Pain is a natural reflex of the body caused by the distress signal due to intense or damaging stimuli, transmitted by the central nervous system with an aim to protect against damage.
However, according to pain management, pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage.
In other words, pains can be are transmitted by the CNS due to the previous pain experience, including false alarms.
Pain can be classified into several types, including
* Nociceptive pain arises due to the actual damage of the body tissue transmitted by the nerves to the brain.
* Neuropathic pain arises from damage to the nervous system, caused by actual damage to nerves cells or neurons.
Chronic pain is a pain that lasts more than 3 months. There is a general belief that people who fatigue, sleep disturbance, decreased appetite, and mood changes, often also accompanied by chronic pain.
Pain relief is the use of a substance including medicines for reducing pain.
Conventionally, the goal of treatment of chronic pain is to reduce pain and improve function, so the person can resume day-to-day activities. In other words, the aim of treatment in conventional treatment is to improve the quality of life and physical activity by managing the pain in such a way depending on types of chronic pain.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound which processes pain relief property with no side effects researchers investigated the effects of prophylactic administration of zerumbone (Zer, ginger) on allodynia and hyperalgesia in a mouse model of chronic constriction injury (CCI)-induced neuropathic pain.
According to the tested assays, injection of Zer at the doses of 10 and 50 mg/kg attenuated pain symptoms on all days without any signs of sedation in the rotarod test at ED50 values.
The same doses also decreased the mechanical allodynia, cold allodynia, thermal hyperalgesia, and mechanical hyperalgesia were 9.25, 9.507, 8.289, and 9.801 mg/kg, respectively.
According to the blood sample, the efficacy of ginger in the reduction of pain was probably associated with the inhibition of spinal levels of proinflammatory cytokines, including IL-1β, IL-6, and tumor necrosis factor-α.
Dr. Gopalsamy B, the lead scientist said, "Zer exhibits its antiallodynic and antihyperalgesic properties via reduced sensitization at nociceptor neurons possibly through the suppression of inflammatory mediators".
In order to reveal more information about ginger compounds associated with the pain relief, researchers examined -gingerol and -shogaol, two components of a processed Ginger extract, the traditional Japanese herbal medicine hangeshashinto (HST) in the inhibition of voltage-activated Na+ currents.
In animal study, T-gingerol and -shogaol inhibited the stimulant-induced release of substance P, a mediator of pain sensation and action potential generation in cultured rat sensory neurons.
In a rat OUM model, OUM-induced mechanical pain was alleviated 30min after the swab application of HST.
Furthermore, combined with ginseng, a swab application of a mixture of -gingerol. and -shogaol induced sufficient analgesia of OUM-induced mechanical or spontaneous pain.
Based on the finding, Dr. Hitomi S, the lead scientist said, "These findings suggest that Na+ channel blockage by gingerol/shogaol plays an essential role in HST-associated analgesia of OUM-induced pain".
Take all together, ginger processed a high amount of bioactive compounds -gingerol. and -shogaol may be used alone or combined with other herbal remedies for the treatment of pain, pending to the confirmation of large sample size and multicenter human study.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
(1) Antiallodynic and antihyperalgesic activities of zerumbone via the suppression of IL-1β, IL-6, and TNF-α in a mouse model of neuropathic pain by Gopalsamy B1, Farouk AAO1, Tengku Mohamad TAS1, Sulaiman MR1, Perimal EK. (PubMed)
(2) -gingerol and -shogaol, active ingredients of the traditional Japanese medicine hangeshashinto, relief oral ulcerative mucositis-induced pain via action on Na+ channels by Hitomi S1, Ono K2, Terawaki K3, Matsumoto C3, Mizuno K3, Yamaguchi K4, Imai R3, Omiya Y3, Hattori T3, Kase Y3, Inenaga K. (PubMed)
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