Oral cancer also known as mouth cancer is a medical condition characterized by irregular cell growth in the tissue of the oral cavity, due to the alternation of cell DNA.
Most cases of oral cancer begin in the cells on the surface of the inner lining of oral tissue.
However, at the advanced stage, oral cancer cells can travel a distance away to infect other healthy tissue and organs, leading to the secondary metastasis.
According to the statistic provided by the American Cancer Society, in 2018, approximately 51,540 people were diagnosed with oral cavity or oropharyngeal cancer. The disease causes the death of an estimated 10,030 people.
The 5-year survival rate of oral cancer is 66%, including all stages.
Family history, smoking, alcohol drinking, infected by HPV virus, poor hygiene and genetic preposition are some of the risk factors associated with the disease.
Some researchers suggested that oral sex may be one of the major prevalent risk factors involved in the development of oral cancer. Dr. Rajiv Saini in the examination of the connection of oral sex and oral cancer, wrote, "The diverse conduit in the oral cavity that provides as a gateway of exposure of infection from the oral cavity to bloodstream include any open sores, cuts, abrasions, or bleeding gum disease such as gingivitis and periodontitis".
"Accumulating molecular and pathologic evidence has strengthened the hypothesis that HPV infection could play a role in the etiology of some oral squamous cell carcinomas.
And, "To reduce the risk of infection during unprotected oral sex, limit exposure to sexual fluids and ensure that no cuts or lesions are present in the mouth or on the genitals. Good oral health, free from bleeding gums, lip sores, cuts, broken skin, and oral epithelium, enormously reduces the chances of transmission of infection among the partners indulging in oral sex".
These results strongly suggested people who perform oral sex before, during and after sexual intercourse may be at risk of oral cancer due to infected by the HPV virus.
Researchers on finding a natural compound for the inhibition of oral cancer examined the [6]-Shogaol ([6]-SHO), a major constituent of ginger anti-tumor activity.
[6]-SHO showed a significant effect in preventing oral squamous cell carcinoma by activating proapoptotic factors in vitro and in vivo experimental model.
In the inflammation and cell proliferation assays, injection of [6]-SHO inhibited the oral cancer cell line through cytotoxicity induced by the expression of proinflammatory cytokines, proteins associated with cell apoptosis and anti-cell survival mechanisms.
Furthermore, in the oral cancer cells, oral administration of [6]-SHO strongly inhibited phosphorylation in stimulating the enzymes which carry energy the cancer cells and enzymes in the degradation of cellular response to inflammation.
Dr. Annamalai G, the lead scientist said, " [6]-SHO is a novel functional agent capable of preventing DMBA induced inflammation and cell proliferation associated tumorigenesis by modulating multiple signaling molecules".
Additionally, in order to reveal more information about 6-Gingerol anti-oral cancer properties, researchers investigated the compound in human oral (SCC4, KB) with or without wortmannin, rapamycin, and cisplatin.
6-Gingerol showed dose-dependent cytotoxicity in the oral cell line.
Combinations of 6-gingerol with wortmannin and cisplatin showed additive effects, while with rapamycin, it showed 50% cytotoxicity equivalent to that of IC50 of 6-gingerol alone.
Treatment with 6-gingerol exhibited S-phase arrest in SCC4 cells. But 6-Gingerol, wortmannin, and rapamycin treatment showed almost two-fold higher expression of proteins associated with cancer cells apoptosis.
Dr. in the final report wrote," 6-gingerol appears to be a safe and potent chemotherapeutic/chemopreventive compound acting through cell cycle arrest and induction of apoptosis in human oral....cells".
Taken altogether, ginger processed bioactive ingredient 6-gingerol and [6]-Shogaol may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of oral cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) [6]-Shogaol attenuates inflammation, cell proliferation via modulate NF-κB and AP-1 oncogenic signaling in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis by Annamalai G1, Suresh K. (PubMed)
(2) 6-Gingerol Mediates its Anti Tumor Activities in Human Oral and Cervical Cancer Cell Lines through Apoptosis and Cell Cycle Arrest by Kapoor V1, Aggarwal S1, Das SN. (PubMed)
(3) Oral sex and oral cancer: A virus link by Rajiv Saini. (PMC)
Get Pregnant Naturally
".....Utilizing Traditional Chinese Medicine in Tonifying Energy flow to the Reproductive System Channels In Men and Women for Natural Conception, including Couple Who were diagnosed with Unexplained causes of Infertility...." Chantel M.
Sunday, April 7, 2019
Phytochemical Allyl isothiocyanate, the Potential Anti Brain Cancer Bioactive Compound
Phytochemical Allyl isothiocyanate may be next pharmacotherapeutic target to identify the chemo drug for the treatment of brain cancer without inducing any side effects.
Phytochemicals, the natural chemical constituent, protect the plants against diseases and form their outer's color.
Brain and spinal cord make up the nervous system. Brain and Spinal Cord tumors originated are not very common.
Brain cancer is a medical and chronic condition characterized by cell growth disorderly in the brain tissue.
Benign tumors are noncancerous, and malignant tumors are cancerous. More than 190.000 people in the US are diagnosed with a brain tumor each year alone.
Most brain types of brain cancer in the older adult ages 50 to 60 are Chordomas. The cancer is a rare and slow growing, but it can invade adjacent bone and put pressure on the nearby neural tissue.
Meningiomas, the most common type of benign brain tumor of the age group 40-50s. However, a small percentage of these tumors can be malignant.
According to the statistic provided by the Canadian cancer society, Every day about 25 Canadians is diagnosed with a brain tumor.
The 5-year survival rate of brain cancer is only 25%, compared to over 60% for cancers overall. Most adults with a diagnosis of aggressive glioblastoma survive only 1–2 years after their diagnosis.
The exact causes of brain cancer are debatable. Researchers di not know why people with the same health conditions, family history, some are at a higher risk to develop brain cancer while others do not.
Some researchers suggested genetic preposition and acquired gene mutation due to long-term exposure to chemical toxins may be the prevalent risk factor that causes the alternation of brain cell DNA.
Most common symptoms of brain cancer depending on the stage are persistent headaches and localized pain, gradual loss of sensation and movement, speech difficulty and persistent pain
If you are experiencing some of the above symptoms, please make sure you check with your doctor immediately to rule the brain cancer possibility.
Allyl isothiocyanate is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in horseradish, mustard, wasabi, etc.
Most primary tumors are caused by abnormal cells growth that surrounds and support neurons, with a small number may be caused by a gene defect from exposure to radiation or toxic chemicals.
In the examining the side effects of Allyl isothiocyanate from the available data suggest that urinary concentrations of AITC equivalent are at least ten times higher than in the plasma, and tissue levels of AITC equivalent in the urinary bladder were 14-79 times higher than in other organs after oral AITC administration to rats for the treatment of cancer.
These results indicated AITC may be most effective in the bladder as a cancer chemopreventive compound, as AITC at high-dose levels exhibited a low degree of cytotoxicity and genotoxicity in animal cancer studies.
Once again, the experiment reaffirmed the effect of AITC in the exhibition of many desirable attributes of a cancer chemopreventive agent.
In the reassessment of Allyl isothiocyanate (AITC) in the reduced risk of cancer, researchers at the National Chung Hsing University conducted an experiment to examine the effects of the phytochemical in the brain cancer cells.
In compared to other cancer cell lines inhibition, AITC significantly decreased proliferation and viability of human brain malignant glioma GBM 8401 cells in a dose-dependent manner with IC50 9.25+/-0.69 microM for 24 h-treatment.
In cell differentiated assay, AITC induced significantly G2/M arrest and sub-G1 phase (apoptotic population) in GBM 8401 cells.
AITC markedly reduced the CDK1/cyclin B activity and protein levels which are responsible for cancer cell proliferation and survival.
Furthermore, AITC-induced apoptotic cell death through enhancing the proteins associated with cells death programming.
Dr. Chen NG, the lead scientists at the final report, said, "AITC is a potent anti-human brain malignant glioma drug and it shows a remarkable action on cell cycle arrest before a commitment for apoptosis is reached".
Taken altogether, it is safe to suggest that Phytochemical Allyl isothiocyanate may be used as chemopreventive and functional phytochemical for high-risk of brain cancer individual and an adjunct therapy combined with primary medicine for the treatment of brain cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Allyl isothiocyanate triggers G2/M phase arrest and apoptosis in human brain malignant glioma GBM 8401 cells through a mitochondria-dependent pathway by Chen NG, Chen KT, Lu CC, Lan YH, Lai CH, Chung YT, Yang JS, Lin YC.(PubMed)
(2) Allyl isothiocyanate as a cancer chemopreventive phytochemical by Zhang Y.(PubMed)
Saturday, April 6, 2019
Phytochemical Sulforaphane (Dithiolthiones) Kills Cervical Cancer Cells, According to Studies
Scientists may have found a bioactive compound isolated from cruciferous vegetables for the prevention and treatment of cervical cancer with no side effects, according to studies.
The cervix is an opening passage in the center of the ectocervix, that connects the uterus to the vagina in female reproductive organs. Cervix acts as a transition area for vaginal lining (squamous epithelium) change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.
Cervical cancer is a medical condition caused by irregular and disordered cell growth in the tissue of the cervix.
Most cases of cervical cancer start in the cells on the surface of the inner lining of the cervix. At the early stage, most patients do not experience any symptoms.
However, at the later stage, the overgrowth tumor may suppress the nearby blood vessels and nerve tissue, leading to abnormal bleeding and severe abdominal pain.
At this stage, cancerous cells from cervix also can travel a distance away to infect other healthy tissue and organ, through lymph and blood circulation, causing the secondary metastasis.
Most common cervical metastasis includes the vagina, the uterus, the uterus, the tissue nearby lymph nodes in the pelvis, back of the abdomen tissue and ligaments around the cervix and uterus
According to the statistic, cervical cancer is most often diagnosed between the ages of 35 and 44 and only 15% of cervical cancers are diagnosed in women over age 65.
The five years survival rate of invasive cervical cancer is 92% if diagnosed in the early stages.
What causes cervical cells DNA alternation? Researchers do not know. But researchers do know that immune system deficiency, smoking, the increase in age, long-term use of oral contraceptives and exposure to diethylstilbestrol are some of the prevalent risk factors associated with the onset of the disease.
Some researchers also suggested women who have several sexual partners or often change of sexual partners are at increased risk of infected by the Human papillomavirus (HPV), one of the major cause of cervical cancer.
Dr. Diane Cooper, the lead scientist in the cancer researcher in the examine the sexual activity in the risk of cervical cancer of among South African women wrote, "cervical cancer risk is associated with increased sexual activity. Initiatives to encourage later commencement of sex, and limiting the number of sexual partners would have a favorable impact on the risk of cancer of the cervix and other sexually transmitted infections".
These results clearly suggested that women who are sexually active and have a number of sexual partners should take extreme precautions to protect themselves against HPV infection.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
On finding natural chemoprevention which holds great potential for cancer management as lower, clinically tolerable doses of individual agents for the treatment of cervical cancer, the cancer team at the Manipal University examined the effect of combination treatment of sulforaphane (SFN) and eugenol on HeLa cells.
Injection with variable dose combinations of SFN and eugenol showed a significant effect in inducing cell cytotoxicity and apoptosis at the lower and synergistic effect at higher sub-lethal doses to the cancer cells.
Futhermore, application of chemo drugs gemcitabine combined with the low- and high-dose of SFN combinations showed no significant cell death at lower doses compared to that of cell cytotoxicity in gemcitabine alone.
These results clearly suggested that SFN can only elevate the efficiency and lower the dose of certain chemo drugs which act on certain pathways in inducing cytotoxicity and cell death with decreasing side effects.
Additional examination of the effect of SFN and eugenol combinations researchers found that SFN significantly inhibits the expression of the proteins associated with cell proliferation and production of inflammatory cytokines.
Dr. Hussain A, the lead scientists in the final report wrote, "2 (or more) chemopreventive agents can act antagonistically or synergistically necessitating elucidation of possible mechanistic interactions for favorable and reliable outcomes of dietary components in the field of cancer prevention".
Compared to chemo drugs, injection of sulforaphane alone exerted a strong effect in inducing dose-dependent selective cytotoxicity in HeLa cells without causing harm to the to normal cells.
The finding emphasized that the bioactive compound processes a safe cytotoxicity profile compared to conventional chemo medicine.
Also, sulforaphane alone was found to expresse its efficacy through analysis of genes similar to that of SFN and eugenol combination.
In human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells, SFN inhibited the viability of both HeLa and HepG2 cells by inducing apoptosis, observed by the formation of apoptotic bodies and the accumulation of the sub-G1 phase.
In-depth differentiation of SFN activity, researchers discovered that SFN not only induces cell death through the cancer cells cycle arrest but also activates the genes associated with the programming cell death and cell apoptosis by blocking the expression of cell proliferative proteins.
Taken altogether, sulforaphane SFN may be considered chemo and natural medicine for the prevention and combined with certain primary medicine for the treatment of cervical cancer with a reduced side effect through lowering the dose of the applied chemo drug.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Concurrent sulforaphane and eugenol induces differential effects on human cervical cancer cells by Hussain A1, Priyani A, Sadrieh L, Brahmbhatt K, Ahmed M, Sharma C.(PubMed)
(2) Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells by Sharma C1, Sadrieh L, Priyani A, Ahmed M, Hassan AH, Hussain A.(PubNed)
(3) Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3 by Park SY1, Kim GY, Bae SJ, Yoo YH, Choi YH.(PubMed)
(4) Determinants of sexual activity and its relation to cervical cancer risk among South African Women by Diane Cooper,
1 Margaret Hoffman,1 Henri Carrara,1 Lynn Rosenberg,2 Judy Kelly,2Ilse Stander,3 Lynnette Denny,4 Anna-Lise Williamson,5,6 and Samuel Shapiro. (PMC)
The cervix is an opening passage in the center of the ectocervix, that connects the uterus to the vagina in female reproductive organs. Cervix acts as a transition area for vaginal lining (squamous epithelium) change to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.
Cervical cancer is a medical condition caused by irregular and disordered cell growth in the tissue of the cervix.
Most cases of cervical cancer start in the cells on the surface of the inner lining of the cervix. At the early stage, most patients do not experience any symptoms.
However, at the later stage, the overgrowth tumor may suppress the nearby blood vessels and nerve tissue, leading to abnormal bleeding and severe abdominal pain.
At this stage, cancerous cells from cervix also can travel a distance away to infect other healthy tissue and organ, through lymph and blood circulation, causing the secondary metastasis.
Most common cervical metastasis includes the vagina, the uterus, the uterus, the tissue nearby lymph nodes in the pelvis, back of the abdomen tissue and ligaments around the cervix and uterus
According to the statistic, cervical cancer is most often diagnosed between the ages of 35 and 44 and only 15% of cervical cancers are diagnosed in women over age 65.
The five years survival rate of invasive cervical cancer is 92% if diagnosed in the early stages.
What causes cervical cells DNA alternation? Researchers do not know. But researchers do know that immune system deficiency, smoking, the increase in age, long-term use of oral contraceptives and exposure to diethylstilbestrol are some of the prevalent risk factors associated with the onset of the disease.
Some researchers also suggested women who have several sexual partners or often change of sexual partners are at increased risk of infected by the Human papillomavirus (HPV), one of the major cause of cervical cancer.
Dr. Diane Cooper, the lead scientist in the cancer researcher in the examine the sexual activity in the risk of cervical cancer of among South African women wrote, "cervical cancer risk is associated with increased sexual activity. Initiatives to encourage later commencement of sex, and limiting the number of sexual partners would have a favorable impact on the risk of cancer of the cervix and other sexually transmitted infections".
These results clearly suggested that women who are sexually active and have a number of sexual partners should take extreme precautions to protect themselves against HPV infection.
Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.
On finding natural chemoprevention which holds great potential for cancer management as lower, clinically tolerable doses of individual agents for the treatment of cervical cancer, the cancer team at the Manipal University examined the effect of combination treatment of sulforaphane (SFN) and eugenol on HeLa cells.
Injection with variable dose combinations of SFN and eugenol showed a significant effect in inducing cell cytotoxicity and apoptosis at the lower and synergistic effect at higher sub-lethal doses to the cancer cells.
Futhermore, application of chemo drugs gemcitabine combined with the low- and high-dose of SFN combinations showed no significant cell death at lower doses compared to that of cell cytotoxicity in gemcitabine alone.
These results clearly suggested that SFN can only elevate the efficiency and lower the dose of certain chemo drugs which act on certain pathways in inducing cytotoxicity and cell death with decreasing side effects.
Additional examination of the effect of SFN and eugenol combinations researchers found that SFN significantly inhibits the expression of the proteins associated with cell proliferation and production of inflammatory cytokines.
Dr. Hussain A, the lead scientists in the final report wrote, "2 (or more) chemopreventive agents can act antagonistically or synergistically necessitating elucidation of possible mechanistic interactions for favorable and reliable outcomes of dietary components in the field of cancer prevention".
Compared to chemo drugs, injection of sulforaphane alone exerted a strong effect in inducing dose-dependent selective cytotoxicity in HeLa cells without causing harm to the to normal cells.
The finding emphasized that the bioactive compound processes a safe cytotoxicity profile compared to conventional chemo medicine.
Also, sulforaphane alone was found to expresse its efficacy through analysis of genes similar to that of SFN and eugenol combination.
In human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells, SFN inhibited the viability of both HeLa and HepG2 cells by inducing apoptosis, observed by the formation of apoptotic bodies and the accumulation of the sub-G1 phase.
In-depth differentiation of SFN activity, researchers discovered that SFN not only induces cell death through the cancer cells cycle arrest but also activates the genes associated with the programming cell death and cell apoptosis by blocking the expression of cell proliferative proteins.
Taken altogether, sulforaphane SFN may be considered chemo and natural medicine for the prevention and combined with certain primary medicine for the treatment of cervical cancer with a reduced side effect through lowering the dose of the applied chemo drug.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Concurrent sulforaphane and eugenol induces differential effects on human cervical cancer cells by Hussain A1, Priyani A, Sadrieh L, Brahmbhatt K, Ahmed M, Sharma C.(PubMed)
(2) Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells by Sharma C1, Sadrieh L, Priyani A, Ahmed M, Hassan AH, Hussain A.(PubNed)
(3) Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3 by Park SY1, Kim GY, Bae SJ, Yoo YH, Choi YH.(PubMed)
(4) Determinants of sexual activity and its relation to cervical cancer risk among South African Women by Diane Cooper,
1 Margaret Hoffman,1 Henri Carrara,1 Lynn Rosenberg,2 Judy Kelly,2Ilse Stander,3 Lynnette Denny,4 Anna-Lise Williamson,5,6 and Samuel Shapiro. (PMC)
Herbal Ginger, the Potent and Natural Therapy for Rheumatic Diseases
Rheumatism is autoimmune and inflammatory diseases marked by inflammation and pain in the joints, muscles, or fibrous tissue, especially rheumatoid arthritis.
In other words, rheumatic diseases are a medical and chronic condition characterized inflammation that affects your joints tendons, ligaments, bones, and muscles, including a group of diseases associated with arthritis.
Depending on the types of rheumatic diseases, conventional treatment may include medication for reducing the symptoms, physiotherapy and stress management. The aim of the treatment is to alleviate pain and improve the quality of life. Sadly, none of the drugs has been found safe; all are known to produce from mild to serious side-effects.
Most common symptoms of rheumatic diseases are joint pain, reduced motion in a joint, particularly, joints inflammation that induces swelling, redness, on the affected area.
If you experience some of the above symptoms, you may have rheumatic diseases, please make sure you check with your doctor to rule out the possibility.
There is no single cause of rheumatic diseases. Researchers believe groups of factors such as genes and environmental influences may be associated with the onset of the diseases, including the increase in age, gender, family history, exposure to environmental toxic substance and smoking.
However, the most common risk factor of rheumatic diseases in the Western world is obesity. Dr. the lead scientist, in the examination of the risk of obesity for the onset of rheumatic diseases, said, "The growing body of evidence recognizing the adipose tissue (AT) as an active endocrine organ secreting bioactive mediators involved in metabolic and inflammatory disorders, together with the global epidemic of overweight and obesity, rise obesity as a hot topic of current research".
" The chronic state of low-grade inflammation present in the obese condition and the multiple pleiotropic effects of adipokines on the immune system has been implicated in the pathogenesis of several inflammatory conditions including rheumatic autoimmune and inflammatory diseases".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural ingredient or whole food for the prevention and treatment of rheumatic autoimmune and inflammatory diseases with no side effects, scientists at the Odense University examine the traditional use of ginger against rheumatism.
The study included 56 patients (28 with rheumatoid arthritis, 18 with osteoarthritis and 10 with muscular discomfort) randomly assigned to the use of powdered ginger against their afflictions.
Amongst the arthritis patients more than three-quarters experienced, to varying degrees, relief in pain and swelling. All the patients with muscular discomfort experienced relief in pain.
None of the patients reported adverse effects during the period of ginger consumption which ranged from 3 months to 2.5 years.
Further analysis of the results, researchers found that ginger exerts the similar effects of that of conventional medicine as an important mediator of inflammation.
Dr. Srivastava KC, the lead scientist wrote in the final report, "at least one of the mechanisms by which ginger shows its ameliorative effects could be related to the inhibition of prostaglandin and leukotriene biosynthesis., i.e. it works as a dual inhibitor of eicosanoid biosynthesis".
Additionally, compared to conventional medicine such as non-steroidal anti-inflammatory drugs and corticosteroids which treat rheumatic diseases through inhibiting the cyclooxygenase associated with the symptoms of inflammation and pain, ginger demonstrated the similar effects and improve quality of the life in patients with rheumatic diseases, without inducing any side effects during the course of the experiment.
These results clearly suggested that ginger may be considered a functional food for the prevention and treatment of rheumatism with no adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders by Srivastava KC1, Mustafa T. (PubMed)
(2) Ginger (Zingiber officinale) and rheumatic disorders by Srivastava KC1, Mustafa T. (PubMed)
(3) Obesity as a Risk and Severity Factor in Rheumatic Diseases (Autoimmune Chronic Inflammatory Diseases) by Elisa Gremese,1 Barbara Tolusso,1 Maria Rita Gigante,1 and Gianfranco Ferraccioli. (PMC)
In other words, rheumatic diseases are a medical and chronic condition characterized inflammation that affects your joints tendons, ligaments, bones, and muscles, including a group of diseases associated with arthritis.
Depending on the types of rheumatic diseases, conventional treatment may include medication for reducing the symptoms, physiotherapy and stress management. The aim of the treatment is to alleviate pain and improve the quality of life. Sadly, none of the drugs has been found safe; all are known to produce from mild to serious side-effects.
Most common symptoms of rheumatic diseases are joint pain, reduced motion in a joint, particularly, joints inflammation that induces swelling, redness, on the affected area.
If you experience some of the above symptoms, you may have rheumatic diseases, please make sure you check with your doctor to rule out the possibility.
There is no single cause of rheumatic diseases. Researchers believe groups of factors such as genes and environmental influences may be associated with the onset of the diseases, including the increase in age, gender, family history, exposure to environmental toxic substance and smoking.
However, the most common risk factor of rheumatic diseases in the Western world is obesity. Dr. the lead scientist, in the examination of the risk of obesity for the onset of rheumatic diseases, said, "The growing body of evidence recognizing the adipose tissue (AT) as an active endocrine organ secreting bioactive mediators involved in metabolic and inflammatory disorders, together with the global epidemic of overweight and obesity, rise obesity as a hot topic of current research".
" The chronic state of low-grade inflammation present in the obese condition and the multiple pleiotropic effects of adipokines on the immune system has been implicated in the pathogenesis of several inflammatory conditions including rheumatic autoimmune and inflammatory diseases".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
With an aim to find a natural ingredient or whole food for the prevention and treatment of rheumatic autoimmune and inflammatory diseases with no side effects, scientists at the Odense University examine the traditional use of ginger against rheumatism.
The study included 56 patients (28 with rheumatoid arthritis, 18 with osteoarthritis and 10 with muscular discomfort) randomly assigned to the use of powdered ginger against their afflictions.
Amongst the arthritis patients more than three-quarters experienced, to varying degrees, relief in pain and swelling. All the patients with muscular discomfort experienced relief in pain.
None of the patients reported adverse effects during the period of ginger consumption which ranged from 3 months to 2.5 years.
Further analysis of the results, researchers found that ginger exerts the similar effects of that of conventional medicine as an important mediator of inflammation.
Dr. Srivastava KC, the lead scientist wrote in the final report, "at least one of the mechanisms by which ginger shows its ameliorative effects could be related to the inhibition of prostaglandin and leukotriene biosynthesis., i.e. it works as a dual inhibitor of eicosanoid biosynthesis".
Additionally, compared to conventional medicine such as non-steroidal anti-inflammatory drugs and corticosteroids which treat rheumatic diseases through inhibiting the cyclooxygenase associated with the symptoms of inflammation and pain, ginger demonstrated the similar effects and improve quality of the life in patients with rheumatic diseases, without inducing any side effects during the course of the experiment.
These results clearly suggested that ginger may be considered a functional food for the prevention and treatment of rheumatism with no adverse effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders by Srivastava KC1, Mustafa T. (PubMed)
(2) Ginger (Zingiber officinale) and rheumatic disorders by Srivastava KC1, Mustafa T. (PubMed)
(3) Obesity as a Risk and Severity Factor in Rheumatic Diseases (Autoimmune Chronic Inflammatory Diseases) by Elisa Gremese,1 Barbara Tolusso,1 Maria Rita Gigante,1 and Gianfranco Ferraccioli. (PMC)
Piperine Plus Curcumin, the Anti Cognitive Impairment Bioactive Compounds
Phytochemical piperine may be the next therapeutic ingredient for the prevention and treatment of cognitive impairment, some scientists suggested.
Cognition is the process of the brain including the attention of working memory, producing and comprehending language, learning, reasoning, problem-solving, and decision making.
Cognitive impairment is the condition, affecting a person's thinking, communication, understanding or memory. Cognitive impairment can be acute or chronic.
Acute cognitive impairment is a short-term health problem caused by delirium, an acutely disturbed state of mind due to drugs (toxicity and withdrawal), electrolyte disturbance, lack of drugs, liver disease, infection, reduced sensory input, intracranial urinary retention/fecal impaction or m Myocardial/metabolic/pulmonary.
Chronic cognitive impairment is a permanent medical condition associated with problems of language, ideomotor and constructive praxis, visual gnosis, spatial attention, learning abilities, and executive functions.
There is no single cause of cognitive impairment. Some researchers suggested that depending on the locations of the brain that were affected, patients may be at risk of Alzheimer's disease if the brain change is caused by the abnormal clumps of beta-amyloid protein (plaques) and microscopic protein clumps of tau, Lewy bodies, if the change is a result of microscopic clumps of another protein associated with Parkinson's disease, dementia with Lewy bodies and some cases of Alzheimer's disease.
Small strokes or reduced blood flow through brain blood vessels can also cause chronic cognitive impairment.
According to the observation of the patient MRI, patients brain with cognitive impairment also showed shrinkage of the hippocampus, a brain region important for memory, enlargement of the brain's fluid-filled spaces (ventricles) and reduced use of glucose, the sugar that's the primary source of energy for cells.
Risk factors associated with the onset of chronic cognitive impairment include the increase in age, genetic preposition, certain medical conditions, such as diabetes, high blood cholesterol, and pressure, being obese and lack of exercise.
According to the joint study led by the Health Innovations Research Institute, obesity is also one of the major risk factors of cognitive impairment in the Western world.
Dr. Jason C. D. Nguyen, the lead author in the team wrote in the final report, "The incidence of obesity in middle age is increasing markedly, and in parallel, the prevalence of metabolic disorders including cardiovascular disease and type II diabetes is also rising. Numerous studies have demonstrated that both obesity and metabolic disorders are associated with poorer cognitive performance, cognitive decline, and dementia".
Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
On finding natural ingredients for the prevention of cognitive impairment caused by oxidative damage in the brain neurons, researchers at the University Institute of Pharmaceutical Sciences examine the cognition protective effects of piperine co-administration with curcumin.
Cognitive impairment and oxidative stress mice induced by chronic stress (CS) were selected to the study.
Before administration of piperine + curcumin, chronic stress mice showed a significantly impaired memory performance (delayed latency time to reach the platform) and decreased locomotor activity along with sucrose consumption.
Furthermore, without infection of piperine + curcumin, the tested mice also demonstrated a significant impairment in oxidative parameters observed by the elevated malondialdehyde, nitrite concentration and decreased reduced glutathione, catalase levels) and reduced hydrolytic metabolism in transmitting information between neurons.
Application of piperine + curcumin restored all parameters induced by chronic stress, including the normalized the cognitive function, improved the antioxidant status against overexpression of free radicals.
Most importantly, co-administration of piperine (20mg/kg; p.o.) with curcumin (100 and 200mg/kg, p.o.) significantly elevated the cognitive protective effect compared to individual use.
Dr. Rinwa P, the lead scientist said in the final report, "piperine enhanced the bioavailability of curcumin and potentiated its protective effects against CUS induced cognitive impairment and associated oxidative damage in mice".
In order to reconfirm the co-administration of piperine with curcumin the neuroprotective effects, researchers elucidate the neuroprotective mechanism of curcumin and its co-administration with piperine against olfactory bulbectomy induced depression in rats.
Before injecting piperine + curcumin, tested rat showed depression-like symptoms as evidenced by increased immobility time in FST, hyperactivity in open field arena, and anhedonic like response in SPT along with alterations in mitochondrial enzyme complexes, increased serum corticosterone levels and oxidative damage similar to those of the previous study.
The overexpression of pro-inflammatory cytokines, proteins associated with the neuron apoptosis and oxidative stress in tested rat caused by olfactory bulbectomy were also inhibited by the co-administration of piperine with curcumin.
The in-depth analysis suggested that the combination of piperine plus curcumin treatment significantly and dose-dependently restored all behavioral, biochemical, mitochondrial, molecular and histopathological alterations associated with OBX induced depression.
Dr. Rinwa P said, "curcumin along with piperine exhibits neuroprotection against olfactory bulbectomy induced depression possibly by modulating oxidative-nitrosative stress-induced neuroinflammation and apoptosis".
Taken altogether, the discovery strongly supports the use of piperine and curcumin for the prevention and treatment of cognitive impairment, pending to the reconfirmation of larger sample size and multicenter possibility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) iperine potentiates the protective effects of curcumin against chronic unpredictable stress-induced cognitive impairment and oxidative damage in mice by Rinwa P, Kumar A.(PubMed)
(2) Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression by Rinwa P, Kumar A, Garg S.(PubMed)
(3) Protective effect of curcumin and its combination with piperine(bioavailability enhancer) against haloperidol-associated neurotoxicity: cellular and neurochemical evidence by Bishnoi M, Chopra K, Rongzhu L, Kulkarni SK.(PubMed)
(4) Obesity and cognitive decline: role of inflammation and vascular changes by Jason C. D. Nguyen,1 A. Simon Killcross,2 and Trisha A. Jenkins. (PMC)
Cognition is the process of the brain including the attention of working memory, producing and comprehending language, learning, reasoning, problem-solving, and decision making.
Cognitive impairment is the condition, affecting a person's thinking, communication, understanding or memory. Cognitive impairment can be acute or chronic.
Acute cognitive impairment is a short-term health problem caused by delirium, an acutely disturbed state of mind due to drugs (toxicity and withdrawal), electrolyte disturbance, lack of drugs, liver disease, infection, reduced sensory input, intracranial urinary retention/fecal impaction or m Myocardial/metabolic/pulmonary.
Chronic cognitive impairment is a permanent medical condition associated with problems of language, ideomotor and constructive praxis, visual gnosis, spatial attention, learning abilities, and executive functions.
There is no single cause of cognitive impairment. Some researchers suggested that depending on the locations of the brain that were affected, patients may be at risk of Alzheimer's disease if the brain change is caused by the abnormal clumps of beta-amyloid protein (plaques) and microscopic protein clumps of tau, Lewy bodies, if the change is a result of microscopic clumps of another protein associated with Parkinson's disease, dementia with Lewy bodies and some cases of Alzheimer's disease.
Small strokes or reduced blood flow through brain blood vessels can also cause chronic cognitive impairment.
According to the observation of the patient MRI, patients brain with cognitive impairment also showed shrinkage of the hippocampus, a brain region important for memory, enlargement of the brain's fluid-filled spaces (ventricles) and reduced use of glucose, the sugar that's the primary source of energy for cells.
Risk factors associated with the onset of chronic cognitive impairment include the increase in age, genetic preposition, certain medical conditions, such as diabetes, high blood cholesterol, and pressure, being obese and lack of exercise.
According to the joint study led by the Health Innovations Research Institute, obesity is also one of the major risk factors of cognitive impairment in the Western world.
Dr. Jason C. D. Nguyen, the lead author in the team wrote in the final report, "The incidence of obesity in middle age is increasing markedly, and in parallel, the prevalence of metabolic disorders including cardiovascular disease and type II diabetes is also rising. Numerous studies have demonstrated that both obesity and metabolic disorders are associated with poorer cognitive performance, cognitive decline, and dementia".
Piperine is a phytochemical alkaloid in the class of organosulfur compound, found abundantly in white and black pepper, long pepper, etc.
On finding natural ingredients for the prevention of cognitive impairment caused by oxidative damage in the brain neurons, researchers at the University Institute of Pharmaceutical Sciences examine the cognition protective effects of piperine co-administration with curcumin.
Cognitive impairment and oxidative stress mice induced by chronic stress (CS) were selected to the study.
Before administration of piperine + curcumin, chronic stress mice showed a significantly impaired memory performance (delayed latency time to reach the platform) and decreased locomotor activity along with sucrose consumption.
Furthermore, without infection of piperine + curcumin, the tested mice also demonstrated a significant impairment in oxidative parameters observed by the elevated malondialdehyde, nitrite concentration and decreased reduced glutathione, catalase levels) and reduced hydrolytic metabolism in transmitting information between neurons.
Application of piperine + curcumin restored all parameters induced by chronic stress, including the normalized the cognitive function, improved the antioxidant status against overexpression of free radicals.
Most importantly, co-administration of piperine (20mg/kg; p.o.) with curcumin (100 and 200mg/kg, p.o.) significantly elevated the cognitive protective effect compared to individual use.
Dr. Rinwa P, the lead scientist said in the final report, "piperine enhanced the bioavailability of curcumin and potentiated its protective effects against CUS induced cognitive impairment and associated oxidative damage in mice".
In order to reconfirm the co-administration of piperine with curcumin the neuroprotective effects, researchers elucidate the neuroprotective mechanism of curcumin and its co-administration with piperine against olfactory bulbectomy induced depression in rats.
Before injecting piperine + curcumin, tested rat showed depression-like symptoms as evidenced by increased immobility time in FST, hyperactivity in open field arena, and anhedonic like response in SPT along with alterations in mitochondrial enzyme complexes, increased serum corticosterone levels and oxidative damage similar to those of the previous study.
The overexpression of pro-inflammatory cytokines, proteins associated with the neuron apoptosis and oxidative stress in tested rat caused by olfactory bulbectomy were also inhibited by the co-administration of piperine with curcumin.
The in-depth analysis suggested that the combination of piperine plus curcumin treatment significantly and dose-dependently restored all behavioral, biochemical, mitochondrial, molecular and histopathological alterations associated with OBX induced depression.
Dr. Rinwa P said, "curcumin along with piperine exhibits neuroprotection against olfactory bulbectomy induced depression possibly by modulating oxidative-nitrosative stress-induced neuroinflammation and apoptosis".
Taken altogether, the discovery strongly supports the use of piperine and curcumin for the prevention and treatment of cognitive impairment, pending to the reconfirmation of larger sample size and multicenter possibility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) iperine potentiates the protective effects of curcumin against chronic unpredictable stress-induced cognitive impairment and oxidative damage in mice by Rinwa P, Kumar A.(PubMed)
(2) Suppression of neuroinflammatory and apoptotic signaling cascade by curcumin alone and in combination with piperine in rat model of olfactory bulbectomy induced depression by Rinwa P, Kumar A, Garg S.(PubMed)
(3) Protective effect of curcumin and its combination with piperine(bioavailability enhancer) against haloperidol-associated neurotoxicity: cellular and neurochemical evidence by Bishnoi M, Chopra K, Rongzhu L, Kulkarni SK.(PubMed)
(4) Obesity and cognitive decline: role of inflammation and vascular changes by Jason C. D. Nguyen,1 A. Simon Killcross,2 and Trisha A. Jenkins. (PMC)
Celery, the Best Anti Chronic Inflammatory Disease Functional Veggie
Celery may have a profound and positive effect on the prevention and treatment of chronic inflammatory diseases, some scientists found.
Inflammation is a natural reaction to a systematic immune response which protects our body against the stimuli or invasive pathogens.
Acute inflammation is a result of the immune white blood cell response to tissue damage or injury by stimulating the production of proinflammatory cytokines with an aim to kill off the microorganism which tries to enter the body through the wound.
Chronic inflammation is a condition of low-grade inflammation adopted by the immunity caused by the immune inability to kill off all invaders in the acute phase of infection.
Some researchers in the examine the immune evolution over thousands of year suggested that the immune system has evolved to destroy the foreigner pathogens after entering in specific time within 3 -8 weeks, otherwise, it will adapt to the change.
Chronic inflammation also is an autoimmune disease caused by the immune system mistakenly attacks the bodily tissue.
Epidemiological studies suggested that aging that causes low production of sex hormone, being obese and obese, and smoking are associated with the early onset of chronic inflammatory diseases.
Some researchers suggested that out of a number of risk factors, a poor diet in long-term is one of the major cause of chronic inflammatory diseases.
Dr. Anne M. Minihane, the lead author in the examine the risk of low-grade inflammation in diet composition and health said, " the ability of diet to positively modulate inflammation and provide the much-needed evidence to develop research portfolios that will inform new product development and associated health claims".
The statement clearly suggested that people who follow a healthy diet pattern with high fruits and vegetables and whole grain and low saturated and trans fat, red meat and processed food are less likely to be infected by chronic inflammatory diseases.
Celery is a species of Apium graveolens, belong to the family Apiaceae. It is cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.
With an aim to find a natural whole food for the prevention and treatment of chronic inflammatory disease, researchers looked into the group of flavones that have reported anti-inflammatory activities, and examined the ability of flavone-rich foods to reduce inflammation.
Celery extracts, with the anti-inflammatory activities and rich in flavone aglycones, was selected for the study.
Celery diets with different glycoside or aglycone contents were formulated and absorption was evaluated in mice fed with 5 or 10% celery diets.
Intake of deglycosylation was found to increase the absorption of dietary flavones in vivo and modulates inflammation by reducing TNF-α, the proinflammatory cytokines and NF-κB, which regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses.
The results suggested that celery extract rich in flavones may have the potential for the treatment and prevention of inflammatory diseases.
Additional differentiation of the anti-inflammatory and immunomodulatory activity in-vitro and in-vivo of the compound flavonoids found abundantly in celery, researchers launched an evaluation to examine the effects of the ethanol/water (1:1) extract of the leaves of Apium graveolens var. dulce (celery) on iNOS expression and NO production in a tested macrophage cell line stimulated for 24 h with Escherichia coli lipopolysaccharide (LPS).
Where the inducible nitric oxide synthase (iNOS) is one of the direct consequences of the inflammatory process and overproduction of NO is considered a pro-inflammatory mediator that induces inflammation.
In vitro, treatment of the extract and apiin showed significant inhibitory activity on nitrite (NO) production and iNOS expression observed by the tested cell line assay.
Interestingly, the extract exerted anti-inflammatory activity in-vivo (ID50 730 microg cm(-2)), with a potency seven-times lower than those of indomethacin (ID50 93 microg cm(-2)), the non-steroidal anti-inflammatory drug used as references.
The finding clearly suggested the inhibitory activity of the extract and apiin in-vitro on iNOS expression and nitrite production.
Taken altogether, celery may be considered a functional food for the prevention and treatment of acute and chronic inflammatory diseases without inducing any side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Flavone deglycosylation increases their anti-inflammatory activity and absorption by Hostetler G1, Riedl K, Cardenas H, Diosa-Toro M, Arango D, Schwartz S, Doseff AI. (PubMed)
(2) An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties by Mencherini T1, Cau A, Bianco G, Della Loggia R, Aquino RP, Autore G.(PubMed).
(3) Combination anti-inflammatory therapy: synergism in rats of NSAIDs/corticosteroids with some herbal/animal products by Whitehouse MW1, Butters DE. (PubMed)
(4) Low-grade inflammation, diet composition and health: current research evidence and its translation by Anne M. Minihane, 1 ,* Sophie Vinoy, 2 Wendy R. Russell, 3 Athanasia Baka, 4 Helen M. Roche,5 Kieran M. Tuohy, 6 Jessica L. Teeling, 7 Ellen E. Blaak, 8 Michael Fenech, 9 David Vauzour, 1Harry J. McArdle, 3 Bas H. A. Kremer, 10 Luc Sterkman, 11 Katerina Vafeiadou, 12Massimo Massi Benedetti, 13 Christine M. Williams, 14 and Philip C. Calder. (PMC)
Inflammation is a natural reaction to a systematic immune response which protects our body against the stimuli or invasive pathogens.
Acute inflammation is a result of the immune white blood cell response to tissue damage or injury by stimulating the production of proinflammatory cytokines with an aim to kill off the microorganism which tries to enter the body through the wound.
Chronic inflammation is a condition of low-grade inflammation adopted by the immunity caused by the immune inability to kill off all invaders in the acute phase of infection.
Some researchers in the examine the immune evolution over thousands of year suggested that the immune system has evolved to destroy the foreigner pathogens after entering in specific time within 3 -8 weeks, otherwise, it will adapt to the change.
Chronic inflammation also is an autoimmune disease caused by the immune system mistakenly attacks the bodily tissue.
Epidemiological studies suggested that aging that causes low production of sex hormone, being obese and obese, and smoking are associated with the early onset of chronic inflammatory diseases.
Some researchers suggested that out of a number of risk factors, a poor diet in long-term is one of the major cause of chronic inflammatory diseases.
Dr. Anne M. Minihane, the lead author in the examine the risk of low-grade inflammation in diet composition and health said, " the ability of diet to positively modulate inflammation and provide the much-needed evidence to develop research portfolios that will inform new product development and associated health claims".
The statement clearly suggested that people who follow a healthy diet pattern with high fruits and vegetables and whole grain and low saturated and trans fat, red meat and processed food are less likely to be infected by chronic inflammatory diseases.
Celery is a species of Apium graveolens, belong to the family Apiaceae. It is cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.
With an aim to find a natural whole food for the prevention and treatment of chronic inflammatory disease, researchers looked into the group of flavones that have reported anti-inflammatory activities, and examined the ability of flavone-rich foods to reduce inflammation.
Celery extracts, with the anti-inflammatory activities and rich in flavone aglycones, was selected for the study.
Celery diets with different glycoside or aglycone contents were formulated and absorption was evaluated in mice fed with 5 or 10% celery diets.
Intake of deglycosylation was found to increase the absorption of dietary flavones in vivo and modulates inflammation by reducing TNF-α, the proinflammatory cytokines and NF-κB, which regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses.
The results suggested that celery extract rich in flavones may have the potential for the treatment and prevention of inflammatory diseases.
Additional differentiation of the anti-inflammatory and immunomodulatory activity in-vitro and in-vivo of the compound flavonoids found abundantly in celery, researchers launched an evaluation to examine the effects of the ethanol/water (1:1) extract of the leaves of Apium graveolens var. dulce (celery) on iNOS expression and NO production in a tested macrophage cell line stimulated for 24 h with Escherichia coli lipopolysaccharide (LPS).
Where the inducible nitric oxide synthase (iNOS) is one of the direct consequences of the inflammatory process and overproduction of NO is considered a pro-inflammatory mediator that induces inflammation.
In vitro, treatment of the extract and apiin showed significant inhibitory activity on nitrite (NO) production and iNOS expression observed by the tested cell line assay.
Interestingly, the extract exerted anti-inflammatory activity in-vivo (ID50 730 microg cm(-2)), with a potency seven-times lower than those of indomethacin (ID50 93 microg cm(-2)), the non-steroidal anti-inflammatory drug used as references.
The finding clearly suggested the inhibitory activity of the extract and apiin in-vitro on iNOS expression and nitrite production.
Taken altogether, celery may be considered a functional food for the prevention and treatment of acute and chronic inflammatory diseases without inducing any side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Flavone deglycosylation increases their anti-inflammatory activity and absorption by Hostetler G1, Riedl K, Cardenas H, Diosa-Toro M, Arango D, Schwartz S, Doseff AI. (PubMed)
(2) An extract of Apium graveolens var. dulce leaves: structure of the major constituent, apiin, and its anti-inflammatory properties by Mencherini T1, Cau A, Bianco G, Della Loggia R, Aquino RP, Autore G.(PubMed).
(3) Combination anti-inflammatory therapy: synergism in rats of NSAIDs/corticosteroids with some herbal/animal products by Whitehouse MW1, Butters DE. (PubMed)
(4) Low-grade inflammation, diet composition and health: current research evidence and its translation by Anne M. Minihane, 1 ,* Sophie Vinoy, 2 Wendy R. Russell, 3 Athanasia Baka, 4 Helen M. Roche,5 Kieran M. Tuohy, 6 Jessica L. Teeling, 7 Ellen E. Blaak, 8 Michael Fenech, 9 David Vauzour, 1Harry J. McArdle, 3 Bas H. A. Kremer, 10 Luc Sterkman, 11 Katerina Vafeiadou, 12Massimo Massi Benedetti, 13 Christine M. Williams, 14 and Philip C. Calder. (PMC)
Thursday, April 4, 2019
Avocado, the Best Fruit for Skin health
Skin, a large organ of the body protects our tissue and organs against the invasion of pathogens and fluid loss.
There are many causes of skin damage. Sun exposure is the most common cause of skin damage. Other causes of skin damage include smoking cigarettes, drinking too much alcohol, extreme temperatures, and exposure to toxic chemicals and pollutants in the air outside.
Some researchers suggested that free radicals bombard our body daily are also associated with skin damage in the modern world.
Free radicals are unstable molecules with the unpaired electron on the outer ring. In order for them to become balanced, free radical either donates or intercept an electron from another stable molecule, leading to a chain reaction that can not be stopped until the outer ring election is paired or inhibited by antioxidant.
In fact, free radical formation occurs continuously in the cells as a consequence of both enzymatic and nonenzymatic reactions, they can be generated by our bodies such as the process of metabolism and exogenous sources such as pollution, alcohol, tobacco smoke.
Free radicals can affect our skin in different ways, including the alternation of the DNA, damage of lipid membrane, collagen structures, and inducing photoaging and cancer.
Dr. Borut Poljšak, in the study "Free Radicals and Extrinsic Skin Aging" wrote, "Extrinsic skin damage develops due to several factors: ionizing radiation, severe physical and psychological stress, alcohol intake, poor nutrition, overeating, environmental pollution, and exposure to UV radiation (UVR)". and
"The only protection of our skin is in its endogenous protection (melanin and enzymatic antioxidants) and antioxidants we consume from the food (vitamin A, C, E, etc.)".
These results suggested that although free radical can induce the early onset of skin damage and aging, providing our body with enough antioxidants from the food sources is the best way to counter the process.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
On finding a natural ingredient or essential oil which has a potential effect on skin health without inducing any side effects, researchers explored the effects of various avocado oils on collagen metabolism.
In skin rats fed diets containing 10% (w/w) of the tested oils, researchers found the akin protective effects were totally depended on the types of avocado oil.
Rats fed the unrefined avocado oil extracted with hexane from the intact fruit, including unsaponifiables or the avocado seed oil, showed a significant increase in soluble collagen content in skin, though total collagen content was not affected.
The increased soluble collagen content was attributed to the inhibition of lysyl oxidase activity whose increment is associated with the oxidative stress induced by chronic exposure to skin harmful substances.
The active factor which protects the skin health was found to be present in the unrefined avocado oil and probably originated from the avocado seed, observed by the collagen metabolism which is affected only by fractions containing lipids fraction from the seed.
In order to illustrate the effects of avocado oil on skin health, researchers evaluated the wound-healing activity of a semisolid formulation of avocado oil, SSFAO 50%, or avocado oil in natural, on incisional and excisional cutaneous wound models in Wistar rats.
On the 14 days of application on the wound, 50% SSFAO or avocado oil demonstrate a significant increase in percentage wound contraction and reepithelialization, compared to the petroleum jelly control.
The treatment group also displayed an increase in anti-inflammatory activity, density of collagen, and tensile strength, compared to control groups.
This efficacy of the 50% SSFAO or avocado oil was attributed to the contents of the bioactive compounds, oleic fatty acid (47.20%), followed by palmitic (23.66%), linoleic (13.46%) docosadienoic (8.88%), palmitoleic (3.58%), linolenic (1.60%), eicosenoic (1.29%), and myristic acids (0.33%).
Dr. de Oliveira AP, the lead scientist wrote in the final report, "When used in natural or in pharmaceutical formulations for topical use, avocado oil can promote increased collagen synthesis and decreased numbers of inflammatory cells during the wound-healing process".
In skin exposure to ultraviolet (UV) radiation, unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, reduced significantly UV-induced cellular damage, through increasing cell viability, decreased the secretion of IL-6, a pro-inflammatory cytokine, and PGE(2) in mediated the inflammation process.
Taken altogether, avocado processed abundantly bioactive compounds may be considered a functional food for the promotion of skin health without inducing any side effects
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The effect of various avocado oils on skin collagen metabolism by Werman MJ1, Mokady S, Nimni ME, Neeman I.(PubMed)
(2) Effect of semisolid formulation of persea americana mill (avocado) oil on wound healing in rats by de Oliveira AP1, Franco Ede S, Rodrigues Barreto R, Cordeiro DP, de Melo RG, de Aquino CM, E Silva AA, de Medeiros PL, da Silva TG, Góes AJ, Maia MB.(PubMed)
(3) Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells by Rosenblat G1, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M.(PubMed)
(4) Free Radicals and Extrinsic Skin Aging by Borut Poljšak 1 and Raja Dahmane. (PMC)
There are many causes of skin damage. Sun exposure is the most common cause of skin damage. Other causes of skin damage include smoking cigarettes, drinking too much alcohol, extreme temperatures, and exposure to toxic chemicals and pollutants in the air outside.
Some researchers suggested that free radicals bombard our body daily are also associated with skin damage in the modern world.
Free radicals are unstable molecules with the unpaired electron on the outer ring. In order for them to become balanced, free radical either donates or intercept an electron from another stable molecule, leading to a chain reaction that can not be stopped until the outer ring election is paired or inhibited by antioxidant.
In fact, free radical formation occurs continuously in the cells as a consequence of both enzymatic and nonenzymatic reactions, they can be generated by our bodies such as the process of metabolism and exogenous sources such as pollution, alcohol, tobacco smoke.
Free radicals can affect our skin in different ways, including the alternation of the DNA, damage of lipid membrane, collagen structures, and inducing photoaging and cancer.
Dr. Borut Poljšak, in the study "Free Radicals and Extrinsic Skin Aging" wrote, "Extrinsic skin damage develops due to several factors: ionizing radiation, severe physical and psychological stress, alcohol intake, poor nutrition, overeating, environmental pollution, and exposure to UV radiation (UVR)". and
"The only protection of our skin is in its endogenous protection (melanin and enzymatic antioxidants) and antioxidants we consume from the food (vitamin A, C, E, etc.)".
These results suggested that although free radical can induce the early onset of skin damage and aging, providing our body with enough antioxidants from the food sources is the best way to counter the process.
Avocado is a commercially valuable fruit cultivated in tropical climates throughout the world. It is a green-skinned, pear-shaped fruit that ripens after harvesting and native to the Caribbean, Mexico, South America, and Central America, belonging to the flowering plant family Lauraceae.
On finding a natural ingredient or essential oil which has a potential effect on skin health without inducing any side effects, researchers explored the effects of various avocado oils on collagen metabolism.
In skin rats fed diets containing 10% (w/w) of the tested oils, researchers found the akin protective effects were totally depended on the types of avocado oil.
Rats fed the unrefined avocado oil extracted with hexane from the intact fruit, including unsaponifiables or the avocado seed oil, showed a significant increase in soluble collagen content in skin, though total collagen content was not affected.
The increased soluble collagen content was attributed to the inhibition of lysyl oxidase activity whose increment is associated with the oxidative stress induced by chronic exposure to skin harmful substances.
The active factor which protects the skin health was found to be present in the unrefined avocado oil and probably originated from the avocado seed, observed by the collagen metabolism which is affected only by fractions containing lipids fraction from the seed.
In order to illustrate the effects of avocado oil on skin health, researchers evaluated the wound-healing activity of a semisolid formulation of avocado oil, SSFAO 50%, or avocado oil in natural, on incisional and excisional cutaneous wound models in Wistar rats.
On the 14 days of application on the wound, 50% SSFAO or avocado oil demonstrate a significant increase in percentage wound contraction and reepithelialization, compared to the petroleum jelly control.
The treatment group also displayed an increase in anti-inflammatory activity, density of collagen, and tensile strength, compared to control groups.
This efficacy of the 50% SSFAO or avocado oil was attributed to the contents of the bioactive compounds, oleic fatty acid (47.20%), followed by palmitic (23.66%), linoleic (13.46%) docosadienoic (8.88%), palmitoleic (3.58%), linolenic (1.60%), eicosenoic (1.29%), and myristic acids (0.33%).
Dr. de Oliveira AP, the lead scientist wrote in the final report, "When used in natural or in pharmaceutical formulations for topical use, avocado oil can promote increased collagen synthesis and decreased numbers of inflammatory cells during the wound-healing process".
In skin exposure to ultraviolet (UV) radiation, unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, reduced significantly UV-induced cellular damage, through increasing cell viability, decreased the secretion of IL-6, a pro-inflammatory cytokine, and PGE(2) in mediated the inflammation process.
Taken altogether, avocado processed abundantly bioactive compounds may be considered a functional food for the promotion of skin health without inducing any side effects
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The effect of various avocado oils on skin collagen metabolism by Werman MJ1, Mokady S, Nimni ME, Neeman I.(PubMed)
(2) Effect of semisolid formulation of persea americana mill (avocado) oil on wound healing in rats by de Oliveira AP1, Franco Ede S, Rodrigues Barreto R, Cordeiro DP, de Melo RG, de Aquino CM, E Silva AA, de Medeiros PL, da Silva TG, Góes AJ, Maia MB.(PubMed)
(3) Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells by Rosenblat G1, Meretski S, Segal J, Tarshis M, Schroeder A, Zanin-Zhorov A, Lion G, Ingber A, Hochberg M.(PubMed)
(4) Free Radicals and Extrinsic Skin Aging by Borut Poljšak 1 and Raja Dahmane. (PMC)
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