During the last stage of the menstrual cycle, normally a layer of endometriosis lining on the inside of the uterus is expelled, known as menstruation blood, instead some of the endometriosis tissues grow somewhere in the body to cause endometriosis. Endometriosis also react to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through menstrual period.
1. Nervous system(530)
Valerian helps to treat insomnia and other kinds of sleeping disorder by calming the overactive nervous system caused by excessive or synchronous neuronal activity in the brain as resulting of hormonal imbalance between estrogen and progesterone during menstrual cycle.
Intake of valerian is said to have a property like benezodiazepine drugs, because it is highly sedative which helps to reduce the tension of nervous system(532)(533) such as insomnia, anxiety, and depression during menstrual cycle(530)(534).
2. Intake with vitamin C
Study showed that daily intake of vitamin C from food sources may reduce risk of endometriosis(538). Some women saw no effect of valerian in treating their symptoms of endometriosis(539) because of digestive problem(540). Intake of valerian with vitamin C will help to improve its absorption5401) and enhance the effectiveness.
3. Essential oils
The essential oils made from valerian have a calming effect in abdominal pain. By placing some oils on the skin of the abdomen and gently massage until the oil is completely absorbed will help to relieve the menstrual pain, probably because of its antispasmodic effects(531).
4. Improve liver function(535)
Valerian contains alcohol dehydrogenase (ADH) in alcohol metabolism that helps to break down enzyme in the liver cells. It is important for women with endometriosis who also have a history of drinking problems. By avoiding the alcohol damage to the liver, valerian helps to strengthen the liver in metabolisms of fatty acids(536), and protein(537) that lessen risk of menstrual symptoms.
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(530) Herbal extracts and phytochemicals: plant secondary metabolites and the enhancement of human brain function by Kennedy DO1, Wightman EL.(PubMed)
(531) Effects of valerian on the severity and systemic manifestations ofdysmenorrhea by Mirabi P1, Dolatian M, Mojab F, Majd HA.(PubMed)
(532) Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation by Nam SM1, Choi JH, Yoo DY, Kim W, Jung HY, Kim JW, Kang SY, Park J, Kim DW, Kim WJ, Yoon YS, Hwang IK.(PubMed)
(533) Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial by Hassani S1, Alipour A, Darvishi Khezri H, Firouzian A, Emami Zeydi A, Gholipour Baradari A, Ghafari R, Habibi WA, Tahmasebi H, Alipour F, Ebrahim Zadeh P.(PubMed)
(534) A double-blind, placebo-controlled investigation of the effects of two doses of a valerian preparation on the sleep, cognitive and psychomotor function of sleep-disturbed older adults by Diaper A1, Hindmarch I.(PubMed)
(535) Valeriana jatamansi partially reverses liver cirrhosis and tissue hyperproliferative response in rat by Prasad R1, Naime M, Routray I, Mahmood A, Khan F, Ali S.(PubMed)
(536) Apolipoprotein E isoforms disrupt long-chain fatty acid distribution in the plasma, the liver and the adipose tissue of mice by Conway V1, Larouche A2, Alata W3, Vandal M4, Calon F4, Plourde M5.(PubMed)
(537) Dynamism of rat liver ornithine metabolisms in relation to dietary high-protein stimulation of the urea cycle by Matsuzawa T, Sugimoto N, Ishiguro I.(PubMed)
(538) A prospective cohort study of Vitamins B, C, E, and multivitamin intake and endometriosis by Darling AM1, Chavarro JE2, Malspeis S3, Harris HR4, Missmer SA5.(PubMed)
(539) Antioxidant supplementation reduces endometriosis-related pelvic pain in humans by Santanam N1, Kavtaradze N, Murphy A, Dominguez C, Parthasarathy S.(PubMed)
(540) [Vitamin C treatment of digestive disorders from intolerance to PASabsorption].[Article in Undetermined Language] by PICHAT.(PubMed)