Posted by Chantel Martiromo. research contributed by PubMed
The anthraquinones emodin and aloe-emodin are abundant in rhubarb.
Several lines of evidence indicate that emodin and aloe-emodin have
estrogenic activity as phytoestrogens. In the study to investigate the effects and molecular mechanisms of emodin and aloe-emodin on breast cancer cell proliferation, posted in PubMed, showed that both emodin and aloe-emodin are capable of inhibiting breast cancer cell
proliferation by downregulating ER α protein levels, thereby
suppressing ER α transcriptional activation. Furthermore, aloe-emodin
treatment led to the dissociation of heat shock protein 90 (HSP90) and
ER α and increased ER α ubiquitination. Although emodin had similar
effects to aloe-emodin, it was not capable of promoting HSP90/ER α
dissociation and ER α ubiquitination. Protein fractionation results
suggest that aloe-emodin tended to induce cytosolic ER α degradation.
Although emodin might induce cytosolic ER α degradation, it primarily
affected nuclear ER α distribution similar to the action of estrogen
when protein degradation was blocked. In conclusion, our data
demonstrate that emodin and aloe-emodin specifically suppress breast
cancer cell proliferation by targeting ER α protein stability through
distinct mechanisms. These findings suggest a possible application of
anthraquinones in preventing or treating breast cancer in the future.
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