Pain and swelling is a natural response of the immune and nervous system after a wound or injury by inducing the production of proinflammatory cytokines.
In the acute of infection, after sensing a wound and injury of the body, the immune first lines of white blood cell defense stimulate the production of blood palette to the infected area with an aim to cover the wound or injury and the inflammatory cytokines to kill off organisms trying to enter the body through the opening.
Please note that overexpression of proinflammatory cytokines in this phase has been found to cause abnormal healing with the formation of scars.
The acute phase of infection arrives and leaves quickly as it is resolved quickly by the body.
However, chronic infection is a result of an immune system that can not kill off all infectious organisms in the acute phase of infection, leading to chronic inflammation that last a long time, such as months or years.
Swelling and pain on the joints are one of the most common symptoms in patients with arthritis, particularly in rheumatoid arthritis (RA).
However, some cases of swelling accompanied by symptoms that do not associate to the injury such as fatigue, loss of appetite, and weight gain may be an indication of cancer, heart, liver, or kidney disease.
If you experience some of the aforementioned symptoms, please check with your doctor to rule out the possibility.
Most cases of pain and swelling of the injury and wound can be healed by itself without interfering or injection of over counter pain medication, depending on the size of the opening.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find potential and natural compound for the treatment of pain and swelling with no side effects, researchers evaluated the effect of bromelain after surgical removal of third molars.
The prospective randomized clinical study included 40 patients requiring surgical removal of impacted mandibular third molars.
After the surgery, according to the tested assays, bromelain showed a significant effect in reducing swelling and pain in 28 out of a total of 40 patients.
Based on the findings, researchers said, "Bromelain can be used as a successful oral enzyme therapy for oral surgery patients, especially after removal of impacted third molars".
In order to reveal more information about bromelain anti-pain and swelling activity the team at the University of Mosul College of Dentistry compared the effect of oral bromelain (4 × 250 mg) versus oral diclofenac sodium (4 × 25 mg) on pain, swelling, trismus, and quality of life (QOL) after surgical removal of impacted lower third molars.
The randomized, double-blind, placebo-controlled study included 45 patients requiring extraction under local anesthesia of a single partial bony impacted mandibular third molar randomly divided into 1 of 3 groups: bromelain, diclofenac, and placebo.
According to the results of the analysis, bromelain and diclofenac groups both showed a significant and similar reduction in pain compared with the placebo group at all intervals.
Both bromelain and diclofenac treatment groups also showed a significant difference in the effect on QOL in most subscales and total scores.
Dr. the lead scientist said, "The results of our study have shown that oral bromelain is an effective therapy to improve the QOL after surgical removal of impacted lower third molars, with an effect on the postoperative sequelae comparable to that of preemptive diclofenac sodium".
Taken altogether, bromelain may be considered supplements for the and treatment of pain and swelling, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars by Singh T1, More V2, Fatima U3, Karpe T4, Aleem MA5, Prameela J. (PubMed)
(2) Perioperative bromelain reduces pain and swelling and improves quality of life measures after mandibular third molar surgery: a randomized, double-blind, placebo-controlled clinical trial by Majid OW1, Al-Mashhadani BA. (PubMed)
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