Artichoke may be the generation whole food medicine for the treatment of colorectal cancer caused by oxidative stress, some scientists suggested.
Colorectal cancer is the chronic diseases associated with a malignant tumor in the colon or rectum.
Most cases of colorectal cancer start in the cells on the surface of the inner lining tissue of the colon or rectum.
Due to the slow growth in nature, most people with colorectal cancer do not experience any symptoms until the advanced stage.
Besides most common symptoms of cancer such as unintended weight loss and loss of appetite, late stage of colon cancer can induce symptoms of change of bowel movement, bloody stool and persistent abdominal discomforts, such as cramps, gas or pain.
If you experience some of the above symptoms, please contact your doctor to rule out the possibility of colorectal cancer.
In this stage, cancer cells can also travel a distance away to infect other healthy tissue and organs, leading to a second metastasis.
In the US, colorectal cancer is the third leading cause of cancer death. According to the statistic provided by the American Cancer Society, approximately, there were 97,220 new cases of colon cancer. 43,030 new cases of rectal cancer. in 2018.
The 5-year relative survival rate of localized colorectal cancer is about 92%. Therefore, people who are at a higher risk of colorectal cancer should have their bowel checked every year for preventive measure.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding potential and natural compound for the treatment of colorectal cancer examined the artichoke anticancer activity against DLD1 colorectal cancer cells.
The study included the extracts from wild and cultivated Cynara species obtained from their vegetative parts and receptacles were applied with five different doses from 0.1-1 mg/ml in three time periods (24, 48 and 72 hours) to the tested model.
At IC50 doses, all extracts demonstrated a significant cell apoptotic effect by stimulating the expression of a protein associated with tumor suppression.
Futhermore, at the same IC, artichoke extracts induced cancer cells death by activating the gene expression in regulating cell death.
Moreover, injection of artichoke extracts inhibited the protein involved cell survival and pro profiferative activity.
In other words, artichoke extracts increased the pro-apoptotic (BAX) gene expression and a cell cycle inhibitor (p21) against the tumor.
In the depth analysis, researchers also found that DNA fragmentation, the indication of cell death were also found in the tested DLD1 colorectal cancer cells.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of colorectal cancer, pending to the confirmation of larger sample size and multicenter human study.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) In vitro investigation of cytotoxic and apoptotic effects of Cynara L. species in colorectal cancer cells by Simsek EN1, Uysal T. (PubMed)
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