Inflammation is a natural response of the immune system with an aim to protect the body against the invasion of microbial invasion.
After receiving the message from the brain associated with tissue damage or wound, the immune white blood cells of the first line of defense stimulate the production of blood palette to cover the wound or damage and production of pro-inflammatory cytokines to the site of infection to kill off all the invaders which try to enter the body through the skin open.
Most cases of microbial invasion are stopped in the acute phase of infection. However, at this phase, overproduction of pro-inflammatory cytokines can lead nearby cell death and the formation of scars.
However, if the immune system fails to destroy all microbial invasion in the acute phase of infection within a set period of time in 3 to weeks, it will adapt to the new change, leading to chronic low-grade inflammation.
The continued production of low levels of pro-inflammatory cytokines overtimes can cause damage to organ tissues, leading to irreversible chronic diseases such as cardiovascular disease, diabetes, and cancer.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.
On finding a natural therapy for the treatment of diseases associated with acute and chronic inflammation, researchers examined the effects of Chr-loaded poly (ε-caprolactone)/poly (ethylene glycol) (PCL/PEG) nanofibrous mats in wound healing.
Chrysin (Chr) is a naturally occurring flavone with a wide spectrum of biological functions found in honey.
According to the tested assays, Chr-loaded poly (ε-caprolactone)/poly (ethylene glycol) (PCL/PEG) nanofibrous mats reduced overexpression of production of pro-inflammatory cytokines in subjects induced by lipopolysaccharide (LPS).
Furthermore, excessive production of free radical nitric oxide (NO) associated with the induction of oxidative stress also inhibited by the administration of Chr-loaded poly (ε-caprolactone)/poly (ethylene glycol) (PCL/PEG) nanofibrous mats.
Dr. Deldar Y, the lead scientist said, "These results suggest that the proposed natural substance based nanofibrous mats can accelerate the wound healing process with ...anti-inflammatory activities".
Additionally, in order to reveal more information about Chr-loaded poly (ε-caprolactone)/poly (ethylene glycol) (PCL/PEG) nanofibrous mats anti-inflammatory activity, researchers evaluated its role in tissues regeneration over the repair.
During the epithelial healing process, the nano-fibers exerted anti-inflammatory activity observed by the inhibition of the expressions of pro-inflammatory markers-Cycloxygenase-2 (COX-2).
Interleukin-6 (IL-6), the pro-inflammatory cytokines produced during the acute phase of inflammation was also reduced by the injection of the nano-fibers, similar to that of the aforementioned study.
Based on the findings, researchers wrote, "Considering the role of COX-2 and IL-6, the novel methodology used in this study can also be developed as an assay for anti-inflammatory matrices for wound healing".
Taken altogether, honey processed high amount Chrysin (Chr) may be considered an anti-inflammatory remedy for the prevention and treatment of acute and chronic inflammation with no side effects, pending to the confirmation of large sample size and multicenter human study.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Repositing honey incorporated electrospun nanofiber membranes to provide anti-oxidant, anti-bacterial and anti-inflammatory microenvironment for wound regeneration by Sarkar R1, Ghosh A1, Barui A1, Datta P. (PubMed)
(2) An in vitro examination of the antioxidant, cytoprotective and anti-inflammatoryproperties of chrysin-loaded nanofibrous mats for potential wound healing applications by Deldar Y1,2, Pilehvar-Soltanahmadi Y1,3, Dadashpour M1,3, Montazer Saheb S1, Rahmati-Yamchi M2, Zarghami N. (PubMed)
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