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Saturday, May 4, 2019

Herbal Ginger, May Be the Best Anti Hyperglycemic Functional Remedy

Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly.

Untreated hyperglycemia has been found to induce ketoacidosis characterized by the symptoms shortness of breath, breath that smells fruity and gastrointestinal discomforts such as nausea, vomiting, and dry mouth.

Ketoacidosis is a life-threatening condition caused by your body inability to make enough insulin.

Most cases of hyperglycemia can be controlled by the following diabetes guidance.

By eating a healthy diet high in fiber, such as vegetables, fruits, nuts, legumes (beans, peas, and lentils), whole-wheat flour and wheat bran, accompanied by healthy fish, patients with type 1 and 2 diabetes can control their blood glucose without worrying the onset of hyperglycemia.

Some researchers suggested that hyperglycemia may be harder to control in obese patients with type 2 diabetes due to the alternation of mechanisms associated with the production of insulin.

Dr. Martyn JA, the lead scientist at the Massachusetts General Hospital wrote, "Obesity is a major cause of type 2 diabetes, clinically evidenced as hyperglycemia".


And, "The altered glucose homeostasis is caused by faulty signal transduction via the insulin signaling proteins, which results in decreased glucose uptake by the muscle, altered lipogenesis, and increased glucose output by the liver".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Scientists on finding a natural compound for the treatment of hyperglycemia examined the anti-high blood glucose of [6]-gingerol, a major chemical compound found in ginger.

The study included C57BL/6 mice fed with [6]-gingerol at two different doses on a high-fat diet or standard diet for a period of 17weeks.

[6]-gingerol supplementation fed group showed a significantly reduced plasma glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), advanced glycation end-products (AGEs) and insulin levels caused by high-fat diet.

Where levels of alanine aminotransferase, aspartate aminotransferase are normally used for the testing of liver damage.

Prolonged hyperglycemia also activated the formation of advanced glycation end-products (AGEs), particularly in diabetes population.


Further analysis of the anti-hyperglycemic activity of [6]-gingerol supplement, researchers found that
[6]-gingerol group inhibits the complications of prolonged high blood glucose by reducing the production of the advanced glycation end-products (AGEs) through proteins associated with the stimulating the production antioxidants.

Moreover, the anti-hyperglycemia of [6]-gingerol supplement also was observed by the balancing of antioxidants enzymes produced by the tested mice against levels of overexpression of free radicals caused by the high-fat diet.

Additionally, the levels of oxidative stress also inhibited by the injection of [6]-gingerol supplement observed by enhancing levels of heme oxygenase-1 and glyoxalase 1, the detoxified enzymes.

Dr. Sampath C, the lead scientist at the final report wrote, "[6]-gingerol are potential dietary compounds that can alleviate diabetes-induced complications".

In order to reveal more information about ginger anti-high blood glucose property, researchers evaluated the ginger efficacy in the disruption of slow-wave rhythm caused by acute hyperglycemia.

The study included 22 healthy humans underwent fasting electrogastrography during hyperglycemic clamping to 250 to 290 mg/dl after double-blind placebo or ginger root (1 g).


Ginger treatment group displayed a significant reduction of cardiac dysrhythmia, an abnormal heartbeat caused by acute hyperglycemia.

However, the application of ginger showed no effect on the heartbeat if cardiac dysrhythmia was elicited by a prostaglandin E(1) analog.

The finding suggested that ginger exerted anti-hyperglycemia-induced complications through inhibiting the production of prostaglandins which has a strong effect on the central nervous system in the regulation of blood sugar homeostasis.

Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of diabetic complications caused by prolonged hyperglycemia, pending to the confirmation of large sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway by Sampath C1, Rashid MR1, Sang S2, Ahmedna M3. (PubMed)
(2) Ginger reduces hyperglycemia-evoked gastric dysrhythmias in healthy humans: possible role of endogenous prostaglandins by Gonlachanvit S1, Chen YH, Hasler WL, Sun WM, Owyang C. (PubMed)
(3) Obesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms by Martyn JA1, Kaneki M, Yasuhara S. (PubMed)

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