Skin healing is a natural process to reconstruct the skin back to its originated stage after skin damage.
Skin is a large organ in the human body which only protects our body against foreign invaders but also serves as a third detoxed system after the liver and kidney.
Skin healing is depending on the size of the wound, the small size can be healed quickly without using any medication. However, the large size wound in most cases is required stitches.
Similar to wound healing, at the acute phase of infection, the macrophages of the immune first line of defense stimulating the blood clot to cover the wound or cut and production of proinflammatory cytokines to destroy foreign invaders.
In this phase, patients may experience symptoms of skin redness, tender, and swelling around the wound or cut.
Depending on the size of a skin wound, the next overlap stage is broken blood vessels in the wound is repaired and new tissue is grown followed by the creation of collagen, the fibers that form the foundation for new tissue.
This process continues until the skin is stronger or back to the original form.
In the acute phase of infection, overproduction of pro-inflammatory cytokines induced by immune response may cause damage to healthy cells, leading scar forming.
Additionally, any interruption of these processed may induce the formation of scars.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for speedup wound healing, researchers compared the structural integrity of bromelain (debridement enzyme) in the healing process.
The study included a combinational multiphasic delivery system that delivers biomolecules of bromelain through the fabrication of coaxial electrospinning of different biocompatible polymers.
In vitro, the fabricated scaffold delivery system sustained the release of debriding protease and its bioactive components in a timely fashion showed a significant effect in wound healing.
Furthermore, the fabricated scaffold used in debridement enzyme also promoted the wound healing process by its angiogenic potential through in vitro migration of endothelial cells and increased new capillaries from the existing blood vessel in response to wound healing.
Moreover, in vivo, studies also confirm the efficacy of the fabricated scaffold used in the delivery of bromelain.
Based on the findings, researchers said, "Our results, therefore, open up a new avenue for designing a bioactive combinational multiphasic delivery system to enhance wound healing".
In order to assess the role and clinical advantages of enzymatic debridement by a mixture of proteolytic enzymes enriched in Bromelain (Nexobrid®) on wound healing, researchers examined the mutual experience of applying enzymatic debridement in more than 500 adult and pediatric patients by the consensus panelists.
The statement included the answer of questions related to pain management and anesthesia, the timing of application, technique of application, after-intervention care, skin grafting after enzymatic debridement, blood loss, training strategies and learning curve and areas of future research needs.
According to the statements returned by the participant, 68 consensus statements, enzymatic debridement used showed a higher degree of consensus with a unanimous consensus in 88.2% of statements, and lowest degree of consensus of 70% in only 3 statements.
Taken altogether, bromelain used alone or combined with the multiphasic delivery system may be considered supplements for the speedup wound healing, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Eschar removal by bromelain based enzymatic debridement (Nexobrid®) in burns: An European consensus by Hirche C1, Citterio A2, Hoeksema H3, Koller J4, Lehner M5, Martinez JR6, Monstrey S3, Murray A7, Plock JA8, Sander F9, Schulz A10, Ziegler B11, Kneser U. (PubMed)
(2) Fabrication of core-shell nanofibers for controlled delivery of bromelain and salvianolic acid B for skin regeneration in wound therapeutics by Shoba E1, Lakra R, Syamala Kiran M, Korrapati PS. (PubMed)
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