Cruciferous Vegetables in the Prevention and Treatment of Colorectal Cancer

The colon-rectum formed a part of the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.

Colorectal cancer is a medical condition caused by cell growth irregularly in the tissue of the colon or rectum due to the alternation of cells DNA.

Colorectal cancer is relatively very common and slowly progressing cancer.

Overall, the lifetime risk of colorectal cancer developing is 1 in 22 (4.49%) in men and 1 in 24 (4.15%) in women.

According to the statistics provided by the American Cancer Society, in the US, colorectal cancer is the third most common cancer diagnosed in both men and women compared to other types of cancer.

The lifetime risk of colorectal cancer is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.

Approximately, 140,000 cases of colorectal cancer were diagnosed in the US in 2018. Colorectal cancer also causes the death of over 50, 000 people, representing 8.3% of total cancer death.


In general, the 5-year survival rate for people with colorectal cancer is 65%. However, the 5-year survival rate of localized colorectal cancer is about 90%.

Being overweight or obese. smoking, physical inactivity, excessive alcohol drinking, aging, family and personal history, genetic preposition are some of the prevalent risks of the disease.

Cruciferous vegetables are a group of vegetables, belongings to the family Brassicaceae (also called Cruciferae) with many genera, species, and cultivated all over the world in suitable climate for commercial profits, including cauliflower, cabbage, kale, garden cress, bok choy, broccoli, Brussels sprouts, and green leafy vegetables.

On finding a potential compound for the treatment of cancer, researchers examined the effects of cruciferous vegetables and their active compounds on colorectal cancer.

According to the dietary information, cruciferous vegetables modulated microRNAs (miRNAs) expression in the cancer cells and exerted chemo-preventive effects against colorectal cancers.

Cruciferous vegetables also interacted with the cancer-related gene and relevant signaling pathways to induce apoptosis and cytotoxicity.

Furthermore, by inhibiting the miRNAs expression associated with cancer biomarkers, cruciferous vegetables improved the diagnostic and prognostic biomarkers and utilized in cancer therapeutics.

Based on the findings, researchers wrote, "it is very possible that natural agents (not limited to those in cruciferous vegetables) enhance cancer therapeutic efficacy and elicit chemopreventive effects through modulating key miRNAs".

Taken altogether, cruciferous vegetables may be considered functional foods for the prevention and treatment of colorectal cancer, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cruciferous vegetables and colorectal cancer prevention through microRNA regulation: A review by Pan JH1, Abernathy B2, Kim YJ3, Lee JH3, Kim JH3, Shin EC4, Kim JK. (PubMed)