore, The sinigrin-phytosome complex displayed minimal toxicity towards HaCaT cells.


Injection of the complex also exerted a strong effect towards A-375, a human melanoma cell line.


Dr. Mazumder A, after taking into account of co and confounders wrote at the end of the experiment, " sinigrin-phytosome complex augmented the therapeutic potential of sinigrin towards the wound healing activity".


Taken altogether, sinigrin a bioactive ingredient in cruciferous vegetables may be considered a functional supplement for speedup wound healing, pending to the confirmation of large sample size and multicenter human study.


However, intake of bioactive in the form of supplement should be taken with extreme care, as liver toxicity may be induced if overdosed.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Sinigrin and Its Therapeutic Benefits by Anisha Mazumder, Anupma Dwivedi and Jeanetta du Plessis. (Molecules)
(2) In vitro wound healing and cytotoxic effects of sinigrin-phytosome complex by Mazumder A1, Dwivedi A1, du Preez JL1, du Plessis J2.(Pubmed)
(3) Immune Dysfunction and Bacterial Co-Infections following Influenza by Dennis W. Metzger and Keer Sun. (PMC)