Herbal Bilberry, Protect the Brain Cell Against Memory Impairment

Memory impairment is a condition associated with a slow decline in memory, thinking and reasoning skills. Over time, the condition can worsen enough to affect the quality of life and daily activity.

Memory loss can be temporarily forgotten, such as forgetting to pay a monthly bill and permanent such as no longer know your name. Many factors can cause memory change. However, memory impairment in the elderly in most cases is associated with a gradual loss and death of neurons such as Alzheimer's disease.

Some memory change can be resolved on their own or cured by medical treatment. Others due to the loss of neuron and quantity capacity cannot be revered such as dementia.

According to statistics, dementia affects 47.5 million people worldwide. Every year over 7.7 million new cases are diagnosed. The disease is a leading cause of dependency and mental impairment among the elderly population.

The aim of the treatment of irreversible memory impairment is to improve the quality of life by delaying the progression of underlying diseases such as AD and PD.


Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.

The plant berry has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.

With an aim to find a potential compound for the treatment of memory deficits, with no side effects compared to those of conventional medicine, researchers examined the effects of anthocyanin pigments, a group of flavonoids, and a widespread class of phenolic compounds found abundantly in bilberry.

The study included the examination of elevated plus-maze and radial maze tasks cognitive performance fed approximately 3.2 mg kg(-1)day (oral) the anthocyanins. The lyophilized berries were administered for 30 days before the first training.

According to the step-down inhibitory avoidance, open field analysis, lyophilized berries significantly enhanced short-term memory, but not long-term memory and induced an increase in the number of crossings in the first exposure to the open field.

Interestingly, prolonged treatment with lyophilized berries did not have any significant effects in the elevated plus-maze task but improved working memory in the radial maze, with significant differences observed during sessions 1-2 and 4, but did not alter reference memory in this task.

Researchers after taking into account co and confounders wrote in the final report, "These results suggest that lyophilized berries may be beneficial in the prevention of memory deficits, one of the symptoms related to AD, and corroborate previous findings showing that flavonoids present effects in several learning paradigms".

In other words, the efficacy of bilberry protects the memory function against the onset of deficits was attributed by the bioactive compound anthocyanin.

Taken altogether, bilberry processed abundantly bioactive compound anthocyanoside may be considered a functioning remedy for the prevention and treatment symptom of memory deficits in patients with AD, pending to the validation of larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Effect of lyophilised Vaccinium berries on memory, anxiety and locomotion in adult rats by Ramirez MR1, Izquierdo I, do Carmo Bassols Raseira M, Zuanazzi JA, Barros D, Henriques AT. (PubMed)