Hypertension is a medical condition caused by abnormally high pressure that presses against the wall of the arteries, affecting the heart function in pumping blood to the body.
Hypertension is a member of the cluster of metabolic syndrome that facilitates the risk of cardiovascular disease and types 2 diabetes
Epidemiologically, uncontrolled high blood pressure has been found to induce the risk of heart attack and stroke.
Most patients with high blood pressure are asymptomatic. However, the long-term elevated force of the blood against your artery walls may result in symptoms of headache, dizziness, and shortness of breath, early signs of heart disease and stroke.
According to the statistics provided by the CDC, approximately 75 million American adults (32%) have high blood pressure. In other words, 1 in every 3 American adults is affected by high blood pressure.
Believe it or not, the actual numbers of high blood pressure are substantially higher if people with the stage of prehypertension are also taking into account.
Sadly, only half of the people with high blood pressure in the US are under control.
There are 2 types of hypertension, including primary hypertension that takes years to develop and secondary hypertension associated with other medical conditions, such as kidney and thyroid disease.
Out of many prevalent factors, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a direct implication on the onset of hypertension in American adults.
Dr.Dixon W. Wilde, the lead scientist wrote, "Dietary fat contributes to the elevation of blood pressure and increases the risk of stroke and coronary artery disease".
And, "an elevation of plasma FAs may contribute to the development of hypertension via a process involving the elevation of Ca2+ current density and alteration of channel kinetics in the vascular smooth muscle membrane".
The results strongly suggested the high-fat diet induced elevated FAs associated with the alternation of vascular smooth muscle membrane in the initiation of hypertension.
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belongings to the group of Betalains, found abundantly in beets, chard, etc.
On finding a potential ingredient for the treatment of hypertension, researchers examined the effect of betanin against a hypertensive animal model.
The study included animals divided into six main groups with each group containing 5 animals.
* Group I received the vehicle,
* Group II received dexamethasone injection (20 µg/kg/day, s.c.) for 14 days,
* Group III received an extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days,
* Group IV received an extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days,
* Group V received dexamethasone injection (20 ugs/kg/day, s.c.) and extract of Beta vulgaris (100 mg/kg/day, p.o.) for 14 days and
* Group VI received dexamethasone (DEXA) injection (20 µg/kg/day, s.c.) and extract of Beta vulgaris (300 mg/kg/day, p.o.) for 14 days.
At the end of the experiment after 14 days, the group treated with a combination of dexamethasone and beta vulgaris (100 and 300 mg/kg p.o. for 14 days) showed a significant decrease in heart rate compared to Dexamethasone group.
According to the tested assays, Dexamethasone treated group showed a significant elevation (p<0.05) in systolic blood pressure (SBP), vascular reactivity changes to Catecholamine, compared to the control group.
Injection of beta vulgaris extract (100, 300 mg/kg/day, p.o.) for 14 days in dexamethasone administered rats significantly (p<0.05) demonstrated a significant reversal of such change.
Based on the finding, researchers wrote, "The methanolic-HCl extract of Beta vulgaris has antihypertensive activity in Dexamethasone models".
In other words, betanin detected by phytochemical analysis from beta vulgaris extract protected the heart function and blood vessels through its antihypertensive properties.
Taken altogether, betanin may be considered supplements for the prevention and treatment of hypertension, pending to the confirmation of larger sample size and multicenter human study.
Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Antihypertensive activity of Beta vulgaris on dexamethasone-induced hypertension in rats by Dignesh Patel, Rupali A Patil, and Alkesh Patel. (Research Gate)
(2) High-Fat Diet Elevates Blood Pressure and Cerebrovascular Muscle Ca2+Current
Dixon W. Wilde, Kenneth D. Massey, Glenn K. Walker, Alan Vollmer, and Roger J. Grekin. (Hypertension)
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