Herbal Bilberry Protects the Nerve System against Neurotoxicity

Neurotoxicity refers to the destruction of nerve tissue caused by toxins that have entered the central and/or peripheral nervous system.

In other words, neurotoxicity is a result of any substance including a biological, chemical, or physical agent that causes an adverse effect on the nerve system.

Central nerve system comprised the brain and spinal cord is the complex of nerve tissues that control the activities of the body through the message transmitted by the neurons.

Most common causes of neurotoxicity are exposure to natural or man-made toxic substances, including drug, and medication. Long-term exposure to those toxins has been found to alter the activity of the nervous system.

Most common symptoms of neurotoxicity are a headache, altered sensation, tingling and numbness in the limbs.

In severe cases, neurotoxicity can induce vision loss, loss of memory and cognitive function and change behavior, psychological problems and sexual dysfunction.


Therefore, if you are taking medication and experience some of the aforementioned symptoms, please check with your doctor to rule out the possibility of a medication overdose.


Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers with an aim to discover a natural compound which protects the neurons damage induced neurotransmitter dopamine (DA) by a neurotoxic metabolite, 6-hydroxy DA, through increased expression of ROS examined the effects the antioxidant activities of anthocyanin-rich preparations of Vaccinium species (Vaccinium myrtillus, Vaccinium corymbosum, and Vaccinium oxycoccus).

V. myrtillus preparation: 50% inhibition with 7 microM of total anthocyanins were the most potent inhibition of oxidation and 1.5-4 times higher than that for the other preparations or for the purified anthocyanin.

According to the components analysis, antioxidant activity in the assay correlated strongly with the Vaccinium content of anthocyanins and total cyanidins, but not quercetin or myricetin.

Based in the findings, researchers wrote in the final report, "The results provide evidence for the high potency of anthocyanins towards a potentially neurotoxic reaction, and provide a basis for in vivo testing of these flavonoids and their physiological metabolites in the context of neuro- and mitochondrial-protective effects".

In order to reveal more information about bilberry anti neurotoxic activity, researchers once against evaluated the Vaccinium myrtillus (bilberry) anthocyanoside (VMA) and/or its main anthocyanidin constituents (cyanidin, delphinidin, and malvidin) protection of retinal ganglion cells (RGCs) against neurotoxicity in the induction of retinal damage.

The vitro study included RGC cultures (RGC-5, a rat ganglion cell-line transformed using E1A virus) and cell damage and radical activation induced by 3-(4-morpholinyl) sydnonimine hydrochloride (SIN-1, a peroxynitrite donor).

The vivo study included mice induced retinal damage by N-methyl-D-aspartic acid (NMDA)-

According to the assays, VMA and all three anthocyanidins significantly inhibited SIN-1-induced neurotoxicity and radical activation in RGC-5 in vitro and in mouse forebrain homogenates.
VMA inhibited lipid peroxidation in concentration-dependent manner.

Furthermore, intravitreously injected VMA significantly inhibited the NMDA-induced morphological retinal damage and increased TUNEL-positive cells in the ganglion cell layer.

Where terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) is a method for detecting DNA fragmentation of DNA breaks generated during apoptosis.


The results suggested VMA and its bioactive compound anthocyanidins process neuroprotective effects in vitro and in vivo models of retinal diseases.

Taken altogether, bilberry processed abundantly bioactive compound anthocyanoside may be considered a functioning remedy for the prevention and treatment against neurotoxicity, pending to the validation of larger sample size and multicenter human study.


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How To Get Rid Of Eye Floaters
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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity by Yao Y1, Vieira A. (PubMed)
(2) Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo by Matsunaga N1, Imai S, Inokuchi Y, Shimazawa M, Yokota S, Araki Y, Hara H. (PubMed)

Herbal Ginger, the Natural Treatment for Gastric/Stomach Ulcers

Gastric ulcers or stomach ulcers are conditions characterized by the painful sores in the stomach lining. Unlike the gastric ulcers, peptic ulcers are sores found in the stomach and small intestines.

The exact causes of gastric ulcer are not clearly identified. However, according to the epidemiological studies, a bacterial infection caused by the H. pylori infection has been found in the range of 30 to 50% of people with stomach ulcers.

Gastric ulcers caused by H. pylori infection are more likely to develop in patients over 40 in the US

Other risk factors associated with gastric ulcer include long-term use of certain medications, such as NSAID which has been found to cause more than 50% of peptic ulcers and stress.

Treatment of gastric ulcers is depended totally on the underlying causes, including antacids for the reduced acid in the stomach, and antibiotics for the elimination of Helicobacter pylori.

Unfortunately, people with gastric ulcer infected by the Helicobacter pylori treated with antibiotics have a higher risk of recurrence. In severe cases, surgery may be necessary.


Untreated or uncovered stomach ulcers may induce some complications, including stomach bleeding penetration, and cancer.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a potential ingredient for the treatment of gastric ulcers with no side effects, researchers examined the possible mechanism of the protective effect of ginger on the aspirin-induced gastric ulcer.

The study included 40 adult male albino rats randomized divided into four groups (10 animal per each group) and orally received the followings once daily for 5 days:

Group I: 3 ml of 1% carboxymethyl cellulose;

Group II: ginger powder (200 mg/kg body weight) suspended in 3 mL of 1% carboxymethylcellulose;

Group III: aspirin (400 mg/kg body weight) suspended in 3 ml of 1% carboxymethylcellulose in water.

Group IV: ginger and 30 minutes later, received aspirin suspended in 1% carboxymethylcellulose, in similar doses as received in groups II and III.

Before treatment of ginger, Aspirin-induced a significant increase of the macroscopic ulcer score, and gastric damage observed by the shed and disrupted epithelium, mucosal hemorrhage, submucosal edema and leukocyte infiltration, loss of the mucus of the mucosal surface.

Furthermore, in the proteins perspective, Aspirin significantly increased expression of apoptosis regulator Bax, inducible nitric oxide synthase (iNOS) associated with the production of proinflammatory cytokines and heat shock protein 70 (HSP70) involved stress response.

Injection of ginger protected the gastric integrity by restoring all damage caused by aspirin in the induction of gastric ulcer.

Dr. Salah Khalil M, said, "Ginger ameliorated the histological changes by reducing Bax and iNOS and increasing HSP70 expressions".

In other words, the overexpression of proteins associated with the onset of gastric ulcer also was significantly reduced by the ginger administration.

Take all together, ginger may be considered a functional alternative for the treatment of gastric ulcers, pending to the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources
(1) The postulated mechanism of the protective effect of ginger on the aspirin induced gastric ulcer: Histological and immunohistochemical studies by Salah Khalil M. (PubMed)
(2) Synbiotic (probiotic and ginger extract) loaded floating beads: a novel therapeutic option in an experimental paradigm of gastric ulcer by Singh PK1, Kaur IP. (PubMed)

Herbal Aloe Vera, the Promising Topical Wound Healing Functional Remedy, Researchers Say

Herbal aloe vera may be used for speeding up the skin wound healing with no side effects, some researchers suggested.

Wound healing is the natural process of repair of skin damage and injury.

The process of skin healing in human is gone through several stages. First, the immune system after sensing the skin wound activates the immune first line defense stimulating the constriction of the blood vessel to reduce blood flow, activate platelets, and many different clotting factors to cover the wound area.

Then, the white blood cells also up-regulate the proteins associated with the production of proinflammatory cytokines to the site of infection to kill off all the invasive organisms.

In most cases, due to overproduction of proinflammatory cytokines, patients may experience symptoms of fever, and localized pain, redness, and swelling.

Furthermore, the production of pro-inflammatory cytokines in some case can cause the death of nearby healthy cells, leading to the formation of irreversible scars, as seen in the liver.

After the inflammatory phase, the new blood vessels are formed and the new granulation tissues are built.



The final phase of the wound healing is involved in the remodeling of collagen from type III to type I cellular activity reduces.


If the process of skin healing is interrupted, it may lead to abnormal cell membrane repair, a major cause of skin scars.
MG53 is a protein involved in tissue repair and regeneration and also considered a facilitator of rapid injury repair, a mediator of cell migration, and a modulator of myofibroblast differentiation during wound healing. The defection and down-regulation of MG53 protein may delay wound healing and abnormal scarring.


Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan.

It has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.

The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.

On finding the natural compound or remedy for speeding up the treatment of wound healing, researchers examined the efficacy of aloe vera through searching the data of online medical literature.

Only controlled clinical trials for burn healing were included. There were no restrictions on any language of publication. Only 4 Four with a total of 371 patients were included in this review.


According to the meta-analysis using the duration of wound healing as an outcome measure, the healing time of the aloe vera group was 8.79 days shorter than those in the control group.

The cumulative evidence support that aloe vera can be an effective intervention used in burn wound healing for first to second-degree burns.

Furthermore, in order to maximize the effect of Aloe vera in wound healing, researchers examined the formulate and optimize a herbal gel of Aloe vera extract containing Carbopol 934 as a gelling agent.

During the observation of differences in wound healing between the various treatments when compared to the control group. researchers found that tissue hyperplasia was lower in the control group compared to the other treated groups.


In animals group treated with gel, exerted an 80.14% healing up to 14(th) day compared to the untreated group I (control) animals of showed 52.68%.

Control group animals also showed inflammation and pus formation up to 5(th) day of study, compared to none in the treatment group.


These results supported the use of topical application of Carbopol 934 gel containing Aloe vera extract on the healing of skin wounds.

Taken altogether, herbal Aloe vera may be considered a functional topical remedy for the treatment of skin wound, pending to the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.


References
(1) The efficacy of aloe vera used for burn wound healing: a systematic review by Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C.(PubMed)
(2) Aloe vera for treating acute and chronic wounds. by Dat AD, Poon F, Pham KB, Doust J.(PubMed)
(3) Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study, by Eshghi F, Hosseinimehr SJ, Rahmani N, Khademloo M, Norozi MS, Hojati O.(PubMed)
(4) Formulation development, optimization and evaluation of aloe vera gel for wound healing by Khan AW, Kotta S, Ansari SH, Sharma RK, Kumar A, Ali J.(PubMed)
(5) Modulation of Wound Healing and Scar Formation by MG53 Protein-mediated Cell Membrane Repair by Haichang Li,‡,1,2 Pu Duann,‡,1 Pei-Hui Lin,‡ Li Zhao,‡§ Zhaobo Fan,¶ Tao Tan,‡§ Xinyu Zhou,‡Mingzhai Sun,‡ Minghuan Fu,¶ Matthew Orange,‖ Matthew Sermersheim,‡ Hanley Ma,‡**Duofen He,‡‡ Steven M. Steinberg,‡ Robert Higgins,‡ Hua Zhu,‡ Elizabeth John,§Chunyu Zeng,‡‡ Jianjun Guan,¶ and Jianjie Ma. (PMC)

Herbal Artichoke Inhibits the Parameters Associated with the Onset of Non-Alcoholic Fatty Liver Disease (NAFLD) in Vivo and Human Study

Non-alcoholic liver disease is a medical condition caused by excessive fat accumulated in the liver of people who drink little or no alcohol.

Believe or not, non-alcoholic fatty liver disease (NAFLD) now becomes a universal disorder and the most common liver disease in the Western world.

According to the statistics in 2015, approximately, 20 to 30% of the general population in the Western world suffer from NAFLD. The prevalent rate is substantially higher in the population with type 2 diabetes mellitus (70%) and morbid obesity (90%).

Some researchers in the assessment of the relationship of widespread obesity in risk of NAFLD suggested that non-alcoholic fatty liver disease may be caused by the promotion of the Western diet over the past few decades.

Dr. Kristen Stephenson, in the assessment of the impact of dietary fat on the development of non-alcoholic fatty liver disease in animal model wrote, "WD mouse models consisting of high fat, cholesterol, and a combination of high-fructose corn syrup, sucrose, fructose, or glucose not only lead to metabolic syndrome but also induce NAFLD with fibrosis".

Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.

The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.

Researcher on finding a natural therapeutic for the treatment of Non-alcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease worldwide investigated the artichoke leaf extract (ALE) therapeutic utility in patients with established NAFLD.

The randomized double-blind placebo-controlled parallel-group trial included 100 subjects with ultrasound-diagnosed NAFLD randomized to either ALE 600 mg daily or placebo for a 2-month period.

Compared to the control, the ALE treatment group showed increased hepatic vein flow, reduced portal vein diameter and liver size, according to the Doppler sonography. In other words, ALE treatment improved liver function.

Inflammatory and oxidative stress such as serum ALT, AST levels and total bilirubin were also decreased upon the injection of ALE observed by the improved AST/ALT ratio.

Furthermore, ALE supplementation also reduced total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and triglyceride concentrations. All these parameters were elevated in patients with NAFLD.


Dr. Panahi Y, the lead scientist, after taking into account other factors, wrote, " This study has shown beneficial effects of ALE supplementation on both ultrasound liver parameters and liver serum parameters (ALT, AST, APRI ratio, and total bilirubin) in patients with NAFLD".

In order to reveal more information about artichoke anti NAFLD activity, researchers elucidated the physiological responses and mechanisms of JA intervention with a comprehensive transcriptome analysis.

The study included Wistar rats fed a control diet, a 60 % fructose-enriched diet (FRU), or an FRU with 10 % JA (n 6-7) for 4 weeks with an oral glucose tolerance test was carried out on day 21.

According to the assays, dietary JA supplementation improved the IR and hepatic TAG accumulation induced by the Fructose feeding.

JA also inhibited the gene expression of malic enzyme 1 (Me1), associated with fatty acid synthesis; decorin (Dcn), related to fibrosis; and cytochrome P450, family 1, subfamily a, polypeptide 2 (Cyp1a2) and nicotinamide phosphoribosyltransferase (Nampt), associated with inflammation.

Based on these results, researchers proposed that 10 % of JA supplementation may be beneficial for the prevention of the onset of NAFLD.


Taken altogether, artichoke may be considered a functional remedy for the treatment of NAFLD with no side effects, pending to the validation of larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial by Panahi Y1, Kianpour P2, Mohtashami R3, Atkin SL4, Butler AE5, Jafari R6, Badeli R7, Sahebkar A. (PubMed)
(2) Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats by Chang WC1, Jia H2, Aw W2, Saito K2, Hasegawa S3, Kato H. (PubMed)
(3) Updates on Dietary Models of Nonalcoholic Fatty Liver Disease: Current Studies and Insights by Kristen Stephenson,* 1 Lindsey Kennedy,†‡ 1 Laura Hargrove,‡ Jennifer Demieville,†Joanne Thomson,† Gianfranco Alpini,*†‡ and Heather Francis. (PMC)

Herbal Bilberry Stimulates the Cytotoxic Effects Against Cancer, Scientists Say

Cytotoxicity is a process or action that destroys the living cells, through activating the production of pro-inflammatory cytokines and proteins associated with cell apoptosis and programmed cell death.

Free radical cytotoxicity is the ability of ROS in exerting the oxidative stress in the cancer cells, leading to apoptosis.

Cancer is a class of diseases characterized by irregular cells growth due to DNA alternation.

Most cancers do not cause any symptoms at an early stage. However, at the later stage, a larger size of the tumor can press on the nearby blood vessels and nerve cells, causing localized bleeding and severe pain.

Most common symptoms of cancer are unintended weight loss, loss of appetite, fatigue or tiredness and gastrointestinal discomforts and symptoms depending on the location of cancer.

If you experience some of the above symptoms, please check with your doctor to rule out the p[ossibility of the disease.


The causes of cancer are unknown. Researchers can not explain why people with the same health conditions, family history in the same family, some are susceptible to cancer, while others do not.


In normal cells, overproduction of free radicals or oxidative stress can affect the cell lipid, protein, leading to cell damage or alteration of cell DNA.


Most cases of natural remedy in initiating the cytotoxic effects against cancer without causing nearby healthy cells death probably are associated with the stimulation of the production of antioxidant produced by the host and the presence of antioxidants of the remedy.

Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The herbal plant has been used as foods and herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

Researchers on finding a natural compound with cytotoxic potency examined the bilberry chemical compound in facilitating the onset of cytotoxicity against cancer and neutralizing the neuro cytotoxicity against the formation of plague on K562 Human Erythroleukemic cancer cells and Alzheimer's diseases (AD), respectively.

GroES self-assemble into amyloid fibrils similar to those observed in various neurodegenerative diseases was found to induce cells toxicity.


Before application of bilberry anthocyanins, injection of soluble intermediate aggregates of GroES exhibited neuronal cell death, rather than forming mature fibrils.

Pretreatment with anthocyanins isolated from bilberry, not only inhibited both fibril formation but also neutralized the toxicity of intermediates.

The findings strongly suggested anthocyanins processes an inhibitory effect on the amyloid fibril formation of various conformational disease-causing proteins.

Oppositely, in cancer perspective, anthocyanins stimulated the tumor suppressor genes to induce apoptosis in cancer cells.


Dr. Seth P. Thibado and colleagues in the study to enhance the chemical compound the bioavailability, observed the cytotoxicity of anthocyanins in an encapsulated in 5.5 nm diameter liposomal micelles, called NutraNanoSpheres (NNS), at a concentration of 2.5 mg/50 µl [25% (w/w) anthocyanins].

Bilberry NNS induced the apoptotic/cytotoxic effects on K562 Human Erythroleukemic cancer cells.

The concentrations of bilberry demonstrated the greatest levels of percentage inhibition of 60–70% at 0.018–1.14 mg/ml (n=6) and 60% inhibition at 4 mg/ml, compared to control.

And, the lowest percentage of inhibition (30%) occurred at 2 mg/ml. The lethal dose 50 was determined to be 0.01–0.04 mg/ml of Bilberry per 105 K562 cells at 72 h of cell culture exposure.

At 48 h incubation, the highest percentage of inhibition was only 27%,.

The findings clearly suggested that NutraNanoSpheres (NNS) demonstrates direct cytotoxic effects, at a concentration which is 8–40 times lower than the levels required for bilberry if not encapsulated.

Taken altogether, bilberry processed abundantly bioactive ingredient anthocyanins may be considered a functional remedy in modulation the cytotoxic activity against cancer, pending to the confirmation of large sample size and multicenter human study.


Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Bilberry anthocyanins neutralize the cytotoxicity of co-chaperonin GroES fibrillation intermediates by Iwasa H1, Kameda H, Fukui N, Yoshida S, Hongo K, Mizobata T, Kobayashi S, Kawata Y. (PubMed)
(2) Anticancer effects of Bilberry anthocyanins compared with NutraNanoSphere encapsulated Bilberry anthocyanins by Seth P. Thibado,1 Jerry T. Thornthwaite,2 Thomas K. Ballard,2 and Brandon T. Goodman. (PMC)

How to Prevent Osteoporosis - Eat Your Cooked Tomato, Scientists Say

Osteoporosis is a condition associated with low bone mass and deterioration of bone tissue.

The disease is most common in older adults as the result of the bone made by the body can not cover the bone loss due to an increased serum of osteoclast mediator involved in bone resorption.

Consequently, the bone in osteoporotic patients become weak and breaking easily from a fall.
Believe it or not, in serious cases, bone can also be broken due to sneezings or minor bumps.

According to the statistics provided by the International Osteoporosis Foundation, approximately 44 million U.S. women and men aged 50 and older suffer from osteoporosis and low bone mass.

There are over 200 million women worldwide affected by osteoporosis, including one-tenth of women aged 60, one-fifth of women aged 70, two-fifths of women aged 80 and two-thirds of women aged 90.

The most common cause of osteoporosis is the reduced production of hormones, particularly estrogen in women and androgen in men due to aging or other conditions such as medical condition.


(Diseases associated with osteoporosis include rheumatoid arthritis and rheumatological conditions, steroid hormone Deficiency, primary hyperparathyroidism, diabetes, and chronic kidney and liver disease).

In older women, menopause accompanied by lower estrogen levels are found in patients with osteoporosis.


According to the epidemiological studies, being a woman and being older, family history with osteoporosis, a small frame, and structure, ethnicity, follow a long-term calcium deficient diet are some of the prevalent factors of disease.


However, out of the aforementioned risk factors, some researchers suggested smoking may be one of the major culprits in inducing the risk of the condition in the Southeast Asain.

The research team at the University of Pennsylvania in the study of how smoking causes osteoporosis, said, ""It has been known from many epidemiological studies that smokers usually show bone loss, and their bone density is much lower than non-smokers' bone density,"

and "What we show here is that excessive formation of osteoclasts by cigarette chemicals causes bone loss".

In other words, if you are a smoker, your risk of osteoporosis is increased substantially compared to a non-smoked individual.

Tomato is red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.

With an aim to find a potential compound for the treatment of osteoporosis against bone resorption, researchers examined the lycopene a carotenoid commonly found in tomatoes and tomato products against osteoporosis risk.

The study included 23 healthy postmenopausal women, 50-60 years old, provided blood samples at baseline and following a one-month lycopene-depletion period according to the St. Michael 's Hospital, Toronto, ON, Canada. PARTICIPANTS AND STUDY DESIGN.
According to the results of sample analysis, one-month lycopene-depletion period diet showed a significantly decreased serum lycopene, lutein/zeaxanthin and levels of antioxidants glutathione peroxidase (GPx).
Furthermore, the lycopene restriction diet not only increased lipid and protein oxidation but also depression of levels of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), significantly.

These results lead to significant increased of the levels cross-linked N-telopeptide of type I collagen (NTx), a marker of osteoclast-mediated bone resorption.


In other words, tomatoes restrictive diet increased the risk of osteoporosis in postmenopausal women.

In order to reveal more information about tomato effect in osteoporosis, researchers conducted a study to determine whether lycopene would act as an antioxidant to decrease oxidative stress parameters, resulting in decreased bone turnover markers, thus reducing the risk of osteoporosis in postmenopausal women.
The study included 60 postmenopausal women, 50-60 years old, following a 1-month washout without lycopene consumption, randomly divided into group consumed either (N = 15/group): (1) regular tomato juice, (2) lycopene-rich tomato juice, (3) tomato Lyc-O-Mato lycopene capsules, or (4) placebo capsules, twice daily for total lycopene intakes of 30, 70, 30, and 0 mg/day respectively for 4 months.

According to the blood sample collected at the end of the experiment, consumed juice or lycopene capsules treated groups for 4 months significantly increased serum lycopene compared to placebo.

Moreover, consumed juice or lycopene capsules treated groups for 4 months exerted a similar effect as the aforementioned study in significantly increasing the total serum antioxidant capacity (TAC) and decreasing lipid and protein peroxidation and NTx compared to the placebo group.

Based on the findings, researchers said, "the daily consumption of lycopene may be important as it acts as an antioxidant to decrease bone resorption in postmenopausal women and may, therefore, be beneficial in reducing the risk of osteoporosis".

Taken altogether, tomatoes and its major bioactive compound lycopene may be considered remedies for the prevention and treatment of osteoporosis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary restriction of lycopene for a period of one month resulted in significantly increased biomarkers of oxidative stress and bone resorption in postmenopausalwomen by Mackinnon ES1, Rao AV, Rao LG. (PubMed)
(2) Supplementation with the antioxidant lycopene significantly decreases oxidative stress parameters and the bone resorption marker N-telopeptide of type I collagen in postmenopausal women by Mackinnon ES1, Rao AV, Josse RG, Rao LG. (PubMed)
(3) Researchers pinpoint how smoking causes osteoporosis by the University of Pennsylvania. (Medical Press)

Herbal Ginger, May Be the Best Anti Hyperglycemic Functional Remedy

Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly.

Untreated hyperglycemia has been found to induce ketoacidosis characterized by the symptoms shortness of breath, breath that smells fruity and gastrointestinal discomforts such as nausea, vomiting, and dry mouth.

Ketoacidosis is a life-threatening condition caused by your body inability to make enough insulin.

Most cases of hyperglycemia can be controlled by the following diabetes guidance.

By eating a healthy diet high in fiber, such as vegetables, fruits, nuts, legumes (beans, peas, and lentils), whole-wheat flour and wheat bran, accompanied by healthy fish, patients with type 1 and 2 diabetes can control their blood glucose without worrying the onset of hyperglycemia.

Some researchers suggested that hyperglycemia may be harder to control in obese patients with type 2 diabetes due to the alternation of mechanisms associated with the production of insulin.

Dr. Martyn JA, the lead scientist at the Massachusetts General Hospital wrote, "Obesity is a major cause of type 2 diabetes, clinically evidenced as hyperglycemia".


And, "The altered glucose homeostasis is caused by faulty signal transduction via the insulin signaling proteins, which results in decreased glucose uptake by the muscle, altered lipogenesis, and increased glucose output by the liver".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Scientists on finding a natural compound for the treatment of hyperglycemia examined the anti-high blood glucose of [6]-gingerol, a major chemical compound found in ginger.

The study included C57BL/6 mice fed with [6]-gingerol at two different doses on a high-fat diet or standard diet for a period of 17weeks.

[6]-gingerol supplementation fed group showed a significantly reduced plasma glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), advanced glycation end-products (AGEs) and insulin levels caused by high-fat diet.

Where levels of alanine aminotransferase, aspartate aminotransferase are normally used for the testing of liver damage.

Prolonged hyperglycemia also activated the formation of advanced glycation end-products (AGEs), particularly in diabetes population.


Further analysis of the anti-hyperglycemic activity of [6]-gingerol supplement, researchers found that
[6]-gingerol group inhibits the complications of prolonged high blood glucose by reducing the production of the advanced glycation end-products (AGEs) through proteins associated with the stimulating the production antioxidants.

Moreover, the anti-hyperglycemia of [6]-gingerol supplement also was observed by the balancing of antioxidants enzymes produced by the tested mice against levels of overexpression of free radicals caused by the high-fat diet.

Additionally, the levels of oxidative stress also inhibited by the injection of [6]-gingerol supplement observed by enhancing levels of heme oxygenase-1 and glyoxalase 1, the detoxified enzymes.

Dr. Sampath C, the lead scientist at the final report wrote, "[6]-gingerol are potential dietary compounds that can alleviate diabetes-induced complications".

In order to reveal more information about ginger anti-high blood glucose property, researchers evaluated the ginger efficacy in the disruption of slow-wave rhythm caused by acute hyperglycemia.

The study included 22 healthy humans underwent fasting electrogastrography during hyperglycemic clamping to 250 to 290 mg/dl after double-blind placebo or ginger root (1 g).


Ginger treatment group displayed a significant reduction of cardiac dysrhythmia, an abnormal heartbeat caused by acute hyperglycemia.

However, the application of ginger showed no effect on the heartbeat if cardiac dysrhythmia was elicited by a prostaglandin E(1) analog.

The finding suggested that ginger exerted anti-hyperglycemia-induced complications through inhibiting the production of prostaglandins which has a strong effect on the central nervous system in the regulation of blood sugar homeostasis.

Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of diabetic complications caused by prolonged hyperglycemia, pending to the confirmation of large sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway by Sampath C1, Rashid MR1, Sang S2, Ahmedna M3. (PubMed)
(2) Ginger reduces hyperglycemia-evoked gastric dysrhythmias in healthy humans: possible role of endogenous prostaglandins by Gonlachanvit S1, Chen YH, Hasler WL, Sun WM, Owyang C. (PubMed)
(3) Obesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms by Martyn JA1, Kaneki M, Yasuhara S. (PubMed)